대학 산업디자인학과의 교육현황과 개선방안

정경원,Jeong, Gyeong-Won 한국대학교육협의회 1994 大學敎育 Vol.71 No.-

Column - 삼성전자와 애플의 소송을 통해 본 디자인권 보호의 양면성

정경원,Jeong, Gyeong-Won 한국발명진흥회 2011 發明特許 Vol.36 No.12

중미의 증언문학

정경원 ( Jeong Gyeong Won ) 한국스페인어문학회 2003 스페인어문학 Vol.0 No.29

The growing attention paid to cultural diversity surely has contributed to the popularity of testimonies like Mench`s, but there are other reasons for the interest they have attracted. In general, testimonies are more accessible to the North American student of Latin American culture and literature than, for instance, the highly complex texts of the Boom writers. The study of testimony and of voices from below also coincides with a surge in interest in popular culture and in the redefinition of the literary canon. Testimony is really nothing new from the time of Conquest, in which testimonies were accorded legal standing so that victims, through eyewitness accounts, could reclaim their due testimonial narrative has expressed urgency, sought redress and justice, and challenged official discourse. Testimonial novel has emerged alongside testimony per se as another form of resistance narrative. Like testimony, the testimonial novel has been translated and widely disseminated for political and cultural reasons. With the testimonial novel, they must also deal with issues of historiography and artistic elaboration, the tensions between ethics and aesthetics, the role of he author, and the economics of production. To create the testimonial novel, writers have combined testimonio with narrative strategies introduced by the Boom, with various features of the old social realist and indigenista approaches, and with elements of magical realism and poetic lyricism. This degree of mediation varies from text to text, complicating attempts at classification and at times actually obscuring the testimonial elements in favor of the novelesque. The primary function of testimonial discourse is the self-representation of the Other like peasants, indigenous peoples, women, children, homosexuals, the poor, political prisoners, guerrilla fighters.

다양한 소수성 물질이 개질된 키토산 나노입자의 약물전달체로서 응용성 고찰

정경원 ( Gyeong-won Jeong ),나재운 ( Jae-woon Nah ),박준규 ( Jun-kyu Park ) 한국공업화학회 2017 공업화학 Vol.28 No.4

천연고분자 키토산은 생체적합하고 생분해성의 특성뿐만 아니라 항암, 항균, 콜레스테롤 저하 등의 다양한 생체활성을 갖고 있어 의료용 분야에서 많이 응용되고 있다. 현재 키토산을 약물전달시스템에 응용한 다양한 약물이 담지 된 키토산 나노입자를 개발하여 질병을 치료할 수 있는 연구가 활발히 진행 중에 있다. 키토산에 존재하는 free 아민(-NH₂) 그룹은 다양한 소수성기를 물리적·화학적 개질을 통해 결합이 가능하며 소수성기가 도입된 키토산은 물에 분산시 자기회합에 의한 shell-core 나노입자를 형성하고 core 부분에 다양한 난용성 약물을 담지하여 물에 대한 용해도를 증가시킬 수 있으며, 단백질, 항암제, 백신 등의 다양한 약물을 담지하여 기존 약물의 부작용을 최소화하여 치료효과를 극대화할 수 있다. 또한, 키토산에 도입된 소수성기에 따라 입자의 크기 및 방출 속도를 제어할 수 있어 다양한 의료용 분야에 응용이 가능하다. 본 총설에서는 다양한 소수성기가 도입된 키토산 나노입자의 제조 및 특성과 특성에 따른 약물전달시스템의 응용성에 관하여 논의 하고자 한다. Natural polymer chitosan has been widely applied to medical fields due to its biochemical activities such as anticancer, antibacterial and lowering cholesterol in addition to biocompatibility and biodegradability. Currently, researches are being actively conducted to develop various drug-encapsulated chitosan nanoparticles for curing different diseases by applying chitosan to a drug delivery system. The free amine (-NH₂) group present in chitosan can bind to various hydrophobic groups by physical and chemical modification and the chitosan with hydrophobic groups can form shell-core nanoparticles by self-assembly when dispersed in water. In addition, an insoluble drug can increase the solubility against water when it was encapsulated in the core of chitosan nanoparticles. Also, the therapy effect can be maximized by minimizing side effects of drugs such as proteins, anticancer drugs and vaccines when they were encapsulated in the core of chitosan nanoparticles. Moreover, it is possible to control the particle size and release rate according to the hydrophobic group introduced to chitosan, so that it can be applied to a wide range of medical fields. The purpose of this review is to discuss the preparation and property of chitosan nanoparticles modified with various hydrophobic groups, and the application to drug delivery systems according to their property.

쿠바 한인 후손들의 정체성 상실 과정 연구

정경원 ( Jeong Gyeong Won ),신정환 ( Sin Jeong Hwan ) 한국스페인어문학회 2003 스페인어문학 Vol.0 No.28

Este estudio tiene como fin averiguar co´mo se ha desarrollado el proceso de la pe´rdida de identidad coreana de los coreanos en Cuba, lo cual sera´ el punto de partida para llevar a cabo la tarea de la recuperacio´n de la identidad nacional. Podemos enumerar cuatro causas de descoreanizacio´n. Primero, los coreanos orgullosos de su genealogi´a del pueblo u´nico han perdido sus rasgos e´tnicos en Cuba con el correr del tiempo y se ve la pe´rdida total de la coreanidad e´tnica dentro de poco tiempo. Segundo, respecto a la lengua, ma´ximo rasgo de la identidad cultural, ya dejo´ de funcionar la ensen~anza del coreano hace cincuenta an~os, de modo que ningu´n coreano puede hablar el idioma materno con fluidez. Tercero, se ha desarticulado la red sistema´tica entre los coreanos y todos los coreanos llegaron a conseguir la nacionalidad cubana, de tal manera que se vei´a la ra´pida asimilacio´n de los coreanos en la sociedad cubana. Cuarto, la nueva situacio´n poli´tica por la revolucio´n de Castro ocasiono´ doble aislamiento de los coreanos: se ha cerrado la puerta con el mundo occidental mientras que Corea del Norte no ha aprotado nada para la comunidad coreana. En este sentido, nos podemos dar cuenta de que la separacio´n de la peni´nsula coreana constituye un gran obsta´culo para la recuperacio´n de la identidad nacional de los coreanos en Cuba.

관상동맥질환 치료를 위한 생체흡수형스텐트의 개발 동향

정경원 ( Gyeong-won Jeong ),김태훈 ( Tae-hoon Kim ),나재운 ( Jae-woon Nah ),박준규 ( Jun-kyu Park ) 한국공업화학회 2018 공업화학 Vol.29 No.5

협심증, 심근경색과 같은 관상동맥 질환은 급속도로 증가하고 있다. 관상동맥 질환은 콜레스테롤과 칼슘과 같은 플라크들이 혈관벽에 흡착되어 발생한다. 심혈관 중재시술은 풍선 카테터와 금속스텐트를 이용하여 좁아진 관상동맥혈관을 확장시키는 비수술적 시술방법이다. 금속재질의 스텐트는 관상동맥질환에 의한 사망자를 감소시키는데 효과적이었지만 영구적으로 혈관에 금속재질 스텐트가 이식되어 있기 때문에 지속적인 염증과 후기 혈전증 등이 발생되었다. 따라서, 스텐트와 같은 영구적 보철물에 의한 합병증과 재협착 등을 해결하기 위한 생체 흡수성 혈관 지지체의 개발은 급속도로 증가되고 있다. 이 리뷰에서는 생체흡수형스텐트의 성공적인 개발을 위한 동향에 대해서 논하고자 한다. The coronary artery disease (CAD) is rapidly increasing such as angina pectoris and atherosclerosis. The CAD is induce by cholesterol and calcium like plaque absortion to artery wall. The percutaneouss coronary intervention is non-invasive treatment that narrowed-artery is expand by using balloon catheter and bare metallic stent. The metallic stents have been effective in reducing the dead by coronary artery disease, but the permanent presence of the metallic stent has been associated with persistent inflammation, and incidence of late thrombosis. Therefore, development bioresorbable vascular scaffold (BRS) is rapidly increasing for treatment of long-term complications and arterial restenosis by permanentmetal prosthesis such as stent. The review discusses the BRS trend for successfully development.

유해녹조로부터 추출된 지질의 전이 에스테르화 반응에 의한 바이오디젤 전환

정경원(Gyeong-Won Jeong),홍웅길(Woong-Gil Hong),안준혁(Jun-Hyuk Ahn),나재운(Jae-Woon Nah) 한국고분자학회 2017 폴리머 Vol.41 No.6

현재 우리나라는 인구 밀도의 증가로 인해 에너지 소비량이 점점 증가하고 있는 추세이고, 이러한 에너지 소비 증가는 유가의 폭등과 화석연료의 고갈을 초래하며 대기중의 이산화탄소 농도를 증가시켜 심각한 환경오염을 유발하기 때문에 이를 대응하기 위한 신재생에너지의 개발이 필요하다. 본 연구에서 이러한 석유 및 화석 연료를 대체하기 위한 방법으로 4대강 유역의 유해녹조를 이용하여 최적의 지질 추출조건을 확립하고, 바이오디젤로 사용 가능성을 규명하고자 하였다. 이전에 보고된 연구논문에서 개발된 항녹조 물질을 유해녹조에 처리하여 응집되어 부유한 유해녹조를 포집하여 건조 후 다양한 용매와 초음파 처리 유무에 따라 최적의 추출 조건을 확인한 결과 초음파 처리와 동시에 chloroform/methanol/water 혼합용매를 이용했을 시 가장 많은 지질이 추출됨을 확인하였고, 이 조건에서 추출된 지질을 이용하여 fatty acid methyl ester(FAME)로 전환했을 시 바이오디젤로 사용하기 가장 적합함을 확인할 수 있었다. 이러한 결과를 통해 4대강 유역의 유해녹조를 재활용한다면 차세대 에너지로 활용할 수 있을 것으로 기대된다. At present, the energy consumption of Korea is increasing due to the increase of population density. Such an increase in energy consumption leads to a rise in oil prices and depletion of fossil fuels, and increases the concentration of carbon dioxide in the atmosphere, thereby causing serious environmental pollution. It is necessary to develop new and renewable energy to overcome this. The purpose of this study is to establish the optimum conditions of lipid-extraction using harmful green algae in the four rivers to substitute a petroleum and fossil fuels, and to investigate the possibility of using them as biodiesel. The antigreen-tide substances developed in the previously reported research papers were treated on the harmful green algae, and the flocculated and floating harmful green algae were collected. After drying, the optimal extraction conditions were confirmed according to the presence of various solvents and the ultrasonic treatment. As a result, in the chloroform/methanol/water mixed solvent, the most lipid was extracted and it was confirmed that it was most suitable for utilization as biodiesel when converted to fatty acid methyl ester (FAME) using extracted lipid under this condition. These results suggest that if the harmful green algae of the four major rivers are recycled, they can be utilized as next generation energy.

Von Recklinghausen 병에 동반된 자발성 혈흉

강미정 ( Mi Jeong Kang ),정이영 ( Lee Young Chung ),김수진 ( Su Jin Kim ),강정훈 ( Jung Hun Kang ),정경원 ( Gyeong Won Jeong ),박동준 ( Dong Jun Park ),이종덕 ( Jong Deog Lee ),황영실 ( Young Sil Hwang ) 대한결핵 및 호흡기학회 1999 Tuberculosis and Respiratory Diseases Vol.47 No.4

키토산이 코팅된 PLGA 나노입자의 제조 및 특성

유수경 ( Su-gyeong Yu ),나재운 ( Jae-woon Nah ),정경원 ( Gyeong-won Jeong ) 한국공업화학회 2021 공업화학 Vol.32 No.5

본 연구는 생체적합성 및 생분해성의 특성을 갖는 PLGA (poly lactic-co-glycolic acid)를 이용하여 이중(w/o/w) emlusion과 유화 용매-증발 기법을 통해 PLGA 나노입자(PNP)를 제조하였고, 이에 키토산을 전하 상호작용을 통해 키토산이 코팅된 PLGA 나노입자(CPNP)를 제조하여 입자의 안정성과 생체이용률을 극대화할 수 있는 경구 투여용 약물 전달체로 사용 가능성을 입증하고자 하였다. CPNP의 화학적 구조는 1H-NMR 및 FT-IR을 통해 분석하였으며, 모든 특성 피크가 나타남으로써 성공적으로 제조되었음을 확인하였다. 또한, CPNP의 입자 크기, 제타 전위 및 형태학적 이미지는 DLS와 TEM을 이용하여 각각 분석하였으며, TGA를 통해 CPNP의 열적 분해 거동을 관찰하였다. 또한, CPNP의 세포 독성은 HEK293 및 L929 세포에서 MTT assay를 수행하여 확인하였고, 모든 농도에서 70% 이상의 세포 생존율을 확인함으로써 독성이 없음을 입증하였다. 이러한 결과를 통해 본 연구에서 개발된 CPNP가 경구용 약물 전달체로써 사용 가능성이 있음을 제안한다. In this study, poly lactic-co-glycolic acid (PLGA) nanoparticles (PNP) were prepared through double (w/o/w) emlusion and emulsifying solvent-evaporation technique using PLGA, which has biocompatibility and biodegradability. To maximize stability and bioavailability of the particles, chitosan-coated PLGA nanoparticles (CPNP) were prepared by charge interaction between PNP and chitosan. We demonstrated that CPNP can be utilized as a drug carrier of oral administration. The chemical structure of CPNP was analyzed by 1H-NMR and FT-IR, and all characteristic peaks appeared, confirming that it was successfully prepared. In addition, particle size and zeta potential of CPNP were analyzed using dynamic light scattering (DLS) while morphological images were obtained using transmission electron microscope (TEM). Thermal decomposition behavior of CPNP was observed through thermogravimetric analysis (TGA). In addition, the cytotoxicity of CPNP was confirmed by MTT assay at HEK293 and L929 cell lines, and it was proved that there is no toxicity confirmed by the cell viability of above 70% at all concentrations. These results suggest that the CPNP developed in this study may be used as an oral drug delivery carrier.

저분자 알지네이트를 이용한 각막상피 보호용 콘텍트렌즈의 제조 및 항균성 평가

최유성 ( Yoo-sung Choi ),정경원 ( Gyeong-won Jeong ) 한국키틴키토산학회 2022 한국키틴키토산학회지 Vol.27 No.3

In order to improve the wettability of contact lenses and to impart antibacterial properties against P. aeruginosa, E. coli and S. aureus a major bacterium that causes keratitis, alginate, low molecular weight as a natural polysaccharide, was added. Contact lenses were manufactured using 2-hydroxyethyl methacrylate(2-HEMA), 1-vinyl-2-pyrrolidinone(NVP) and ethylene glycol dimethacrylate(EGDMA). The addition of low molecular weight alginate salt(LMWAS) was carried out by the IPN method. The manufactured contact lenses were checked for moisture content, light transmittance, and antibacterial properties. It was confirmed that the moisture content augmented when the amount of LMWAS was increased, and the light transmittance did not change significantly. The antibacterial effect and minimum inhibitory concentration(MIC) were examined in strain such as P. aeruginosa, E. coli and S. aureus. It was confirmed that the LMWAS(Mw: 4082 Da) was indicated a minimum inhibitory concentration(MIC) of 0.10% against P. aeruginosa, E. coli and S. aureus and it was confirmed that the same antibacterial properties were exhibited even after mixing with the actual lens composition. These results suggest that LMWAS-combined contact lenes can be utilized as functional lenes to protect corneal epithelium.