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페닐알킬 피페라진 유도체 합성과 ${\alpha}$-Glucosidase 저해활성
장인혜,이은영,황보경,김인규,손경희,최란,이응석,우미희,손종근,나영화,Chang, In-Hye,Lee, Eun-Young,HwangBo, Kyoung,Kim, In-Kyu,Sohn, Kyung-Hee,Choi, Lan,Lee, Eung-Seok,Woo, Mi-Hee,Son, Jong-Keun,Na, Young-Hwa 대한약학회 2011 약학회지 Vol.55 No.6
As an effort to find a new scaffold for ${\alpha}$-glucosidase inhibition, we have prepared total 11 phenylalkylated piperazine derivatives and tested their ${\alpha}$-glucosidase inhibitory activities. Compounds 8 ($IC_{50}=2.73{\pm}0.075mM$) possessing two 3-methoxyphenethyl group on 1,4-position of piperazine showed comparable potency to acarbose used as reference. But other compounds were inactive to ${\alpha}$-glucosidase. The result indicated that proper substituents on the piperazine can engender ${\alpha}$-glucosidase inhibitory activities on the piperazine derivatives.
약학회담(藥學會談) : 페닐알킬 피페라진 유도체 합성과 a-Clucosidase 저해활성
장인혜 ( In Hye Chang ),이은엉 ( Eun Young Lee ),황보경 ( Bo Kyoung Hwang ),김인규 ( In Kyu Kim ),손경희 ( Kyung Hee Sohn ),최란 ( Lan Choi ),이응석 ( Eung Seok Lee ),우미희 ( Mi Hee Woo ),손종근 ( Jong Keun Son ),나영화 ( Young 영남대학교 약품개발연구소 2012 영남대학교 약품개발연구소 연구업적집 Vol.22 No.0
As an effort to find a new scaffold for a-glucosidase inhibition, we have prepared total 11 phenylalkylated piperazine derivatives and tested their a-glucosidase inhibitory activities. Compounds 8 (IC50=2.73±0.075 mM) possessing two 3-methxyphenethyl group on 1.4 position of piperazine showed comparable potency to acarbose used as reference. But other compounds were inactive to a-glucosidase. The result indicated that proper substituents on the piperazine can engender a-glucosidase inhibitory activities on the piperazine derivatives.