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- 저자 : 임인서(In Seo Lim) (검색결과 3 건)
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임인서(In Seo Lim),이건웅(Gun Young Lee),전상현(Sang Hyun Chun),김근호(Gheun Ho Kim),구자룡(Ja Ryong Goo),전노원(Rho Won Chun),채동완(Dong Wan Chae),김형직(Hyung Jik Kim),노정우(Jung Woo Noe) 대한내과학회 1995 대한내과학회지 Vol.49 No.5
N/A Objectives: Several factors have been raised as contributing to morbidity and mortality among patients with end-stage renal disease treated with hemodialysis. We performed this study to evaluate morbidity and the factors contributing to them in chronic hemodialysis patients. Methods. We analyzed retrospectively the demo- graphic chracteristics, regularly tested laboratory findings (CBC, blood chemistry, chest X-ray, ECG), hospitalization rate, and gross mortality among 84patients in the Hallym University Medical Center from February I, 1992 to January 31, 1994. Results: 1) Age distribution of the patients was 54±13(mean±SD) years (range, 23-79 years); 41 patients were men, 43patients were women: 30patients(35.7%) had diabetes. The duration of hemodialysis was 33±30 months (range, 3-125 months). 2) Forty four patieints(52.4%) required hospitalization during the 2-year follow-up period, and the most common causes of hospitalization were infection and cardiovascular disease. 3) A total of 1H(21.4%) of the patients died the 2-year follow-up period, and cardiovascular disease was commonest cause of death. 4) The factors such as advancing age, the duration of hemodialysis, and diabetes were neither associated with the risk hospitalization nor with that of death. The serum albumin concentration in dead patients(3.4±0.4g/d1) was lower(p<0.001) than that in survived patients(3.8±0.4g/dL). As compared with patients who had serum albumin concentration ≥3.5g/dL, patients with serum albumin concentration <3.5g/dL had increased odds ratio(8.14) for death. The serum creatinine concentration in dead patients (9.5+3.0g/dL) was lower(p<0.%! than that in survived patients(11.8±3.1g/dL). Conclusion: We concluded that regularly tested serum albumin concentration was the most important predictive factor for death in chronic hemodialysis patients.
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김동규,박성우,김학양,배수동,임성희,임인서,정용영 대한내과학회 1996 대한내과학회지 Vol.50 No.5
Pure virilizing adrenocortical tumor in adult female is a rare disorder. We report a case of pure androgen-producing adrenocortical tumor in a 29-year-old woman who was evaluated for hirsutism and secondary amenorrhea for 18months. Her serum testosterone (4.47 ng/mL) and DHEA-S($gt;1,000㎍/ dL) levels and 24-hour-urine 17-KS excretion (84.1mg/day) were remarkblyhigh and were not suppressed by low-dose dexamethasone. Her serum cortisol level and 24-hour-urine free cortisol excretion were normal and decreased after low-dose dexamethasone administration. Abdomen CT revealed an 11 cm-sized mass with central necrosis in the right adrenal gland, On MRI, the lesion had high signal intensity on T₂-weighted image. A right adrenalectomy was performed. The tumor weighed 410gm and was 13×12×4 cm in size. The histologic examination revealed nuclear pleomorphism and high mitotic index in tumor cells without capsular invasion. Her serum testosterone and DHEA-S levels and 24-hour-urine 17-KS excretion assessed 1week after the operation were normal. The hirsutism had disappeared gradually and menstruation was observed 2 months after operation. She has been followed-up for 38 months since the operation and is at present healthy without evidence of tumor recurrence or distant metastasis.
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원발성 부갑상선 기능항진증 2예에서 수술 전후 내당능 및 인슐린 분비능의 변화
최용석,박성우,유형준,임성희,최문기,전상현,이건용,임인서 대한내분비학회 1994 Endocrinology and metabolism Vol.9 No.1
It is reported that patients with primary hyperparathyroidism(PHPT) have disturbances in carbohydrate metabolism: in particular, hyperinsulinemia and insulin resistance are characteristic early metabolic aberrations of this disease. However, it is not clear whether changes of insulin secretion or insulin sensitivity are observed in all patients with PHPT, including those with normal glucose tolerance. Also, it is not clear whether these changes are reversible after surgical correction of PHPT. In the present study, glucose tolerance and insulin secretion were evaluated in 2 symptomatic patients with PHPT during 100g oral glucose tolerance test before and after parathyroid adenoma removal. Comparing these patients before and after surgery, glucose tolerance was not significantly different. However, C-peptide and insulin secretion was low after surgical correction of PHPT compared to the preoperative situation. This observation suggests that insulin hypersecretion in patients with PHPT precedes glucose intolerance and this early disturbance is reversible after surgery(J Kor Soc Endocrinol 9:54-58, 1994).
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