김치유래 Lactobacillus plantarum K-21의 DPPH 라디칼 제거활성 증진 및 다양한 항산화 효과

김예린,김예담,전채민,박규림,이오미,손홍주 한국환경과학회 2022 한국환경과학회지 Vol.31 No.8

Lactic Acid Bacteria (LAB) are among the representative probiotics that have been used for a long time in fermented food. Although there are many studies on detecting the radical scavenging activity of LAB, few studies have been conducted on the environmental factors that improve scavenging activity. This study investigated the environmental factors affecting the DPPH radical scavenging and various antioxidant activities of Kimchi-derived Lactobacillus plantarum K-21 with antihypertensive and radical scavenging activities. The optimal conditions for scavenging DPPH radicals were glucose 2%, bactopeptone 0.5%, Tween 80 0.05%, L-cysteine 0.05%, and an initial pH 6.5 at 35℃. Under optimal conditions, the DPPH radical scavenging activity was 94.8±2.2%, which was 1.5 times higher than that of the basic medium. In addition, L. plantarum K-21 had other antioxidant activities; ABTS radical scavenging (93.6±1.5%), hydroxyl radical scavenging (8.5±0.9%), metal chelating (65.9±0.5%), NO scavenging (53.1±19%), SOD-like (25.1±1.5%), and reducing power (11.7±1.4%) activities were detected. Therefore, L. plantarum K-21 may act not only as a starter for lactic acid-fermented foods with improved functionality but also as a drug for various diseases caused by oxidative stress.

The Korean Influenza National Immunization Program: History and Present Status

윤재원,노지윤,송준영,전채민,김윤주,정희진 대한감염학회 2017 Infection and Chemotherapy Vol.49 No.4

The Korean influenza national immunization program was first established as an interim program in 1997, administering the influenza vaccine to low-income elderly adults. In 2005, the program assumed its present form of providing free influenza vaccination to adults aged ≥65 years. After turning over the influenza vaccination for elderly adults to the private sectors in 2015, the influenza vaccination coverage rate among this population increased to >80%. In addition, after the 2009 H1N1 influenza epidemic crisis, the vaccine was domestically produced. By reaching a 75% vaccination coverage rate in the target groups, it was possible to put an end to the influenza pandemic and fix the shortcomings of the system that existed at that time. The influenza vaccination program, provided free of cost, was extended to include infants aged <12 months in 2016 and ≤59 months in 2017 in order to reduce the influenza burden in these populations. However, the vaccine effectiveness remains low despite the high vaccination rates in elderly adults. Therefore, several areas, such as the adoption of quadrivalent influenza vaccine, adjuvanted influenza vaccine, and high-dose influenza vaccine and the expansion of vaccination target groups, still need to be addressed.

임산부를 대상으로 한 BCG접종법의 바른 인식과 선택 교육의 효과

이승희(Seung Hee Lee),전채민(Chae Min Chun),전진호(Jin Ho Chun) 한국역학회 2008 Epidemiology and Health Vol.30 No.2

Purpose: The most effective and basic Tb preventive measure is BCG vaccination. Even though the Intradermal vaccination method in BCG vaccination is known to be the most accurate method in preventing the advanced Tb, nowdays most of the Korean civilian hospitals utilize multipuncture BCG vaccination method ,which is quite contrary to the national standard intradermal vaccination method. Therefore I decided to inform and educate the pregnant women who would be in a position to choose the BCG vaccination method. This will help them understand the BCG vaccination methods properly. We should urge the intradermal method which is acknowledged as the national standard vaccination method. Methods: The questionnaire was mailed twice to 214 pregnant women requring the antenatal care who visited any of the 9 health centers in Busan from the period of Aug to Oct. 2007. The 1st questionnaire was done in 214 pregnant women prior to education concerning the BCG vaccination methods and Tb, and the 2nd questionnaire was done after education. Contents of the questionnaire were general knowledges for BCG vaccination method, intention of selection for BCG vaccination, knowledges for the adverse effect, etc. Data analysis was performed utilizing SPSS (ver12) and the pregnant women’s change in concept was comparatively analyzed with percentage, χ2 -test. Results: Considering the general characteristics of the pregnant women who participated in the study, the highest percentage was noticed in their 15-28 gestational weeks (60.8%), Age over 30 (70.1%), Education level-college graduate (76.6%). Recognition to the presence of two types BCG vaccination method was 27.6% before education and 95.3% after education which showed a marked improvement (p=0.0001). After education, 82.2% of pregnant women decided to choose intradermal BCG vaccination method at birth which was 23.4% before education (p=0.0003). Despite the fact that intradermal BCG method is the national standard vaccination method, some of them prefer multipuncture BCG vaccination method, because most of the scars (41.3%), the civilian hospitals do it (35.7%), because of the lack of the education and information from the health centers and public institutions (17.4%). The future selection of BCG vaccination methods as follows: before education, intradermal BCG vaccination 31.0%, multipuncture BCG vaccination 14.6%, uncertain 54.4%, and after education, intradermal BCG vaccination 72.4%, multipuncture BCG vaccination 2.8%, uncertain 24.8% (p<0.0001). Conclusions: The pregnant women were not fully aware of intradermal and multipuncture BCG vaccination methods. Through education and information, it was possible for them to thoroughly recognize the BCG vaccination methods. In order to urge the intradermal BCG vaccination method, the health centers and public institutions need to educate and inform the pregnant women regarding the intradermal BCG vaccination method which is the standard vaccination method in Korea.

모성 본능 중심의 산전교육에 의한 산모의 모성 행동과 태도 변화 - Korean Gentle Birth (KGB) Program의 효과 평가 -

김영란,민유선,장우식,남문희,전채민,전진호,손혜숙 한국모자보건학회 2012 한국모자보건학회지 Vol.16 No.2

Objectives: To evaluate the effects of a well-designed, maternity-oriented antenatal education program (Korean Gentle Birth, KGB) that introduced from the Leboyer Birth and modified in Korea. Methods: Subjects were over 16 weeks primipara pregnant women who visited an obstetric hospital (one of the current six membership health organization of KGB in Korea) in Kimhae city for antenatal care and informed consented to join in this study; the total 182, 89 with KGB (case) and 93 with only general antenatal care without KGB (control). They were collected during four terms of the KGB from August 2010 to March 2011. Value of maternity, cognition to antenatal education, attitudes to labor, interests and cooperations of the spouse, executing mother-infant attachment and the desirable maternal performance after delivery were surveyed with direct interview using questionnaire. Data analysis was performed using MedCalc (ver 11.5, Mariakerke, Belgium). Level of each categories' responses were presented and compared as the score out of 100. The rate and mean compared by chi-square test, t-test, and paired t-test. And, multiple logistic regression (MLR) analysis conducted on the over five times use of ‘room in one' and the over one year's intention of breast feeding. p<0.05 was considered statistically significant. Results: There were no differences in age, education, income, whether planned pregnancy, and experiences of abortion between the two groups. Instead, attitude of pregnant education was higher in case than control (p=0.003) with proportion of above education group, 84.3% and control group 79.4%, respectively. As result of comparison between the two groups, almost surveyed items were significantly higher in case than control group (p<0.05). And, as result of comparison between the pre- and post- in the case, almost surveyed items significantly improved in post survey (p<0.001). As result of the MLR, the OR (95% CI) of the over five times use of ‘room in one' and the over one year's intention of breast feeding were significantly higher in KGB group compared to control group; 6.6 (2.8~15.5) and 13.9 (5.4~35.5), respectively. Conclusion: Maternity identification and desirable maternal behaviors apparently improved with the KGB. This efforts considered that to support strengthening maternity and build-up the sound culture for pregnancy and birth. When performing antenatal care, introduction and application of the KGB is highly recommended. Hope to this study actively used to motivate interests and conduct further studies related to the GB concepts and orientations.

모성 본능 중심의 산전교육에 의한 산모의 모성 행동과 태도 변화 -Korean Gentle Birth (KGB) Program의 효과 평가-

김영란,민유선,장우식,남문희,전채민,전진호,손혜숙 한국모자보건학회 2012 한국모자보건학회 학술대회 연제집 Vol.2012 No.2

Prevalence of Spirometrically-defined Restrictive Ventilatory Defect in Korea: The Fourth-2, 3, and Fifth Korean National Health and Nutrition Examination Survey, 2008-2012

이정연,황용일,박용범,박재용,Ki Uk Kim,오연목,윤형규,윤호일,신승수,이상엽,이창훈,이흥범,임성철,정성수,오경원,김연아,전채민,유광하 대한의학회 2015 Journal of Korean medical science Vol.30 No.6

The aim of the study was to evaluate the prevalence of restrictive ventilatory defect and to determine the risk factors in subjects with spirometrically-defined restrictive ventilatory defect. We used the population-based, fourth-2, 3 (2008, 2009) and fifth (2010-2012) Korea National Health and Nutrition Examination Survey (KNHANES) to analyze 15,073 subjects, aged ≥ 40 yr who underwent spirometry. Chest radiographs were also analyzed to identify restrictive lung disease. Spirometrically-defined restrictive ventilatory defect (FEV1/FVC ≥ 70% and FVC < 80% of mean predicted value) was detected in 11.3% (n = 1,709) of subjects aged ≥ 40 yr. The prevalence increased to 12.3% on using the lower limit of normal (LLN) criteria. Approximately 99.4% of subjects were classified as mild restrictive. Among these, 11.3% had inactive tuberculosis (TB) lesion, 2.2% cardiac disease, 2.0% previous operation scar or radiation injury and/or mediastinal disease, and 7.4% other pulmonary disease suggestive of restrictive lung diseases on chest radiograph. Evidence of previous TB history was independently associated with restrictive ventilatory defect (odds ratios [OR], 1.78; 95% confidence interval, 1.45-2.18) after adjustment for gender, age, smoking, area for residence and body mass index. The prevalence of restrictive ventilatory defect among the nationwide population in Korea was 11.3% with fixed ratio criterion and 12.3% with LLN criterion. Most cases were of the mild restrictive category and previous TB history is the independent risk factor for restrictive ventilatory defect.