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윤제문,장미애,기창석,김상진 대한진단검사의학회 2016 Annals of Laboratory Medicine Vol.36 No.2
Stickler syndrome is a genetically heterogeneous disorder that affects the ocular, auditory, and musculoskeletal systems. Ocular-only variant of Stickler syndrome type 1 (OSTL1) is characterized by high risk of retinal detachment without systemic involvement and is caused by alternatively spliced exon 2 mutation of COL2A1. We report the cases of two Korean families with OSTL1 carrying likely pathogenic variants of COL2A1. All patients presented with membranous vitreous anomaly, peripheral retinal degeneration, and/or rhegmatogenous retinal detachment, but no systemic manifestations. By genetic analysis, two likely pathogenic non-exon 2 variants, c.2678dupC (p.Ala895Serfs*49) and c.3327+ 1G>C, were identified in COL2A1. Our results demonstrate that COL2A1 defects in OSTL1 are not confined to mutations in exon 2. Together with molecular data, ophthalmologists should consider genetic diagnosis of Stickler syndrome in patients with vitreous anomaly to prevent blindness from retinal detachment. To our knowledge, this is the first report of genetically confirmed OSTL1 in Korea.
다공구조 내에 고분자 충진된 유연한 투명나무 복합제 패널 제조 연구
윤제문,김영훈,정찬영 한국고분자학회 2023 폴리머 Vol.47 No.2
본 연구는 쉽게 깨지지 않고, 유연한 투명한 나무 패널 제조에 관한 것이다. 가시광 영역의 빛을 흡수하는lignin을 제거(delignification)하고 그 공간에 투명성을 제공하는 polyvinyl alcohol(PVA)과 유연성을 제공하는 저분자화합물을 혼합한 물질로 채워 유연하고 투명한 나무패널을 제조하였다. Delignification 공정, 혼합고분자 함침, 나무패널의 내부구조, 광투과율, 그리고 유연성 등을 조사하였다. 분석결과로부터 PVA 물질만 함침된 투명나무는550 nm wavelength에서 65.8%로 높은 광투과율을 보인 반면에, 저분자 화합물이 혼합된 투명나무는 그 양이 많을수록 광투과율은 10%대로 낮아졌지만, 유연성은 크게 향상되었다. 이러한 결과를 바탕으로 높은 유연성과 투명성을지닌 목재가 향후 취약한 유리재료를 대체할 유용한 재료가 될 것으로 판단된다.
수정체초음파유화술 후에 생긴 인공수정체 탈구의 선행 요인의 빈도와 치료 결과
윤제문(Je Moon Yoon),현주(Joo Hyun),임동희(Dong Hui Lim),정의상(Eui Sang Chung),정태영(Tae Young Chung) 대한안과학회 2016 대한안과학회지 Vol.57 No.1
Purpose: To report the predisposing factors and surgical outcomes of intraocular lens dislocation (IOL) after phacoemulsification. Methods: We performed a retrospective study of 131 eyes in 120 patients who were diagnosed with IOL dislocation after phacoemulsification between January 2008 and December 2013. The main outcomes are possible predisposing factors, characteristics of IOL dislocation, and outcomes of rectification surgery, including visual acuity (VA), and refractive status before and at 3 months after surgery. Results: The main conditions associated with IOL dislocation were as follows: status after vitrectomy (27.5%), long axial length(9.2%), neodymium-doped yttrium aluminium garnet (Nd:YAG) posterior capsulotomy (8.4%), uveitis (6.1%), trauma (5.3%), mature cataract (3.8%), and pseudoexfoliation (2.3%). Mean uncorrected VA improved significantly after rectification surgery (p= 0.00), and best-corrected VA also improved significantly (p = 0.01). Mean value of spherical equivalent tended to decrease, although the decrease was not significant (p = 0.07). Whereas astigmatism showed a significant increase (p = 0.01). 6 eyes (4.6%)were associated with recurrence of IOL dislocation. Conclusions: Possible major predisposing factors for IOL dislocation are status after vitrectomy, long axial length, Nd:YAG posterior capsulotomy, uveitis, and trauma. The surgical outcome and improvement of postoperative visual acuity were satisfactory.