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정인두 ( In Du Jeong ) 대한소화기학회 2017 대한소화기학회지 Vol.69 No.2
The prevalence of gastroesophageal reflux disease (GERD) and the incidence of some of its complications have risen strikingly over the last few decades. With the accumulation in our understanding on the pathophysiology of GERD along with the development of proton pump inhibitors, the diagnostic and therapeutic approaches to the GERD have changed dramatically over the past decade. However, The GERD still poses a problem to many clinicians since the spectrum of the disease has evolved to encompass more challenging presentations such as refractory GERD and extraesophageal manifestations. The aim of this article was to provide a review of available current diagnostic tests of the GERD, includes proton pump inhibitor test, ambulatory pH monitoring, impedance pH monitoring, mucosa impedance, and high resolution manometry. This review discusses different modalities for the work up of GERD. (Korean J Gastroenterol 2017;69:96-101)
최신 연구 소개 : 점막 임피던스 검사가 위식도역류질환과 비역류성질환을 구별할 수 있을까?
정인두 ( In Du Jeong ) 대한소화기학회 2015 대한소화기학회지 Vol.65 No.4
Mucosal Impedance Discriminates GERD from Non-GERD Conditions (Gastroenterology 2015;148:334-343)
정인두 ( In Du Jeong ),박무인 ( Moo In Park ) 대한소화기학회 2016 대한소화기학회지 Vol.68 No.3
The prevalence of gastroesophageal reflux disease (GERD) and the incidence of some of its complications have risen strikingly over the last few decades. With the increase in our understanding of the pathophysiology of GERD along with the development of proton pump inhibitors, the diagnostic and therapeutic approaches to GERD have changed dramatically over the past decade. However, GERD still poses a problem to many clinicians since the spectrum of the disease has evolved to encompass more challenging presentations such as refractory GERD and extra-esophageal manifestations. The aim of this article is to provide a review of available current translational research on GERD. This review includes acid pocket, ambulatory pH monitoring, impedance pH monitoring, mucosa impedance, and high resolution manometry. This article discusses current translational research on GERD. (Korean J Gastroenterol 2016;68:127-131)
Cyclophosphamide 충격요법으로 호전된 전신성 홍반성 루푸스에 병발된 폐고혈압
최승원 ( Seung Won Choi ),정인두 ( In Du Jeong ),박종호 ( Jong Ho Park ),박재후 ( Jae Hoo Park ),이종수 ( Jong Soo Lee ),김진우 ( Jin Woo Kim ) 대한류마티스학회 2002 대한류마티스학회지 Vol.9 No.1
Pulmonary hypertension is an uncommon but serious complication of systemic lupus erythematosis (SLE). Usually its outcomes are ominous and may progress to heart failure and even sudden death. The pathophysiology is still unknown, but several mechanisms, such as pneumonitis, vasculitis, thromboembolism or thrombosis in situ have been proposed. There is no definitive therapy for this condition. Although supportive measures with vasodilators remain the mainstay of treatment, the responses are generally disappointing. We describe a case of improvement of pulmonary hypertension in SLE treated with cyclophosphamide pulse therapy as documented by hemodynamic data. Immunosuppressive treatment with cyclophosphamide was effective in this condition, suggested an immune mediated pathogenesis.
조기 대장암의 내시경 절제술 후 림프절 전이의 위험 인자
임경훈 ( Kyung Hoon Lim ),정석원 ( Seok Won Jung ),정인두 ( In Du Jeong ),방성조 ( Sung Jo Bang ),신정우 ( Jung Woo Shin ),박능화 ( Neung Hwa Park ),최혜정 ( Hye Jeong Choi ),최대화 ( Dae Hwa Choi ),김도하 ( Do Ha Kim ) 대한장연구학회 2008 Intestinal Research Vol.6 No.2
Background/Aims: Although endoscopic resection is widely used for the treatment of early colorectal cancer, the risk factors for lymph node metastasis are not clear. This study was designed to determine the risk factors for lymph node metastasis in patients with colorectal cancer who are treated by endoscopic resection. Methods: The medical records of patients with histologically-proven early colorectal cancers who were treated by endoscopic resection between January 2002 and September 2008 were retrospectively reviewed. Information regarding the demographic data of patients and the clinicopathologic characteristics were recorded and analyzed. Results: Twenty-nine patients who underwent subsequent surgical treatment after endoscopic resection for early colorectal cancer were enrolled in this study. Six patients (20.7%) had lymph node metastases on surgical pathologic examination. The predictive factors for lymph node metastasis were tumor morphology (non-polypoid flat tumors [p=0.019]), absence of background adenomas (p=0.033), and deep submucosal invasion ≥2,000 um (p=0.012). Unexpectedly, the presence of vascular invasion was not associated with lymph node metastasis. Conclusions: The presence of vascular invasion might not be an absolute indication for additional surgical treatment of early colorectal cancer; however, deep submucosal invasion, accompanied by a gross tumor with a non-polypoid flat morphology, and the absence of background adenomas are potential risk factors for lymph node metastasis. (Intest Res 2008;6:103-109)