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산전 유전질환진단에 있어서 세포유전학적인 핵형 분석 , FISH 및 PRINS 의 임상적인 이용에 관한 연구
김영주(Young Ju Kim),우복희(Bock Hi Woo),양훈진(Hun Jin Yang),박미영(Mi Young Park),이영희(Young Hi Lee),안정자(Jung Ja Ahn) 대한산부인과학회 1999 Obstetrics & Gynecology Science Vol.42 No.1
N/A Objective: Increasingly it is being recognized that genetic factors play a significant role in causing malformation. There are many available prenatal diagnostic methods including cytogenetic karyotyping using amniocentesis and cordocentesis, fluorescence in situ hybridization(FISH), and primed in situ labelling(PRINS). Our purpose was to attempt to discuss the clinical use of cytogenetic karyotyping, FISH, and PRINS. Methods: We conducted 222 cases of cytogenetic karyotyping using amniocentesis and cordocentesis, l0 cases of FISH, and 10 cases of PRINS from January 1996 to July 1998 at Ewha Womans University Mokdong Hospital. Age distribution, chromosomal abnormalities by age group, indication, karyotype, and baby outcomes were performed. Results: Overall incidence of chromosomal abnormalities was 7.7%(17cases) and chromosomal abnormalities were most frequently noted in 30-34 year old women and 35-39 year old women(2.3%, respectively). Among 222 cases, 25-29 year old women were highest(30.2%). Chromosomal abnormalities among cytogenetic karyotyping cases were Down syndrome, Edward syndrome, Patau syndrome, Deletion(8), Inversion(9), etc. The 5 cases of healthy baby among chromosomal abnormalities were delevered. Among 213 cases of karyotyping using amniocentesis, abnormal karyotyping cases were 15 cases. Among 15 cases, 8 cases were terminated and 5 cases of healthy baby were delivered. Among 9 cases of karyotyping using cordocentesis, 2 cases of chromosomal abnormalities(Edward, Down syndrome) were found and 3 cases healthy baby were delivered. Among 10 cases of FISH results, 6 case of FISH results were the same with G-banding and were different from G-banding. Among 10 cases of PRINS results, we got the PRINS results from 7 cases. Conclusion: It is concluded that cytogenetic karyotyping, FISH, and PRINS are very useful to detect chromosomal abnormalities.
라마즈 산전교육이 초산부의 분만 진행 시간과 분만 형태에 미치는 효과에 대한 연구
김영주(Young Ju Kim),한경려(Kyung Ryu Han),안정자(Chung Ja Ann),우복희(Bock Hi Woo) 대한산부인과학회 1998 Obstetrics & Gynecology Science Vol.41 No.12
N/A Objective: Currently, preparation for childbirth is becoming an increasingly popular addition to patient education. Because of this interest, it seems advisable to review the evidence on the effect of prepared childbirth. The objective of this study is to evaluate the effectiveness of Lamaze preparation on labor and delivery. Methods: To investigate whether prepared-childbirth courses offer measurable physical advantages, we compared the labor and delivery characteristics of 80 primiparas who had taken Lamaze-training classes with 76 control patients who had not. We reviewed retrospectively obstetrical records of 156 pregnant women delivered in Ewha Womans University MokDong Hospital from January to December, 1997. Result: The length of the first stage of labor in the group that attended childbirth preparation classes was 5.70 hours and 6.93 hours in the comparison group. This difference was statistically significant (P= .040). The mean duration of the second stage of labor in attenders was 42.43 minutes and 41.16 minutes in the nonattenders(P= .719). Average duration of labor in attenders was 1.07 hours shorter than in nonattenders (P= .075). The cesarean section rate in attenders was 25% compared with 36.8% in nonattenders (P= .10920). Conclusion: No statistical significance was found in this study. However we need to be aware that the length of first stage of labor was shorter and the rate of cesarean section was lower in prepared group. Childbirth education should be integrated into prenatal health care to be readily available for all women.
공공의료와 민간의료 자원을 활용한 선천성 이상 감시체계 모델
김광준(Kwang Jun Kim),임종한(Jong Han Leem),하은희(Eun Hee Ha),임문환(Moon Whan Im),홍윤철(Yun Chul Hong),이보은(Bo Eun Lee),문혜성(Hye Sung Moon),안정자(Jung Ja Ahn),우복희(Bock Hi Woo) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.7
목적 : 한국에서 선천성 이상과 저체중아의 발생 원인을 규명하기 위하여, 역학적인 선천성이상모니터링 체계를 구축하는 것이 필요하다. 본 연구의 목적은 선천성 이상의 발생률과 발생 양상을 평가할 수 있는 선천성이상 감시체계의 새롭고 실제적인 모델을 설계하고, 시범적으로 인천시 연수구에서 이를 구축하는 것이다. 연구 방법 : 보건소와 민간 병의원이 협력하여 선천성이상을 모니터링 할 수 있는 감시체계를 구축하였으며, 인터넷 웹에 기반을 둔 전산화 보고체계와 자료관리체계가 만들어졌다. 훈련된 간호사가 2년동안 출생 신고서, 보건소 및 병의원 보고자료, 분만실 자료, 의무기록 등을 능동적으로 수집하였다 (1차년도 1998.12.1- 1999.11.31; 2차년도 2000.1.1-2000.12.31). 결과 : 1, 2차년도의 모니터링을 통하여, 본 연구에서는 1차년도 총출산 2482건중 25건, 2차년도 총 출산 3490건중 28건의 선천성이상 건수를 확인하였다. 총 출산아 1000명중 선천성이상 출산율은 1, 2차년도에 각각 10.1, 8.0이었다. 1차년도에 선천성이상의 가장 큰 비율은 근골격계 계통으로 전체의 28.0%이였다. 1차년도 소화기, 심혈관, 구개열 및 구개순 선천성이상의 비율은 전체의 20.0%, 12.0%, 12.0%이였다. 2차년도에 선천성이상의 가장 큰 비율은 소화기 계통으로 전체의 21.4%이였다. 2차년도 심혈관, 근골격계 선천성이상의 비율은 전체의 17.9%, 14.3%이였다. 결론 : 결론적으로, 우리는 인천시 연수구에서 인구집단을 대상으로 한 선천성이상 감시체계를 구축할 수 있었다. 한국에서 인구집단을 기반으로 한 선천성이상 감시체계를 구축하기 위한 가장 현실적인 방안은 우선 한 지역에서 보고에 참여하는 공공 및 민간병원 보고자를 조직하고, 보고체계 및 자료관리체계를 구축하며 실제적으로 적용 가능하고 효율적인 모델을 만들고, 이를 근거로 타지역에 이 모델을 확산시키는 것이다. Objective : To discover the etiology of birth defects and low birth weight, it is necessary to establish epidemiological birth defects monitoring system in Korea. Our aim was to develop new practical model in Incheon to establish birth defects monitoring system to evaluate the incidence rate and patterns of birth defects in Korea. Methods : Public health center and private hospitals and clinics participated in this monitoring system. Web based reporting system have been built. Trained nurses actively collected the records obtained from delivery units in the participating hospitals during 2 years (first year: December 1st, 1998-November. 31, 1999; second year: January 1 st, 2000-December 31 th, 2000). Results : Through this monitoring system at 1 st year and 2 nd year, we observed 25 birth defect cases from 2482 births, 28 birth defect cases from 3490 births including live births and stillbirths. The incidence of birth defect per thousand person was 10.1, 8.0 respectively. At 1st year, the highest proportion of birth defects was 28.0% in musculoskeletal system. The proportion of birth defects in gastrointestinal system, cardiovascular system and cleft lip & cleft palate were 20.0%, 12.0%. 12.0%. At 2 nd year, the highest proportion of birth defects was 21.4% in gastrointestinal system The proportion of birth defects in cardiovascular system and musculoskeletal system were 17.9% and 14.3%. Concluion : In conclusion, we could build population-based monitoring system for birth defects successfully in Yonsu gu, Incheon. To establish population-based monitoring system for birth defects in Korea, it is necessary to organize the reporters of public health center and private hospitals and clinics, to build an available reporting system, and to extend participating centers for birth defects monitoring systems.
우복희,이용주 梨花女子大學校 醫科大學 醫科學硏究所 1980 EMJ (Ewha medical journal) Vol.3 No.4
Choriocarcinoma arises sometimes after hydatidiform mole, occasionally after abortion, and rarely after normal term pregnancy and ectopic pregnancy. Recently we had the opportunity to observe 26-year-old female patient who had choriocarcinoma following term pregnancy. In this paper, we report a case of choriscarcinoma following term pregnancy with a brief review of related literature.