소화기암 가족력이 소화기암 발생에 미치는 위험 평가

정주원 ( Joo Won Chung ),박재준 ( Jae Jun Park ),임윤정 ( Yun Jeong Lim ),이준 ( Jun Lee ),김선문 ( Sun Moon Kim ),한정호 ( Joung-ho Han ),전성란 ( Seong Ran Jeon ),이홍섭 ( Hong Sub Lee ),김용성 ( Yong Sung Kim ),송시영 ( Si You 대한소화기학회 2018 대한소화기학회지 Vol.71 No.6

Background/Aims: This study was performed to evaluate the relationship between family history of gastrointestinal (GI) cancers and incidence of any GI cancer in the Korean population. Methods: Between January 2015 and July 2016, 711 GI cancer patients and 849 controls in 16 hospitals in Korea were enrolled. Personal medical histories, life styles, and family history of GI cancers were collected via questionnaire. Results: There was a significant difference in the incidence of family history of GI cancer between GI cancer patients and controls (p=0.002). Patients with family history of GI cancer tended to be diagnosed as GI cancer at younger age than those without family history (p=0.016). The family members of GI cancer patients who were diagnosed before 50 years of age were more frequently diagnosed as GI cancer before the age of 50 years (p=0.017). After adjusting for major confounding factors, age (adjusted odds ratio [AOR] 1.065, 95% confidence interval [CI]; 1.053-1.076), male gender (AOR 2.270, 95% CI; 1.618-3.184), smoking (AOR 1.570, 95% CI; 1.130-2.182), and sibling’s history of GI cancer (AOR 1.973, 95% CI; 1.246-3.126) remained independently associated with GI cancers. Conclusions: GI cancer patients tended to have a first relative with a history of concordant GI cancer. Personal factors (old age and male) and lifestyle (smoking) contribute to the development of GI cancer, independently. Individuals with high risk for GI cancers may be advised to undergo screening at an earlier age. (Korean J Gastroenterol 2018;71:338-348)

N2 Nodal Stage의 결장직장암에서 재발에 대한 위험 인자

정주원(Joo-Won Jeong),이철민(Chul-Min Lee),이승현(Seung-Hyun Lee),안병권(Byung-Kwon Ahn),백승언(Sung-Uhn Baek) 대한종양외과학회 2012 Korean Journal of Clinical Oncology Vol.8 No.2

배경 : 결장직장암에서 림프절 전이 여부와 정도는 근치적 수술 후 발생하는 재발 및 전이를 예측하는 중요한 인자 중 하나이다. 결장직장암의 림프절 전이에 대한 병기가 N2인 경우에서 임상적 및 병리학적 인자에 따른 수술 후 재발 및 전이 여부를 조사하여 위험 인자를 알아보고자 한다. 대상 및 방법 : 2004년 1월부터 2006년 12월까지 결장 및 직장의 원발성 선암으로 진단되어 수술을 받은 675명의 환자 중 림프절 전이에 대한 병기가 N2인 환자 130명을 대상으로 하여 성별, 연령, 수술 전 암태아성항원, 종양의 위치, 종양의 크기 및 병기, 병리적 인자들을 조사하였다. 결과 : 림프절 전이에 대한 병기가 N2인 환자 중 근치적 절제수술을 받은 환자는 총 87명이었다. 성별 분포는 남자 43명, 여자 44명이었으며, 평균 연령은 60.3세(34~86세)였다. 종양의 위치는 결장 25예, 직장 62예였으며, 종양의 크기는 평균 5.8cm(2.0~19cm)이었다. TNM 병기 중 T병기는 T2, T3, T4가 각각 1예, 80예, 6예이었으며, 수술 후 획득된 림프절 수는 평균 21.1개(7~110개)였다. 추적 관찰 기간은 평균 30.5개월(5~48개월)이었으며, 이 중 재발 및 전이를 보인 경우는 34예(39.1%)였다. 성별, 종양의 크기, 수술 전 암태아성항원, 림프절 전이 비율, 종양 세포의 혈관 침습, 림프관 침습, 신경 침습 분포에 따른 재발 및 전이 여부에는 유의한 차이가 없었다. 결론 : 림프절 전이에 대한 병기가 N2 stage인 결장직장암에서 재발 및 전이에 대한 임상적 및 병리적 위험 인자를 찾을 수 없었다. 향후 대규모 환자들을 대상으로 면역화학적 혹은 유전자적 인자의 관련 여부에 대한 연구가 더 필요할 것이다. Purpose : The aim of this study is to figure out the clinicopathologic factors associated with recurrence in colorectal cancers with four or more lymph node metastasis (N2 stage). Material and Method : From 2004, Jan to 2006, Dec, a total of 675 patients with colorectal adenocarcinoma were underwent surgery in our hospital. One hundred thirty patients with N2 stage were selected for retrospective review with medical records. Clinicopatholotic factors, such as sex, age, preoperative CEA, tumor location, tumor size, tumor differentiation, T-stage, were studied. Results : Of the 130 patients, eighty-seven patients were underwent radical surgery for colorectal adenocaricinoma. Mean age was 60.6(34-86 years). Tumors were located in the colon, 25 patients and the rectum 62 patients. Mean tumor size was 5.8 (2.0-19cm). With TNM classification, T2, T3, T4 were 1, 80, 6 patients, respectively. Mean number of retrieved lymph node was 21.1(7-110). Mean follow-up period was 30.5 (5-48 months). Recurrence was identified in 34 patients (39.1%). According to tumor differentiation, recurrence rate was 36.8% of well and moderate differentiation, 54.5% of poor differentiation (p=0.327). Recurrence rate was 37.5% in T3 stage, and 66.7% in T4 stage (p=0.267). Conclusions : Recurrence rate was not different significantly according to clinicopathologic factors in colorectal adenocarcinoma with N2 stage after radical surgery. Further study is necessary to identify the risk factor for recurrence in colorectal adenocarcinoma with N2 stage.

일부 농천지역 노인들의 의료이용에 관한 연구

이정미 ( Jeong Mi Lee ),정주원 ( Joo Won Jeong ),길상선 ( Sang Sun Kil ) 전북대학교 의과학연구소 2001 全北醫大論文集 Vol.25 No.1

To find out the state of illness, patterns of medical care utilization, and factors which determine medical care utilization for the aged face-to-face interview survey was carried out for 4,410 the rural elderly who live in the Jeonbuk province from July 1.2000 to Sep, 30. The major findings of this study were as follows; 1. The morbidity rate of chronic illness during last 3 months was 53.7% for all surveyed the elderly; 59.9 for female and 48.0 for male. 2. As expected, 80 years old or above group showed the highest morbidity rate, 59.6% and the 65-69 years age group was the lowest, 49.1%. 3. The elderly whose family income is less than 490,000 won per month, and who receive benefits from the public medical assistance program had relative higher morbidity rate than other groups and the difference was statistically significant(p<0.01). 4. The most frequent chronic illness was arthritis disease and hypertensions, 33.3% and 25.1%. Need of medical care utilization of the elderly for 2 weeks is 51.2% and satisfaction of medical care utilization of the elderly is 83.8%. 5. 38.1% of 1,876 persons who were suffering from chronic illness were in need of medical care but unmet; among the remaining 61.9% who utilized medical care. 6. The elderly who are medical aid and whose family size is 1 less then per month zhowed relative higher utilization rate than other groups and the difference was statistically significant(p<0.01). 7. The most common reason why the aged did not utilize, in spite of, need medical care was tolerable symptom, 76.2%.

자발적인 운동 중에 생쥐 뇌의 해마 치아이랑에서의 calbindin-D28k 면역염색성의 시간적 변화

문민호(Minho Moon),정주원(Joo-Won Jeong),허영범(Youngbuhm Huh),김정혜(Junghye Kim),안희경(Heekyung Ahn),박 찬(Chan Park) 대한해부학회 2006 Anatomy & Cell Biology Vol.39 No.2

자발적인 운동은 성체의 해마 (hippocampus) 내 치아이랑 (dentate gyrus)에서 신경세포생성(neurogenesis)의 급격한 증가를 유발한다. 본 연구에서는 자발적인 운동에 의해 유도되는 치아이랑의 신경세포생성의 증가에 따른 기존 과립세포의 활성 변화를 calbindin-D28k에 대한 면역조직화학법을 이용하여 관찰하였다. 먼저 운동 중에 변화하는 치아이랑의 신경줄기세포의 분열과 분화의 양상을 관찰하기 위하여 Ki-67과 doublecortin에 대한 면역염색을 시행하였다. 그 결과 Ki-67에 염색된 세포의 수는 1주 운동군에서 가장 많았고 6주 운동군에서는 1주 운동군에 비하여 감소하였으나, 대조군에 비하여 증가하는 경향을 보였다. 새로 형성된 과립세포를 보여주는 doublecortin에 대한 염색성은 1주 운동군에서 증가하고 6주 운동군에서는 1주 운동군에 비하여 감소하였다. 또한 치아이랑과 CA3 영역을 연결하는 mossy fiber에 염색된 doublecortin의 염색성도 1주 운동군에서 가장 높았다. 이는 운동에 의하여 새로운 과립세포의 형성이 운동 초기에 많이 일어나고 있음을 보여준다. 성숙한 과립세포의 활성을 보여주는 calbindin-D28k의 치아이랑의 과립세포층에서의 염색성은 1주 운동군에서 유의한 감소를 나타냈으며, 6주 운동군에서는 대조군의 염색정도로 회복하는 경향을 보였다. 또한 CA3 영역에서의 calbindin-D28k의 염색성도 운동 1주군에서 감소하였다. 이상의 결과는 운동에 의한 새로운 신경과립세포의 유입의 변화 양상과 기존 신경과립세포의 활성의 변화가 시기적으로 연관성이 있음을 보여준다. Voluntary running is known to dramatically increase the cell proliferation and neurogenesis in the dentate gyrus of the adult mouse hippocampus. However, it is crucial to realize that adding excitatory neurons could result in serious maladaptive outcomes for hippocampal circuit function. To investigate the response of mature granule cells on the increase of cell proliferation during voluntary running, we investigated the temporal change of calbindin-D28k (a marker for mature granule cells) using immunohistochemistry during voluntary running with upregulated neurogenesis. By using immunohistochemsitry for Ki-67 and doublecortin (DCX), we observed that the cell proliferation and differentiation of granule cells increased at 1 week of voluntary running. We found that, at 6 weeks of voluntary running, the cell proliferation and differentiation of granule cells returned to sedentary control levels. On the other hand, calbindin-D28k immunoreactivity decreased in the granular cell layer of the dentate gyrus and CA3 region of hippocampus after 1 week of voluntary running. At 6 weeks of voluntary running, the density of the calbindin-D28k in the granular cell layer and CA3 region was returned to the sedentary control level. These results demonstrate that the cell proliferation and differentiation are increased at early point of voluntary running, and the granule cell activity in the dentate gyrus is temporally changed for response to the increase of cell proliferation and differentiation during voluntary running.

민원인 비윤리 행동과 직무만족이 민원서비스 근무자의 EVLN 반응에 미치는 영향

박흥식 ( Heung Sik Park ),정주원 ( Joo Won Jeong ) 서울대학교 한국행정연구소 2012 行政論叢 Vol.50 No.2

정부가 최근 민원서비스 분야에서 민원인 비윤리 행동의 지속적 증가를 ``새로운 행정문제``로 다루기 시작했다는 점에서, 이 연구에서는 EVLN 반응 모형을 도입, 민원서비스 근무자의 민원인 비윤리 행동에 대한 반응의 분포와 수준이 현재 어떤 상태인가? 민원인 비윤리 행동의 경험이 근무자의 EVLN 반응을 예측할 수 있는 유효한 변수인가? 그런 경우, 근무자의 어떤 반응을 특별히 촉발하는가? 직무만족은 또 이에 대해 어떤 영향을 미치는가? 등을 검토하였다. 설문조사 방법을 이용, 지방자치단체 총878명으로부터 응답을 받아 분석에 사용하였다. 분석결과, 민원서비스 근무자들에게서는 충성(loyalty), 다음은 발언(voice) 반응의 강도가 가장 높게 나타났다. 근무자 ``발언``은 불만이 있을 때, 어떻게 개선할지에 대한 대안 제시 등의 반응이라는 점에서, 현재의 분석 결과는 민원서비스 근무자의 민원인 비윤리 행동에 대한 가장 두드러진 반응은 ``건설적 그러나 수동적``인 것임을 보여준다. 이밖에 민원인 비윤리 행동 경험의 영향은 단지 이탈(exit)에 대해서만 유의하였다. 매스 미디어가 민원인 비윤리 행동을 심각한 이슈로 보도하고, 정부가 이를 행정서비스 제공 상의 ``새로운 문제``로 인식하는 상황에서 EVLN 모형에 의한 민원서비스 근무자의 반응은 일단 이탈(exit)의 고민, 스트레스 수준에 해당되고, 특히 불만족 집단에서의 이러한 반응의 강도가 높다는 점에서 교육이나 대응 프로그램은 ``이탈`` 반응 관리에 초점이 맞춰져야 할 것이다. The exit-voice-loyalty-neglect (EVLN) model is a refined typology that identifies four ways that employees respond to the consequences of adverse work conditions, problematic events, and dissatisfaction, etc. In this study, government employee responses on civil applicants` unethical behaviors were examined by applying an exit, voice, loyalty, and neglect (EVLN) typology. All categories of behavioral responses were assumed to differ on two dimensions, namely, destructive/constructive and active/passive. Several hypotheses were tested using data collected from local government employees. The results revealed that loyalty was the highest of the four responses. Civil applicants` unethical behavior, in particular, seemed to promote exit. Employee job satisfaction suppressed exit and neglect, but increased voice. The satisfied group was lower than the dissatisfied group in terms of exit, The dissatisfied group does not always have higher neglect. In addition, the effects of demographic variables on the four responses provided additional evidence that EVLN responses are significantly influenced by the employee gender, age, and education level.

YOLOv5 기반 토마토 병해충 검출 시스템

양유준(Yang Yu Jun),이명훈(Lee Meong Hun),정주원(Jeong Joo Won),여현(Yoe Hyun) 한국통신학회 2023 한국통신학회 학술대회논문집 Vol.2023 No.6

MQTT, ESP-NOW 통신 기반 스마트팜 네트워크 시스템 설계

임상민(Lim Sang Min),여현(Yoe Hyun),안유라(An Yu Ra),정주원(Jeong Joo Won),이명훈(Lee Meong Hun) 한국통신학회 2023 한국통신학회 학술대회논문집 Vol.2023 No.2

ICT기반 곤충사 환경 자동제어 시스템 설계

고경일(Ko Kyeong Il),이명훈(Lee Meong Hun),정주원(Jeong Joo Won),여현(Yoe Hyun) 한국통신학회 2023 한국통신학회 학술대회논문집 Vol.2023 No.2

납 취급 근로자의 Monte-Carlo simulation을 이용한 노출 및 건강위해성평가

염정호 ( Jung Ho Youm ),권근상 ( Keun Sang Kwon ),이주형 ( Ju Hyoung Lee ),정주원 ( Joo Won Jeong ) 한국산업위생학회 2006 한국산업보건학회지 Vol.16 No.2

Objective: This study was conducted to quantify chronic lead exposure from various media(ie. working environment, food, ambient air), and to certify the usefulness of exposure assessment using Monte-Carlo simulation in the fields of occupational health. Methods: Data were obtained from Korean Industrial Health Association, Korea Food and Drug Administration, and the Ministry of Environment. Then lead worker`s exposure was estimated indirectly from various media and parameters (ie. volume inhaled, body weight, dietary intake, etc.). Uncertainty was analyzed by Monte Carlo simulation with Crystal Ball software. Exposure doses and hazard indices were simulated with various hypothetical scenarios including weekly working hours and respiratory protective equipment. Results: Without respiratory protective equipment, the total exposure dose per kilogram of body weight of lead workers was estimated as 5.45×10(-3) mg/kg/day, and hazard index was estimated as 2.26, and exposure contributions were calculated as follows: working environment(82.42%); foods(17.57%); and ambient air(0.01%). But, if working condition has changed-reduction of working hours and using respiratory protective equipment, the total exposure dose per kilogram of body weight was estimated between 1.34×10(-3)-1.49×10(-3) mg/kg/day, and hazard index was estimated between 0.56-0.62. Conclusions: This study suggested that occurrence of hazardous impact(ie. increased blood pressure) through lifetime lead exposure would be expected, and that the Monte-Carlo simulation was useful for the fields of occupational health.