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녹용이 조골세포(造骨細胞) 성장에 미치는 유전자 발현 profile 분석에 대한 연구
이종우,김덕곤,Lee, Jong-Woo,Kim, Doeg-Kon 대한한방소아과학회 2002 대한한방소아과학회지 Vol.16 No.1
Recently, increased attention has been paid to the growth of the height of children and adolescents. To accelerate growth, velvet antlers are typically used in Oriental medicine. The present study investigated the effects of velvet antlers of velvet antlers on bone growth using the cell line of Human Osteosarcoma (Hos), derived from the bone-generating cells essential to bone growth. In order to give certain stress to this Hos, the medium contained 1% FBS was used for culturing for Hos cell instead of 10% in control. In this condition of which the proliferation had been significantly decreased, the ethanol extract of upper part of velvet antlers was added, As a result, the cells proliferation rate was significantly increased. Using Oligonucleotide DNA microarray, comparison and analyses were done to see what kind of specific genes would be differentially expressed. The result showed that as opposed to the control group, the stressed group indicated a decrease in the expressions of 6 kinds of genes such as, Id1, retinoid X receptor(RXRB) and 14-3-3 epsilon, etc. The velvet antler treated group, as opposed to the control group, showed a decreased in the expressions of 8 kinds of genes such as Id1, etc. and an increase in the expressions of 24 kinds of genes. The number of genes that showed differences in the velvet antler treated group compared with the stressed group was 7 the expression of 1 kind of gene was decreased, and the expressions of 6 kinds of genes were increased. Considering the mechanism by which velvet antlers affected the growth of osteoblast through reviewing the functions of these genes, the following results were attained. The constraint in the proliferation of Hos cells resulting from the medium contained 1% FBS seems to be caused by three important factors: 1) the decrease of the expression of 14-3-3 epsilon involved in the signal transduction and metabolism of growth, 2) the decrease of the expression of Id1 gene involved in the metabolism of bone formation, and 3) the decreased of expression of RXRB gene involved in the metabolism of retinoci acid. It is suggested that the improvement of the cell proliferating effects by velvet antler treatment, in stressed condition si mediated by increment of 6 genes particularly 14-3-3 epsilon, RXRB, and IGF2, with are the crucial factors for the cell growth and differentiation, metabolism of retinoic acid and osteoblast proliferation, respectively.
이종우,김학원,김홍두,Lee, Jong U,Kim, Hak Won,Kim, Hong Du Korean Chemical Society 2001 Bulletin of the Korean Chemical Society Vol.22 No.2
Photocyclizable poly(cinnam-4'-yl methyl methacrylate) derivatives bearing methoxy benzene (PMCMMA), anthracene (PACMMA), and coumarin (PCCMMA) have been synthesized via Heck type reaction. Three different types of polymers are photoreactable usin g linearly polarized UV light and applicable as liquid crystal alignment layer. Anthracence and coumarin containing polymers (PACMMA, PCCMMA) have better thermal stability than PMCMMA. This observation may be attributed to the glass transition temperature elevation due to the bulky size and another photocrosslinking site provided by anthracene or coumarin group.
이종우,Lee, Jong-Woo 한국건축역사학회 2013 건축역사연구 Vol.22 No.3
This research takes as its object a body of historical researches by a new generation of French architects in the 1970s, who tried to confront the deep crisis in architecture since the years 1960. The research begins by noting that the ideology of the architect as an autonomous and transcendental subject, an ideology held by the architects of the previous generation, was a main target that young architects wanted to criticize and overcome. From this observation, the research focuses on a antihumanistic project which gave basis for a significant number of historical researches on modern architecture and was the result of a reappropriation of the French structuralism intensively developed in the human and social sciences of that time in France. After a series of textual analyzes, we argue that a new perspective on the city and the relationship of the latter with the architecture on the one hand, and the proposal for an "modest" architect as an alternative figure after rejection of the autonomous and transcendental one on the other hand, have been derived as the outcome of anti-humanist historiographic works. Finally, we assume that these historical adventure gave conceptual basis for postmodern architecture in France, freed from the modern myth of unity of author and that of work of art, but tinted by a moralism requesting modesty to architects.
AHP 기법을 이용한 탄약의 둔감화 추진 우선순위 결정
이종우,유삼현,김주희,박영호,김재훈,김태양,Lee, Jongwoo,Yoo, Samhyun,Kim, Juhee,Park, Youngho,Kim, Jaehoon,Kim, Taeyang 한국군사과학기술학회 2014 한국군사과학기술학회지 Vol.17 No.6
Insensitive Munition(IM) reduces the explosive weakness of munitions, at the same time, maintains its performances in the moment of discharge, which improves safety of soldiers and minimizes unexpected accidents and casualties from being shot in case of transportation, storage and military operation. Development of IM has been focused as the global trend, which was required to satisfy the demand of army that is to minimize the loss of non-battle forces and to retain the competitiveness in export abroad. In this study, we categorize all the munitions used by ROK Army, then determine the priority of IM by deploying AHP(Analytic Hierarchy Process) method. In conclusion, we suggest the priority of IM which is suitable to the affairs of ROK Army.
이종우,유삼현,김인수,김태양,최현호,윤우섭,김영철,Lee, Jong-Woo,Yoo, Sam-Hyun,Kim, In-Soo,Kim, Tae-Yang,Choi, Hyun-Ho,Yoon, Woo-Seob,Kim, Young-Cheol 한국군사과학기술학회 2011 한국군사과학기술학회지 Vol.14 No.1
In this paper, the results of experimental analysis for the chemical composition and strengh verification of Bailey Panel Bridge have been presented. Some of main sections of bailey bridge colllected from military engineer troops were prepared for the chemical composition and strengh verification. The composition test and strength verification were conducted by using the optical microscope and Scanning Electron Microscope(SEM), Automatic Control Spark Emission Spectrometer(OBLF), X-ray Fluorescence Spectroscopy(XRF) and Instron measurement. The results showed that currently used sections of bailey bridge passed the strength verification and could be operated in drill of troops and battle fields.