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박진한,신정호,송인권 大韓神經精神醫學會 1994 신경정신의학 Vol.33 No.1
The authors investigated neuroendocrine findings of HPA and HPT axes by DCT, DST, and TRH stimulation tests in patients with seasonal depressive disorder(SDD). Subjects were consisted of 11 inpatients(3 males, 8 females) with SDD and 10 control inpatients(10 females) with non-seasonal depressive disorder(NSDD) at the Department of Psychiatry, Yonsei University Wonju Medical College from Sep. 1, 1991 to Dec. 31, 1992. The results were as the following: 1) For DCT in SDD patients, 8 patients(72.6%) showed abnormal cortisol secretion, two(18.2%) with distorted diurnality and six(54.5%) with over-secretion pattern, which did not show significant difference from the control patients. 2) For DST, non-suppression rate was similiar in both group(36.4% for SDD vs 40.0% for NSDD). 3) Blunted TRH stimulation test was noted in 5 among 11 SDD patients(45.5%) compared to 1 among 10 control patients(10.0%). 4) With DST and TRH stimulation test result, the diagnostic senstivity for patients with SDD(63.7%) was higher than that for NSDD patients(50.0%). 5) In patients with SDD, symptoms of decreased libido, increased duration of sleep and daytime drowsiness items by Boyce and Parker were more prevalent(p<0.05), and symptoms of early morning awakening, decreased duration of sleep were less prevalent(p<0.05).