서울시 녹지 연결망의 시계열 분석 및 정책적 함의

장병우(Chang, Byungwoo),박신영(Park, Sinyoung),정진아(Jeong, Jina),강완모(Kang, Wanmo) 한국지적정보학회 2021 한국지적정보학회지 Vol.23 No.1

본 연구는 그래프 이론을 적용하여 지난 35년(1984~2019년)간의 서울시 녹지 연결망의 변화를 다각적으로 비교·분석하고 정책적 함의를 제시하고자 하였다. Landsat 위성영상의 다중시기 정규식생지수를 통해 녹지 패치를 도출하고, 다양한 공간규모에서 직선거리와 최소비용경로에 따른 패치 및 비-패치 기반의 연결망 분석 기법을 적용했다. 연구 결과, 1984년부터 2019년까지 녹지 연결성이 회복되고 향상되었음을 정량적으로 확인하였고, 연결망 보전·관리에 있어서 중요한 녹지를 도출하였다. 비-패치 기반의 연결망 모형을 통해 시간 흐름에 따른 서울시의 핵심 녹지축 변화를 추적하여 북악산에서 남산, 국립서울현충원, 관악산으로 이어지는 녹지축의 회복을 확인할 수 있었다. 용산공원 신규 조성에 따른 연결성 기여도 평가 결과, 녹지 면적 증가 대비 연결성 증진 효과가 매우 높은 것으로 모의되었다. 또한, 용산공원은 서울시의 핵심 녹지축을 강화시키고, 확장시킬 수 있는 녹지로도 확인되었다. 연구 결과들은 서울시 도시생태계와 시민들의 삶의 질을 높일 수 있는 생활권 녹지공간 확충과 지속 가능한 도시기본계획 체계화 및 관리계획 수립을 위한 정책결정 과정에서 많은 기여를 할 수 있을 것으로 기대된다. We analyzed the temporal changes of green space network in Seoul from 1984 to 2019 using graph theory to suggest policy implications. For the analysis, we extracted green space patches using Landsat NDVI (Normalized Difference Vegetation Index) time-series data. Patch- and non-patch-based network analyses were applied using Euclidean distance and least-cost distance at multi-spatial scales. The patch-based network analysis confirmed the notable recovery and improvement of the network connectivity during the study period. We identified the important green spaces that are pivotal in preserving and managing the green space network. In addition, based on the non-patch-based network analysis, we found the recovery trend of main green corridors connecting the area from north to south. The establishment of Yongsan Park contributed greatly to the improve the connectivity, compared to the increased area of the green space. The result also showed that Yongsan Park can strengthen and expand the green corridor. We hope our research provides useful information for policymakers to expand neighborhood green spaces and develop sustainable urban master plans.

Clinical and Pathologic Correlation of Endometrium Detected by Transavaginal Sonography in Postmenopasual Woman

문혜성 ( Hey Sung Moon ),장병우 ( Byeung Woo Chang ),손영수 ( Young Soo Son ),김종일 ( Jong Ill Kim ),우복희 ( Bock Hi Woo ) 대한산부인과학회 1993 대한산부인과학회 학술대회 Vol.71 No.-

제 71 차 춘계학술대회 : 일반연제발표 ; 폐경기후 여성에서 질식초음파검사에 의한 자궁내막 이상병리상태 예측에 관한 연구

문혜성(Hey Sung Moon),장병우(Byeung Woo Chang),손영수(Young Soo Son),김종일(Jong Ill Kim),우복희(Bock Hi Woo) 대한산부인과학회 1993 춘계학술대회 Vol.- No.-

자궁 경부암 환자의 림파선 폐 전이 1례 보고 : A Case Report

장병우,임옥경,박미혜,신효경,김향미,손영수,우복희,정호인,서정수 梨花女子大學校 醫科大學 醫科學硏究所 1994 EMJ (Ewha medical journal) Vol.17 No.1

Diffuse pulmonary Iymphangitic involvement secondary to cervical carcinoma is a rare form of pulmonary metastatic disease. A patient with recurrent squamous cell carcinoma of cervix presented with rapid deterioration with marked respiratory symptoms suggestive of pulmonary embolism and right heart faiure, with which the disease is often confused. Pulmonary Iymphangitic spread of the cancer was found postmortem. The pathogenesis of pulmonary Iymphangitic carcinomatosis is reviewed and diagnostic evaluation discussed.

폐경기 여성에서 경피적 에스트로젠 투여후 생물학적 영향에 대한 연구

우복희,유한기,신효경,박미혜,임옥경,장병우,신정현 대한산부인과학회 1994 Obstetrics & Gynecology Science Vol.37 No.9

1992년 9월부터 5월까지 이화여자대학교 부속병원 산부인과 외래를 내원한 폐경기 환자 43명을 대상으로 경피적 에스트라디올(Estraderm TTS) 50 micro g투여(치료군 I)와 100 micro g투여(치료군 II)에 따르는 생물학적 영향에 따른 연구를 시행하여 다음과 같은 결론을 얻었다. 1. 혈중 에스트론치의 변동은 치료군 I, II에서 각각 34.2+-3.42 pg/dl, 34.0+-5.72 pg/dl로 통계학적으로 유의한 증가를 보였으나(p$lt;0.05) 양 군간에 치료후 변동은 유의한 차이가 없었다(p$gt;0.05). 혈중 에스트라디올 치의 변동은 치료군 I에서 14.9+-1.54 pg/dl이고 치료군 II에서 15.3+-0.89 pg/dl로 통계학적으로 유의한 증가를 보였으며(p$lt;0.05) 치료군 I, II 간의 치료후 변동간에는 유의한 차이가 없었다(p$gt;0.05). 2. 혈중 FSH의 변동은 치료군 I과 치료군 II에서 각각 23.5+-4.55 mIU/ml, 24.5+-3.05 mIU/ml, LH의 변동은 치료군 I과 치료군 II에서 각각 14.5+-2.19 mIU/ml, 22.0+-3.53 mIU/ml로 FSH와 LH 모두 통계학적으로 유의한 감소를 보였으며(p$lt;0.05) FSH와 LH 모두 양 군간에 치료후 변동은 유의한 차이가 없었다(p$lt;0.05). 3. 혈중 renin substate치의 변화는 치료군 I과 치료군 II에서 각각 0.31+-0.002ng/ml, sex hormone binding globulin(SHBG)치의 변화는 2.3+-0.35nM/l으로 통계학적으로 유의하지 않았으며(p$gt;0.05) 양군간에 치료후 변동도 유의한 차이가 없었다(p$gt;0.05). 4. 혈중 총 콜레스테롤, trglyceride, 고밀도 지단백 농도의 변화는 치료군 I에서 각각 9.6+-1.58 mg/dl, 1.4+-0.01 mg/dl, 6.5+-0.29 mg/dl, 2.4+-0.01 mg/dl, 1.0+-1.55 mg/dl로 통계학적으로 유의한 변화를 보이지 않았으나(p$gt;0.05) 저밀도 저단백 농도의 변화는 치료군 I과 치료군 II에서 각각 18.8+-16.36 mg/dl, 18.5+-0.94 mg/dl로 유의성있게 감소하였다(p$lt;0.05). 양군간의 치료후 변동간에는 유의한 차이가 없었다(p$lt;0.05). 5. 골밀도를 간접적으로 측정한 소변내 칼슘, calcium/creatinine비, hydroxyproline/creatinine비는 양 치료군에서 통계학적으로 유의한 감소를 보였다(p$lt;0.05). 이상의 결과 경괴적 에스트라디울 투여법은 경구적 투여법이 필요로 하는 일일 용량보다 적은 량으로 치료혈중 농도를 유지하며 지속적인 생물학적 활성을 나타내며 간에서의 'first pass effect'을 최소화시키면서 효과적인 여성 호르몬의 증가 및 이에 다른 심혈관계 질환의 예방과 골다공의 예방에 적절한 치료법으로 사료된다. Systemic side effects that result from oral administration of estrogens to postmenopausal women may be minimized by use of the trasdemal route. We administred transdermal estrodiol, 50 ug(to 23 postmenopausal women), 100 ug (to 20 postmenopausal women) cyclically for 3 months to 43 postmenopausal women to study the bilogical effect. The results were follows: 1. The plasma estradiol and estrone after trasdermal estradiol therapy in Group II were increased significantly(p0.05). 2. The plasma FSH and LH after transdermal estradiol therapy in Group I and Group II were decreased significantly (p0.05). 3. The change of plasma SHBG and Renin substrate after transdermal estradiol therapy in Group I and Group II were not statistically significant(p$gt;0.05), and difference of changes between two groups was not statistically significant(p$gt;0.05). 4. The changes of plasma total cholesterol, triglyceride, and HDL-cholesterol after transdermal estradiol therapy in Group I and Group II were not statistically significant(p$gt;0.05) but plasma LDL-cholesterols after transdermal estradiol therapy in both groups were statistically significant(p0.05). 5. The changes of urinary calciu, calcuim/creatinine ratio, hydroxyproline/creatinine ratio were not statistically significant in both groups(p0.05). These data indicate that transdermal estradiol can elicit many of the desirable actions of estrogen while avoiding the pharmacologic effects of oral estrogens on hepatic proteins.

자궁경부암에서 Glutathione-S-Transferase와 P-glycoprotein의 발현에 대한 연구

배석년,김도강,김수평,김용욱,장병우,변태섭 대한산부인과학회 1998 Obstetrics & Gynecology Science Vol.41 No.1

Expression of glutathione-S-transferase-π and multidrug resistance gene was examined immunohistochemically in relation to the response to neoadjuvant chemotherapy with cisplatin and etoposide in 23 patients with primary squamous cell carcinoma of uterine cervix(Stage ⅠB2 and ⅡA). Glutathione- S-transferase-π was detected in 19 patients(82.6%). Eleven patients(47.8%) showed positive staining for both proteins. After radical hysterectomy, 11 patients showed pathological response from no residual malignancy to microinvasive cancer. Six of 12(50.0%) tumors showing positive glutathione-S-transferase-π staining were drug resistant(no change or progressive disease), whereas six of 11(54.5%) tumors showing negative gutathione-S-transferase-π staining were drug resistant. This difference in the response rates of the two groups was not significant(p > 0.05). Ten of 19(52.6%) tumors showing positive multidrug resistance staining were diug resistant(no change or progressive disease), whereas 2 of 4(50.0%) tumors showing negative multidrug resistance staining were drug resistant. This difference in the response rates of the two groups was not significant(p > 0.05). Five of 11(45.5%) tumors showing positive staining for both gene were drug resistant, Whereas two of 4 (50%) showing negative staining for both gene were drug resistant. This difference in the response rates of the two groups was not significant(p > 0.05). These data suggest that glutathione S-transferase-π and multidrug resistance gene were not useful predictive markers of drug resistance composed of cisplatin and etoposide in squamous cell carcinoma of uterine cervix.

빈혈을 동반한 자궁근종 환자에서 경구용피임약을 이용한 자가수혈효과에 대한 임상연구

김종일,장병우 대한산부인과학회 1997 Obstetrics & Gynecology Science Vol.40 No.11

Oral contraceptive user had less menstrual blood loss, which reduced the risk of iron dei- ficiency anemia by 50%. The incidence of menorrhagia, irregular menses and intermenstrual bleeding is also singificantly reduced in the user of oral contraceptives. In most women with leiomyomas, low-dose oral contraceptive use provide the noncontraceptive benefit of a reducti-on of menstrual flow, with resultant improvement in hematocrit. So, we confirmed that anemic leiomyoma patients with oral contraceptive use showed autotransfusion effects given by preo-perative administration orally during some period.

국소마취하에 Le Fort Operation에 의한 자궁탈교정술

김종일,장병우 대한산부인과학회 1996 Obstetrics & Gynecology Science Vol.39 No.12

Objective: Our purpose was to evaluate and compare the Le fort partial colpocleisis in the medically compromized elderly population using intravenous sedation and local anesthesia, and conventional surgical repair using general anesthesia. Study design: A retrospective data collection sequential seriese of 10 patients performed Le Fort partial colpocleisis using local anesthesia. The patients age, operative time, change in hemoglobin, days of hospitalization, medical illness, duration of catheter insertion, complication and follow up of are retrospective group of 23 women with complete uterine prolapse who had a vaginal hysterectomy, anterior with posterior colporrhaphy performed by the same surgical team during same period. Result: The median age of Le fort partial colpocleisis was 71.2 years(range 64 to 82 years), wherease median age in the vaginal hysterectomy group was 59.6 years(range 45 to 75 years)(p$lt;0.05). The median operating time under anesthesia of Le Fort partial colpocleisis was 70.07 minutes(range 37 to 805 minutes) compared with the vaginal hysterectomy median time of 149.57 minutes(range 75 to 225 minutes)(p$lt;0.05). The amount of Median blood loss during Le Fort partial colpocleisis was 133 ml compares with vaginal hysteretomy was 327.6 ml(p$lt;0.05). The median hospital stay both Le Fort partial colpocleisis and vaginal hysterectomy was 4.7 days each other(range, Le Fort partial colpocleisis 4 to 6 days, vaginal hysterectomy 6 to 13 days)(p$lt;0.05). The Mediann duration of foley catheter insertion day in Le Fort partial colpocleisis was 1 day all cases and 4.3 days in vaginal hysterectomy(p$lt;0.05). The complications were comparable with the exception of 3 cases of mild degree urinary tract infuction in the Le Fort partial colpocleisis group. Conclusion : All 10 patients had the Le Fort partial colpocleisis offers significant advantages in selected population of eldery, medically compromised condition. The Le Fort partial colpocleisis was succesful surgical repair under local anesthesia without the need of general inhalation.

조기진통 및 조기양막파수 임부의 혈청과 태반조직에서의 Interleukin-6 발현에 관한 연구

김성숙,우복희,손영수,김향미,장병우,조수연,변광호,최인표 대한산부인과학회 1995 Obstetrics & Gynecology Science Vol.38 No.1

저자는 1992년 1월부터 12월까지, 1993년 8월부터 1994년 3월까지 20개월간 조기진통 (13명 group I)과 조기양막파수(26명 group II)를 주소로 이화대학병원 산부인과에 입원한 임부 39명 과 산전진찰을 위해 외래로 내원한 정상임부 8명을 대상으로 혈청내 IL-6 생물학적 활성도 의 CRP 양성유무 그리고 백혈구수치의 측정 및 태반 조직에 대한 IL-6의 면역 조직화학적 염색을 시행하여 다음과 같은 결과를 얻었다. 1. group I,II 의 연령분포, 산과력, 입원시 임신주수, 자궁경부의 개대 및 소실정도에는 두 군 간에 의한 차이가 없었으나 Bishop score 에는 유의한 차이가 있었다. 2. 혈청내 CRP 농도를 0.8mg%이상을 양성으로 정의할 때 group I 과 group II에서 각각 23.1%, 38.5%의 양성률을 보였으나 두 군간에 유의한 차이가 없었다. 3. 백혈구 수치의 평균값은 group I이 12,943+-3,440 cells/mm3, group II 12,308+-3,954 cell/mm3 으로 두군간에 유의한 차이가 없었고 백혈구 수치가 15,000 cell/mm3이상을 임상적 으로 융모양막염이 발생한 경우로 정의할 때 group I과 group II에서 융모양막염의 발생률은 각각 38.4%, 15.3%fmf 보여 두군간에 유의한 차이가 없었다. 4. 태반조직의 면역조직화학적 염색검사는 group I, II 모두에서 염증의 정도가 심할수록 탈 락막 간질세포에 강한 양성을 보였으며, 일부 융모막 융모와 영양배엽 그리고 염증세포에서 도 양성반응을 보였으며, CRP 검사와 백혈구 수치 결과에 따른 반응에서 음성의 결과를 보 인 경우에서도 태반 조직의 면역조직화학적 염색에서는 강한 양성반응을 보인 경우가 있었다. 5. 혈청내 IL-6의 생물학적 활성도 측정결과 정상대조군에서 742+-503 u/ml 대상환자군 (group I, group II)에서 6,991 +- 3,773 u/ml의 활성도를 보여 두 군사이에 유의한 차이를 보였다. 6. 신생아의 체중은 group I 과 group II에서 각각 1.94 +- 0.6 kg, 2.63 +- 1.0 kg 으로 두군 간에 유의한 차이가 없었으며 1분 및 5분 Apgar score도 group I에서 각각 7.6 +- 2.9 점, 8.2 +- 3.5점, group II에서는 8.4 +- 2.0점과 9.4 +- 1.9점으로 유의한 차이가 없었다. 감염에 의한 임신조직의 염증반응은 임부 혈청내 IL-6의 생물학적 활성도를 증가시키고 CRP 양성반응과 백혈구 수치 상승 등을 유발할 뿐만아니라, 임신조직(태반조직) 자체에도 강한 염증반응의 결과로 인한 IL-6의 과발현 현상을 일으킴을 알 수 있다. The prevention of premature deliveries still remains a major problem in obstetrics. This study was purposed to evaluate total 39 pregnant women with premature labor(13 cases, Group I) and spontaneous premature rupture of membrane (26 cases, Group II) who were admitted to the Department of Obstetrics and Gynecology. For control group , eight normal pregnant women were selected via OPD to the Department of Obstetrics and Gynecology, Ewha Womans University Hospital from January, 1992 to December, 1992 and from August, 1993 to March 1994. The author confirmed the IL-6 bioactivity and IL-6 expression on placenta by immunohistochemical stain method in premature labor group and spontaneous premature rupture of membrane group . The results were as follows : 1. There were no statistical difference of the clinical charachteristics between group I and group II, except in terms of bishop score. 2. CRP positive rate was 23.1% in group I and 38.5% in group II. There was no statistical difference between two groups. 3. Mean values of WBC count in group I and group II were 12,943+-3,440 cells/mm3, 12,308+-3,954 cell/mm3 respectively. There was not significant difference between two groups. 4. Placental IL-6 expression in premature labor group and spontaneous premature rupture of membrane group was similar. It showed stronger positivity on decidual stromal tissue as the inflammatory processes progress more severely. 5. Serum IL-6 bioactivity was in 742+-503 u/ml in control group and 6,991 +- 3,773 u/ml in comparative group (group I and group II). The IL-6 levels of comparative group were sinificantly higher that those of control group . 6. In terms of birth weight, 1 min and 5 min Apgar score of neonate premature labor and SPRM groups. there were not statistical differences between the two groups. (19.4+-0.6kg, 7.6kg+-2.9 and 8.2 +-3.5 in group I : 1.63 +- 1.0kg, 8.4 +- 2.0 and 9.4 +- 1.9 in group II) In conclusion, infection induced preterm labor has been attributed to inflammatory mediatros, such as Interleukin-6 liberated from gestational tissues in response to bacterial products. In premature labor and SPRM groups, serum IL-6 bioactivity was more markedly elevated than in control group (normal pregnant woman). Strong positive expression of IL-6 in immunohistochemical stain was showed in decidual stromal cells of placenta.

제왕절개 자궁적출술의 임상적 고찰

김도강,김수평,노덕영,신진웅,장병우,변태섭,서천옥,이희중,강규섭 대한산부인과학회 1998 Obstetrics & Gynecology Science Vol.41 No.10

Objective: This report was undertaken to determine the present status of cesarean hysterectomy which was originally devised to prevent postcesarean infection and hemorrhage, and its conditions have gradually been widened to include many conditions in which removal of the uterus is necessary or desirable. Material & method: 53 cases of cesarean hysterectomy performed at Taejon St, Mary`s Hosp. from Jan. 1992 to Aug. 1997, was discussed and evaluated retrospectively. Results: There were 19, 823 deliveries during this period. Cesarean hysterectomy was performed in 53 cases of 8, 558 cesarean sections [0.56%] and 11, 265 normal spontaneous vaginal deliveries [0.04%], an total indication of 0.28%. In total subjects of 53 cases in this series, the subject were 31 cases of uterine atonic bleeding, 9 cases of adhesive placenta, 6 cases of placenta previa, 5 cases of uterine myoma with pregnancy and 2 cases of uterine rupture. All patients who had cesaren hysterectomy received transfusion from 1 pint to 40 pints. The post operative complications were atonic bladder, disseminated intrav ascular coagulopathy, febrile morbidity and wound infection. There was one maternal death due to acute, severe homorrhage and DIC. Conclusion: Postoperative complications still remain the main causes of maternal mortality. Therefore careful prenatal care, momentary judgement of right operation time, fresh blood transfusion and reduction of operation time are very important.