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오가피(五加皮) 추출액(抽出液)이 면역(免疫), 항암(抗癌) 및 비만(肥滿)에 미치는 실험적 효과
노영호,이금수,김천중,전병관,정현우,Rho, Young-Ho,Lee, Geum-Su,Kim, Cheon-Joong,Jeon, Byung-Gwan,Jeong, Hyun-Woo 대한동의생리학회 2005 동의생리병리학회지 Vol.19 No.2
This experimental Study was designed to investigate the effects of Acanthopanacis Cortex Extract(ACE) on the immunity, anti-cancer and obesity in mice. The results were as follows; ACE was significantly increased in the proliferation of thymocytes and splenocytes, and NO production from peritoneal macrophages in normal mice. ACE was significantly increased in the proliferation of thymocytes and splenocytes, and NO production from peritoneal macrophages in L1210 cells transplanted mice. ACE was significantly decreased in the proliferation of L1210 cells in L1210 cells transplanted mice. ACE was significantly inhibited body weight and tumor weight in S-180 cells transplanted mice. ACE was significantly increased in the mean survival days in S-180 cells transplanted mice. ACE was significantly decreased in the body weight in rats fed high fat diet. ACE was significantly decreased in the serum total cholesterol level, free fatty acid level, total lipid level, phospholipid level in rats fed high fat diet. According to above results, the authors suggest that ACE is able to be used for the herb of physiological-action.
Initial Risk Assessment of Acetanilide with Respect to Ecological Integrity
Lee, Su-Rae,Choi, Seon-Ju,Lee, Mi-Kyung,Nam, U-Kyung,Chung, Sun-Hwa,Seog, Geum-Su,Park, Kwang-Sik,Kim, Kyun,Kim, Yong-Hwa 한국환경독성학회 2000 환경독성보건학회지 Vol.15 No.1
아세트아닐리드는 의약품과 염료의 합성과정에서 중간체로서 공기와 폐수를 통하여 환경 중에 방출 될 수 있다. 아세트아닐리드는 호기적 조건하에서 신속히 생분해되고 OH래디컬의 존재하에 간접적으로 광분해된다. 생물농축계수는 4.5로 추정되므로 수생생물에서의 생물농축은 낮을 것으로 예상된다. 아세트아닐리드에 관한 생태독성학적 데이터 조사결과 4종 어류에 대한 급성독성치만 보고되어 있으며, EUSES시스템에 의하면 어류에서의 최저 PNEC값 (예상 무작용농도)은 0.01㎎/l이고 표면수에서의 PEC값(예상 환경농도)은 지역수준에서 최악의 경우 9.1?0^(-5)㎎/l이다. 지역수준에서 표면수에 대한 아세트아닐리드의 RCR(위해성지수)은 9.1?0^(-3)으로 추정되어 어류에 대한 안전성을 충분하다. 그러나 국지 수준에서의 RCR은 물과 침적물에서 각각 1.3과 1.6이므로 제조공장 주변에서는 생태독성 위험이 존재할 것으로 추정된다. 아세트아닐리드의 환경위해성 평가를 보다 정확하기 하기 위해서는 물벼룩과 조류에 대한 급성독성 자료가 보완되어야 할 것이며, 따라서 이에 대한 실험이 진행되어야 할 것으로 사료된다. Acetanilide may be released into the environment through air and wastewater from its production and use sites as an intermediate in the synthesis of phar-maceuticals and dyes. Acetanilide is biodegraded rapidly under aerobic conditions and decomposed by indirect photolysis in the presence of OH radicals. An estimated bioconcentration factor of 4.5 suggests that bioaccumulation in aquatic organisms is low. Ecotoxicological data on acetanilide exist on acute toxicity to fishes of 4 species only. According to the EUSES system, the lowest PNEC (Predicted no effect concentration) in fishes is 0.01 mg/l and PEC (Predicted environmental concentration) for surface water on a regional scale is 9.1?0^(-5) mg/l as the worst case. RCR (Risk characterization ratio) of acetanilide for surface water on a regional scale was estimated as 9.1?0^(-3), which is safe enough C(=)or fishes. RCR on a local basis slightly exceeds the value I in water and sediment; that is, 1.3 and 1.6, respectively, which suggests the existence of ecotoxicological risk at the vicinity of the manufacturing site. For the refinement of environmental risk assessment on acetanilide, more data should be collected regarding prolonged fish toxicity, acute toxicity to ward daphnia and algae. It is, therefore, recommended that acetanilide should be a candidate for further work to supplement the lacking data until it is proved to be safe in the ecotoxicological aspects.