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윤영안,장미애,이지성,민원기,권계철,이용화,이유경 대한진단검사의학회 2018 Annals of Laboratory Medicine Vol.38 No.1
Dear Editor, Thorough quality management is paramount because diagnostic tests play an important role in medical decisions and can involve a complex, multistep process, from sampling to reporting the test results. In general, the reliability of a diagnostic test is based on two factors: diagnostic product standardization and practice standardization. While diagnostic product standardization is established on a legal basis with administrative assistance, practice standardization is less well established and can, to a large extent, depend on the private sector. In Korea, this private sector involvement is mediated through the Korean Laboratory Accreditation Program (KLAP)
Subcutaneous Phaeohyphomycosis Caused by Exophiala salmonis
윤영안,박경선,이장호,성기선,기창석,이남용 대한진단검사의학회 2012 Annals of Laboratory Medicine Vol.32 No.6
We report a case of subcutaneous infection in a 55-yr-old Korean diabetic patient who presented with a cystic mass of the ankle. Black fungal colonies were observed after culturing on blood and Sabouraud dextrose agar. On microscopic observation, septated ellipsoidal or cylindrical conidia accumulating on an annellide were visualized after staining with lactophenol cotton blue. The organism was identified as Exophiala salmonis by sequencing of the ribosomal DNA internal transcribed spacer region. Phaeohyphomycosis is a heterogeneous group of mycotic infections caused by dematiaceous fungi and is commonly associated with immunocompromised patients. The most common clinical manifestations of subcutaneous lesions are abscesses or cystic masses. To the best of our knowledge, this is the first reported case in Korea of subcutaneous phaeohyphomycosis caused by E. salmonis that was confirmed by molecular analysis and identification of morphological characteristics. This case suggests that E. salmonis infections are no longer restricted to fish.
False Elevation of the Concentration of Thyroid- Stimulating Hormone: A Case Report
윤영안,Hwal-Rim Jeong,Young-Jin Choi 대한임상검사정도관리협회 2022 Journal of Laboratory Medicine And Quality Assuran Vol.44 No.3
Analytical errors owing to endogenous interfering substances may occur for some patient specimens. Interference can lead to false-positive or falsenegative results, or both, which may lead to a false diagnosis or inappropriate treatment. We report a case of false elevation of thyroid-stimulating hormone concentrations measured using an electrochemiluminescent immunoassay in a clinically euthyroid 10-year-old Korean boy with central precocious puberty. If the clinical presentations and test results of a patient are inconsistent, a clinician should suspect interference in clinical laboratory tests.
Effect of Accreditation on Accuracy of Diagnostic Tests in Medical Laboratories
장미애,윤영안,송정한,김정호,민원기,이지성,이용화,이유경 대한진단검사의학회 2017 Annals of Laboratory Medicine Vol.37 No.3
Background: Medical laboratories play a central role in health care. Many laboratories are taking a more focused and stringent approach to quality system management. In Korea, laboratory standardization efforts undertaken by the Korean Laboratory Accreditation Program (KLAP) and the Korean External Quality Assessment Scheme (KEQAS) may have facilitated an improvement in laboratory performance, but there are no fundamental studies demonstrating that laboratory standardization is effective. We analyzed the results of the KEQAS to identify significant differences between laboratories with or without KLAP and to determine the impact of laboratory standardization on the accuracy of diagnostic tests. Methods: We analyzed KEQAS participant data on clinical chemistry tests such as albumin, ALT, AST, and glucose from 2010 to 2013. As a statistical parameter to assess performance bias between laboratories, we compared 4-yr variance index score (VIS) between the two groups with or without KLAP. Results: Compared with the group without KLAP, the group with KLAP exhibited significantly lower geometric means of 4-yr VIS for all clinical chemistry tests (P<0.0001); this difference justified a high level of confidence in standardized services provided by accredited laboratories. Confidence intervals for the mean of each test in the two groups (accredited and non-accredited) did not overlap, suggesting that the means of the groups are significantly different. Conclusions: These results confirmed that practice standardization is strongly associated with the accuracy of test results. Our study emphasizes the necessity of establishing a system for standardization of diagnostic testing.
혈중납이 흰쥐의 Microsomal Cytochrome P-450 Monooxygenase 활성도에 미치는 영향
박기현,장성근,윤영안,김기웅,박종안 순천향대학교 1993 논문집 Vol.16 No.3
In rats treated with lead nitrate and/or red ginseng extract mixture we observed a change in the level of hepatic cytochrome P-450 and electron transport system for P-450 dependent reaction, and content of Zincprotoporphyrin(ZPP) and Hemoglobin(Hb) in whole blood. The content of cytochrome P-450 and ?? , and the activity of ECHEase, AHHase and NADPH-cytochrome C(p-450) reductase were slowly decreased according to the dosage of lead nitrate. On the other hand, the activity of ?? reductase was increased according to the dosage of lead nitrate, but in case of treatment with red ginseng mixture, this enzyme activity was slightly decreased. In whole blood, the content of hemoglobin and ZPP were not shown any critival change but lead content increased according to dosage of lead nitrate. These results suggest that content and activity of cytochrome P-450-dependent monoxygenase may be dependent on specificity of substrates, and the acute exposure of lead nitrate and red ginseng extract mixture was not affected any biological significance.