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RISS 인기검색어
- 검색키워드
- 저자 : 정현화(Hyun Wha Jeong) (검색결과 3 건)
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김준현(Joon Hyun Kim),신정국(Jeong Kuk Shin),정현화(Hyun Wha Jeong),박기옥(Ki Ok Park),유창현(Chang Hyun Yoo) 대한소화기학회 1996 대한소화기학회지 Vol.28 No.4
N/A Background/Aims: In research field, a depancreatized animal model is used for the study of diabetes, evaluation of the proper effect of pancreas on systemic organs, and pancreas/islet transplantation. Owing to the diffuse nature of rat pancreas, complete removal is difficult. Total pancreatectomy has been carried out with success by Foglia and Scow, which is serious and uncertain in its results. It should bring about rapid death of the animal in the absence of supplementary treatment. In the conventional rubbing technique using cotton-tipped applicators, the most serious complication was gastric distention. A new experimental model of surgical diabetes with total pancreatectomy was devised, which used classic surgical procedure and overcomed the complication of gastric distention. Methods: Two groups of Sprague Dawley rats weighing 250 to 300 g were studied: group 1, conventional technique of Scow-20 rats; group 2, new technique-20 rats. In group 2, two weeks before pancreatectomy side-to-side antiperistaltic gastrojejunostomy and ligation of pyloric ring were performed to prevent postoperative gastric distention. We compared operative mortality, complications, blood glucose levels, and survival period between two groups. The Chi-Square test was used to determine the statistical significance of differences. Results: Our model of total pancreatectomy results in less coplications and mortality rate(group 1:7/20; group 2:2/20), and longer median survival period than Scows technique (group 1:5 days; group 2:15 days) and diabetes is produced in both group. Conclusions: We believe that the procedure described here is an improvement, as it produces surgical diabetes safely. (Korean J Gastroenterol 1996; 28:549 - 555)
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임상 연구 : 복막투석환자에서 복강 내 칼시트리올 충격요법의 부갑상선 호르몬 억제효과
송호철 ( Ho Cheol Song ),유선홍 ( Sun Hong Yoo ),정현화 ( Hyun Wha Jeong ),김용균 ( Yong Gyun Kim ),신석준 ( Seok Joon Shin ),김병수 ( Byung Soo Kim ),김영옥 ( Young Ok Kim ),김용수 ( Yong Soo Kim ),최의진 ( Euy Jin Choi ) 대한신장학회 2008 Kidney Research and Clinical Practice Vol.27 No.6
목적: 투석중인 말기신부전 환자에서 신성 골이양증은 중요 합병중에 하나이며 이의 치료를 위해 칼시트리올이 주로 사용되고 있다. 혈액투석의 경우 칼시트리올 정주요법이 많이 연구되고 임상에서 사용되고 있으나 복막투석 환자의 경우 정주요법의 한계로 인하여 정주요법 보다는 경구요법과 복강 내 주입이 임상에서 시도 되고 있다. 특히 복강 내 주사의 경우 경구요법의 대안으로 제시되고 있으나 아직 이에 대한 치료방법이 확립되지 않은 실정이다. 이에 본 연구에서는 복막투석중인 환자를 대상으로 하여 복강 내 칼시트리올 충격요법의 효과와 부작용의 발생빈도를 알아보고자 이 연구를 시행하였다. 방법: 2006년 1월부터 2007년 1월까지 가톨릭대학교 성가병원에서 6개월 이상 안정적으로 복막투석중이며 연구에 동의한 자를 대상으로 하였고, iPTH의 측정치가 300 pg/mL 이상의 환자를 대상으로 연구를 진행하였다. 대상환자는 한번에 2 ㎍씩 주 2회 복강내로 칼시트리올을 투여하였다. 연구기간 중 고칼슘혈증 (>10.5 mg/dL)과 고인산혈증 (>6.5 mg/dL)의 발생시 연구에서 제외하였다. 결과: 대상환자 18명중, 복막염과 고인산혈증으로 각각 1명이 연구에서 제외되었다. 대상환자의 원인질환은 당뇨병성 신증, 사구체신염, 고혈압증 신증이었다. 3개월간의 복강내 칼시트리올주입 후 iPTH측정치가 투여 전 (490±234 pg/mL)에 비해 3개월 투여 후 (318±315 pg/mL) 의미 있게 감소하였다 (p<0.05). 3개월 동안의 복강 내 투여기간 중 고칼슘혈증은 발생은 없었으며, 1명에서 고인산혈증의 발생으로 연구에서 제외되었다. 투여 후 30% 미만으로 iPTH가 감소한 군이 30% 이상 감소한 군에 (반응군에) 비해 투여 전 iPTH가 유의하게 높았다 (p<0.05). 결론: 복막투석 환자에서 발생한 이차성 부갑상선의 치료에 복강 내 칼시트리올 충격요법은 비교적 낮은 부작용의 빈도로 치료할 수 있는 수단이며 확립된 치료방법을 위해 보다 많은 전향적 연구가 필요하리라 사료된다. Purpose: In hemodialysis patients with secondary hyperparathyroidism, intravenous administration of calcitriol became widely utilized. In CAPD patients, however, the intravenous administration of calcitriol is not practical. The purpose of the present study was to determine the effect and safety of intraperitoneal (IP) calcitriol pulse therapy in CAPD patients. Methods: All patients undergoing CAPD between January 2006 and January 2007 and willing to give informed consent were eligible. Inclusion criteria were age greater 18 years, on CAPD for at least 6 months, and secondary hyperparathyroidism (intact PTH >300 pg/mL). Intraperitoneal calcitriol was given by direct infusion into the dialysate (2.0 ㎍) twice per week. If hypercalcemia (>10.5 mg/dL) and hyperphosphatemia (>6.5 mg/dL) developed, the patients were excluded from study. Results: Eighteen patients were enrolled into the study. Among them, 16 patients completed the study period. After IP calcitriol for 3 months, there was a significant drop of iPTH level from the pretreatment level of 490±234 pg/mL to the level of 318±315 pg/mL (p<0.05). There were no definite hypercalcemia during the study period, and only 1 patient was excluded from study due to hyperphosphatemia. Conclusion: In CAPD patients, IP calcitriol pulse therapy is effective in treating secondary hyperparathyroidism, and that IP calcitriol pulse therapy is associated with a low incidence of hypercalcemia and hyperphosphatemia.
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비스테로이드성 소염진통제의 장기 사용으로 유발된 하행십이지장 협착 1 예
박수헌,김진일,임동준,정인식,김재광,정규원,선희식,최규용,지정선,정현화,백창렬,노치호,민도준,한준열 대한소화기내시경학회 2001 Clinical Endoscopy Vol.23 No.2
In endoscopic clinical research studies of patients who take NSAIDs, 10% to 20% of patients develop gastric ulcers and 4% to 10% develop duodenal ulcers. Ulcers associated with chronic NSAIDs use are typically painless and are located in the prepyloric region of the stomach. These characteristics make NSAIDs potential causes of gastric outlet obstruction. There were multiple cases of single or multiple strictures that were found in the esophagus, small bowel and colon. Most of duodenal strictures were confined to bulbar area. Only one case of duodenal second portion diaphragmlike stricture was reported in association with acetylsalicylic acid. We experienced one case of chronic NSAIDs induced duodenal 2nd portion stricture in ankylosing spondylitis and rhemathoid arthritis patient and reported with a review of literature.
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