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- 저자 : 은미정 ( Mi Jung Eun ) (검색결과 5 건)
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김진호,문준성,문선중,이지은,최재원,은미정,천경아,조인호,윤지성,원규장,이경희 신덕섭,이형우 영남대학교 의과대학 2005 Yeungnam University Journal of Medicine Vol.22 No.2
Central diabetes insipidus (DI) is a syndrome characterized by thirst, polydipsia and polyuria. Langerhans cell histiocytosis is one of the etiologies of DI. Recently we experienced a central DI associated with Langerhans cell histiocytosis. The 44 years old female patient complained right hip pain polydipsia and polyuria. We carried out water deprivation test. After vasopressin injection, urine osmotic pressure was increased form 109mOsmol/Kg to 327mOsmol/Kg (300%). Brain MRI showed a thickened pituitary stalk and at hot bone CT.CT guided biopsy revealed abnormal histiocytes proliferation and abundant lymphocytes, The final diagnosis was central DI associated with systemic Langerhans cell histiocytosis invading hip bone, L-spine and pituitary stalk. Desmopressin and etoposide chemotherapy were performed to the patient.
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제2형 당뇨병 환자에서 ^99mTc-DTPA aerosol scintigraphy를 이용한 폐포 상피세포 투과성의 평가
윤지성,은미정,이시형,김재홍,홍영훈,원규장,조인호,이형우 대한내분비학회 2002 Endocrinology and metabolism Vol.17 No.2
Background: Diabetes mellitus is often accompanied by complicated microangiopathy, such as, retinopathy, nephropathy, peripheral neuropathy, cardiovascular autonomic neuropathy or macroangiopathy, as well as by coronary artery disease and cerebrovascular disease. However, there have been few reports concerning the pulmonary involvement of diabetes. Recently, capillary basement membrane thickening, nonenzymatic glycosylation of tissue proteins, abnormalities of endothelial cells and increased damage by free radicals were reported as the underlying basis for the reduced lung permeability. ^99mTc-DTPA aerosol scintigraphy is a noninvasive, accurate method, which evaluates the permeability of lung epithelial membranes. The clearance rate of ^99mTc-DTPA in lungs may correlate inversely with the lung's epithelial permeability. We investigated the relationship between microangiopathies and the lung epithelial permeability in patients with diabetes using ^99mTc-DTPA aerosol scintigraphy. Method: The study group comprised of 33 patients with type 2 diabetes mellitus, with no clinical evidence of past or present respiratory disease. The patients were divided into two groups in relation to the complications. Group 1: 16 patients with more than one of the complications of retinopathy, nephropathy, cardiovascular autonomic neuropathy and/or peripheral neuropathy, and comprised of 3 males and 13 females, with a mean age of 52.9±9.6 years. Group 2: 17 patients with no complications, and comprised of 5 males and 12 females with a mean age of 52.8 ± 11.5 years. Group 3: as a control group, comprised of 11 healthy people: 4 males 4 and 7 females with a mean age of 44.2 ± 12.5 years. ^99mTc-DTPA aerosol scintigraphy was performed in the subjects by inhalation of 30 mCi ^99mTc-DTPA aerosol and oxygen (9 l/min) using an aero-vent jet nebulizer as the lung delivery system. To evaluate the diabetic complications, CAN (Cardiovascular Autonomic Neuropathy), and NCV (Nerve Conduction Velocity) tests for peripheral neuropathy, fundoscopy for retinopathy and 24 hours urine microalbumin for nephropathy were performed. Results: The mean durations of diabetes in Groups 1 and 2 were 11.1 ± 4.7 years and 3.8 ± 2.1 years, respectively (p<0.05). The mean clearance rates of ^99mTc-DTPA were found to be 72.1 ± 19.5 min, 52.6 ± 19.7 min, and 47.1 ± 10.9 min for Groups 1, 2, and 3, respectively. The mean clearance rate of Group 1 was significantly longer than for Groups 2 and 3 (p<0.05). In other words, the pulmonary epithelial permeability was reduced in diabetic patients with complications compared to the patients without complication and/or the normal controls. Significant positive correlation was found between the pulmonary clearance rate of ^99mTc-DTPA, and peripheral neuropathy and cardiovascular autonomic neuropathy (p<0.05). Conclusions: The lungs may be a target organ for diabetes, and impaired pulmonary epithelial permeability seems to be closely related to other diabetic microangiopathies. Therefore, we recommend that ^99mTc-DTPA aerosol scintigraphy be used as a technique for assessing lung injury in diabetic patients
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원석용,고민환,이태형,은미정,김정숙,김옥경 영남대학교 기초/임상의학연구소 2001 Yeungnam University Journal of Medicine Vol.18 No.2
To determine mean clitoral and glans size of Korean female newborn Materials and Methods: The size of glans and clitoris of 68 Korean female newborns born at Yeungnam University Medical Center were measured from May in 1999 to August in 1999. Results: The mean size of the 68 newborns were 2.38±1.14 mm in glans length, 2.55±1.48 mm in glans width and 4.66±1.93 mm in clitoral length. In the premature infants the mean clitoral size was 1.92±1.58 mm in glans length, 1.78±1.24 mm in glans width and 3.86±2.16 mm in clitoral length. In the full term infants 2.53±1.12 mm in glans length, 2.75±1.58 mm in glans width and 4.94±1.89 mm in clitoral length, In low birth weight infants clitoral size was measured 1.55±1.10 mm in glans length, 2.04±2.03 mm in glans width and 3.29±1.87 mm in clitoral length. In normal birth weight infants 2.53±1.13 mm in glans length, 2.68±1.48 mm in glans width and 4.92±1.91 mm in clitoral length. In high birth weight infants 1.54±0.50 mm in glans length, 1.63±0.53 mm in glans width and 3.18±1.04 mm in clitoral length. Conclusion: There was no significant correlation between gestational age and clitoral size or glans size, but significant negative correlation was found between birth weight and clitoral size or glans size.
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김재홍,이형우,이시형,조인호,윤지성,오정현,남상엽,윤현대,원규장,은미정 대한당뇨병학회 2001 Diabetes and Metabolism Journal Vol.25 No.4
Background: IL-1β has been implicated to play an important role in the autoimmune β cell lesion of type 1 diabetes because of its inhibition of insulin secretion and direct islet cytotoxicity. Thus, this study evaluated the effect of aminoguanidine on No production, insulin release and hsp 70 expression in cultured rat islets exposed to IL-1β. Method: Islets isolated from Sprague-Dawley rats were cultured with IL-1β, aminoguanidine AG and GSNO, individually and in combination for 24hours. Accumulated nitrite production, insulin release and islet expression of hsp 70 were measured. Results: IL-1β increased nitrite production, inhibited insulin release, and increased hsp 70 expression. AG alone had no effect on nitrite production, insulin release and hsp 70 expression. In combination, AG completely blocked IL-1β but increased nitrite production, reversed IL-1β inhibited insulin release and reversed IL-1β increased hsp 70 expression. Moreover, nitric oxide NO donor, GSNO stimulated hsp 70 expression. Conclusion: Findings from this study suggest that hsp 70 may be one potential protein that is expressed in response to NO and that participates in islet recovery from NO mediated islet damage.
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