하악골에 발생한 골아세포종의 치험례

정세헌,윤현중,이상화,Jeong, Se-Heon,Yoon, Hyun-Joong,Lee, Sang-Hwa 대한구강악안면외과학회 2008 대한구강악안면외과학회지 Vol.34 No.6

Osteoblastoma is a relatively rare benign bone tumor representing less than 1% of all bone tumors. The tumor usually involves the spine and sacrum of young individuals, less than 10% being localized to the skull, and nearly half of these affect the mandible, especially the posterior segments. In clinical finding, osteoblastoma present mainly with pain, swelling, and expansion of bone cortex. Radiographic appearances are variable, but frequently a well-delineated radiolucent lesion containing varying amounts of mineral deposits is seen. Histologically, ostoeblastoma is consists of irregular trabeculeae of osteoid and immature bone present within highly vascular connective tissue matrix. Osteoblastoma must be differentiated from a number of bone-producing lesions, including osteoid osteoma, fibrous dysplasia, ossifying fibroma, fibrous dysplasia, and osteosarcoma. If diagnosis may be mistaken for osteosarcoma, there are risks of more aggressive and irreversible treatment. Differential diagnosis of osteoblastoma is important. The preferred treatment of osteoblastoma is conservative approach and surgical excision. Recurrence following surgical intervention is rare. We treated osteoblastoma located in premolar area of mandible by excision with preservation of vital structure, such as nerves and teeth. So we report our clinical treatment with literature review

Manual Scaling of Ionograms Measured at Jeju (33.4°N, 126.3°E) Throughout 2012

정세헌,김용하,김기남 한국우주과학회 2018 Journal of Astronomy and Space Sciences Vol.35 No.3

The ionosphere has been monitored by ionosondes for over five decades since the 1960s in Korea. An ionosonde typically produces an ionogram that displays radio echoes in the frequency-range plane. The trace of echoes in the plane can be read either manually or automatically to derive useful ionospheric parameters such as foF2 (peak frequency of the F2 layer) and hmF2 (peak height of the F2 layer). Monitoring of the ionosphere should be routinely performed in a given time cadence, and thus, automatic scaling of an ionogram is generally executed to obtain ionospheric parameters. However, an auto-scaling program can generate undesirable results that significantly misrepresent the ionosphere. In order to verify the degree of misrepresentation by an auto-scaling program, we performed manual scaling of all 35,136 ionograms measured at Jeju (33.43˚N, 126.30˚E) throughout 2012. We compared our manually scaled parameters (foF2 and hmF2) with auto-scaled parameters that were obtained via the ARTIST5002 program. We classified five cases in terms of the erroneous scaling performed by the program. The results of the comparison indicate that the average differences with respect to foF2 and hmF2 between the two methods approximately correspond to 0.03 MHz and 4.1 km, respectively with corresponding standard deviations of 0.12 MHz and 9.58 km. Overall, 36 % of the auto-scaled results differ from the manually scaled results by the first decimal number. Therefore, future studies should be aware of the quality of auto-scaled parameters obtained via ARTIST5002. Hence, the results of the study recommend the use of manually scaled parameters (if available) for any serious applications.

구조적 불연속에 기인하는 원통구조물의 응력집중현상에 관한 유한요소법에 의한 연구

김두만,정세헌 한국산업안전학회 1988 한국안전학회지 Vol.3 No.2

The stress concentration phenomena due to the structural incontinuty are studied by finite element method. In this study, a circular cylinder is treated. Under the axial load, the membrance action is dominate and the 24 D.O.F. cylindrical membrane finite element is used. The assembly of this element can successfully represent the original structure geometrically. The internal displacement function is such organized that the inter element compatibility condition is fully satisfied. In this study, the stress concentration factors due to the presence of a hole on the cylinder wall are obtained, and the factors versus the location of the hole is computed and plotted. It is found that the hole effect on the stress concentration disappears beyond the neighboring region of the hole size from the edge of the hole. Those results are useful for practical design in determining the region where the re-inforcing is necessary.

Transobturator Tape for Female Stress Urinary Incontinence: Preoperative Valsalva Leak Point Pressure Is Not Related to Cure Rate or Quality of Life Improvement

유제국,유성현,정세헌,윤부현,유호송,김선옥,권동득 대한비뇨의학회 2014 Investigative and Clinical Urology Vol.55 No.4

Purpose: We investigated whether the Valsalva leak point pressure (VLPP) is valuablefor predicting postoperative outcome measurement after transobturator suburethraltape (TVT-O) implantation for treating stress urinary incontinence (SUI) in women. Materials and Methods: A total of 204 female patients who underwent TVT-O placementfor treatment of SUI from March 2008 to February 2012 were enrolled in this retrospectivestudy. All patients completed the incontinence quality of Life questionnaire(I-QoL), a self-reported quality of life measure specific to urinary incontinence, and thecure rate of incontinence was measured before and 6 months after surgery. Cure wasdefined as no leakage of urine postoperatively both subjectively and objectively. Wecompared pre- and postoperative I-QoL scores according to preoperative VLPP andStamey grade. Results: The numbers of patients with Stamey grades I, II, and III were 99 (48.5%),84 (41.2%), and 21 (10.3%), respectively. A total of 30 (14.7%), 87 (42.6%), and 87 patients(42.6%) showed VLPP≤60, 60<VLPP≤90, and VLPP>90 cm H2O, respectively. Preoperative VLPP was not significantly different according to preoperative I-QoL orchange in I-QoL after surgery. However, I-QoL after surgery improved in patients witha high preoperative Stamey grade (p=0.001). Conclusions: VLPP was not a factor related to surgical outcome from the midurethralsling procedure. Stamey grade rather than VLPP was important for predicting subjectivequality of life and improved incontinence-related quality of life after surgery.

Predicting Factors for Stent Failure-Free Survival in Patients With a Malignant Ureteral Obstruction Managed With Ureteral Stents

유성현,류제국,정세헌,황의창,장원석,황인상,유호송,김선옥,정승일,강택원,권동득,박광성,황준일,김근수 대한비뇨의학회 2013 Investigative and Clinical Urology Vol.54 No.5

Purpose: To determine predictive factors for stent failure-free survival in patients treated with a retrograde ureteral stent for a malignant ureteral obstruction. Materials and Methods: We retrospectively reviewed 71 patients who underwent insertion of a cystoscopic ureteral stent due to a malignant ureteral obstruction between May 2004 and June 2011. Performance status, type of cancer, hydronephrosis grade,location of the obstruction, presence of bladder invasion, C-reactive protein (CRP), serum albumin, and inflammation-based prognostic score (Glasgow prognostic score,GPS) were assessed using a Cox proportional regression hazard model as predicting factors for stent failure. Results: A univariate analysis indicted that hypoalbuminemia (<3.5 g/dL; hazard ratio [HR], 2.43; 95% confidence interval [CI], 1.21 to 4.86; p=0.012), elevated CRP (≥1mg/dL; HR, 4.79; 95% CI, 2.0 to 11.1; p=0.001), and presence of a distal ureter obstruction (HR, 3.27; 95% CI, 1.19 to 8.95; p=0.021) were associated with stent failure-free survival. A multivariate analysis revealed that the presence of a mid and lower ureteral obstruction (HR, 3.27; 95% CI, 1.19 to 8.95; p=0.007), GPS ≥1 (HR, 7.22; 95%CI, 2.89 to 18.0; p=0.001), and elevated serum creatinine before ureteral stent placement (>1.2 mg/dL; HR, 2.16; 95% CI, 1.02 to 4.57; p=0.044) were associated with stent failure-free survival. Conclusions: A mid or lower ureteral obstruction, GPS ≥1, and serum creatinine before ureteral stent insertion >1.2 mg/dL were unfavorable predictors of stent failure-free survival. These factors may help urologists predict survival time.

The Effects of 3-Isobutyl-1-methylxanthine (IBMX) on Nuclear and Cytoplasmic Maturation of Porcine Oocytes In Vitro

곽성성,장성훈,정세헌,전유별,Dibyendu Biswas,현상환 사단법인 한국동물생명공학회 2012 한국동물생명공학회지 Vol.27 No.3

The 3-isobutyl-1-methylxanthine (IBMX) is non-selective phosphodiesterase and is able to prevent resumption of meiosis by maintaining elevated cyclic AMP (cAMP) concentrations in the oocyte. The present study was conducted to analyze: (1) nuclear maturation (examined by the Hoechst staining), (2) whether cytoplasmic maturation (examined by the intracellular glutathione (GSH) concentration) of porcine oocytes is improved during meiotic arrest after prematuration (22 h) with IBMX. Before in vitro maturation (IVM), oocytes were treated with 1 mM IBMX for 22 h. After 22 h of pre-maturation, the higher rate of IBMX treated group oocytes were arrested at the germinal vesicle (GV) stage (42.3%) than control IVM oocytes (10.1%). It appears that the effect of IBMX on the resumption of meiosis has shown clearly. In the end of IVM, the reversibility of the IBMX effect on the nuclear maturation has been corroborated in this study by the high proportions of MII stage oocytes (72.5%) reached after 44 h of IVM following the 22 h of inhibition. However, intracellular GSH concentrations were lower in the oocytes treated with IBMX than the control oocytes (6.78 and 12.94 pmol/oocyte, respectively). These results demonstrate that cytoplasmic maturation in porcine oocytes pre-treated with IBMX for 22 h did not equal that of control oocytes in the current IVM system. These results indicate that pre-maturation with IBMX for 22 h may not be beneficial in porcine IVM system.

강직성 척추염 환자에서 발생한 척추 골절

박태식,이동열,허원,송준석,정세헌,여만수,박화성 대한척추신경외과학회 2009 Neurospine Vol.6 No.2

Ankylosing spondylitis (AS) is a chronic inflammatory rheumatic disease. Pathologic changes occurred in patients with AS result in a weakened vertebral column with increased susceptibility to fractures, even though a trivial injury. Fractures usually tends to involve the lower cervical spine, but rarely, they are also occurred in thoracolumbar spine. We present our experiences of three cases of spinal fracture in patients with AS, cervical, thoracic, and lumbar spine, with a review of literatures. Ankylosing spondylitis (AS) is a chronic inflammatory rheumatic disease. Pathologic changes occurred in patients with AS result in a weakened vertebral column with increased susceptibility to fractures, even though a trivial injury. Fractures usually tends to involve the lower cervical spine, but rarely, they are also occurred in thoracolumbar spine. We present our experiences of three cases of spinal fracture in patients with AS, cervical, thoracic, and lumbar spine, with a review of literatures.

방사선학적 악성이나 조직학적으로 양성을 보인 신경절교종 -증 례 보 고-

김환수 ( Hwan Soo Kim ),정세헌 ( Se Heun Joung ),허원 ( Weon Heo ),이동열 ( Dong Youl Rhee ) 대한뇌종양학회 대한신경종양학회 2014 Brain Tumor Research and Treatment Vol.2 No.1

Gangliogliomas are rare tumors of the central nervous system, composed of neoplastic ganglion cells and neoplastic glial cells. They are characterized by slow growing, low incidence of malignancy, surgically curable, and usually occurred in children and young adults. We report a case of ganglioglioma occurred in 21 year-old male which radiological findings were compatible with the malignancy but histologically diagnosed as benign, with review of literatures.

40대 이상 한국인의 굴절이상 유병률

조인영,최경한,최영훈,배시성,카마우 버지니아,정세헌,유근창 대한시과학회 2020 대한시과학회지 학술대회 Vol.2020 No.11

적갈색방사선학적 악성이나 조직학적으로 양성을 보인 신경절교종 - 증례보고 -

허원 ( Weon Heo ),김환수 ( Hwan Soo Kim ),정세헌 ( Se Heun Joung ),이동열 ( Dong Youl Rhee ) 대한뇌종양학회·대한신경종양학회·대한소아뇌종양학회 2012 대한뇌종양학회지 Vol.11 No.2

Gangliogliomas are rare tumors of the central nervous system, composed of neoplastic ganglion cells and neoplastic glial cells. They are characterized by slow growing, low incidence of malignancy, surgically curable, and usually occurred in children and young adults. We report a case of ganglioglioma occurred in 21 year-old male which radiological findings were compatible with the malignancy but histologically diagnosed as benign, with review of literatures.