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- 저자 : 정재규 ( Jae Gu Jung ) (검색결과 4 건)
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정재규,임윤정,Jae Gu Jung,Yun Jeong Lim 대한소화기암연구학회 2013 Journal of digestive cancer reports Vol.1 No.1
Peritoneal carcinomatosis (PC) is defined as the dissemination of cancer cells in the peritoneal cavity resulting in deposition of malignant cells onto parietal or visceral peritoneal surfaces, and is associated with malignant ascites. In general, PC has been treated similarly to metastatic cancers of the primary tumor, but associated with unfavorable outcomes as compared to other sites of metastatic disease from the same primary tumor origin. It has been known to have the median survival of only 3-6 months with supportive care alone. PC is an intractable problem to physicians because of its poor prognosis and limited treatment options. Recent studies have reported that a combination of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy improved survival in PC of colorectal cancer. This paper gives overviews of the characteristics, symptoms, prognosis, and diagnosis of PC and current treatment options on PC of stomach, colorectal, and unknown primary origin.
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점막하 종양으로 발현한 원발성 식도 점막 연관 림프조직 림프종 1예
정재규 ( Jae Gu Jung ),강현우 ( Hyoun Woo Kang ),한석재 ( Suk Jae Hahn ),최종순 ( Jong Sun Choi ),김응중 ( Eung Joong Kim ) 대한소화기학회 2013 대한소화기학회지 Vol.62 No.2
We report a case of primary mucosa-associated lymphoid tissue (MALT) lymphoma in the esophagus that manifested as a large submucosal tumor (SMT). Primary esophageal lymphoma is very rare, occurring in less than 1% of all patients with gastrointestinal lymphoma. Only a few cases of MALT lymphoma in the esophagus have been reported in the English literature. A 53-year-old man was referred to Dongguk University Ilsan Hospital (Goyang, Korea) in July 2012 for further evaluation and treatment of an esophageal SMT. Endoscopy showed a cylindrically elongated submucosal mass with normal overlying mucosa in the mid esophagus, 25-30 cm from the incisor teeth. He underwent surgery to confirm the diagnosis. Pathologic findings showed diffuse small atypical lymphoid cells which were stained with Bcl-2, CD20, but not with CD3, CD5, CD23, Bcl-6, or cyclin D1. These cells showed a positive monoclonal band for immunoglobulin heavy chain gene rearrangement. Based on the pathological, immunohistochemical, and molecular biological features, the esophageal mass was diagnosed as extranodal marginal zone B-cell lymphoma of the MALT type. (Korean J Gastroenterol 2013; 62:117-121)
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자가면역성 간염에 동반된 Epstein-Barr virus에 의한 간염 1예
정재규 ( Jae Gu Jung ),문동규 ( Dong Gyu Moon ),양홍준 ( Hong Jun Yang ),권정현 ( Jung Hyun Kwon ),강진한 ( Jin Han Kang ),정은선 ( Eun Sun Jung ),윤승규 ( Seung Kew Yoon ) 대한내과학회 2008 대한내과학회지 Vol.74 No.6
평소 건강히 지내던 25세 여자 환자가 급성 간염의 양상으로 내원하였고 A형, B형, C형 간염 항체검사에서 음성소견이 나왔으나 EBV 간염의 혈청학적 검사와 자가 면역 항체 검사에서 양성 소견 관찰되어 동반 간질환 평가를 위해 간조직 생검을 실시하였다. 그 결과 간조직은 만성 자가면역성 간염소견을 보이고 있었으며 동소보합결합(in situ hybridization)법을 통해 EBV에 의한 간염이 동반되어 있음을 증명하였다. 이후 대중적 처치로 간기능의 호전을 보이다가 다시 악화되어 부신피질 호르몬 사용 후 호전된 증례를 보고하는 바이다. Autoimmune hepatitis (AIH), a rare cause of chronic liver disease in Korea, is a chronic, predominantly periportal hepatitis characterized by hypergammaglobulinemia, tissue autoantibodies, and responsiveness to immunosuppressive therapy. Here we report a rare case of Epstein-Barr virus (EBV) hepatitis in the presence of a previous diagnosis of AIH. A 25-year-old woman was admitted to the hospital with fever and myalgias. Laboratory data showed elevated aminotransferases, hypergammaglobulinemia, increased anti-nuclear antibody (ANA) titer, positive anti-smooth muscle antibody (ASMA) test, negative anti-mitochondrial antibody (AMA) test, and negative antibody against liver kidney microsome-1 (anti-LKM-1) test. Serologic viral markers of EBV indicated a recent EBV infection. Liver biopsy was performed to search for evidence of accompanying autoimmune liver disease. Liver biopsy findings were consistent with chronic active hepatitis. In-situ hybridization performed on the liver tissue confirmed the presence of EBV DNA. The patient has been treated with prednisolone and has shown subsequent improvement in clinical symptoms and liver function tests.(Korean J Med 74:658-662, 2008)
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폐암과 병발한 류마티스 관절염 환자에서 항암요법에 따른 임상경과
최선욱 ( Son Ook Choi ),정재규 ( Jae Gu Jung ),형복진 ( Bok Jin Hyoung ),박상미 ( Sang Mi Park ),정현정 ( Hyun Jung Jung ),박보형 ( Bo Hyoung Park ),심병용 ( Byoung Yong Shim ),김완욱 ( Wan Uk Kim ),김훈교 ( Hoon Kyo Kim ) 대한류마티스학회 2006 대한류마티스학회지 Vol.13 No.2
A 54-year-old male was admitted due to lung cancer and polyarthralgia involving wrist, hand, shoulder, and ankle joints. Five months ago, he had been diagnosed as adenocarcinoma of the lung, and treated with three cycles of chemotherapy using gemcitabine and cisplatin. In the course of chemotherapy, he had complained symmetrical polyarthralgia of hand and shoulder joints, resembling rheumatoid arthritis (RA). After treatment with chemotherapeutic agents, he still had severe polyarthritis refractory to anti-rheumatic drugs, including prednisolone, hydroxylchloroquine, and methotrexate, and thus referred to our hospital. We changed the previous anti-cancer regimens to cisplatin plus docetaxel, a semisyntheic taxane molecule, which is known to suppress experimental polyarthritis. With additional three cycles of cisplatin plus docetaxel, RA disease activity as well as polyarthralgia was nearly completely resolved, and the extent of lung cancer was not aggravated. Although RA patients have an increased risk of malignancy, the outbreak of RA was very rare in lung cancer patients. Here we report a case of coincident lung cancer and rheumatoid arthritis, which was successfully treated by docetaxel plus cisplatin chemotherapy.
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