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Fuzzy-Basian법에 의한 R.C도로교의 신뢰성 및 안전도평가
정철원 ( Jung Chul-won ),이중빈 ( Lee Cheung-bin ),나기현 ( Na Gi-hyun ),박주원 ( Park Ju-won ) 한국구조물진단유지관리공학회 1997 한국구조물진단유지관리공학회 학술발표대회 논문집 Vol.1 No.1
In this paper, an attempt is made to apply the concept of Fuzzy-Bayesian theory to the Reliability Analysis of R.C(Reinforced Concrete) Bridge, uncertainty states are represented in terms of fuzzy sets which define several linguistic variables such as “good”, “average”, ”poor”, etc. Especially, the concept of fuzzy conditional probability aids to derive a new reliability analysis which includes the subjective assessment of engineers without introducing any additional correction factors. Several numerical examples are presented to illustrate the method proposed herein.
정철원 ( Jung Chul-won ),윤병조 ( Yun Boung-jo ) 한국구조물진단유지관리공학회 1998 한국구조물진단유지관리공학회 학술발표대회 논문집 Vol.2 No.1
Failure probabilities can be estimated by a variety of methods such as FOSM(first order, second moment), AF0SM(advanced FOSM), etc. These methods require the evaluation of the derivatives of the failure equation, which is difficult and even impossible in many situations. In this paper PEM(point estimation technique) is described by which the failure probability could be obtained using the values of the failure function alone evaluated at a number of preselected points. Depending on the number of variables in the problem, the number of points for the function evaluation could be large. To identify the stability of cantilever retaining wall in safe state by the deterministic method, these potential modes of such geotechnical failures as overturning, horizontal sliding and bearing capacity are analyzed using PEM.
다양한 산화물 기판 위에 RF 마그네트론 스퍼터링 방법으로 성장된 ZnO 박막의 특성 비교
이재욱,정철원,한석규,최준호,홍순구,조형균,송정훈,이정용,Lee, Jae-Wook,Jung, Chul-Won,Han, Seok-Kyu,Choi, Jun-Ho,Hong, Soon-Ku,Cho, Hyung-Koun,Song, Jung-Hoon,Lee, Jeong-Yong 한국전기전자재료학회 2007 전기전자재료학회논문지 Vol.20 No.4
ZnO thn films are grown on five kinds of oxide substrates including $c-Al_2O_3(0001),\;r-Al_2O_3(01-12)$, MgO(100), MgO(111), $NdGaO_3(110)$ by rf magnetron sputtering and effects substrate types on properties of ZnO thin films ate investigated. In order to compare the substrate effects one growth condition is selected and all the films are grown by the same growth condition. Structural and optical properties of the ZnO films ate different depending on the substrates although the films ate not epitaxial but polycrystalline. The ZnO film grown on $NdGaO_3(100)$ substrate shows the best overall properties among the films grown on substrates investigated in this study.
손상균 ( Sang Kyun Sohn ),정철원 ( Chul Won Jung ),조덕연 ( Deog Yeon Jo ),정준원 ( June Won Cheong ),대한혈액학회만성골수성백혈병연구회 ( Chronic Myelogenous Leukemia Working Party The Korean Societ ),김대영 ( Dae Young Kim ),이정옥 ( 대한내과학회 2015 대한내과학회지 Vol.88 No.4
Background/Aims: The first edition of the Korean treatment guidelines for chronic myelogenous leukemia (CML) was published in 2006. We intend to update those guidelines to include the use of next-generation tyrosine kinase inhibitors (TKIs). Methods: New guidelines were developed in 2012 based on the results of a survey and a consensus meeting of various Korean experts, the reports of recent clinical studies, and updated guidelines from external study groups. Results: An assessment of risk factors is strongly recommended before treating newly diagnosed chronic phase CML. Imatinib, dasatinib, and nilotinib are reimbursable in Korea as first-line treatments, and the patient`s age, comorbidities, and possible adverse events should be considered in the choice of treatment. Molecular studies are recommended for assessing treatment efficacy instead of invasive cytogenetic response evaluations, and an early response is believed to correlate with a good prognosis. Second-line TKIs can be considered for patients who fail or are intolerant of first-line therapy, pending analysis of ABL tyrosine kinase mutation status. For treating advanced stages, a combination of TKIs with cytotoxic agents and hematopoietic cell transplantation is recommended. The adverse effects of TKI therapy can be managed via dose reduction and supportive care, or switching to an alternate TKI. Conclusions: The use of TKIs has improved the outcome of CML treatment. Treatment-free remission after discontinuing TKIs might be possible in select patients who achieve sufficient response, indicating that curative treatment for CML can be expected in the future.
Fuzzy 개념을 이용한 RC도로교의 건전성평가 모델 개발
나기현,박주원,이증빈,정철원,Na, Ki-Hyun,Park, Ju-Won,Lee, Cheung-Bin,Jung, Chul-Won 한국구조물진단유지관리공학회 1998 한국구조물진단유지관리공학회 논문집 Vol.2 No.2
In this study, an attempt is made to apply the concept of fuzzy-bayesian theory to the integrity assessment of RC highway bridge, and uncertainty states are represented in terms of fuzzy sets which define several linguistic variables such as "very good", "good", "average", "poor", "very poor", etc. Especially, the concept of fuzzy conditional probability aids to derive a new reliability analysis which includes the subjective assessment of engineers without introducing any additional correction factors. The fuzzy concept are also used as reliability indexes for the condition assessment based on the proposed models, the proposed fuzzy theory-based approach with the results of visual inspection and extensive field load tests are applied to the integrity assessment of a new RC highway bridge, namely, Jichok bridge.
송서영(Seo Young Song),김원석(Won Seog Kim),이혜란(Hye Ran Lee),정현식(Hyun Sik Hyun),이남수(Nam Su Lee),오성용(Sung Yong Oh),김지향(Ji Hyang Kim),김기현(Ki Hyun Kim),남은미(Eun Mi Nam),오영륜(Young Ryun Oh),정철원(Chul Won Jung),윤성수 대한내과학회 2001 대한내과학회지 Vol.61 No.3
N/A Background : To study clinical characteristics and treatment outcomes of adenocarcinoma of unknown primary site (ACUPS). Methods : A retrospective analysis of 81 patients who were diagnosed as ACUPS, seen at Samsung Medical Center from May, 1995 to July, 1999, was performed. Results : The median age of the patients was 58 years. The common sites of metastases were the lymph node, liver, lung, bone. In 49 of 81 patients (60.5%), the dominant tumor location was below the diaphragm. The majority of patiens (76 of 81) were initially treated with systemic chemotherapy including cisplatin. Responses were evaluable in 70 of 76. Eighteen of 70 patients (25.7%) responded to chemotherapy and complete remission was observed in 6 patients. The overall median survival of 81 patients was 5.6 months. The median survival of the responding patients was 18.3 months but the median survial of the nonresponding patients was 4.6 months (p<0.01). In univariate and multivariate analysis, age, performance status and response to initial chemotherapy were significant prognostic factors for overall survial. Conclusion : Poor survival rate and treatment response were observed in ACUPS but complete response and long-term survival were observed in several patients.(Korean J Med 61:234-239, 2001)
증례 : 혈액종양 ; Micafungin을 투여받은 백혈병 환자에서 발생한 Trichosporon 감염증
손서영 ( Seo Young Sohn ),노정원 ( Jung Won Noh ),이가연 ( Ga Yeon Lee ),장복순 ( Bok Soon Chang ),김동환 ( Dong Hwan Kim ),장준호 ( Jun Ho Jang ),정철원 ( Chul Won Jung ) 대한내과학회 2009 대한내과학회지 Vol.77 No.5S
T. ashaii 감염증은 주로 혈액 종양 환자에서 항암 치료 후 발생하는 기회감염증으로 치명적인 경과를 취한다. 최근 호 중구 감소성 발열 환자에서 micafungin 사용 후 돌발성 T. ashaii 감염증이 보고된 바 있다. 생체 외 결과에서 T. ashaii는 azole 계통의 새로운 항진균제에 감수성이 있는 것으로 나타났으나 사람에서 발생한 감염증을 효과적으로 치료한 예는 드물다. 본 저자들은 voriconazole을 사용하여 성공적으로 T. ashaii 감염증을 치료한 1예를 경험하여 보고하는 바이다. Micafungin is a recently approved echinocandin with broad spectrum activity against Candida and Aspergillus species. However, this agent has limited activity against a number of fungi, including Trichosporon. We report a case of Trichosporon asahii fungemia in a 65 year old woman with acute myeloid leukemia that developed after 10 days of empirical micafungin therapy. Trichosporonosis was successfully treated with voriconazole and she achieved complete hematologic remission. After consolidation therapy, T. ashaii fungemia redeveloped, despite empirical amphotericin therapy for neutropenic fever. This was also controlled successfully with voriconazole. Because the use of micafungin is expected to increase, due to its effective antifungal activity, the possibility of breakthrough trichosporonosis should be considered in patients receiving micafungin. Voriconazole may be effective in controlling disseminated T. ashaii infection in neutropenic patients. (Korean J Med 77:S1318-S1322, 2009)