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In Situ Hybridization 으로 확진된 Herpes 식도염 1예
윤성균,한인수,이상호,박영훈,백선흠,남상민,박현철,황일순,추현광,김주현,박성혜,박흠례 대한내과학회 1993 대한내과학회지 Vol.44 No.1
저자등은 만성 alcoholism 환자에서 만성 췌장염 및 췌장 가낭종에 의한 심와부와 좌상복부통으로 내원하여 우연하게 실시된 식도 내시경 및 조직 생검으로 의진되어 In situ hybridization에 의하여 확진하게된 Herpes virus에 의한 식도염 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Herpes simplex esophagitis is a rare disease. Mostly, it occurs in hospitalized, immunosuppressed, and preterminal patients with or without malignancy. It is confirmed by In situ hybridization, immunohistochemistry, or direct visualization of virus by electronmicroscopy. Among them the former is an useful technique for rapid detect viral nucleic acids in the tissue sections. We report a esophageal ulceration with pancreatic pseudocyst. Herpetic esophagitis was suggested by characteristic endoscopic and light microscopic findings, and it was confirmed by In situ hypridizaion in the tissue section. With symptomatic treatment, this patient was recovered from esophageal ulceration.
Toulene diisocyanata ( TDI ) 를 사용하는 가구 공장 근처 주민에게 발생된 외부환경의 TDI에 의한 기관지 천식 1례
최재웅,윤성균,정보인,정진이,김연선,강문호 대한천식알레르기학회 1991 천식 및 알레르기 Vol.11 No.5
TDI-induced bronchial asthma is one of the well known occupational asthma. There are few reports about its hazard to the people living in the icinity of isocyanate workplace, and TDI asthma not related to occupation has not been reported in our country. We report a case of TDI asthma in an inhabitant near to a furniture factory where polyurethane was sprayed on the furniture with spray guns. The outlet of ventilator of TDI workplace was set toward the patients house so he is thought to have been exposed to TDI much more than other people living around the factory. Total IgE(PRIST) was 365. 81 IU/ml, skin prick test with 55 common inhalant allergens was all negative and methacholine inhalation test was positive (PC20: llmg/ml). TDI challenge test in the vicinity of the workplace showed maximal 64% fall of FEV1 at 40 minutes of exposure. Further asthmatic attack was prevented by avoidance of exposure to TDI. This case suggests that TDI asthma may occur also in nonworkers who live near to isocyanate workplace.