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임상현(Sang-Hyun Lim),김희연(Hee-Yeon Kim),박민희(Min Hee Park),박유화(Yu Hwa Park),함헌주(Hun Ju Ham),이기연(Ki Yun Lee),김경희(Kyung-Hee Kim),박동식(Dong Sik Park),김성문(Songmun Kim) 한국식품영양과학회 2010 한국식품영양과학회지 Vol.39 No.12
돌단풍 잎의 항산화, 항염, 항당뇨, 항비만 활성을 탐색하고자 강원도 양구에서 자생하고 있는 돌단풍의 잎을 채집하여 에탄올과 증류수로 각각 추출하였다. 항산화 활성은 DPPH 라디칼 소거반응, 총 폴리페놀 함량 및 총 플라보노이드 함량을 측정하여 검정하였다. 돌단풍 잎의 에탄올과 물 추출물의 DPPH 라디칼 소거능 IC50값은 각각 549.86과 62.14 ㎍/mL이었고, 총 폴리페놀 함량은 에탄올 추출물이 307.63 ㎎/g으로 물 추출물의 총 폴리페놀 함량인 86.96 ㎎/g보다 높게 나타났으나 총 플라보노이드 함량은 에탄올과 물 추출물 각각 118.98과 110.16 ㎎/g으로 비슷한 함량을 나타냈다. 항염 활성은 RAW264.7 세포에 LPS와 돌단풍 잎 추출물을 동시에 10 ㎎/mL 처리하여 NO 생성량을 측정하였으나 효과는 없었다. 항당뇨 활성은 α-glucosidase와 α-amylase 저해활성을 측정하였으며, 돌단풍 에탄올과 물 추출물의 α-glucosidase IC50값은 각각 5.62와 425.63 ㎍/mL이었고, α-amylase IC50값은 각각 4,623.87과 10,000 ㎍/mL 이상으로 돌단풍 에탄올 추출물의 항당뇨 활성은 매우 뛰어났다. 항비만 활성 탐색은 pancreatic lipase의 활성저해를 측정하였으며, 그 결과 돌단풍 잎의 에탄올과 물 추출물의 IC50값은 모두 10,000 ㎍/mL 이상으로 항비만 활성은 없는 것으로 나타났다. 이러한 결과 돌단풍 잎 추출물의 항산화, 항당뇨의 기능성활용 가공식품 및 건강기능식품으로의 개발이 기대된다. In this study, the bioactivities of ethanol (EEAR) and water extract (WEAR) from the leaf of Aceriphyllum rossii were investigated. In the anti-oxidative activity, IC50 of DPPH radical scavenging activity was respectively 549.86 and 62.14 ㎍/mL by EEAR and WEAR. Anti-inflammatory activity of EEAR and WEAR has been evaluated on inhibition of lipopolysaccharide (LPS)-induced nitric oxide (NO) release by the macrophage RAW 264.7 cells. EEAR and WEAR inhibited inflammatory by 5.58 and 16.85% in 10 ㎎/mL, respectively. In the anti-diabetic activity, IC50 of α-glucosidase inhibitory activity was 5.62 and 425.63 μg/mL by EEAR and WEAR. IC50 of α-amylase inhibitory activity of EEAR and WEAR was 4,623.87 and over 10,000 ㎍/mL, respectively. In the anti-obesity, all lipase inhibitory activity (IC50) of EEAR and WEAR was up 10,000 ㎍/mL. Finally, EEAR and WEAR exhibited anti-oxidative and anti-diabetic activity. It suggests that Aceriphyllum rossii could be potentially used as a resource of bioactive materials for health functional foods.
변형 주관절에 뒤따른 척골 신경 마비에 대한 Medial Epicondylectomy
김종기,이기연,유영락,김남규,정환영 대한신경외과학회 1974 Journal of Korean neurosurgical society Vol.3 No.2
We have reported our experience with 5 cases, each of whom had tardy ulnar palsy, which was treated by media) epiccndylectomy without anterior transplantation of ulnar nerve, and each of whom had good result in 2 yearsfollow-up study. All patients had cubitus valgus deformity which was followed to the fracture-dislocation of the elbow region. The operative procedure employed in this sreies is carried out with the patient spine, the humerus abducted end externally rotated, and the elbow flexed so that the extensor surface of the forearm may rest comfortably en a padded arm board. A skin incision 5 to 6 cm long made parallel to the ulnar nerve but a centimeter or more in front of it, centered on the prominence of the condyle. After fully exposing the medial epicondyle and the supracondylar ridge sub-periosteally, they are removed with rongeurs. No sharp edge should be left and the bone should be removed sufficiently checking X-ray during the operation for the evaluation of bone shape hidden in the soft tissues. Following epicodylectomy, all patients gained relief from pain and had gradual ??turn of motor function. Because of less risk to traumatize to nerve branches, to interfere with blood supply, and to adhere the neighboring tissues, end of ability to move the elbow through a full range immediately, we believe this method gives results superior to anterior transplentation operation.