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Refolding of Acid-Unfolded Globin to Hemoglobin
이종우,Lee Jong-Woo The Korean Society for Biomedical Laboratory Scien 2005 Journal of biomedical laboratory sciences Vol.11 No.1
Hemoglobin is oxygen carrier protein within erythrocyte in blood. Apoprotein of this, globin, is synthesized in the cytosol but it's cofactor, heme, is synthesized in the mitochondria. It has not been known very well how globin receives the heme from mitochondria and folds to hemoglobin. In this folding process, the initial structure of globin seems to be very important. A small volume of globin at acid pH was added rapidly into the bulk of an egg phosphatidylcholine $60\%$ liposome, containing hemins, at neutral pH according to the Rapid Dilution method. It was observed that an acid-induced unfolding structure of globin is initially needed to receive hemins from the lipid bilayer of liposomes. Also, this conclusion was confirmed with the absorption spectrum of the refolded globin separated by centrifugation.
녹용이 조골세포(造骨細胞) 성장에 미치는 유전자 발현 profile 분석에 대한 연구
이종우,김덕곤,Lee, Jong-Woo,Kim, Doeg-Kon 대한한방소아과학회 2002 대한한방소아과학회지 Vol.16 No.1
Recently, increased attention has been paid to the growth of the height of children and adolescents. To accelerate growth, velvet antlers are typically used in Oriental medicine. The present study investigated the effects of velvet antlers of velvet antlers on bone growth using the cell line of Human Osteosarcoma (Hos), derived from the bone-generating cells essential to bone growth. In order to give certain stress to this Hos, the medium contained 1% FBS was used for culturing for Hos cell instead of 10% in control. In this condition of which the proliferation had been significantly decreased, the ethanol extract of upper part of velvet antlers was added, As a result, the cells proliferation rate was significantly increased. Using Oligonucleotide DNA microarray, comparison and analyses were done to see what kind of specific genes would be differentially expressed. The result showed that as opposed to the control group, the stressed group indicated a decrease in the expressions of 6 kinds of genes such as, Id1, retinoid X receptor(RXRB) and 14-3-3 epsilon, etc. The velvet antler treated group, as opposed to the control group, showed a decreased in the expressions of 8 kinds of genes such as Id1, etc. and an increase in the expressions of 24 kinds of genes. The number of genes that showed differences in the velvet antler treated group compared with the stressed group was 7 the expression of 1 kind of gene was decreased, and the expressions of 6 kinds of genes were increased. Considering the mechanism by which velvet antlers affected the growth of osteoblast through reviewing the functions of these genes, the following results were attained. The constraint in the proliferation of Hos cells resulting from the medium contained 1% FBS seems to be caused by three important factors: 1) the decrease of the expression of 14-3-3 epsilon involved in the signal transduction and metabolism of growth, 2) the decrease of the expression of Id1 gene involved in the metabolism of bone formation, and 3) the decreased of expression of RXRB gene involved in the metabolism of retinoci acid. It is suggested that the improvement of the cell proliferating effects by velvet antler treatment, in stressed condition si mediated by increment of 6 genes particularly 14-3-3 epsilon, RXRB, and IGF2, with are the crucial factors for the cell growth and differentiation, metabolism of retinoic acid and osteoblast proliferation, respectively.
이종우,김학원,김홍두,Lee, Jong U,Kim, Hak Won,Kim, Hong Du Korean Chemical Society 2001 Bulletin of the Korean Chemical Society Vol.22 No.2
Photocyclizable poly(cinnam-4'-yl methyl methacrylate) derivatives bearing methoxy benzene (PMCMMA), anthracene (PACMMA), and coumarin (PCCMMA) have been synthesized via Heck type reaction. Three different types of polymers are photoreactable usin g linearly polarized UV light and applicable as liquid crystal alignment layer. Anthracence and coumarin containing polymers (PACMMA, PCCMMA) have better thermal stability than PMCMMA. This observation may be attributed to the glass transition temperature elevation due to the bulky size and another photocrosslinking site provided by anthracene or coumarin group.
AHP 기법을 이용한 탄약의 둔감화 추진 우선순위 결정
이종우,유삼현,김주희,박영호,김재훈,김태양,Lee, Jongwoo,Yoo, Samhyun,Kim, Juhee,Park, Youngho,Kim, Jaehoon,Kim, Taeyang 한국군사과학기술학회 2014 한국군사과학기술학회지 Vol.17 No.6
Insensitive Munition(IM) reduces the explosive weakness of munitions, at the same time, maintains its performances in the moment of discharge, which improves safety of soldiers and minimizes unexpected accidents and casualties from being shot in case of transportation, storage and military operation. Development of IM has been focused as the global trend, which was required to satisfy the demand of army that is to minimize the loss of non-battle forces and to retain the competitiveness in export abroad. In this study, we categorize all the munitions used by ROK Army, then determine the priority of IM by deploying AHP(Analytic Hierarchy Process) method. In conclusion, we suggest the priority of IM which is suitable to the affairs of ROK Army.
패턴 매칭과 자동 규칙 생성에 기반한 2단계 주식 트레이딩 시스템
이종우,김유섭,김성동,이재원,채진석,Lee, Jong-Woo,Kim, Yu-Seop,Kim, Sung-Dong,Lee, Jae-Won,Chae, Jin-Seok 한국정보처리학회 2003 정보처리학회논문지B Vol.10 No.3
일반적인 동적 매매 환경에서의 금융 예측 시스템은 주어진 목적을 최적으로 만족시키는 매매 형태를 찾고자 한다. 본 논문은 수익률을 극대화시키기 위하여 추출과 여과라는 두개의 단계로 구성된 새로운 형태의 주식 매매 시스템을 제안한다. 주식 추출 단계에서는 특정 시계열 패턴에 부합하는 주식을 추출하는데, 이러한 시계열 패턴은 기술 지표 값들의 조합으로 표현된다. 그리고 여과 단계에서는 추출된 주식 집합에 여과 규칙들을 적용하여 실제 매매 대상이 되는 주식들을 골라내는데, 여과 규칙은 과거 주가 데이터로부터 자동으로 유도되었다. 이를 위하여, 우리는 먼저 방대한 과거 일별 주가 데이터로부터 기술 지표 값들을 계산하였다. 계산된 기술 지표 값들은 시계열 패턴을 추출하는데 사용되고 이 값들의 이산화 구간들의 분포가 양성 및 음성 데이터들에 대하여 계산된다. 본 논문에서는 독특한 분포를 보이는 구간에 존재하는 기술 지표 값들이 주가의 향후 움직임을 예측하는 데 도움을 준다는 가정을 하였다. 그리고 여과 규칙은 바로 이런 독특한 분포를 보이는 구간 내의 데이터 값들로부터 자동으로 유도되었다. 우리는 시뮬레이션을 통해, 본 논문에서 제시한 트레이딩 시스템이 시장 평균 수익률을 상회한다는 사실을 확인함으로써 위의 가정에 대한 검증을 할 수 있었다. In the context of a dynamic trading environment, the ultimate goal of the financial forecasting system is to optimize a specific trading objective. This paper proposes a two-phase (extraction and filtering) stock trading system that aims at maximizing the rates of returns. Extraction of stocks is performed by searching specific time-series patterns described by a combination of values of technical indicators. In the filtering phase, several rules are applied to the extracted sets of stocks to select stocks to be actually traded. The filtering rules are automatically induced from past data. From a large database of daily stock prices, the values of technical indicators are calculated. They are used to make the extraction patterns, and the distributions of the discretization intervals of the values are calculated for both positive and negative data sets. We assumed that the values in the intervals of distinctive distribution may contribute to the prediction of future trend of stocks, so the rules for filtering stocks are automatically induced from the data in those intervals. We show the rates of returns when using our trading system outperform the market average. These results mean rule induction method using distributional differences is useful.
현실과 반영 : 1970년대 사회-문화적 네트워크로서의 프랑스 건축전문지
이종우,Lee, Jong-Woo 한국건축역사학회 2012 건축역사연구 Vol.21 No.1
This research aims to demonstrate the sociocultural significance of architectural journals produced in the 1970s during which a fundamental reconsideration of architectural discipline has been made. To this end, we established a method of analysis adapted to the characteristics of architectural journals of that period. In this formulation, the relative autonomy of architectural journal with regard to various actors and institutions involved in its production emerged as a major criterion for the analysis of a journal. From this methodological reflection, we analyzed two French architectural journals, AMC published between 1973 and 1981 and l'Architecture d'Aujourd'hui between 1974 and 1977, which were produced both in close relation with parisian architectural schools (UPA) in the context of reestablishment of architectural education and beginning of architectural research in France after the events of May 1968. If these journals reflected and strengthened the architectural reality and especially the social network of their protagonists, it is equally important to note that they have transformed it into cultural network, and this by the mechanism proper to their preparation and their textual organization.