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임백빈(Baek Vin Lim),박진국(Jin Kook Park),장명제(Myoung Jei Chang),신말순(Mal Soon Shin),김창주(Chang Ju Kim) 한국사회체육학회 2004 한국사회체육학회지 Vol.0 No.21
수영 운동이 쥐의 해마 치상회에 세포 생성에 미치는 영향을 5-bromo-2`-deoxyuridine(BrdU) 면역 조직화학법을 이용하여 연구하였다. 첫 번째 실험에서 수영 운동집단은 1분 수영군, 5분 수영군, 10분 수영군, 20분 수영군으로 나누어 3일간 수영운동을 실시하였다. 두 번째 실험은 1일 수영군, 3일 수영군, 7일 수영군, 14일 수영군으로 분류하여 1일 10분씩 수영운동을 실시하였다. 본 실험의 결과, 10분간의 수영 운동이 치상회의 세포생성을 가장 효과적으로 증가시켰으며, 또한 7일간의 수영 운동이 세포생성을 가장 많이 시키는 것으로 나타났다. 이러한 결과로 미루어보아 수영운동이 치상회의 세포생성을 증가시키는 운동요법으로 사용될 수 있을 것으로 생각된다.
수영이 흰쥐 해마 치상회에서 산화질소합성효소의 발현에 미치는 영향
임백빈 ( Baek Vin Lim ),박진국 ( Jin Kook Park ) 한국운동영양학회 2004 Physical Activity and Nutrition (Phys Act Nutr) Vol.8 No.3
The purpose of the present study was to investigate the effect of swimming on nitric oxide synthase expression in the hippocampal dentate gyrus of the Sprague-Dawley (SD) rats. The male SD rats weighing 250±10 g (6 weeks old) were used in the experiment. In the first part of the experiment (involving session duration-dependence swimming), the rats were divided into five groups to investigate an optimum duration of swimming exercise for the prevention of the NO-dependent neuronal damage: control group, 1-min-swimming group, 5-min-swimming group, 10-min-swimming group, and 20-min-swimming group (n = 10 in each group). In the second part of the experiment (involving training duration-dependence swimming), the rats were divided into five groups: control group to investigate an optimum program of swimming training for the prevention of the NO-dependent neuronal damage, I-day-swimming group, 3-day-swimming group, 7-day-swimming group, and 14-day-swimming group (n = 10 in each group). The rats in the session duration-dependence swimming groups were made to swim for 1 min, 5 min, 10 min, and 20 min once a day for 3 consecutive days, respectively. The rats in the program duration-dependence swimming groups were made to for 10 min once a day for 1 day, 3 days, 7 days, and 14 days, respectively. The swimming apparatus consisted of a swimming pool with 60 cm in height and 120 cm in diameter, which was filled with water at a temperature of 30-32℃ up to 45 cm from the bottom. With respect to the session-duration-dependence swimming groups. the two swimming groups of 10 min or longer duration significantly decreased the number of NADPH-d-positive cells in the dentate gyrus compared to either the control group (p = 0.001) or the I -min swimming group (p = 0.001) or the 5-min swimming group (p = ??). With respect to the program-duration swimming groups, all the swimming groups regardless of its training frequencies had significantly decreased NADPH-d-positive cells in the dentate gyrus compared to the control group (p = 0.03). In conclusion, these results of the current study suggest that a single bout of swimming lasting longer than 10 min, regardless of its frequency, may be an effective means for the prevention of NO-dependent neuronal damage.
고온과 저온 환경에서의 트레드밀 운동이 흰쥐 해마에서 c-Fos 발현과 비복근에서의 HSP 70 발현에 미치는 영향
임백빈(Baek-Vin Lim) 한국생활환경학회 2009 한국생활환경학회지 Vol.16 No.6
In the present study was to examine the effect of treadmill exercise under heat and cold stress conditions on c-Fos expression in the hippocampus and HSP 70 expression in the gastrocnemius muscle. c-Fos expression represents neuronal activity and plays a crucial role in the brain development. Physical exercise is known to enhance neuronal plasticity and activity. Heat shock protein 70 (HSP 70) is the best characterized stress-responsive gene with enhanced expression and thought to be a protective factor against environmental stress in a cell. For this study, male Sprague-Dawley rats weighing 250±10 g (7 weeks in age) were used. The rats were randomly divided into six groups (n=10 in each group): the control in 4℃ group, the exercise in 4oC group, the control in 22℃ group, the exercise in 22℃ group, the control in 35℃ group, and the exercise in 35℃ group. The environmental temperature at 22℃ set as the normal conditions, 4℃ was as the cold stress conditions and 35℃ was as the heat stress conditions. In the cold conditions, the temperature was 4oC with relative humidity 40%. In the normal conditions, the temperature was 22℃ with relative humidity 40%. In the heat stress conditions, temperature was 35℃ with relative humidity 20%. Animals were sacrificed immediately after finishing the last session of treadmill exercise on the 5 weeks of the experiment. The present results showed that exposure under normal, cold and heat stress conditions exerted no signifiant effect on the c-Fos expression. However, the c-Fos expression in the hippocampus was increased by treadmill exercise, showing that cold stress and heat stress acted as the decreasing factor of c-Fos. The HSP 70 expression in the gastrocnemius was increased by treadmill exercise for 5 weeks under normal, cold and heat conditions, however, the increasing of HSP 70 was not appeared that exposure under the cold and heat stress conditions. The present study revealed that treadmill exercise exerted improvement effect on impairment of environmental stress through enhancing of c-Fos and increasing of HSP 70.
이침(耳鍼)이 절식(絶食)시킨 흰쥐의 대뇌피질(大腦皮質)에서 CCK 활성변화(活性變化)에 미치는 영향(影響)
김이화,김연정,임백빈,장미현,정주호,김창주,Kim, Ee-Hwa,Kim, Youn-Jung,Lim, Baek-Vin,Jang, Mi-Hyun,Chung, Joo-Ho,Kim, Chang-Ju 대한침구의학회 2000 대한침구의학회지 Vol.17 No.3
Stimulation of the auricle is known to be effective in reducing obesity. The aim of the present study is to investigate whether stimulating a specific auricular acupuncture point is effective on suppression of appetite. Cholesystokinin (CCK) is known to induce a powerful feeding response after central administration and particularly abundant in the cerebral cortex. In food-deprived rats exhibiting a strong drive for feeding, decreased CCK release was markedly detected in the cerebral cortex of the brain. Needling the fasted rats on the specific auricular region increased the CCK level of the cerebral cortex. In conclusion, stimulating the specific auricular points increases CCK-expression in the cerebral cortex of the fasted rats and may be useful for controlling obesity.
이침(耳鍼)이 절식(絶食)시킨 흰쥐의 뇌신경세포(腦神經細胞) 활성변화(活性變化)에 미치는 영향(影響)
김이화,김연정,임백빈,장미현,정주호,김창주,Kim, Ee-Hwa,Kim, Youn-Jung,Lim, Baek-Vin,Jang, Mi-Hyun,Chung, Joo-Ho,Kim, Chang-Ju 대한침구의학회 2001 대한침구의학회지 Vol.18 No.1
Objective : The aim of this study was to investigate the effectiveness of stimulation of specific auricular acupuncture points on appetite suppression. Methods : The fasted rats were deprived of food and water for 48 hours. Stimulation of tho inner auricular region of the rat correspond to the human stomach acupuncture point was made for leptin, tryptophan hydroxylase (TPH) and c-fos expression in the brain of the fasted rats by immunohistochemistry. Results : The immunoteactivities of leptin in the periventricular nucleus of the auricular acupunctured group with fasted were significantly higher compared to those of the fasted group. The immunoreactivities of TPH in the median raphe neucleus and reticulotegmental neucleus pons of the auricular acupunctured group with fasted were significantty higher compared to those of the fasted group. And the immunoreactivities of c-fos in the dentate gyrus of the auricular acupunctured group with fasted were significantly lower compared to those from the fasted group. Conclusions : We conclude that the auricular acupuncture altered leptin and TPH-expression in the brain of the fasted rats. The results suggest that auricular acupuncture may inhibit food intake.
지구성 운동이 만성 알코올 중독 쥐에서 태어난 새끼 쥐의 해마 신경세포 생성 및 인지기능에 미치는 영향
이명화(Myoung-Hwa Lee),임백빈(Baek-Vin Lim),김창주(Chang-Ju Kim),신말순(Mal-Soon Shin) 대한스트레스학회 2009 스트레스硏究 Vol.17 No.1
본 연구에서는 만성 알코올 중독 흰쥐에서 태어난 새끼 쥐에서 트레드밀 달리기가 신경세포 생성과 공간학습 기억력에 미치는 영향을 실험하였다. 수컷 쥐 25마리와 암컷 쥐 25마리를 하루 동안 교배시켜 임신을 유도하였다. 임신한 쥐는 대조군과 알코올 중독군으로 나누었다. 임신 15일부터 분만 하루 전까지 대조군에는 생리 식염수를 주사하였고 알코올 중독군에는 kg 당 1 g의 알코올을 복강에 주사하였다. 대조군에서 태어난 새끼 쥐는 대조군(20마리)으로 분류하였고, 알코올 중독 쥐에서 태어난 새끼 쥐는 알코올 중독군(18마리)과 알코올 중독 후 운동군 (20마리)로 나누었다. 운동군은 출생 21일 후부터 트레드밀 달리기를 하루 30분씩 7일간 시행하였다. 본 실험 결과 알코올 중독 어미 쥐에서 태어난 새끼 쥐는 공간학습 기억력이 감소하였고 해마 치상회에서의 신경세포 생성이 감소되어 있었다. 반면 알코올 중독 어미 쥐에서 태어났지만 트레드밀 운동을 시행한 새끼 쥐는 공간학습 기억력이 향상되었고 해마치상회에서의 신경세포 생성이 증가되었다. 본 실험을 통하여 출생 후 트레드밀 달리기는 임신 중 만성 알코올 중독에 의한 새끼 쥐들의 뇌 발달 장애를 경감시키는 효과가 있음을 알 수 있었다. In the present study, we investigated the influence of postnatal treadmill running on the cell proliferation and spatial learning ability of rat pups born from the chronic alcohol-intoxicated maternal rats. Male Sprague?Dawley rats (n=25) and female Sprague?Dawley rats (n=25) were mated for 1 day. After confirming of pregnancy, 1 g/kg alcohol or saline was injected to the pregnant rats once daily from the 15th day of pregnancy to 1 day before delivery. After delivery, offspring were assigned into one of the three groups: the control group, the maternal alcohol-treated group, and the maternal alcohol-treated and exercise group. The young rats born from the alcohol-treated dams were randomly assigned into the two groups: the maternal alcohol-treated group (n=18) and the maternal alcohol-treated and exercise group (n=20). Starting from the 21 days after birth, the rat pups in the exercise group were made to run on a motorized treadmill for 30 min once a day for 7 consecutive days. Our results demonstrated that prenatal alcohol exposure significantly decreased cell proliferation in the hippocampal dentate gyrus and disturbed spatial memory capability of the rat pups. Postnatal treadmill exercise significantly increased cell proliferation in the dentate gyrus and improved the spatial memory capability of the rat pups. Here in this study, we showed that treadmill exercise could overcome reducing of the chronic prenatal alcohol exposure-induced cell proliferation, and thus facilitated the recovery of spatial learning memory impairment induced by prenatal alcohol exposure. (Korean J Str Res 2009;17:45∼52)
김연정,장미현,신민철,임백빈,정주호,반건호,백은경,박재형,김이화,김창주,Kim Youn-Jung,Jang Mi-Hyun,Shin Min-Chul,Lim Baek-Vin,Chung Joo-Ho,Bahn Gyun-Ho,Paik Eun-Kyung,Park Jae-Hyung,Kim Ee-Hwa,Kim Chang-Ju 경락경혈학회 2002 Korean Journal of Acupuncture Vol.19 No.1
목적 : 소아의 정신적 및 신체적 발달지연에 사용되고 있는 신기환이 해마의 신경세포 생성에 미치는 영향을 관찰하고자 하였다. 방법 : 신기환이 세포생성에 미치는 영향을 알아보기 위하여 해마 세포인 HiB5에 신기환을 처리, 배양하여 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay를 통해서 세포생성을 관찰하였다. 또한 3주령의 Sprague-Dawley (S-D)계 흰쥐의 중완혈에 신기환 약침을 자침후 해마의 치상회에서 bromodeoxyuridine (BrdU) immunohistochemistry를 시행하여 세포생성을 관찰하였다. 결과 : HiB5 배양세포에서는 신기환을 처리시 배양시간과 농도별로 세포생성율이 증가하였다. 또한, 대조군의 치상회에서 BrdU 양성세포수는 $128.50{\pm}9.53$, 1 mg/kg 신기환 자침군은 $157.08{\pm}10.82$ 및 10 mg/kg 신기환 자침군은 $204.80{\pm}17.68$로 나타났다. 이러한 결과로 신기환은 어린 S-D계 흰쥐의 치상회에서 세포생성을 증가시키는 것으로 사려된다.