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뇌전증 경련 억제를 위한 실시간 폐루프 신경 자극 시스템 설계
김소원,김선희,이예나,황서영,강태경,전상범,이향운,이승준,Kim, Sowon,Kim, Sunhee,Lee, Yena,Hwang, Seoyoung,Kang, Taekyeong,Jun, Sang Beom,Lee, Hyang Woon,Lee, Seungjun 대한의용생체공학회 2015 의공학회지 Vol.36 No.4
Epilepsy is a chronic neurological disease which produces repeated seizures. Over 30% of epileptic patients cannot be treated with anti-epileptic drugs, and surgical resection may cause loss of brain functions. Seizure suppression by electrical stimulation is currently being investigated as a new treatment method as clinical evidence has shown that electrical stimulation to brain could suppress seizure activity. In this paper, design of a real-time closed-loop neurostimulation system for epileptic seizure suppression is presented. The system records neural signals, detects seizures and delivers electrical stimulation. The system consists of a 6-channel electrode, front-end amplifiers, a data acquisition board by National Instruments, and a neurostimulator and Generic Osorio-Frei algorithm was applied for seizure detection. The algorithm was verified through simulation using electroencephalogram data, and the operation of whole system was verified through simulation and in- vivo test.
멀티채널 전극을 이용한 쥐의 뇌 내 여러 영역의 활동전위 동시 기록ㆍ자극을 통한 뇌 활동 연구 및 감각기관 제어
이예나(Ye-Na Lee),이지원(Jee-Won Lee),이유진(You-Jin Lee),정희지(Hee-Ji Jung),장서영(Seo-Young Jang),유하람(Ha-Ram Yu),정소현(So-Hyun Jung),전상범(Sang Beom Jun) 대한전자공학회 2015 대한전자공학회 학술대회 Vol.2015 No.11
Whisker-barrel-motor system is a rat"s system of choice for exploring an environment and collecting information of location, shape, size and texture of objects around it[1]. Studying whisker-barrel-motor system of rats allows us to control animal"s behavior and analyze biological neural networks in vivo using live animal. In this article, multi-channel microelectrode array technology and whisker-barrel-motor system are carefully considered. This study can be applied to basic neuroscience and brain-computer interface study for controlling animal"s behavior.