1,3-Dichloro-2-Propanol (1,3-DCP)에 의한 세포의 손상기전

정지학 ( Ji Hak Jeong ),신익재 ( Ik Jae Sin ),신영민 ( Yeong Min Sin ),박흥재 ( Heung Jai Park ),안원근 ( Won Gun An ) 한국환경과학회 2007 한국환경과학회지 Vol.16 No.2

저근백피 추출물이 유선암 세포에서의 신생혈관 형성에 미치는 영향

정지학(Ji Hak Jeong),윤용갑(Young Gab Yun),전병훈(Byung Hun Jeon),박혜련(Hae Ryoun Park),안원근(Won Gun An) 한의병리학회 2004 동의생리병리학회지 Vol.18 No.6

임신중 발생한 난소종양의 임상적 고찰

서정욱(Jeong Wook Seo),노정훈(Jeong Hoon Rho),오관영(Kwan Young Oh),박미혜(Mi Hye Park),김은경(Eun Kyung Kim),양윤석(Yun Seok Yang),황인택(In Taek Hwang),정지학(Ji Hak Jung),박준숙(Joon Sook Park) 대한산부인과학회 2000 Obstetrics & Gynecology Science Vol.43 No.9

목적 : 임신 중 동반된 자궁부속기종양에 대한 임상양상 및 임신경과에 미치는 영향을 알아보고자 본 연구를 하였다.방법 및 재료 : 1995년 1월부터 1999년 12월까지 만 5년간 본원에서 경험한 임신 중 동반된 자궁부속기종양 69례를 분석하였다. 추적관찰 중 자연소멸되었거나 자궁외 임신과 동반된 경우는 제외되었다. 임상양상을 조사하였으며 임신 중 수술적 처치 및 보존적 치료가 임신경과에 미치는 영향을 분석하였다. 결과 :1. 발생빈도는 같은 기간의 총 분만수 10,550예에 69례로 1:153(0.65%)이었고 악성으로는 1예(1/10,550)의 점액성 경계성 종양이 발견되었다. 2. 연령은 25세∼29세군이 가장 많았으며(42.0%) 다산모보다 초산모에서 더 흔했다.(59.4%:40.6%)3. 난소종양으로 인한 합병증은 염전이 10예(14.6%)로 가장 많았으며 기타 출혈이나 파열의 예는 없었다.4. 진단시기는 임신 제 1삼분기가 53.6%, 제 2삼분기가 14.5%, 제 3삼분기가 31.9%였고 진단방법은 초음파와 내진에 의하였으며 제왕절개수술중 우연히 발견된 경우도 20예(29.0%)였다. 5. 수술시기는 제왕절개술중 우연히 발견된 20예를 제외하고 제 1삼분기에 67.6%, 제 2삼분기에 24.3%, 제 3삼분기에 8.1%순이었다.6. 총 69예중 제왕절개수술중 우연히 발견된 20예와 난소종양수술과 동시에 인공유산시킨 22예를 제외한 27예에서 이중 18예는 수술적 처치로 나머지 9예에서는 비수술적 요법으로 치료받으며 임신의 경과를 관찰했다.7. 임신경과는 수술적 처치를 받은 군(18예)에서 만삭질식분만이 12예(66.7%), 만삭 제왕절개수술이 5예(27.8%), 조산이 1예였으며 평균 분만주수는 38.8주였다. 비수술군(6예)에서는 만삭질식분만이 1예(16.7%), 만삭제왕절개수술이 4예(67.0%), 조산이 1예였다.8. 병리조직학적 소견으로는 양성 낭성기형종이 35.7%, 점액성 낭선종이 22.9%, 장액성 낭선종이 14.3%, 단순낭종이 14.3%였다.9. 제왕절개수술이 32예에서 행해졌는데 25례에서 산과적 이유로, 나머지 7예에서 난소종양을 주소로 수술하였다.결론 : 최근 산전진찰에 초음파의 이용으로 임신 중 자궁부속기종양의 발견율이 증가하는 추세이며 이의 처치에 있어서 임신에 미치는 영향을 고려할 때 방법의 선택에 있어 신중을 기해야 한다. 본 논문은 임신 중 자궁부속기종양의 임상양상을 조사하였으며 수술적, 비수술적 처치 및 수술시기가 임신의 경과에 미치는 영향을 비교, 분석하였다. Objective : Our purpose was to evaluate the clinical appearance and outcome of pregnancy associated with ovarian tumors. Methods : A review was performed of patients who were seen with an ovarian tumor in pregnancy from January 1995 to December 1999. We excluded ovarian tumors that resolved spontaneously and were found simultaneously with ectopic pregnancy. Results : 1. The incidence of ovarian tumors in pregnancy was 69 in 10,550 deliveries.(1:153) One case of mucinous borderline malignancy was found. 2. The ovarian tumors occuring in pregnancy were the most common at 25 to 29 years old-pregnant women(42.0%) and more common in nulliparous pregnant women(59.4%) than in multiparous women.(40.6%) 3. The most common complication of ovarian tumors in pregnancy was torsion which is 10 cases(14.6%) 4. Pre-operative diagnosis of ovarian tumors was made in the first trimester(53.6%), second trimester(14.5%), and third trimester(31.9%) 5. Excluding the 20 cases of cesarean section, operation was performed at first trimester in 25cases(67.6%), at second trimester in 9 cases (24.3%), at third trimester in 3 cases (8.1%). 6. The surgical management was performed from 18 women and the conservative therapy was done at 6 cases. 7. According to the outcome of pregnancy, among 18 cases in which the ovarian tumor was removed, vaginal delivery occurred at term in 12 cases (66.7%), cesarean section in 5 cases(27.8%) and premature delivery in 1 case. Among the other cases in which conservative management was performed, term vaginal deliveries were done in 1 case(16.7%), cesarean section in 4 cases(67.0%) and premature delivery in 1 case(16.7%). 8. The histologic features of the exised ovarian tumors were benign cystic teratoma 25 cases (35.7%), mucinous cystadenoma 16 cases(22.9%), serous cystadenoma 10 cases(14.3%) and simple cyst 10 case(14.3%) 9. The cesarean section was performed in 32 cases including emergency operation. In 25 cases, common cause was due to obstetrical problem( elective repeat cesarean section, fetal malpresentation, labor disorder) and in the rest 7 cases was due to adnexal masses. Conclusion : Although the incidence of ovarian cancer in pregnancy is low, the incidental finding of an adnexal mass in pregnancy is more common. Because complications of surgery are increased in pregnancy, operative management needs to be considered. Our data was consistent with what has been reported clinical study to determine optimal management of an ovarian tumor in pregnancy.

임신 19 주에 선천성 후부 요도 판막 증후군 태아에서 시행된 방광 - 양막강 문합술 1 예

노정훈(Jeong Hoon Rho),박미혜(Mi Hye Park),임진섭(Jin Seob Lim),하중규(Joong Gyu Ha),오관영(Kwan Young Oh),양윤석(Yun Seok Yang),황인택(In Taek Hwang),정지학(Ji Hak Jeong),박준숙(Jun Sook Park) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.11

An ultrasonographic examination revealed increased fetal bladder size and decreased AFI as well as fetal bilateral hydronephrosis at 173 weeks` gestation. Diagnosis of the fetal posterior urethral valve syndrome was made. Percutaneous fetal bladder puncture with aspiration and amniocentesis was performed. The fetus was normal male karyotype and with a predicted good renal function(sodium concentration, chloride concentration, and osmolarity at 74 mEq/L, 60 mEq/L, and 148 mOsm, respectively). So, the fetus underwent amnioinfusion and vesico-amniotic shunting procedure (VASP) using a double-basket catheter at 194 weeks` gestation in order to prevent development of dysplastic kidneys and hypoplastic lungs. The healthy male baby was delivered at 384 weeks` gestation and had normally functioning kidney. Cutaneous vesicostomy was performed for the newborn since the urethral orifice was small. The one year old infant is now well and waiting for urethroscopic valve ablation procedure.

근치적 자궁절제술을 시행받은 자궁경부암 환자의 임상적 고찰

정성운(Seong Un Jeong),조성중(Sung Joong Cho),김장환(Jang Hwan Kim),이남우(Nam Woo Lee),김경진(Kyung Jin Kim),박미혜(Mi Hae Park),황인택(In Tak Hwang),정지학(Ji Hak Jung) 대한산부인과학회 1999 Obstetrics & Gynecology Science Vol.42 No.8

목적: 근치적 자궁절제술을 시행 받은 자궁경부암환자의 임상적 고찰을 통해 수술 후 치료 성적을 분석해 보고자 한다. 연구방법: 1983년 1월부터 1992년 12월까지 을지 대학병원에서 광범위 근치적 자궁절제술을 시행 받은 자궁경부암 환자 중 추적관찰이 가능했던 162예를 대상으로 하였다. 결과: 나이 분포는 40대와 50대, 30대순이었고 환자의 임상 병기 분포는 Ia기가 12예(7.4%), Ib기가 84예(51.9%), IIa기가 39예(24.1%) 그리고 IIb기가 27예(16.7%)였다. 조직 병리학적 형태는 편평상피세포암이 91.9%, 선암이 4.9%, 선편평암이 3.1%이고 골반 임파절 전이 빈도는 I기가 22.9%, II기가 31.8%였으며 전체 임파절 전이 빈도는 26.4%였다. 광범위 근치적 자궁절제술 후 방사선 치료의 빈도는 I기가 63.5%, II기가 75.8%였다. 재발율은 7.4%였고 가장 흔히 재발되는 부위는 질교합부였다. 우리는 또한 환자의 5년 생존율을 평가했는데 그 결과는 Ia기는 100%, Ib기는 95.2%(4예), IIa는 87.2%(5예), IIb는 77.8%(6예)였다. 결론: 연령별 환자의 분포는 40대와 50대가 30.9%로 가장 높은 발생 빈도를 보였고 임상 병기별 분포는 Ib기가 51.9%로 가장 많은 빈도를 보였으며 병리 조직학적 분포는 편평 상피 세포암이 91.9%로 대다수를 보였고 전체 임파절 전이빈도는 26.4%였으며 가장 흔한 재발부위는 질교합부였다. 5년 생존율은 Ia기가 100%, Ib기가 95.2%, IIa기가 87.2%, IIb기가 77.8%였다. Objective: The purpose of this study was to analyze the clinical study for patients with cervical cancer who had undergone radical hysterectomy. Method: The subjects of this study were one hundred and sixty two patients with cervical cancer who had undergone radical hysterectomy at Eulji Medical College Hospital, Taejon, Korea, from January 1983 to December 1992. We reviewed the medical record retrospectively and analyzed the data. Result: The distribution of patients by age was found in the order of 50 decade and 60 decade, 40 decade. Those by the clinical stages were as follows: Stage Ia, 12 cases(7.4%); Stage Ib, 84 cases(51.9%); Stage IIa, 39 cases(24.1%); Stage IIb 27 cases(16.7%). The results of histopathologic type were distributed as follows: squamous cell carcinoma was 91.9%, adenocarcinoma was 4.9% and adenosquamous cell carcinoma was 3.1%. The histologic subtypes of squamous cell carcinoma(149 cases) were as follows: Large cell non-keratinizing type was 75.9%, large cell keratinizing type was 14.8% and small cell type was 1.2%. The frequancy of lymph node metastasis was 22.9% in stage I and 31.8% in stage II. The overall incidence of lymph node metastasis was 26.4%. The frequency of external radiation therapy done after radical hysterectomy was 63.5% in stage I and 75.8% in stage II. The 5-year survival rate was as follows: The Ia was 100%; Stage Ib, 95.2%(4cases); Stage IIa, 87.2%(5cases); Stage IIb, 77.8%(6cases). The incidence of recurrence was 7.4% and recurrent sites were vaginal stump , rectum and pelvic wall. Conclusion: The highest incidence of cervix cancer in age distribution was 50 decade(30.9%) and 60 decade(30.9%). The most common clinical stage was Ib(51.9%) and most frequent pathologic type was squamous cell carcinoma(91.9%). The overall incidence of lymph node metastasis was 26.4% and The most common site of recurrence was vaginal stump. The 5-year survival rate was 100% in the stage Ia, 95.2% in the stage Ib, 87.2% in the stage IIa, 77.8% in the stage IIb.

CGH를 이용한 한국인 자궁경부 편평상피세포암 세포주의 염색체 DNA 변이 분석

오관영 ( Kwan Young Oh ),박수연 ( Soo Yun Park ),정지학 ( Ji Hak Jeong ),황인택 ( In Taek Hwang ),박준숙 ( Joon Sook Park ),박미혜 ( Mi Hye Park ),전선희 ( Shun Hee Chun ),김승철 ( Seung Chul Kim ),김종일 ( Jong Il Kim ) 대한산부인과학회 2005 Obstetrics & Gynecology Science Vol.48 No.3

목적: 비교 유전자 부합법 (comparative genomic hybridization, CGH)은 일종의 새로운 FISH 방법으로 기존의 세포유전학적 분석으로는 용이하지 않았던 모든 염색체 상의 상대적인 염색체 변이를 한번에 알 수 있게 해준다. 이에 본 연구를 한국인의 자궁경부 편평상피 세포암 세포주를 이용해 염색체 DNA 변이를 분석해 보고자 하였다. 연구 방법: 본 연구에서는 한국인 자궁경부 편평상피세포암 세포주 SNU-17, SNU-682와 Objective: Comparative genomic hybridization (CGH) is a new fluorescence in situ hybridization (FISH) technique to identify genomic aberrations in cancers. The purpose of this study was to analyze non-random chromosomal DNA aberrations involved in cervica

Methotrexate를 이용한 보존적 치료로 성공한 유착태반

이병관 ( Byung Kwan Lee ),강경화 ( Kyung Hwa Kang ),노정훈 ( Jeong Hoon Rho ),오관영 ( Kwan Young Oh ),양윤석 ( Yoon Seok Yang ),황인택 ( In Taek Hwang ),정지학 ( Ji Hak Jung ),박준숙 ( Joon Suk Park ) 대한산부인과학회 2005 Obstetrics & Gynecology Science Vol.48 No.2

Placenta accreta is a rare condition and is associated with considerable maternal morbidity and mortality. Though hysterectomy is a definitive therapy, there are some occasions that conservation of the uterus is desired by the patient and bleeding is not

외음부 평활근종 1예

조동식 ( Dong Sig Cho ),이관구 ( Kwan Koo Lee ),김경진 ( Kyung Jin Kim ),황인택 ( In Taek Hwang ),정지학 ( Ji Hak Jeong ) 대한산부인과학회 1997 Obstetrics & Gynecology Science Vol.40 No.12

Leiomyomas of the vulva are uncommonly reported. These tumor appear as a solitary firm mass varying in size. As a rule, Leiomyoma arise from the smooth muscle of the erectile tissue in the vulva, although they also arise from the round ligament of the uterus. We experienced a case of leiomyoma in vulva, and present it with a brief review of the literatures.

임신중 철분제제 투여가 임산부 혈색소치와 신생아 체중에 미치는 영향

황인택 ( In Taek Hwang ),박미혜 ( Mi Hye Park ),양윤석 ( Yun Seok Yang ),오관영 ( Kwoan Young Oh ),정지학 ( Ji Hak Jeong ),박준숙 ( Joon Suk Park ) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.7

N/A Objective :This study was performed to evaluate the effects of oral administration of iron supplements during pregnancy on maternal hemoglobin concentrations and birth weights. Method: Data from clinical records of 141 pregnant women and their babies were analysed. Studied mothers were classified to 3 groups such as non iron supplement group (group I ), 2-3 months supplement group (group II), and over 4 months supplement group (group III) by the duration (months) of oral supplement prescribed. Results : There was positive correlation between hemoglobin levels and iron supplement duration. Proportions of anemia showed decreasing basis with the increasing iron supplement duration. The maternal hemoglobin levels showed decreasing basis with the increasing birth weight. There was positive correlation between iron supplement duration and maternal hemoglobin levels, but there was no significant correlation between iron supplement duration and birth weight. For the group I (non-supplement group), maternal hemoglobin levels were decreased with the increasing birth weight but there was no significant correlations between hemoglobin levels and birth weights with increased iron supplement duration. Conclusion :There was a significant inverse correlation between matemal hemoglobin levels and birth weight in non-iron supplement group but there was no significant correlations between hemoglobin levels and birth weights with increased iron supplement duration.

폐경후 여성에서 척추 골밀도 변화에 대한 다변량 회귀분석

양윤석 ( Yun Seok Yang ),오관영 ( Kwoan Young Oh ),박미혜 ( Mi Hye Park ),황인택 ( In Taek Hwang ),정지학 ( Ji Hak Jeong ),박준숙 ( Joon Suk Park ) 대한폐경학회 2001 대한폐경학회지 Vol.7 No.1

N/A Objective : Using multiple linear regression models, We have determined the relationship between the dependent variables, spinal bone mineral density(BMD) and easily obtained biometrical variables in 250 postmenopausal women Method : The main outcome measures were patient`s age, menstrual and menopausal factors (age at menarche, age at menopause, duration after menopause), anthrophometric factors(height, weight, BMI), obstetric history(number of delivery, abortion and feeding). Dual energy X-ray absorptiometry(DXEA) was performed at L2-4 region of Lumbar spine in 250 postmenopausal women during the 2 year from June 1998 to June 2000. these data were analyzed using SPSSWIN 9.0 statistic program. Results : After stepwise multiple regression analysis, spinal BMD in postmenopausal women is 0.563-0.0077(duration of menopause, year)+0.0054(body weight, ㎏)(p<0.001, R2=0.30) Conclusion : This study suggests that multiple regression models examining determinants of bone density at the lumbar regions showed that prolonged duration of menopause and decreased body weight in postmenopausal women were statically significant predictors of bone demineralization.