GATA-3 is a Key Factor for Th1/Th2 Balance Regulation by Myristicin in a Murine Model of Asthma

이규,이창민,정인덕,정영일,천성학,박희주,최일환,안순철,신용규,이상율,염석란,김종석,박영민,Lee, Kyu,Lee, Chang-Min,Jung, In-Duk,Jeong, Young-Il,Chun, Sung-Hak,Park, Hee-Ju,Choi, Il-Whan,Ahn, Soon-Cheol,Shin, Yong-Kyoo,Lee, Sang-Yull,Yeom, S Korean Society of Life Science 2007 생명과학회지 Vol.17 No.8

Myristicin은 육두구에서 발견되는 고농축 정유 중 하나인 물질이다. 하지만 Th1/Th2 면역반응에서 육두구의 항알레르기 효과는 아직 밝혀지지 않았다. 최근에 Th1/Th2 전사인자로서 T-bet, GATA-3가 밝혀졌는데 이번 실험에서 myristicin이 ovalbumin(OVA)으로 유도한 천식(asthma) 생쥐모델에서 Th1,Th2 싸이토카인과 유전자 발현을 조절할 수 있는가에 대하여 알아보았다. 또한 기관지 폐포 세척액을 회수하여 백혈구의 수적 변화, 제2형 협조T세포(Th2 cell)가 생산하는 IL-4, IL-5의 생산에 미치는 영향과 폐조직에서 matrix metalloproteinase (MMP)-9 활성을 측정하였다. 그 결과 기관지 폐포 세척액에서 OVA로 감작하여 천식을 유도한 실험군에서는 호산구의 현저한 증가, Th2 형 싸이토카인(IL-4, IL-5)의 증가가 관찰되었다. 그러나 myristicin을 투여한 그룹에서는 OVA의 감작에 의하여 증가한 각종 염증성 지표들이 감소하거나 정상화 되었다. 또한 OVA에 의하여 증가된 기도저항성이 myristicin 투여에 의하여 감소하였으며 폐조직의 염증성 소견도 뚜렷하게 감소되었다. 이와 같은 연구 결과는 myristicin이 천식의 치료에 유용하게 쓰일 수 있음을 시사해준다. Myristicin, l-allyl-3,4-methylenedioxy-5-methoxybenzene, was one of the major essential oils of nutmeg. However, its anti-allergic effect in the Th1/Th2 immune response was poorly understood. Recently, it was shown that T-bet and GATA-3 was master Th1 and Th2 regulatory transcription factors. In this study, we have attempted to determine whether myristicin regulates Th1/Th2 cytokine production, T-bet and GATA-3 gene expression in ovalbumin (OVA)-induced asthma model mice. Myristicin reduced levels of IL-4, Th2 cytokine production in OVA-sensitized and challenged mice. In the other side, it increased $IFN-{\gamma}$, Th1 cytokine production in myristicin administrated mice. We also examined to ascertain whether myristicin could influence eosinophil peroxidase (EPO) activity. After being sensitized and challenged with ovalbumin (OVA) showed typical asthmatic reactions. These reactions included an increase in the number of eosinophils in bronchoalveolar lavage fluid, an increase in inflammatory cell infiltration into the lung tissue around blood vessels and airways, and the development of airway hyper-responsiveness (AHR). The administration of myristicin before the last airway OVA challenge resulted in a significant inhibition of all asthmatic reactions. Accordingly, these findings provide new insight into the immunopharmacological role of myristicin in terms of its effects in a murine model of asthma.

한옥구조에서 전통한식 벽체와 셀룰로오스 단열벽체의 실내 환경성능 평가

이규인(Lee, kyu-In),안은섭(Ahn, Eun-Seop) 대한건축학회 2012 대한건축학회 학술발표대회 논문집 Vol.32 No.2

생태적인 공동주택 외부공간의 예비평가지표에 대한 전문가 중요도 인식에 관한 연구

이규인(Lee Kyu-In),김민석(Kim Min-Seok) 대한건축학회 2008 대한건축학회논문집 Vol.24 No.7

The objective of this study is to develop preliminary assessment indicators of the external spaces for ecological housing complexes in Korea. For this purpose, assessment indicators from international and national research materials and assessment criteria, newly developed indicators were synthesized. These indicators were distributed by 4 principals of eco system which are circulation, stability, independence, and diversity, and were organized to the preliminary indicators pool. And then, the survey on the importance level of preliminary indicators has been done through experts who have design experiences of external spaces of housing complexes. Based on the survey results, applying priorities of assessment indicators were suggested. These assessment indicators can be used as a basement of developing assessment method of external spaces for ecological housing complexes, and it also can be used for developing assessment model and planning standards for the development of ecological housing complexes.

지속가능한 도시재생의 추진전략수립 연구

이규인(Lee Kyu-In),이장욱(Rhee Jang-Ook) 대한건축학회 2010 대한건축학회논문집 Vol.26 No.3

The aim of this study is to develope the promote strategy of sustainable urban regeneration. For the purpose of this study, the previous paper specified 12 key issues of sustainable urban regeneration through reviewing principals and topics from mainly British experiences and domestic research materials, established 38 planning objectives of sustainable urban regeneration through literature reviews and research group debates and set the step-by-step model for sustainable urban regeneration through surveying professionals. On the basis of the previous study, this paper analyzes the attitude about mainly the planning goals of sustainable urban regeneration between professionals's and residents' after further surveying residents. Finally, it defines 4 main categories which contains each group of planning goals that needs different promote strategies of sustainable regeneration. It also gives some advice according to the categories of promote strategy group. The results of this study are expected to serve some clues for dealing with the practice of sustainable urban redevelopment.

친환경 건축물 인증 공동주택의 거주자 만족도 조사를 통한 평가기준 개선방향 연구

이규인(Lee Kyu-In),염동우(Yeom Dong-Woo) 대한건축학회 2009 대한건축학회논문집 Vol.25 No.12

As international considerations about the Environmental Assessment on Green Buildings increase, KGBCC(Korean Green Building Certification Criteria) was developed in 2000 and has operated since 2002 in Korea. The objective of this study is to research residents' awareness about KGBCC, residents' satisfaction level, and the cause of dissatisfaction about KGBCC assessment standards which based on residents of the KGBCC certified apartments. For the research, the questionnaire about awareness of KGBCC, satisfaction level, and the cause of dissatisfaction were surveyed through residents of the KGBCC certified apartment in Samsan District, Inchon. The survey results were analyzed and compared with the assessment score, and improvement ways of KGBCC were suggested.

OFDM 셀룰러 시스템에서 부반송파 기반의 가상 다중안테나 기법

이규인,고현수,우경수,고요한,김영준,안재영,조용수,Lee, Kyu-In,Ko, Hyun-Soo,Woo, Kyung-Soo,Ko, Yo-Han,Kim, Yeong-Jun,Ahn, Jae-Young,Cho, Yong-Soo 한국통신학회 2006 韓國通信學會論文誌 Vol.31 No.10C

본 논문에서는 OFDM 기반의 셀룰러 시스템에서 실제 다중 수신안테나를 사용하지 않고 부반송파를 가상의 다중 수신안테나로 간주하여 MIMO 기법을 적용할 수 있는 부반송파 기반 가상 수신안테나 기법을 기술한다. 부반송파 기반 가상 안테나 기법은 단일 수신안테나에서도 셀간 간섭 제거 또는 SDMA를 수행할 수 있는 기법으로 송수신단에서 다중 안테나를 사용하는 경우에도 쉽게 확장가능하다. 부반송파 기반 가상 안테나 기법은 스마트 안테나 기법을 적용한 가상 스마트 안테나 기법과 MIMO 기법을 적용한 가상 다중 안테나 기법으로 분류된다. 특히 수신단이 주파수 재 사용률이 1인 셀 경계지역에 있을 때 인접 셀의 간섭을 효과적으로 제거할 수 있는 기법으로 간섭의 정도에 따라 유동적으로 자원할당이 가능한 방법이다. 모의실험을 통해 동일한 데이터 전송률에서 기존 셀간 간섭 제거 기법보다 부반송파 기반 가상 안테나 기법이 우수함을 보인다. In this paper, we introduce the concept of a subcarrier-based virtual multiple antennas (SV-MIMO) for OFDM cellular systems, where the multiple antenna techniques are performed on a set of subcarriers, not on the actual multiple antennas. The virtual multiple antenna system can support multiple users simultaneously as well as reduce inter-cell interference (ICI) form adjacent cells with a single antenna. Also, this technique is easily extended to multiple antenna environments. The virtual multiple antenna techniques can be divided into a virtual smart antenna technique and a virtual MIMO technique. Especially, this method effectively reduces ICI at cell boundary with frequency reuse factor equal to 1, and can support flexible resource allocation depending on the amount of interference. It is shown by simulation that the proposed method is superior to conventional method under the same condition of data transmission.

도시재생사업 환경평가를 위한 과제도출 및 주민의식조사

이규인(Lee Kyu-In),이장욱(Rhee Jang-Ook),이은희(Lee Eun-Hee) 대한건축학회 2011 대한건축학회논문집 Vol.27 No.1

The final goal of this serial study is to develope the environmental assessment for urban regeneration projects. Getting to this goal, this paper sets the aim that is to draw the tasks of environmental assessment as the first step. This paper also carries out a residents survey with these tasks drawn from lots of related schemes, studies, exemplary cases and on-site researches. Through this process, it established 3 visions, 7 goals and 33 tasks of environmental assessment for urban regeneration projects. Futhermore, it selected 10 key tasks through analysing the result of residents survey. With these visions, goals, tasks and also 10 key tasks, it is expected to develop the environmental assessment index and standard step-by-step for korean urban regeneration.

실험체를 통한 황토벽체의 실내 환경성능 평가

이규인(Lee, Kyu-In),윤성일(Yin, Cheng-Ri) 대한건축학회 2012 대한건축학회 학술발표대회 논문집 Vol.32 No.2

[특집/지속가능한 도시건축의 이념과 실천] 지속가능한 정주지의 계획 및 실천

이규인(Lee Kyu-in) 대한건축학회 2003 建築 Vol.47 No.12

OFDM 시스템에서 Compact CORDIC을 이용한 주파수 오프셋 동기화 구현 기법

이규인,유성욱,김종한,이재곤,조용수,Lee Kyu-In,Yu Sung-Wook,Kim Jong-Han,Lee Jae-Kon,Cho Yong-Soo 한국통신학회 2006 韓國通信學會論文誌 Vol.31 No.7C

본 논문에서는 OFDM(Orthogonal Frequency Division Multiplexing) 시스템의 반송파 주파수 동기화부 구현을 위하여 Compact CORDIC 처리기를 제안한다. Compact CORDIC 처리기는 반송파 주파수 옵셋 추정 및 보상시에 요구되는 OFDM 시스템의 독특한 특성을 이용하여 제안되었으며, Compact CORDIC 전처리부와 Compact CORDIC 처리부로 구성된다. Compact CORDIC 전처리부에서는 신호의 정규화를 효율적으로 수행하며, Compact CORDIC 처리부에서는 Vector 모드 CORDIC 과 Rotation 모드 CORDIC 연산을 효율적으로 결합하여 동시에 처리하여 반송파 주파수 동기화를 수행한다. FPGA 구현을 통하여 제안된 Compact CORDIC 처리기가 기존 CORDIC 방법보다 성능이 우수하며 구현 복잡도가 크게 감소함을 확인한다. In this letter, we propose a compact CORDIC processor for implementation of carrier frequency synchronization block in an OFDM (Orthogonal Frequency Division Multiplexing) system. The compact CORDIC processor is proposed by using inherenct properties of an OFDM system for estimation and compensation of carrier frequency offset, and is composed of a compact CORDIC preprocessor and a compact CORDIC processor. The compact CORDIC preprocessor plays a role of normalizing input signal efficiently, and the compact CORDIC processor is proposed to perform the vectoring mode and rotational mode jointly in CORDIC operation for carrier frequency synchronization. It is shown by FPGA implementation that the proposed compact CORDIC processor can achieve better performance with a significantly reduced hardware complexity than the conventional CORDIC approach.