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이언,김영보 대한신경외과학회 1994 Journal of Korean neurosurgical society Vol.23 No.3
Research or therapy involving human fetal tissue has been subject of intense political and ethical debate in many country for almost two decades. Especially. Transplantation of cells or tissues from aborted fetuses to treat Parkinson's disease shows great clinical promise but it has some ethical or legal controversy. We can expect that demand of fetal brain tissue is increased explosively near future. So we have to establish our own eithical guidelines urgently. In this article authors report several basic medical or ethical issues which the fetal mesencephalic transplantation brings up inevitably and suggest our own ethical guidelines.
이언,김영보,김미훈,안성기,강동수,박철완 대한신경외과학회 1995 Journal of Korean neurosurgical society Vol.24 No.9
During thalamotomy, we have to use the various kinds of brain reference points. From 1989 to 1992, the authors performed streotactic thalamotomy or pallidotomy in 169 patients suffering from tremor. We measured and estimated the important intracerebral reference points. These data were very meaningful for stereotactic functional neurosurgery in the Korean medical community because it is obtained from Korean people. We have also estimated the average location of targets for tremor submission.
이언 한국통신학회 2020 정보와 통신 Vol.37 No.4
최근 기술의 진보가 의료계에 혁명적 변화를 초래하고 있다. 이러한 변화는 의료를 넘어 우리 생활에 큰 영향을 미치고 있다. 인공지능과 초고속통신기술, 코로나19감염증 등으로 인해 의료계가 어떠한 변화를 겪고 있는지, 사람들의 건강과 의료에 접근 방식은 어떻게 달라지고있는지 살펴보는 일은 앞으로 인공지능의 의료적용 기술이 어떠한 방향으로 발전해 갈 것인가를 파악하는데 매우 중요하다. 기술의 발전은 개인과 사회의 필요에 기반을 두고 있다. 이러한 현실인식을 바탕으로 확실한 방향성과 함께 인공지능 기술을 발전시켜 나가지 않으면 인공지능 선진국이 되는 일은 불가능할 것이다. 아울러 기술발전으로부터 소외된 국가나 사람에게도 최소한의 필수 의료는 받을 수 있도록 하는 일도 소홀히 해서는 안된다. 의료시스템의 지속가능성은 심각한 도전에 직면해있다. 올바른 방향성을 전제로한 기술의 발전은 이러한 위기를 극복하게 하는 중요한 열쇠이다.
이언,유영미,유찬종,Lee, Uhn,Yoo, Young Mi,Yoo, Chan Jong 대한신경외과학회 2000 Journal of Korean neurosurgical society Vol.29 No.2
Objective : Essential tremor(ET) is the most common movement disorder, however, there has been little agreement in the neurologic literature regarding diagnostic criteria for ET. Familial ET is an autosomal dominant disorder presenting as an isolated postural tremor. The main feature of ET is postural tremor of the arms with later involvement of the head, voice, or legs. In previous studies, it was reported that ET susceptibility was inherited in an autosomal dominant inheritance. As previous results, it would suggest that ET might be associated with defect of mitochondrial or nuclear DNA. Recent studies are focusing on molecular genetic detection of movement disorders, such as essential tremor and restless legs syndrome. Moreover, authors have analysed mitochondrial DNA(mtDNA) from the blood cell of positive control(PC) and ET patients via long and accurate polymerase chain reaction(LA PCR). Materials & Methods : Blood samples were collected from PC and 9 ET patients. Total DNA was extracted twice with phenol followed by chloroform : isoamylalcohol. For the analysis of mtDNA, LA PCR was performed by mitochondrial specific primers. Results : With this technique, deletions of large quantities were detected within several regions of mtDNA in ET patients except for D-loop and CO I regions. Conclusion : The authors believe that ET is a genentic disorder with deficiency of mitochondrial DNA multicomplexes and mitochondiral dysfunction could be one of major causative factors of ET. Mitochondrial dysfunction may play an important role in the pathogenesis and possibility of disease progression among familial group with ET patients.
새 수용성 척수조영제 "Iopamidol" 27례 시행경험
이언,김주승,오석전,조해동,유영락,김남규,정환영 대한신경외과학회 1983 Journal of Korean neurosurgical society Vol.12 No.4
27 myelographies with Iopamidol and 27myelographies with metrizamide were performed in order to compare adverse reactions, radiographic quality and effects on vital signs of the two contrast media after injection into the spinal subarachnoid space. Headache and nausea were less severe using Iopamidol. The most striking difference was found in adverse neurobehavioral reactions and associated electroencephalographic abnormalities which were noted in 7.4% of the metrizamide group but were not seen with the use of Iopamidol. Iopamidol was more stable than metrizamide in CSF. Image quality and diagnostic accuracy of Iopamidol myelography was equivalent to metrizamide for intrathecal application.
유비쿼터스병원 운영사례-2)가천의과대학교 길병원 Ubiquitous-Hospital
이언,Lee, Eon 대한병원협회 2007 대한병원협회지 Vol.36 No.5
가천의과대학교 길병원의 유비쿼터스 병원을 크게 3부분으로 나누어 소개하고자 한다. 첫째 2003년 부터 구축을 시작하여 탄탄한 병원경영의 밑거름이 되고 있는 디지털병원,고객의 편리와 안전을 먼저 생각하는 스마트 시스템,마지막으로 현재 시스템 구축 막바지에 있는 eGMR 순으로 각각의 개요와 특성에 대해 풀어가기로 한다