수소제조를 위한 다공성 FeCrAl 금속 합금 Foam의 NiO 촉매 담지 및 미세구조 분석

이유진,안건형,박만호,이창우,최상현,정주용,조성종,이근재,안효진,Lee, Yu-Jin,An, Geon-Hyoung,Park, Man-Ho,Lee, Chang-Woo,Choi, Sang-Hyun,Jung, Ju-Yong,Jo, Sung-Jong,Lee, Kun-Jae,Ahn, Hyo-Jin 한국재료학회 2014 한국재료학회지 Vol.24 No.8

NiO catalysts were successfully coated onto FeCrAl metal alloy foam as a catalyst support via a dip-coating method. To demonstrate the optimum amount of NiO catalyst on the FeCrAl metal alloy foam, the molar concentration of the Ni precursor in a coating solution was controlled, with five different amounts of 0.4 M, 0.6 M, 0.8 M, 1.0 M, and 1.2 M for a dip-coating process. The structural, morphological, and chemical bonding properties of the NiO-catalyst-coated FeCrAl metal alloy foam samples were assessed by means of field-emission scanning electron microscopy(FESEM), scanning electron microscopy-energy dispersive spectroscopy(SEM-EDS), X-ray diffraction(XRD), and X-ray photoelectron spectroscopy(XPS). In particular, when the FeCrAl metal alloy foam samples were coated using a coating solution with a 0.8 M Ni precursor, well-dispersed NiO catalysts on the FeCrAl metal alloy foam compared to the other samples were confirmed. Also, the XPS results exhibited the chemical bonding states of the NiO phases and the FeCrAl metal alloy foam. The results showed that a dip-coating method is one of best ways to coat well-dispersed NiO catalysts onto FeCrAl metal alloy foam.

일차성 불면증 환자에서의 주간 졸림증과 연관된 수면변인에 대한 연구

이유진,이진성,손창호,이은혜,문필성,정도언,Lee, Yu-Jin,Lee, Jin-Sung,Sohn, Chang-Ho,Lee, Eun-Hye,Moon, Pil-Sung,Jeong, Do-Un 대한수면의학회 2005 수면·정신생리 Vol.12 No.2

목 적:본 연구에서는 일차성 불면증으로 진단받은 환자들과 대조군 사이의 주간 졸림증 정도를 비교하고 불면증 환자에서의 주간 졸림증과 야간 수면다원검사에서 산출한 수면 변인 사이의 상관관계를 평가해 보고자 하였다. 방 법:서울대학교병원 수면 클리닉에서 일차성 불면증으로 진단받은 환자 87명과 88명의 대조군을 대상으로 하였다. 한국판 엡워스 졸림증 척도로 두 군의 주관적인 주간 졸림증을 평가하여 비교하였고 불면증 환자군에서 야간수면다원검사상의 수면변인과 엡워스 졸림증 척도 사이의 상관관계를 평가하였다. 결 과:불면증 환자군(남자 43명, 여자 44명; 평균연령 $50.7{\pm}11.9$)의 엡워스 졸림증 척도가 대조군(남자 43명, 여자 45명; 평균연령 $52.0{\pm}14.0$)에 비해 유의하게 낮았다. 연령을 통제하였을 때, 불면증 환자군의 엡워스 졸림증척도 점수는 수면변인 중 총 수면시간(total sleep time, min), 수면 효율(sleep efficiency%), 2단계 수면 분율(stage 2 sleep time%)과 유의한 음의 상관관계를 보였다(각각 r=-0.232, p=0.034; r=-0.215, p=0.049; r=-0.349, p=0.001). 또한, 수면 중 각성 횟수(number of awakenings), 수면 중 2분 이상 각성한 횟수(number of awakenings>2 mins), 수면 중 각성시간(wake after sleep onset, min)과는 유의한 양의 상관관계를 보였다(각각 r=0.412, p=0.000; r=0.473, p=0.000; r=0.367, p=0.001). 불면증 환자군의 엡워스 졸림증 척도는 수면 잠복기(sleep latency, min), 1단계 수면 분율(stage 1 sleep time%), 서파 수면분율(slow wave sleep time%), 렘수면 분율(REM sleep time%)과 유의한 상관관계를 보이지 않았다. 결 론:본 연구에서 불면증 환자는 대조군에 비해 주간 졸림증 정도가 더 낮았으며, 불면증 환자의 주간 졸림증은 수면의 양적 질적 저하와 연관되어 있었다. Objectives: The purpose of this study was to assess the difference of subjective daytime sleepiness level between primary insomnia patients and healthy control subjects. We also investigated the relationship between subjective daytime sleepiness level and variables of nocturnal polysomnograghic sleep architecture of insomnia patients. Method: Total subjects were 87 patients with primary insomnia diagnosed with polysomnography and 88 normal controls. The daytime sleepiness level in each group was measured by Korean version of Epworth Sleepiness Scale (ESS). The correlations of ESS score and nocturnal polysomnographic variables were calculated in the patient group. Results: Patients with insomnia had the lower ESS scores than the control group. In patients group, the ESS score showed significant negative correlations with total sleep time, sleep efficiency%, and stage 2 sleep time%. The ESS score also showed significant positive correlations with number of awakenings, number of awakenings more than 2 minutes, and wake after sleep onset time. Conclusions: Insomnia patients showed lower level of subjective daytime sleepiness that may indicate their higher alertness comparing to control subjects. Daytime sleepiness of patients with insomnia was associated with polysomnographic variables including total sleep time, sleep efficiency%, stage 2 sleep time% and disrupted continuity of nocturnal sleep.

Human Immunodeficiency Virus-1 Tat 단백에 의한 인간 CD99유전자의 조절기전에 대한 연구

이유진,김예리,이미경,이임순,Lee, Eu-Gene,Kim, Ye-Ri,Lee, Mi-Kyung,Lee, Im-Soon 한국미생물학회 2008 미생물학회지 Vol.44 No.4

HIV에 감염된 환자의 경우 다양한 종류의 암이 발생하는 것으로 알려져 있다. 이러한 암종의 높은 발생률의 원인으로, 감염에 의한 면역세포의 감소 및 결핍과 같은 간접적인 이유 뿐 아니라, HIV 바이러스 단백질의 발현이 직접적으로 병의 발생에 관여한다는 보고가 있다. 본 연구에서는 HIV 환자에서 높게 나타나는 암의 발생에 대한 기전을 이해하기 위하여 HIV-1 Tat 유전자와, 다수의 암 발생과 관련이 있는 세포막단백 CD99와의 관계를 규명하였다. 먼저 CD99의 발현에 미치는 Tat의 영향을 알아보기 위하여 HIV-1 Tat 발현 안정화 세포주를 확립하고 Tat 단백에 의한 CD99 유전자의 발현 양상 변화를 분석하였다. 실험결과 Tat의 발현에 의하여 CD99 유전자의 발현이 활성화되는 것이 관찰되었으며 이와 반대로 STAT3의 발현은 낮아졌다. CD99 프로모터는 CpG 함량이 높기 때문에 Tat 단백이 DNA 메칠화를 통해서 CD99 유전자의 발현을 조절하는지 확인하기 위하여 methylation specific PCR을 수행하였고 Tat의 발현이 높은 곳에서 특이적으로 CD99 프로모터 부위가 탈메칠화되는 것을 발견하였다. Tat 발현 세포에서만 특이적인 발현 차이를 보이는 유전자 분석을 위한 Differentially Expressed Gene keratin 17과 collagen, type IV 증가됨이 확인되었다. 위의 결과는 HIV Tat 단백이 직접 세포 단백들을 조절하여 암을 발생시킬 수 있다는 보고를 뒷받침한다. HIV affects many organ systems. Patients with HIV infection have substantially increased risk of developing various cancers, primarily by opportunistic infection with oncogenic viruses due to their immunocompromised status. However, extensive evidence also indicates that the viral protein, Tat itself, may playas a major factor in the development of AIDS-related neoplasms. The molecular mechanism underlying Tat's oncogenic activity may include deregulation of cellular genes. Therefore, in this study, we examined the effect of HIV-l Tat on CD99 as one of the target cellular genes, which is a well-known tumor marker in several cancers. By using established HeLa clones that are stably expressing Tat, we found that CD99 is upregulated by endogenous Tat, whereas STAT3 is down regulated. Upon the screening of genes differentially expressed between Tat-stable cells and the control cells by using the gene fishing technique, DEG, we detected 3 genes which expression is affected by the presence of Tat. Furthermore, the methylation specific PCR analysis of the stably Tat expressing cell lines revealed that the CD99 promoter is de methylated in the presence of Tat. Taken together, these results open a potential role of CD99 in AIDS-related oncogenesis via epigenetic regulation by HIV-1 Tat.

엇갈린 교합에서 implant와 magnetic attachment를 이용한 국소의치 증례

이유진,이성복,이석원,박수정,안수진,Lee, Yu Jin,Lee, Richard sungbok,Lee, Suk Won,Park, Su Jung,Ahn, Su Jin 대한치과보철학회 2017 대한치과보철학회지 Vol.55 No.1

부분 무치악 환자에서 구강 기능의 회복을 위한 보철 계획을 수립할 때, 잔존하는 치아에 따라 다양한 치료 방법을 선택할 수 있다. 특히 대합이 상실된 소수의 잔존치가 불안정한 교합을 야기하는 엇갈린 교합의 경우, 대합 되는 위치에 임플란트를 식립함으로써 교합지지를 회복할 수 있다. 이 증례에서는 발치 후 엇갈린 교합이 된 환자에서 의치의 하중을 견딜 수 있도록 상악 잔존치에 대응하는 하악 무치악 부위에 임플란트를 식립하고 자석유지장치(magnetic attachment)를 연결하는 국소의치를 제작하였다. 또한 상악 전치의 돌출과 하악 입술 지지도가 부족한 것을 개선하고 싶어한 환자의 요구사항에 따라 상악 전치부 보철적 수복 및 하악 의치를 통해 심미적 안모를 회복하였다. 5개월 정기검진 결과, 환자는 저작 기능 및 심미적인 면에서 만족하였고 의치의 안정성 또한 잘 유지되고 있기에 이를 보고하고자 한다. When attempting to restore the oral function of a partially edentulous patient, there are a number of prosthetic treatment options available, depending on the structure of remaining teeth. For example, when only one set of maxillary and mandibular teeth are diagonally in place across from each other, it is difficult to gain stable occlusion. In this case, implants can be put in place at the corresponding edentulous area to achieve balance. By doing so, a stable occlusion can be achieved. For this case report, a patient with crossed occlusion after extraction was treated with maxillary RDP (removable dental prosthesis) and mandibular implant-supported RDP (removable dental prosthesis). Moreover, an implant fixture was placed under the posterior molar of the distal extension base diagonally across from the remaining maxillary teeth. Then, magnetic attachment was implemented. According to the patient who received the treatment, the result was functionally and aesthetically satisfactory.

직업성질환 역학조사 26 - 코크스로 방출물 노출과 직업성 암

이유진,김은아,Lee, Yu-Jin,Kim, Eun-A 대한산업보건협회 2011 산업보건 Vol.281 No.-

홧병클리닉을 방문한 환자들의 임상 증상과 MMPI 상의 성격 특징에 대한 연구

이유진,백경원,김하경,연규월,임원정,Lee, Yu-Jin,Baek, Kyung-Won,Kim, Ha-Kyung,Yun, Kyu-Wol,Lim, Weon-Jeong 한국정신신체의학회 2008 정신신체의학 Vol.16 No.2

연구목적 : 본 연구는 홧병 클리닉을 방문한 환자를 대상으로 임상증상과 MMPI상의 성격특성을 조사해 보고자 하였다. 방법 : 2005년 12월부터 2006년 7월(7개월간)까지 이대 동대문 병원 내 가슴앓이 홧병 클리닉에 내원한 31명의 여성 환자($45.4{\pm}8.4$세)를 대상으로 호소하는 증상에 대해 반구조화된 면담을 실시하였고 신체적 검사를 시행하였다. 광고를 통해 모집된 31명의 여성 대조군($42.9{\pm}8.0$세)을 포함한 전체 대상군에게 MMPI를 완성하도록 하였다. 결과 : 홧병 클리닉 환자들이 호소한 주 증상은 31명 모두 가슴 답답함 혹은 통증을 호소하였으며, 소화기계 증상은 총 19명(61.3%)에서 있었다. 호흡기계 증상은 13명(41.9%)에서 관찰할 수 있었으며, 수면 장애는 12명 (38.7%)에서 있었다. 불안, 우울감 같은 정신과적 증상은 12명(38.7%)이 호소하였다. 8명(27.6%)의 환자에서 시행한 검사상 소화기계 질환이 진단되었다. 나이와 교육수준을 통제했을 때, 홧병 환자군에서 MMPI 소항목 척도 중 Hs(Hypochondriasis), D(Depression), Hy(Hysteria), Pt(Psychasthenia) 점수가 유의하게 높았다(p=0.001, p=0.049, p=0.000 and p=0.029, ANCOVA, respectively). 결론 : 본 연구에서 홧병 클리닉을 방문한 환자들은 다양한 신체 질환을 호소하였고, 27.6%의 환자에서 실제 신체질환이 진단되었다. 또한, 홧병클리닉 환자들의 성격 특징은 건강염려적이고, 우울하며, 스트레스에 미숙하고, 불안하였다. Objectives : The current study aimed at assessing clinical symptoms and personality characteristics on MMPI of patients in Hwa-Byung clinic. Methods : Thirty-one female patients($45.4{\pm}8.4$ years old) who visited to the Hwa-Byung Clinic in Ewha womans Dongdaemoon hospital were recruited. Semistructured interviews and laboratory tests for symptoms were performed for the patients group. Patients group and control group($42.9{\pm}8.0$ years old) completed MMPI. Results : All patients had symptoms of chest tightness or chest pain. 19(61.3%) out of 31 patients had gastrointestinal complaints. There were respiratory symptoms in 13(41.9%) patients. 12 patients(38.7%) suffered from difficulties in their sleep. 12 patients(38.7%) had psychiatric symptoms including anxiety or depressed mood. 8 patients(27.6%) were diagnosed as gastrointestinal diseases by the laboratory test. After controlling age and education, scores of Hs, D, Hy, Pt on MMPI in patients group were significantly higher than control group (p=0.001, p=0.049, p=0.000, and p=0.029, ANCOVA, respectively). Conclusion : In the current study, patients who have visited Hwa-Byung clinic showed various somatic symptoms including chest tightness, gastrointestinal symptoms, complaints in respiratory system and psychiatric symptoms. Based on laboratory tests, considerable proportion of patients was diagnosed as physical illnesses. Additionally, patients in Hwa-Byung clinic have a tendency to be more hypochondriatic, depressed, hysteric and anxious.

인진오령산가감이 유효했던 자가면역성 간염의증 환자 1례

이유진,김수현,양정윤,조기호,문상관,정우상,권승원,진철,Lee, Yu Jin,Kim, Soo-hyun,Yang, Jung Yun,Cho, Ki-Ho,Moon, Sang-Kwan,Jung, Woo-Sang,Kwon, Seungwon,Jin, Chul 대한중풍순환신경학회 2019 대한중풍학회지 Vol.20 No.1

■ Objectives In this case report, we address a case of a 83-year-old female patient diagnosed with suspicious autoimmune hepatitis. ■ Methods A patient was treated with herbal medication, Injinoryung-san gagam. We evaluated the improvements of symptoms by AST, ALT, GGT, ALP and total score of Fatigue Severity Scale(FSS). ■ Results After 4 weeks of taking Injinoryung-san gagam, there were decrease in abnormal liver enzyme levels with improvement of the patient's fatigue. ■ Conclusion This study suggested that Injinoryung-san gagam might be effective in autoimmune hepatitis patient's liver enzyme levels and fatigue recovery.

성장클리닉에 내원한 소아의 골연령과 체성분 및 신체 계측치의 상관성에 대한 연구

이유진,윤혜진,곽민아,백정한,Lee, Yu-Jin,Yun, Hye-Jin,Kwak, Min-A,Baek, Jung-Han 대한한방소아과학회 2009 대한한방소아과학회지 Vol.23 No.2

Objectives : The purpose of this study was to examine relationships between bone age and body composition to make efficient clinical reviews on children's growth. Methods : 157 of children in age of 3 years to 16 years old were participated in this study(88 of boys and 69 of girls). They visited the department of pediatrics, OO university oriental hospital and were measured their body composition and bone age. Results : 1. An age and bone age, height, weight, and body mass index were positively correlated, and also a bone age and height, weight, and body mass index were positively correlated. 2. The level of soft lean mass, body fat mass, and MPH were increased in boys in higher height percentile. Children's predicted adult height was higher in children in higher height percentile. 3. The level of body fat mass was increased as weight percentile increased. Bone age, MPH was increased as weight percentile increased, especially in case of boys. In girl's case, the level of soft lean mass, their predicted adult height, the difference between children's bone age and their actual age was increased as weight percentile increased. Conclusions : Measuring bone age and body composition is the effective way to estimate children's growth and development in future.

백중환이 유효했던 연수 경색 후 발생한 중추성 통증 환자 1례

이유진,박호정,김근영,조기호,문상관,정우상,권승원,진철,Lee, Yu Jin,Park, Hojung,Kim, Geun Young,Cho, Ki-Ho,Mun, Sang-Kwan,Jung, Woo-Sang,Kwon, Seungwon,Jin, Chul 대한한방내과학회 2021 大韓韓方內科學會誌 Vol.42 No.5

Objective: This study addressed a case of central post-stroke pain described as right arm painful with coldness and left lateral medullary infarction. Methods: A patient, 71 years old female with medullary infarction, was treated with a Korean herbal medication (BackJun-pill). The improvement of symptoms was evaluated using the Numeral Rating Scale and reports of coldness and pain in the affected areas. We also measured the body temperature difference between the left and right arms using digital infrared thermographic imaging (DITI). Results: After six weeks of treatment with Korean medicine, the patient's pain and sensation of coldness decreased. Conclusions: This clinical case study suggests that BackJun-pill may be effective for alleviating pain and coldness due to central post-stroke pain.

복진정제 및 수면제 유발 사건수면

이유진,Lee, Yu-Jin 대한수면의학회 2012 수면·정신생리 Vol.19 No.1

Parasomnias induced by hypnosedatives are rare but serious side effect. Such parasomnias have not been reported with all hypnosedatives. However, frequent use of hypnosedatives, particularly nonbenzodiazepine receptor agonists is associated with parasomnias. Associated symptoms are sleep eating, sleepwalking with object manipulation, sleep conversations, sleep driving, sleep sex and sleep shopping etc. Mechanisms include high affinity for $GABA_A$ receptor, interruption of the consolidation phase of memory formation by drug, pharmacokinetic or pharmacodynamic drug-drug interaction and concomitant administration with alcohol. Managements for parasomnias induced by hypnosedatives involve stopping medication, switch to other medications or nonpharmacological treatment, lowest effective dose of NBRAs (Non-Benzodiazepine Receptor Agonists), taking into consideration drug-drug interactions, identification and treatment of underlying disease states.