운동 강도의 차이가 회복기 혈중 랩틴 농도에 미치는 영향

정수련,김승환,채홍원,강호율 한국운동과학회 2004 운동과학 Vol.13 No.1

정수련, 김승환, 채홍원, 강호율. 운동 강도의 차이가 회복기 혈중 랩틴 농도에 미치는 영향. 운동과학, 제13권 제1호, 35-42, 2004. 본연구의 목적은 운동의 강도가 혈중 랩틴에 미치는 영향을 알아보는 것이다. 8명의 건강한 남자대학생을 대상으로 최대산소섭취량의 50% (LT)와 75% (HT)의 운동강도로 자전거타기를 실시하였다. 이때 운동량은 두강도 모두 약 250 kcal가 되게 하였다. 연구결과 혈중 랩틴 농도는 운동강도별 유의한 차이는 나타나지 않았으나, HT에서 운동전에 비해 유의하게 감소한 것으로 나타났다(p<.05). EPOC는 두강도 모두 운동후 유의하게 높게 나타났고, 운동직후 LT에 비해 HT에서 유의하게 높게 나타났다(p<.05). 혈중 인슐린 농도는 시간별, 운동강도별 유의한 차이가 나타나지 않았다. 혈중유리지방산과 글루코스 수준은 HT에서만 회복시 유의하게 높게 나타났다(p<.05). 혈중 글리세롤 수준은 두 운동강도 모두에서 운동직후 유의하게 높게 나타났다 (p<.05). 그러나 운동강도별 차이는 없었다. 혈중 젖산 수준은 운동후 두강도 모두 유의하게 높게 나타났고, HT에서 LT보다 높게 나타났다(p<.05). 이러한 결과를 통해 일회성 운동후 회복기 3시간동안 동일한 운동량의 운동시 높은 강도의 운동이 혈중 랩틴 농도에 유의한 영향을 미치는 것을 알 수 있다. Jung, S.R., Kim, S.H. Chae, H.W., Kang, H.Y. The Effects of Exercise indensity on plasma leptin concentration in exercise recovery. Exercise Science, 13(1): 35-42, 2004. leptin is an adipocyte-derived hormone that has been shown to regulate body weight and thermogenesis in human and animal(Kraemer et al, 2000). The objective of this study was to investigate the effects of exercise intensity on plasma leptin responses. The 8 college male students were participated in acute bout exercise with two different intensities; 50% (LT) and 75% (HT) of maximal oxygen consumption. The energy expenditure was equal to both intensity (≒ 250 kcal). Plasma leptin levels were significantly reduced after HT (pre > 120min> 180 min), but there was no significant difference between HT and LT. EPOC were significantly increased after acute bout exercise with two different intensity, and HT was higher than LT. Plasma insulin levels were not significantly changed in two groups. Plasma FFA levels were significantly increased after acute bout exercise only HT (p<.05). Plasma glycerol levels were significantly increased after acute bout exercise with two different intensities (p<.05). Plasma glucose levels were significantly increased after acute bout exercise only HT(pre<post, 15min, p<.05). Plasma lactate levels were significantly increased after acute bout exercise with two intensity group, and HT was higher than LT. These data indicate that high intensity exercise did significantly affect plasma leptin levels during the 3h-recovery.

Effect of Endurance Exercise and Methamphetamine Administration on the Expression of Blood-Brain Barrier Related Factors and BDNF in Hippocampus of Male Sprague-Dawley Rat

정수련 한국운동생리학회 2022 운동과학 Vol.31 No.3

PURPOSE: This study aimed to investigate the effect of short-term endurance exercise and methamphetamine administration on bloodbrain barrier (BBB)-related marker and brain-derived neurotrophic factor (BDNF) in the hippocampus of male Sprague-Dawley (SD) rats. METHODS: Forty male SD-rats were randomly assigned to 4 groups and treated for 2 weeks. For the methamphetamine group, 1 mg/ kg (+)-S-Methamphetamine hydrochloride (METH) was intraperitoneally injected daily, and an endurance exercise was performed at 21 m/min for 60 minutes. All treatments were performed daily, and METH or saline was administered after exercise. After 2 weeks of treatment, the head was decapitated under anesthesia, and the hippocampus was separated for western blotting. RESULTS: Two weeks of endurance exercise significantly increased the expression of occludin and claudin-5 in the hippocampus of the rats. Similarly, phosphorylation of CREB/BDNF and AKT/GSK3 signaling pathways were significantly increased. This phenomenon was also observed in the exercise and METH co-treatment groups. However, the single treatment of 1 mg/kg METH did not affect tight junction protein and BDNF expression. CONCLUSIONS: Endurance exercise increased the expression of BBB-related proteins and neurogenesis-related molecules, which were not inhibited by METH administration.

비만처치를 위한 운동트레이닝의 효과분석 시 체지방 감소 및 심폐기능의 중요성

정수련,문상복,김기진 대한비만학회 2016 The Korean journal of obesity Vol.25 No.2

비만과 관련하여 심폐지구력과 비만이 사망률에 독립적으로 영향을 미치는 것으로 잘 알려져 있으나 어떤 요인이 더욱 중요한 영향을 미치는지 명확하게 제시되지 못하고 있다. 선행연구들의 결과를 중심으로 심폐지구력과 비만이 사망률에 미치는 영향을 비교 분석하여 대사성 질환의 예방 및 처치과정에서 도움을 주고자 한다. 비만은 대사성 질환의 유병률과 밀접한 관련성을 나타내며, 사망률을 증가시키는 대표적인 위험요인에 해당한다. 그러나 과체중을 비롯한 가벼운 수준의 비만은 사망률을 일방적으로 증가시키지 않으며, 체중 및 체지방률 증가보다는 체력을 비롯한 특이적 증상이 사망률을 높이는 위험요인이 될 수 있다. 비만 처치과정에서 운동프로그램의 적용 시 체중의 변화 없이 허리둘레 감소, 내장지방 감소, 순환대사 위험요인 감소 등과 함께 신체적 활동과 심폐지구력의 향상에 의한 비만 관련 순환계 질환 위험요소의 감소 노력이 더욱 중요하게 강조되고 있다. 이상에서 비만에 의한 심혈관계 질환의 위험요인으로서는 심폐지구력을 중심으로 한 건강관련 체력 저하의 중요성이 더욱 우세하며, 전체적인 대사성 질환의 위험요인으로서는 체지방 감소를 중심으로 한 체중조절과 신체적 활동을 중심으로 한 생활습관의 변화가 중요하게 강조된다고 볼 수 있다. Obesity is significantly correlated with prevalence of metabolic syndrome and is an important risk factor of mortality. However, overweight or slight obesity does not increase mortality; therefore, physical fitness might be a more important factor of mortality in such people. The main targets of exercise intervention programs for obesity treatment include decreases in waist circumference, visceral fat, and metabolic risk factors without weight change and improvement of cardiorespiratory function. Based on the results of this study, we suggest the importance of physical fitness for the prevention of obesity-related cardiovascular risk factors and the importance of body composition, body weight control, and life-style change for prevention of obesity-related metabolic risk factors.

Exercise-induced PGC-1α transcriptional factors in skeletal muscle

정수련,김기진 한국한의학연구원 2014 Integrative Medicine Research Vol.3 No.4

Skeletal muscle is adapting to the needs of the body by changes of various gene expression that control mitochondrial biogenesis, angiogenesis, and the composition of muscle fiber types. Recently, it was revealed that PGC-1α, which is an auxiliary transcription factor, plays a key role in the aforementioned adaptation phenomena. It means that various signal transduction systems within muscle directly affect the expression and activation of PGC-1α and also PGC-1s activates various programs for muscle adaptation. Therefore, this review assessed PGC-1α to understand the reaction and adaptation phenomena of muscle against the biological stimulus such as exercise and came to the conclusion that PGC-1α and PGC-1β significantly affect skeletal muscle in various ways, and also have an affect on the increase of exercise capacity, inducing of angiogenesis and the prevention of muscle atrophy and degeneration.

Lithium and exercise ameliorate insulin-deficient hyperglycemia by independently attenuating pancreatic α-cell mass and hepatic gluconeogenesis

정수련,이지혜,류한국,Gao Yurong,이재민 대한약리학회 2024 The Korean Journal of Physiology & Pharmacology Vol.28 No.1

As in type 1 diabetes, the loss of pancreatic β-cells leads to insulin deficiency and the subsequent development of hyperglycemia. Exercise has been proposed as a viable remedy for hyperglycemia. Lithium, which has been used as a treatment for bipolar disorder, has also been shown to improve glucose homeostasis under the conditions of obesity and type 2 diabetes by enhancing the effects of exercise on the skeletal muscles. In this study, we demonstrated that unlike in obesity and type 2 diabetic conditions, under the condition of insulin-deficient type 1 diabetes, lithium administration attenuated pancreatic a-cell mass without altering insulin-secreting β-cell mass, implying a selective impact on glucagon production. Additionally, we also documented that lithium downregulated the hepatic gluconeogenic program by decreasing G6Pase protein levels and upregulating AMPK activity. These findings suggest that lithium’s effect on glucose metabolism in type 1 diabetes is mediated through a different mechanism than those associated with exercise-induced metabolic changes in the muscle. Therefore, our research presents the novel therapeutic potential of lithium in the treatment of type 1 diabetes, which can be utilized along with insulin and independently of exercise

Thymoma of the Middle Mediastinum

정수련,김인숙,김진국 대한흉부외과학회 2012 Journal of Chest Surgery (J Chest Surg) Vol.45 No.4

Thymoma is a common anterior mediastinal mass, although thymomas have occasionally been found in the neck, pulmonary hillus, or posterior mediastinum. But a thymoma within the middle mediastinum has rarely been reported. We report a thymoma arising in the middle mediastinum with a review of the literature.

Surgical Experience of Ascending Aorta and Aortic Valve Replacement in Patient with Calcified Aorta

정수련,박표원,최민석,조성호,성기익,이영탁,정재한 대한흉부외과학회 2012 Journal of Chest Surgery (J Chest Surg) Vol.45 No.1

Background: The conventional method of aortic cross-clamping is very difficult and increases the risk of cerebral infarct due to embolism of the calcified aorta in these patients. Accordingly, we analyzed our experience with 11 cases of ascending aorta and aortic valve replacement with hypothermic circulatory arrest. Materials and Methods: From January 2002 to December 2009, 11 patients had ascending aorta and aortic valve replacement with hypothermic arrest at our hospital. We performed a retrospective study. Results: There were 5 males and 6 females, with a mean age of 68 years (range, 44 to 82 years). Eight patients had aortic stenosis, and 3 patients had aortic regurgitation. An aortic cannula was inserted into the right axillary artery in 3 patients and ascending aorta in 6 patients. Two patients with aortic regurgitation had a remote access perfusion catheter inserted though the right femoral artery. The mean cardiopulmonary bypass time was 180 minutes (range, 110 to 306 minutes) and mean hypothermic circulatory arrest time was 30 minutes (range, 20 to 48 minutes). The mean rectal temperature during hypothermic circulatory arrest was 21oC (range, 19oC to 23°C). No patient had any new onset of cerebral infarct or cardiovascular accident after surgery. There was no hospital mortality. Early complications occurred in 1 patient who needed reoperation due to postoperative bleeding. Late complications occurred in 1 patient who underwent a Bentall operation due to prosthetic valve endocarditis. The mean follow-up duration was 32 months (range, 1 month to 8 years) and 1 patient died suddenly due to unknown causes after 5 years. Conclusion: Patients with a calcified aorta can be safely treated with a technique based on aorta and aortic valve replacement under hypothermic circulatory arrest.

폐암과 동반된 부속 심장 기관지 −1예 보고−

정수련,심영목 대한흉부외과학회 2010 Journal of Chest Surgery (J Chest Surg) Vol.43 No.5

An accessory cardiac bronchus (ACB) is a rare congenital anomaly of the trachobronchial tree. It rarely presents with symptoms, and is usually diagnosed incidentally by chest CT, bronchoscopy, or during surgery. We experienced a case of accessory cardiac bronchus found incidentally in the bronchus intermedius with lung cancer in the right lower lobe, and surgically removed. 폐암의 수술적 치료 중 발견된 부속 심장 기관지증은 국내에서 보고된바 없는 드문 병변으로 이에 대해 보고하고자 한다. 53세 남자가 마른기침으로 타 병원을 내원하여 폐암으로 진단 받고 수술 위해 입원하였으며 수술 전 흉부전산화 단층 촬영상 심장 기관지가 발견되어 폐암과 동시 절제하여 좋은 결과를 얻었기에 이에 대해 보고하는 바이다.

Outcomes of Off-Pump Coronary Bypass Grafting with the Bilateral Internal Thoracic Artery for Left Ventricular Dysfunction

정수련,김욱성,정동섭,이재진,이영탁 대한의학회 2014 Journal of Korean medical science Vol.29 No.1

This study evaluated the outcomes of off-pump coronary artery bypass surgery (OPCAB) with severe left ventricular dysfunction using composite bilateral internal thoracic artery grafting. From January 2001 to December 2008, 1,842 patients underwent primary isolated OPCAB with composite bilateral internal thoracic artery grafting. A total of 131 of these patients were diagnosed with a severely depressed preoperative left ventricle ejection fraction (LVEF) (≤0.35). These patient outcomes were compared with the outcomes of 830 patients that had mildly or moderately depressed LVEF (0.36 to 0.59) and 881 patients with normal LVEF (>0.6). The early mortality for patients with severe LVEF was 2.3%. The 3-yr and 7-yr survival rate for patients with severe LV dysfunction was 86.0% and 82.8%, respectively. Multivariate analysis showed that severe LV dysfunction EF increased the risk of all-cause death (P=0.012; hazard ratio [HR],2.14; 95% confidence interval [CI],1.19-3.88) and the risk of cardiac-related death (P=0.008; HR,3.38; 95% CI, 1.37-8.341). The study identified positive surgical outcomes of OPCAB, although severe LVEF was associated with two-fold increase in mortality risk compared with patients who had normal LVEF.

골격근내 PGC-1α발현이 글리코겐 분해효소와 해당효소 발현에 미치는 영향

정수련,김기진,고진호,김상현 한국운동생리학회(구 한국운동과학회) 2013 운동과학 Vol.22 No.4

지구성 운동 트레이닝은 장시간의 고강도 운동을 수행할 수 있는 능력을 증가시키는데, 이는 PGC-1α에 의한 골격근 내 미토콘드리아의 증가 때문이다. 그러나 이러한 적응현상은 장시간, 고강도의 활동이 필수적으로 요구되는 환경에서 생존의 이익을 주기에는 너무 천천히 발생한다. 본 연구에서 지구성 트레이닝 초기 더욱 신속한 탄수화물 대사 적응이 일어남을 발견하였는데, 지구성 트레이닝 초기 글리코겐 분해와 해당 효소의 발현 감소로 근육 내 글리코겐 고갈과 젖산 생성이 지연되고, 이러한 적응현상은 PGC-1α에 의한 것으로 나타났다. 즉 지구성 운동초기에는 PGC-1α에 의해 글리코겐 분해효소와 해당효소의 발현이 감소함으로 탄수화물 절약효과가 나타난다. 글리코겐 고갈과 젖산 생성이 근 피로와 운동수행 중단의 주된 원인임을 생각해 본다면 이러한 현상은 생물학적으로 중요한 의미를 갖는다고 할 수 있다. Endurance exercise training can induce large increases in the ability to perform prolonged strenuous exercise. The major adaptation responsible for this increase in endurance capacity is a PGC-1α-mediated increase in muscle mitochondria. This adaptation occurs too slowly to provide a survival advantage when there is a sudden change in the environment that necessitates vigorous, prolonged exercise. In the present study, we discovered another, more rapid adaptation, a down regulation of expression of the glycogenolytic and glycolytic enzymes in muscle that mediates a slowing of muscle glycogen depletion and lactic acid a ccumulation. This a dap tation, which also a p pears t o be i nduced b y PGC-1α, occurs i n response t o a single e xercise bout and is further enhanced by two additional daily exercise bouts. It is biologically significant, because glycogen depletion and lactic acid accumulation are two of the major causes of muscle fatigue and exhaustion.