국소성 분절성 사구체 신병증의 동물 모델 (FGS/kist 생쥐) 신 조직의 유전자 발현 양상

강희경,이병섭,이철호,하일수,정해일,최용,Kang, Hee-Gyung,Lee, Byong-Sop,Lee, Chul-Ho,Ha, Il-Soo,Cheong, Hae-Il,Choi, Yong 대한소아신장학회 2011 Childhood kidney diseases Vol.15 No.1

목 적: 국소성 분절성 사구체 경화증(Focal segmental glomerulosclerosis, 이하 FSGS)은 소아신부전의 원인 중 가장 흔한 사구체 질환이다. 일차성 FSGS의 병인은 아직 알려져 있지 않으므로, 저자들은 FSGS의 동물 모델을 대상으로 cDNA 마이크로어레이를 이용한 유전자 발현 양상 분석을 통하여 유전자 발현 수준에서의 FSGS의 질환의 특성을 밝히고자 하였다. 방 법: 사람의 일차성 FSGS와 유사한 질병경과를 보이는 동물모델인 FGS/kist 생쥐의 신피질 조직을 대조군 생쥐(FGS/kist 생쥐의 조상 strain인 RFM/kist 생쥐)와 AB 1700 mouse chip을 이용한 마이크로어레이 실험으로 비교하였다. 결 과: FGS 질병특이 유전자가 62개 추출되었다. 이들은 세포주기/사멸, 면역반응과 지질 대사/혈관 질환과 관련된 유전자들로써, 유전자간 network의 중심유전자가 면역반응(TNF, IL-6/4, IFNg)과 세포사멸 조절 유전자(TP 53), 그리고 지질대사의 중요 유전자인 PPARG이었다. 결 론: 이 연구에서 저자들은 자발적인 FSGS의 임상경과를 보이는 FGS/Kist 생쥐의 신장조직의 유전자 발현의 분석을 통하여 신장세포사멸과 면역반응에 뒤따르는 기질 섬유화, 그리고 지질 대사의 이상과 조기 혈관 질환이 FSGS의 병태생리에 기여할 것임을 다시 확인할 수 있었다. 추가적인 연구가 계속된다면 global transcriptome profiling 기법으로 병인 탐색 및 치료방법 개발 에 의미 있는 결과를 도출할 수 있을 것이다. Purpose: Focal segmental glomerulosclerosis (FSGS) is the most common glomerulopathy causing pediatric renal failure. Since specific treatment targeting the etiology and pathophysiology of primary FSGS is yet elusive, the authors explored the pathophysiology of FSGS by transcriptome analysis of the disease using an animal model. Methods: FGS/kist strain, a mouse model of primary FSGS, and RFM/kist strain, as control and the parent strain of FGS/kist, were used. Kidney tissues were harvested and isolated renal cortex was used to extract mRNA, which was run on AB 1700 mouse microarray chip after reverse transcription to get the transcriptome profile. Results: Sixty two genes were differentially expressed in FGS/kist kidney tissue compared to the control. Those genes were related to cell cycle/cell death, immune reaction, and lipid metabolism/vasculopathy, and the key molecules of their networks were TNF, IL-6/4, IFN${\gamma}$, TP53, and PPAR${\gamma}$. Conclusion: This study confirmed that renal cell death, immune system activation with subsequent fibrosis, and lipid metabolism-related early vasculopathy were involved in the pathophysiology of FSGS. In addition, the relevance of methodology used in this study, namely transcriptome profiling, and Korean animal model of FGS/kist was validated. Further study would reveal novel pathophysiology of FSGS for new therapeutic targets.

일상에 내재된 대듦과 근대시민의 실현 -강용흘의 작품을 중심으로

이일수 ( Il Soo Lee ) 영미문학연구회 2009 영미문학연구 Vol.17 No.-

This essay intends to explicate the relationship between the natural tendency to demur that is inherent in our routines and the fulfillment of our role as modern citizens. Anyone who defies the civil rights, established as an essential code for all modern human beings, may well provoke public condemnation. Civil rights or citizenship in general have their genetic origins in the fact that individual ambitions will inevitably lead to vested interests, which when pursued may very likely lead to multifaceted conflicts in the social arenas. Civil negotiation has been called forth as a means to control the desires of individuals, a process that has been well illuminated in the works of a Korean American author, Yonghill Kang. Kang`s works cite the Confucian ideals with regard to human nature and focus on the denial or restriction of individual desire as a manner of living life: Yonghill Kang`s works show that Confucianism could have a substantial influence upon making an individual a genuine citizen of the West. The theory that the "raison d`etre" of individual desires lasts only when their fulfillment is procrastinated to the next moment is referenced and validated in Kang`s works. Having been brought up in the Confucian path, Chung-pa Han could negotiate between his self-defeating moments of procrastination and his desire to become an American citizen. Significantly, his daily life in the colonial Cho-sun and in America has inculcated within him a demurring consciousness upon which one living in the modern era needs to rely when their desires increasingly encroach on what we already are and will be. A citizen, as a modern creation, will never have his/her closure, and this open-ended political agenda of modernity will also be questioned and tried by means of each citizen`s demurring routines.

회장 말단부에 장중첩증을 유발한 염증성 섬유양 용종

이일수(Il Soo Lee),문취용(Chi Young Moon),이인상(In Sang Lee),박봉태(Bong Tae Park),장도현(Do Hyun Chang),박종호(Chong Ho park),최호수(Ho Soo Choi),전광수(Gang Soo Chun),김동진(Dong Chin Kim),이채원(Chae Won Lee )) 대한소화기학회 1994 대한소화기학회지 Vol.26 No.5

Inflammatory fibroid polyps(IFP) is a relatively rare, benign polyp which is composed of fi- brous connective tissue, blood vessels, and infiltration of eosinophils. The majority of inflam- matory fibroid polyps has been reported with pathologic specimen in stomach and small intes tine. Terminal ileal inflammatory fibroid polyps differ from gastric lesion because they are larger and are almost all pedunculated. As a result, they tend to produce intussusception with intestinal obstruction. We present a case of inflamrnatory fibroid polyp of distal ileum causing intussusception with literature review.(Korean J Gastroenterol 1994; 26: 874 878)

앨리스의 시민성

이일수(Il-soo Lee) 19세기영어권문학회 2011 19세기 영어권 문학 Vol.15 No.1

This paper argues that “the wonders” by themselves are impossible without the routine. The routine establishes a base where the wonders can lurk and penetrate the mundane. In Lewis Carroll's Alice's Adventures in Wonderland and Through the Looking Glass, the author calls the reader's attention to the structural, constitutional aspects of the wonders, and of the routine; both are institutionalized within one another. Alice's metamorphosis can be read as the one of the significant wonders which Victorian citizens had created in their routine when they tried to ‘return' to their everyday lives, as Marx exhorted. The new existence surfaces out of her childhood: not the one as the peripheral to the citizen par excellence but as the human agent undertaking the bodily perception of the wonders. This would-be modern woman Alice is meant to pursue her adventures eventually to get somewhere; somewhere that is different from her past home, somewhere where the wonders all of sudden get to the surface of the present.

테스와 세스의 모성 그리고 관망의 도의성

이일수 ( Il Soo Lee ) 영미문학연구회 2011 영미문학연구 Vol.21 No.-

This paper intends to examine the theme of motherhood in Thomas Hardy`s Tess of the D`Urbervilles and Toni Morrison`s Beloved, in terms of ``regarding.`` egarding, according to Freud, is the seminal phase in which subject`s consciousness meditates violence-afflicted victims and violence-afflicting agents. Historically, the proper meaning of motherhood has been strictly circumscribed in terms of women`s servitude and submission to the male dominant system. In these works desperate mothers and their children who had been rejected by arbitrary patriarchal norms performed a certain kind of ``regarding.`` The outcast mothers in the works respectively respond to the societies and performed their independent mothering role. For Tess, her motherhood lies in her regarding the world as a disinterested spectator, which D. H. Lawrence emphatically declared to be a state of mental aristocracy. This regarding consciousness of Tess is the seminal, constituent part of her independent motherhood chiefly embodied in mother`s breast. For Sethe, her motherhood is intimately related with her lost daughter, Beloved. In the scenes of the house 124, the mother is symbolically and literally revisited, regarded, and remembered by her baby-ghost incarnate. The baby-ghost itself also seems to be a modern reader as well as a real victim of slavery in the 19th century American society. According to the Freudian triptych of ``child`s being beaten`` fantasies, one can postulate a subject who can sympathize with and participate in another`s pain, and read in Beloved a new language of maternity which will beget a participating ethics of regarding.

비루한 과거 혹은 여성 -호손과 길먼, 와튼의 괴담서사 읽기

이일수 ( Il Soo Lee ) 영미문학연구회 2014 영미문학연구 Vol.27 No.-

This essay examines ‘the uncanny’ or the abject selfhood that occurred in the gothic stories written by several American writers, Hawthorne, Gilman and Wharton. According to Freud, as long as we strive to overcome our primitive, unconscious instincts, they will surely return to our present in the form of ‘the uncanny.’ Our past is not to be simply forgotten and buried. Its repressed fragments will eventually visit us at the most unexpected moments and, the subsequent fear of them urges us to consciously scrutinize the present repression. Thus, these three writers used their narrative strategies of reclaiming, and historicizing the purged, abject past. Hawthorne, in his “Alice Doanne’s Appeal” and “The Birthmark,” summoned the voice of the past to ask readers what if our blind pursuit of the perfect present, ironically, destroys our life to the root. However, he left a critical void behind as to the female characters’ expressivity. Later the modern female writers such as Gilman and Wharton, in “The Yellow Wallpaper” and in “The Eyes” respectively, managed to inherit his profound literary question as such, and excavated a new, female speaking/writing subject out of the nineteenth-century women’s domesticity.

[특집/국제표준화기구] 자동차산업 품질시스템(ISO/TS 16949)의 현황과 대응

이일수(Il Soo Lee) 한국자동차공학회 2002 오토저널 Vol.24 No.2

비정질 강섬유보강 시멘트복합체의 정역학특성 및 내충격성능 평가를 통한 구조물 적용 가능성 검토

강일수 ( Kang Il-soo ),김규용 ( Kim Gyu-yong ),이보경 ( Lee Bo-kyeong ),이상규 ( Lee Sang-kyu ),손민재 ( Son Min-jae ),남정수 ( Nam Jeong-soo ) 한국건축시공학회 2017 한국건축시공학회 학술발표대회 논문집 Vol.17 No.2

This study examined the effect that the amorphous metallic fibers had on the static mechanical properties and the impact resistance of cement composites to those of hooked steel fibers. The hooked steel fiber exhibited pull-out from the matrix after the peak flexural stress was attained, while the amorphous metallic fiber was not pulled out from the matrix, but was instead cut off. In terms of impact resistance, the amorphous metallic fiber reinforced cement composite was found to be more effective at resisting cracking than the hooked steel fiber reinforced cement composite. Therefore, amorphous metallic fiber should be used in fiber reinforced cement composite materials, and for structural materials, and for protection panels.

Multi-detector Computed Tomography를 이용한 Neck 검사에서 Automatic Exposure Control을 이용한 선량의 최적화

이일수(Il Soo Lee),김문찬(Moon Chan Kim),이민영(Min Yung Lee),남윤철(Yoon Cheol Nam),한동균(Dong Kyoon Han) 대한CT영상기술학회 2010 대한CT영상기술학회지 Vol.12 No.1

Purpose The purpose of die study was to compare diagnostic acceptability, noise and radiation exposure of neck multi-detector computed tomography(MDCT) performed with automatic exposure control(AEC) and fixed mA method. Materials and methods A 50 patient group were divided into 5 groups: used fixed mA, AEC with noise index 7.02, 9.10, 12.22 and 12.60 respectively and evaluated image quality. The CT equipment used GE 64 VCT scanners and neck organ doses were measured using Rando phantom and an optical glass dosimeter and evaluated patient’s image noise and exposure dose. Results There was no significant difference between using AEC technique and fixed mA in diagnostic acceptability and subjective noise. AEC technique resulted in radiation dose reduction of 9.5~35.4% compared with fixed mA technique at noise index 7.02~12.22 in thyroid level. Conslusion AEC method provided acceptable image noise for neck CT and judicious monitoring of radiation dose to patients has to be balanced with diagnostic image quality.

3륜 승용관리기용 중경배토기 설계 제작

최일수 ( Il Soo Choi ),최용 ( Yong Choi ),이범섭 ( Beom Seob Lee ),지금배 ( Keum Bae Ji ),윤영태 ( Young Tae Yun ),유수남 ( Soo Nam Yoo ) 한국농업기계학회 2017 한국농업기계학회 학술발표논문집 Vol.22 No.1

4륜 승용관리기는 보통 후방이나 전방에 작업기를 장착하여 작업하나 3륜 승용관리기는 작업기를 복부에 장착함으로 작업의 정밀도, 편이성, 관측의 용이성 향상과 함께 지상고 제고, 차폭 조절, 조향 등의 성능 개선을 기할 수 있다. 국내에서는 3륜 승용관리기용 복부 장착 부속작업기가 거의 개발되어 있지 않으며, 특히 두류 재배에 있어서 일관기계화 작업을 위한 관리작업기의 개발이 매우 필요한 실정이다. 승용관리기의 중경배토기에 의한 작업은 기존 인력에 의한 작업보다 약 87%의 노력을 절감할 수 있으며, 잡초방제 효과도 인력에 비하여 크게 떨어지지 않고, 수량도 증가하는 것으로 보고되고 있다. 따라서 본 연구는 3륜 승용관리기에 적합한 복부장착형의 중경배토기를 설계 · 제작하였다. 3륜 승용관리기용 중경배토기는 승용관리기의 복부 PTO에서의 구동력 전달을 위한 연결 조인트, 중간축, 기어 및 체인 전동기구, 구동축으로 구성된 동력전달부, 4개의 로타리 날과 후방 1개의 배토날로 구성된 3조의 작업날, 로타리 날과 배토날의 경심 조절을 위한 3조의 바퀴, 흙의 비산 방지를 위한 로타리날 커버 및 케이스, 다양한 조간거리에 적응을 위한 조간조정 나사부, 3륜 승용관리기에의 부착을 위한 프레임 및 부착보조 작업기 이동용 바퀴장치 등으로 구성 설계 · 제작하였다. 로타리 날과 배토날은 기존시판 관리기용 날을 사용하였다. 로타리 날은 진행방향으로 회전하도록 하였으며, 날의 회전반경은 약330 mm, 조당 경운 폭은 약 230 mm 설계하였다. 최대 경심은 100 mm이며, 조간거리의 조절범위는 수동나사에 의하여 620~900 mm 범위로 무단조절 할 수 있도록 하였다. 중경제초기는 3륜 승용 관리기 복부의 평행링크에 부착되므로 작업기의 이동 및 부착 편이를 위하여 이동용 바퀴를 설치하였다. 제작된 중경배토기의 크기는 길이x폭x높이가 660x2072x880 mm, 중량은 약 200 kg으로 제작되었다.