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일 농촌지역 여고생의 흡연실태와 자아존중감 및 문제행동
나영화,박오장 전남대학교 간호과학연구소 2004 Nursing and Health Issues(NHI) Vol.9 No.1
The purpose of this study was to understand smoking status, self-esteem and problematic behaviors of high school girls in a rural community, and to suggest a basic education material for a smoking prevention program of school health. The subjects of this study were 693 high school girls in K. Gun of C. Do. during the period of Mar. 2nd to 15th, 2004. Data was collected using Questionnaires for self-esteem (Rosenberg, 1965), problematic behaviors (cho, 2000). The reliabilities of each instruments were Chronbach's a=.77 and .91. Data was analyzed by frequency and percentage, mean and SD, x2-test, t-test, ANOVA and Scheffe test in SPSS 10.0 program. The result may be summarized as follows: 1. The smoking girls were 3.3% and those who had smoking experiences were 13.8% in the 693 high school girls. 2. The first time of smoking experience was highest in middle school (64.2%), followed by primary school (19.3%), high school (14.7%), and kindergarten (1.8%). 3. Smoking motivation was highest in curiosity (62.0%), followed by reduction of stresses (15.0%), and recommendation of their seniors or friends (14.0%). 4. The most frequent smoking places were bathroom or toilet (37.0%) and game room (26.1%). 5. Smoking amount a day of the smoking girls was most frequent in the less than ten Cigarettes (35.0%) and over than ten ones (35.0%), followed by less than five ones (30.0%). 6. The smoking rate was significantly higher in the girls of below grade point than those of higher (x2=17.603, p=.001), in the dormitory or the other resident than those of their own home (x2=8.628, p=.004) , in the higher eronomic status than lower (x2=32.153, p=.001), in the unhappy family atmosphere than happy family (x2=25.244, p=.001), and in the situation of living with smoking family (x2=17.785, p=.001). 7. The problematic behaviors showed significantly higher in the smoking students than those of smoking experience and non-smokers, and the smoking experience students were significantly higher than those of non-smoking (F=90.530, p=.001).
Chalcones as Novel Non-peptidic μ-Calpain Inhibitors
Eunyoung Lee,나영화,Ji-Eun Eom,Jungsook Kim,Hee-Ju Cho,Min Jung Shin,Inhye Jang,권영주 대한화학회 2011 Bulletin of the Korean Chemical Society Vol.32 No.9
In order to extend the scaffold of non-peptidic calpain inhibitor, we have designed and synthesized 14 chalcone derivatives categorized into two groups based on their structures. Compounds 7 (IC_50 = 16.67 ± 0.42 μM) and 8 (IC_50 = 16.92 ± 0.14 μM) in group A were most selective μ-calpain inhibitor over cathepsins B and L. On the other hand, compound 14 possessing furan ring exhibited inhibitory activities for μ-calpain (IC_50 = 15.39 ± 1.34μM) as well as cathepsin B (IC_50 = 20.59 ± 1.35 μM). The results discovered implicated that chalcone analogues possessing proper size and functional groups can be a potential lead core for selective non-peptidic μ-calpain inhibitor. Furthermore, dual inhibitors for μ-calpain and cathepsin B can also be developed from chalcones by elaborate structure manipulation.
강혜영,신경은,장현지,나영화,조은희 韓國學校保健學會 2004 韓國學校保健學會誌 Vol.17 No.2
Purpose : The purpose of this study was to investigate drinking motives and the drinking-related problems of Korean high school students at a city in Jeonbuk province. Methods : There were 657 students from two academic and two vocational high schools at J city in Jeonbuk province. The sample was collected using a stratified sampling method and the data was collected from June 30th to July 16th 2003. The study instrument used to examine drinking motive was a 20.item summated scale (Cronbach's α = .95) and for drinking-related problems was an 18 item summated scale (Cronbach's α = .91). The data was analyzed using SPSS/PC+ by percentage, χ2.test, t-test and correlations. Results : 1. Drinking experience: Among the high school students, 74.3% of them had drinking episodes. Female students started drinking later (χ2 = 12.857, p = .002) and had more drinking friends (χ2 = 7.785, p = .020) than males. Vocational school students drank more frequently (χ2 = 32.138, p = .001), had more heavy drinking episodes (χ2 = 40.370, p = .001). 2. Drinking motives & Drinking-related problems: The mean score of drinking motives was 31.2 ± 11.12 out of 80 and that of drinking-related problems was 21.8 ± 5.85 out of 72 points. Neither score were stronger was significantly different according to gender and grade. On the other hand, both drinking motives (t = .4.077, p = .001) and drinking-related problems (t = .3.423, p = .001) were stronger in vocational school students than in academic school students. The correlation between drinking-related characteristics and problems were weak (from r = .286 to r = .520) but the correlation within the subcategories of drinking motives was high such as between enhancement and coping (r = .822) and enhancement and social motives (r = .822). Conclusion : The majority of Korean high school students start to drink during their junior high school days. Drinking motives and drinking-related problems were not serious but the drinking motives and the drinking-related problems are stronger among vocational school students. As a result, school-based health education and counseling programs should focus on solving drinking motives than on drinking-related problems.
4-Hydroxy-2’-Nitrodiphenyl Ether Analogues as Novel Tyrosinase Inhibitors
Kiran Sapkota,이은영,Jae-Ho Yang,권영주,최종원,나영화 대한화학회 2010 Bulletin of the Korean Chemical Society Vol.31 No.5
Tyrosinase ubiquitously existing from microorganisms to animals and plants is known to be the most critical and rate limiting enzyme during melanin biosynthesis. In order to develop new tyrosinase inhibitor we have synthesized 14diphenyl ether compounds possessing hydroxyl, bromo, and nitro groups in the structure. Among the compounds prepared, 18 and 19 have shown much stronger inhibition of tyrosinase monophenolase function than arbutin used as a positive control. Both compounds 18 and 19 possess para-hydroxyphenyl moiety in their structure, which might reinforce the importance of p-hydroxyphenyl group in the tyrosinase inhibitory process. In the DPPH radical scavenging activity test, none of the compounds even 18 and 19 showed significant antioxidant activity. The results suggest that elaborate adjustment of diphenyl ether analogues with proper substituents have potential to be developed as new skin whitening agents working on the tyrosinase function.
김원주 ( Wonju Kim ),박선 ( Sun Park Jiu Cho ),조지우 ( Yeonghwa Na ),나영화 ( Huyeol Yang ),양후열 ( Seong Ro Lee ),이성로 한국정보처리학회 2012 한국정보처리학회 학술대회논문집 Vol.19 No.1
적조란 유해조류의 일시적인 대 번식으로 바다를 적색으로 변화시키며 연안 환경 및 바다 생태계에 악영향뿐만 아니라 양식장의 어패류를 집단 폐사 시키는 현상이다. 적조에 의한 양식어업의 피해는 매년 발생하고 있으며 매년 적조방제에 많은 비용을 소비하고 있다. 이 때문에 적조 발생을 미리 예측할 수 있으면 적조에 대한 피해 및 방재 비용을 최소화 시킬 수 있다. 본 논문은 앙상블 학습은 이용한 적조발생 예측 방법을 제안한다. 제안방법은 앙상블 학습의 bagging과 boosting 방법을 이용하여서 적조를 예측의 성능을 향상시킨다. 실험결과 제안방법은 단일 분류기에 비하여서 더 좋은 적조 발생 예측 성능을 보였다.