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홍연석(Yeon-Seok Hong),최현주(Hyun Ju Choi),이인경(Ingyeong Lee),임연정(Yeon-Jeong Lim),박성우(Sung Woo Park),남봉우(Bong Woo Nam),이부자(Bu Ja Lee),박덕환(Duck Hwan Park) 한국식물병리학회 2020 식물병연구 Vol.26 No.3
본 논문에서는 종자전염 식물병원세균을 규정하였다. 국내금지병해충 목록에서 세균 4종 및 파이토플라즈마 2종, 그리고관리병해충 목록 중 세균 35종 및 파이토플라즈마 17종을 대상으로 종자내부 또는 유묘에서 병원세균을 검출한 문헌조사를실시하였다. 금지 식물병원세균 2종, 관리 식물병원세균 18종 및 관리 파이토플라즈마 1종이 종자전염 식물병원세균으로 판명되었다. 이에 이들 종자전염 식물병원세균들에 대한 근거를제시하였으며, 향후 수입종자의 검역을 위한 기본자료로 활용될 수 있을 것으로 생각된다. The goal of this manuscript is to determine seed-borne plant pathogenic bacteria and phytoplasmas among quarantine pests in Korea. Four and two prohibited bacteria and phytoplasmas, respectively, and 35 and 17 restricted bacteria and phytoplasmas, respectively, were assessed whether they are seed-borne or not based on preliminary reports. As results, two species of prohibited bacteria, eighteen species of restricted bacteria, and one species of restricted phytoplasma have been determined as being seed-borne plant pathogenic bacteria. Thus, quarantine fields must account for these lists once inspection has been conducted on imported seeds and also use of these lists can help to reduce the production of new diseases that can spread from infected imported seeds.
현종진,서연석,안형진,임선영,서민호,김혜숙,김창하,김지훈,금보라,김용식,임형준,이홍식,엄순호,김창덕,유호상 대한간학회 2012 Clinical and Molecular Hepatology(대한간학회지) Vol.18 No.1
Background/Aims: The nonspecific clinical presentation of acute hepatitis A (AHA) mandates the detection of anti-hepatitis A virus IgM antibodies (IgM anti-HAV) in the serum for obtaining a definitive diagnosis. However, IgM anti-HAV might not be present during the early phase of the disease. The aim of this study was to determine the optimal time for repeating the IgM anti-HAV test (HAV test) in AHA patients with a negative initial test. Methods: In total, 261patients hospitalized with AHA were enrolled for this retrospective study. AHA was diagnosed when the test for IgM anti-HAV was positive and the serum alanine aminotransferase (ALT) level was ≥400 IU/L. Repeat HAV test was conducted after 1-2 weeks if the initial HAV test was negative but AHA was still clinically suspected. Results: The results of the initial HAV test were negative in 28 (10.7%) patients. The intervals from symptom onset to the initial-HAV-test day and from the peak-ALT day to the initial-HAV-test day were significantly shorter in the negative-initial-HAV-test group, but on multivariate analysis only the latter was significantly associated with negative results for the initial HAV test (β=-0.978;odds ratio [95% confidence interval]=0.376 [0.189-0.747]; P=0.005). The HAV test was positive in all patients when it was performed at least 2 days after the peak-ALT day. Conclusions: The results of HAV tests were significantly associated with the interval from the peak-ALT day to the HAV-test day. The optimal time for repeating the HAV test in clinically suspicious AHA patients with a negative initial HAV test appears to be at least 2 days after the peak-ALT day. (Korean J Hepatol 2012;18:56-62)
늑골로 전이된 간세포암의 경동맥 항암 화학 색전술 시행 후 발생한 양측 하지마비
박상정,엄순호,서연석,김용식,진윤태,이홍식,전훈재,김창덕,류호상,김진동,임선영 대한내과학회 2011 대한내과학회 추계학술대회 Vol.2011 No.1
간세포암을 치료하는 방법 중에서 경동맥 화학 색전술 (Transarterial chemoembolization TACE)은 종양의 괴사를 일으켜 치료하는 방법으로 수술이 불가능한 간세포암 환자를 치료하기 위해서 사용되고 있으나 정상적인 조직에도 손상을 일으켜 구역, 고열과 우상복부 통증, 간 기능저하, 담낭염, 췌장염, 간성 혼수 및 총수담관 폐쇄, 폐동맥 색전 및 뇌 경색 등의 부작용을 야기할 수 있다. 이 중에서 뇌 경색이나 하지마비 등의 신경학적인 부작용은 드문 편이나 발생시 심각한 후유증 및 영구적인 장애를 야기할 수 있으므로 즉각적이고 효과적인 치료가 요구된다. 본 증례에서는 간세포암으로 진단 후 반복적인 경동맥 화학 색전술 및 고주파 열치료 시행을 받은 환자가 우측 7번 늑골로의 전이를 진단 받았고, 이에 대한 치료를 위해 방사선 치료를 시행하였으나 효과를 보이지 않아 늑간동맥을 통한 경동맥 화학 색전술을 시행하였다. 환자는 시술 이후 흉골 이하의 감각 및 운동저하를 호소하였고 신경학적 검사 및 자기공명 영상검사를 시행한 결과 허혈성 척추손상으로 인한 척수병증으로 진단하여 스테로이드 펄스요법을 5일간 시행하였고 이후 지속적인 재활치료 및 근 이완제 및 프레가발린을 사용하였다. 이후 환자는 운동 능력은 호전되었으나 감각이상 및 경직은 유지되고 있는 상태이다. 국내에서는 경동맥 화학 색전술 이후에 발생하는 신경학적인 장애에 대한 보고는 드물고 국내 문헌을 검토한 바에 의하면 간세포암의 우측 늑골로의 전이에 대한 색전술 시행 이후 발생한 양측하지마비가 발생한 증례는 보고된 바가 없어 이에 저자들은 늑골로 전이된 간세포암의 경동맥 화학 색전술 시행 후 발생한 양측하지 마비 1예를 경험하였기에 보고하는 바이다.
정진용 ( Jin Yong Jung ),임선영 ( Sun Young Yim ),김창하 ( Chang Ha Kim ),김진동 ( Jin Dong Kim ),서연석 ( Yeon Seok Seo ),임형준 ( Hyung Joon Yim ),류호상 ( Ho Sang Ryu ),김민주 ( Min Ju Kim ),박범진 ( Beom Jin Park ),엄순호 ( So 대한간암학회 2012 대한간암학회지 Vol.12 No.1
Tumor size is one of the most important factors for decision of therapeutic plan and prognosis of hepatocellular carcinoma (HCC). If the diagnosis of HCC is made earlier in its small size, the prognosis is better. However the diagnosis of small HCC is not easy because small HCC lacks the typical clinical and radiologic feature. We experienced two cases of small HCC less than 1 cm that was confirmed after first treatment.
간세포암 환자의 종양병기 평가에 대한 Up-to-Seven Score의 임상적 유용성
정창호 ( Chang Ho Jung ),서연석 ( Yeon Seok Seo ),이재민 ( Jae Min Lee ),윤석배 ( Seok Bae Yoon ),윤태정 ( Tae Jung Yun ),임선영 ( Sun Young Yim ),안형진 ( Hyonggin An ),엄순호 ( Soon Ho Um ),김창덕 ( Chang Duck Kim ),류호상 ( Ho 대한간암학회 2014 대한간암학회지 Vol.14 No.1
Background/Aims: Up-to-seven criteria was proven to be useful for predicting prognosis after liver transplantation in patients with hepatocellular carcinoma (HCC). The aim of this study was to evaluate that up-to-seven score could be useful method for prediction of prognosis in patients with HCC who did not undergo liver transplantation. Methods: Between January 2006 and December 2008, 216 HCC patients without vascular invasion, lymph node and distant metastasis were analyzed retrospectively. We investigated the prognostic impact of laboratory findings, clinical characteristics, modified UICC T stage, and up-to-seven score in HCC. The survival analyses were performed using Kaplan-Meier Results: Two-hundred sixteen patients with HCC were included. Age was 60.1±11.3 years and 74.5% were male. Chronic hepatitis B was the most common cause of liver disease (60.6%). T stage was T1, T2, and T3 in 36 (16.7%), 118 (54.6%), and 62 (28.7%) patients, respectively. Up-to-even score was 5.5±4.0 and it was <3 (UTS 1), ≥3 and ≤7 (UTS 2), and >7 (UTS 3) in 36 (16.7%), 133 (61.6%), and 47 (21.8%) patients, respectively. The 10 (8.5%) patients of T2 stage were classified into UTS 3 and 25 (40.3%) patients of T3 stage were classified into UTS 2. The prognosis was significantly different in patients with T2 or T3 according to their UTS. Multivariate analysis showed that Child-Pugh score and UTS were significantly associated Conclusions: Up-to-seven score was useful to predict prognosis and to evaluate tumor stage in patients without vascular invasion, lymph node and distant metastasis.