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연구논문 : 생명과학 ; 프로페논 화합물의 배양 대식세포에서 NFκ-B활성화 억제를 통한 NO 및 TNF-α 생성억제
이응석 ( Eung Seok Lee ),주혜경 ( Hye Kyung Ju ),문태철 ( Tae Churl Moon ),이은경 ( Eun Kyung Lee ),장영동 ( Yurng Dong Jahng ),이승호 ( Sung Ho Lee ),손종근 ( Jong Keun Son ),백석환 ( Suk Hwan Baek ),장현욱 ( Hyeun Wook Chang 영남대학교 약품개발연구소 2004 영남대학교 약품개발연구소 연구업적집 Vol.14 No.-
김은경(Eun Kyung Kim),최희성(Hee Sung Choi),이응석(Eung Seok Lee) 대한약학회 1997 약학회지 Vol.41 No.5
N-(tert-Butoxycarbonyl)-omicron-(dicyanoethylthiophosphono)-L-tyrosine(7), the key intermediate for the synthesis of thiophosphotyrosine-containing peptide derivatives, was prepared. For the phosphorylation, we used tau-Boc-tyrosine and phosphoramidite in the presence of 1H-tetrazol. For the protection of thiophosphate moiety, cyanoethyl protecting group was used. Thiophosphotyrosine-containing peptides could be used as tools for the elucidation of mechanism of signal transduction pathway and also prepared as PTK inhibitors, PTPase inhibitors and cytosolic protein binding blockers. It may be contributed for the development of potential anticancer agents.
약학박사 정 시련 교수 정년퇴임 기념호 : 연구논문(재록) ; 생명과학 : 1-Bromopropane의 간독성 및 glutathione 포합
이상규 ( Sang Kyu Lee ),조상욱 ( Sang Wook Jo ),전태원 ( Tae Won Jeon ),전인혜 ( In Hye Jun ),김춘화 ( Chun Hua Jin ),김기환 ( Ghee Hwan Kim ),이동주 ( Dong Ju Lee ),김태오 ( Tae Oh Kim ),이응석 ( Eun Seok Lee ),정태천 ( Tee Cheon 영남대학교 약품개발연구소 2006 영남대학교 약품개발연구소 연구업적집 Vol.16 No.-
약학회담(藥學會談) : 페닐알킬 피페라진 유도체 합성과 a-Clucosidase 저해활성
장인혜 ( In Hye Chang ),이은엉 ( Eun Young Lee ),황보경 ( Bo Kyoung Hwang ),김인규 ( In Kyu Kim ),손경희 ( Kyung Hee Sohn ),최란 ( Lan Choi ),이응석 ( Eung Seok Lee ),우미희 ( Mi Hee Woo ),손종근 ( Jong Keun Son ),나영화 ( Young 영남대학교 약품개발연구소 2012 영남대학교 약품개발연구소 연구업적집 Vol.22 No.0
As an effort to find a new scaffold for a-glucosidase inhibition, we have prepared total 11 phenylalkylated piperazine derivatives and tested their a-glucosidase inhibitory activities. Compounds 8 (IC50=2.73±0.075 mM) possessing two 3-methxyphenethyl group on 1.4 position of piperazine showed comparable potency to acarbose used as reference. But other compounds were inactive to a-glucosidase. The result indicated that proper substituents on the piperazine can engender a-glucosidase inhibitory activities on the piperazine derivatives.
약학박사 정 시련 교수 정년퇴임 기념호 : 연구논문(재록) ; 생명과학 : Parathion의 간독성 및 면역독성에 있어서 대사과정의 역할
김대옥 ( Dae Ok Kim ),이상규 ( Sang Kyu Lee ),전태원 ( Tae Won Jeon ),김춘화 ( Chun Hua Jin ),현선희 ( Sun Hee Hyun ),김은정 ( Eun Jung Kim ),문귀임 ( Gui Im Moon ),김정애 ( Jung Ae Kim ),이응석 ( Eung Seok Lee ),이병무 ( Byung Mu 영남대학교 약품개발연구소 2006 영남대학교 약품개발연구소 연구업적집 Vol.16 No.-
페닐알킬 피페라진 유도체 합성과 ${\alpha}$-Glucosidase 저해활성
장인혜,이은영,황보경,김인규,손경희,최란,이응석,우미희,손종근,나영화,Chang, In-Hye,Lee, Eun-Young,HwangBo, Kyoung,Kim, In-Kyu,Sohn, Kyung-Hee,Choi, Lan,Lee, Eung-Seok,Woo, Mi-Hee,Son, Jong-Keun,Na, Young-Hwa 대한약학회 2011 약학회지 Vol.55 No.6
As an effort to find a new scaffold for ${\alpha}$-glucosidase inhibition, we have prepared total 11 phenylalkylated piperazine derivatives and tested their ${\alpha}$-glucosidase inhibitory activities. Compounds 8 ($IC_{50}=2.73{\pm}0.075mM$) possessing two 3-methoxyphenethyl group on 1,4-position of piperazine showed comparable potency to acarbose used as reference. But other compounds were inactive to ${\alpha}$-glucosidase. The result indicated that proper substituents on the piperazine can engender ${\alpha}$-glucosidase inhibitory activities on the piperazine derivatives.