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임이석(Ee Seok Lim),박용욱(Yong Wook Park),홍창권(Chang Kwun Hong),노병인(Byung In Ro),장진요(Chin Yo Chang) 대한피부과학회 1987 대한피부과학회지 Vol.25 No.2
We report a case of mycosis fungoides in a 37 year-old male patient who had relatively well defined, irregular, erythematous plaques covered with acales on the buttock, lower extremities, anterior chest and back. Histopathological findings showed epidermotropism and Pautrier microabscesses in the epidermis and infiltration of atypical lymphocytes in the upper dermis. Electron microscopic findings showed mycosis cells with convoluted nuclei and prominent nucleolei He had been received PUVA therapy combined with topical and systemic corticosteroid for 4 months. Skin lesions were improved markedly after treatment with total 262 joules/crn2 and then maintained with 14 joules/cm2 in every week.
서성준(Seong Jun Seo),임이석(Ee Seok Lim),홍창권(Chang Kwun Hong),이기룡(Khee Rhyong Lee),송계용(Kye Young Song),노병인(Byung In Ro),장진요(Chin Yo Chang) 대한피부과학회 1988 대한피부과학회지 Vol.26 No.6
We report herein a case of acral lentiginous melanoma in a 65-year-old female. An about 2x3cm sized erythematous to brownish mass with central ulceration was located on the left heel accompanied by enlargement of the left inguinal lymph nodes. Histopathologic findings showed lentiginous proliferation of atypical melanocytes with pseudoepithliomatous hyperplasia and invasion of tumor cells from the epidermis into the dermis. Focal pigmented melanocytes were also noted. Complete surgical excision and chemotherapy with DTIC were done. Marked edematous swelling on the left lower leg was developed after 8 months and 1 month later she was expired.
정상 피부에서의 Superoxide Dismutase 활성도에 관한 연구
임이석,김명남,노병인 중앙대학교 의과대학 의과학연구소 1991 中央醫大誌 Vol.16 No.2
Superoxide dixmutase(SOD) provides a protective defense mechanism against potential cytotoxicity of superoxide radical in the aerobic organism. Although human skin is constantly at risk for developing acute and chronic changes by ultraviolet radiation and phototoxic reactions with exogenous and endogenously produced photosensitizing molecules, studies on SOD in the human skin are rare. Author assayed the level of SOD activities in 40 normal human skin specimens, which were obtained from face/neck(11 specimens), forearm(8 specimens), trunk(11 specimens), and lower extremity(10 specimens). This study was to investigate changes of SOD activity by age, and sexual and regional differences of SOD activities in the normal skin. The results were as follows; 1. Activities of total SOD, Cu,Zn-SOD and Mn-SOD were 29.83±11.90units/mg protein, 20.53±8.82 units/mg protein and 9.21±4.21 units/mg protein respectively in the normal skin. 2. The changes of total SOD, Cu,Zn-SOD and Mn-SOD activities by age were similar each other, and highest in the third decade. But there were no significant differences between age groups in total, Cu,Zn-and Mn-SOD activities. 3. In sun exposed area, there were no significant differences between face/neck and forearm in SOD activities. In unexposed area, there were also no significant differences between trunk and lower extremity in SOD activities. But SOD activities(total, Cu,Zn-, and Mn-SOD) in face/neck were higher significant than those in trunk and lower extremity(P<0.05). 4. SOD activities in exposed area were higher significantly than those in unexposed area (P<0.01). 5. There were no significant differences between male and female in SOD activities. 6. In male, exposed area were significantly higher than unexposed area in SOD activities(P<0.05). But in female, there were no significant differences between exposed area and unexposed area in SOD activities. These finding suggest that there are no differences in the intrinsic SOD activities by age and sex in the normal huma skin, and the differences between exposed and unexposed area are due to the induction of exogenous SOD activity by sun-light(UVR), and author supposes this study is useful to investigate the protective role of SOD in the clinically relevant skin condition.
김재홍,이정욱,소순남,김영태,김중환,한영수,이성열,김동석,이봉구,이상수,윤종성,임이석,이종성,김호준,최성관,이성배,강성범,조규종,안철현,차영수,전환표,이주흥 대한화학요법학회 1989 대한화학요법학회지 Vol.7 No.2
The prevalence of PPNG among pretreatment isolates at a STD clinic in Seoul has been studied and reported annually since 1981. In 1988, 461 strains of N. gonorrhoeae were isolated, among which 258 (56.0%) were PPNGs. The prevalence of PPNG in Seoul is still increasing.