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윤나영,이상훈,심길보,이문희,조현아,Chengliang Xie 한국수산과학회 2013 Fisheries and Aquatic Sciences Vol.16 No.1
To assess the feasibility of phlorotannins from Eisenia bicyclis as cancer chemopreventative agents, we tested whether they induced quinone reductase (QR) in Hepa1c1c7 cells. The ethyl acetate (EtOAc) soluble fraction obtained from E. bicyclis exhibited a QR induction activity in Hepa1c1c7 cells. Successive column chromatography of the active EtOAc fraction resulted in the isolation of four phlorotannins. Their structures were elucidated using one- and two-dimensional nuclear magnetic resonance spectroscopic techniques and characterized as phloroglucinol (1), dioxinodehydroeckol (2), dieckol (3), and fucofuroeckol-A (4). Among these compounds, fucofuroeckol-A (4) showed moderate QR induction activity, and dioxinodehydroeckol (2) exhibited potent QR induction potency with 2.05 ± 0.04 fold induction at a concentration of 50 μM compared to the dimethyl sulfoxide solvent-treated control cells. However, phloroglucinol (1) and dieckol (3) exerted no detectable QR induction activity in Hepa1c1c7 cells. These results suggest that dioxinodehydroeckol could serve as a useful cancer chemopreventive chemical.
한국·일본·독일의 공적 장기요양보험제도 재정부담 완화 과정 비교
윤나영,이동현 한국보건행정학회 2022 보건행정학회지 Vol.32 No.3
The rapidly aging trend of Korea is a major factor that threatens the sustainability of the long-term care insurance system. Therefore,looking at how Japan and Germany mitigated the financial burden when they managed similar long-term care insurance systems willprovide important implications for improving the Korean system in the future. The study was conducted using the literature reviewmethod, and the “country” was set as a unit for the case analysis. The three countries selected are Korea, Japan, and Germany. Recently in Korea, the insurance premium rates of all subjects have been rapidly rising, which can exacerbate the issue ofintergenerational equity. On the other hand, Japan has responded to the aggravating finances for long-term care insurance due toaging by raising coinsurance for selected groups like the wealthy elderly. Germany is selectively raising the insurance premium ratesby additionally increasing the premium rate for childless recipients. A more preventive and quality-oriented care service plan can bepromoted by referring to the recent changes in Japan and Germany. In addition, a more effective and selective increase in paymentburden in Japan and Germany could be considered in response to a recent equity issue in Korea.
생굴(Crassostrea gigas)의 선도 변화에 포장용기가 미치는 영향
윤나영,안병규,인정진,한형구,이우진,서정화,정삼근,심길보 한국수산과학회 2022 한국수산과학회지 Vol.55 No.1
The shelf life of oysters Crassostrea gigas, in two different types of packaging containers, polyethylene (PE) and polyethylene terephthalate (PET), was determined by evaluating the pH, glycogen and soluble protein content, turbidity, and viable cell count. After 7 days of storage, the pH of the packing water in the PE container decreased to 5.88, while the pH in the PET container decreased to 6.03. In the PE container, the glycogen content of the oysters decreased by 0.85 g/100 g and the soluble protein content and turbidity of the packing seawater increased by 1,927.21 mg/100 g and 3.24 McF, respectively. In the PET container, the glycogen content of the oysters decreased by 0.96 g/100 g and the soluble protein content and turbidity of the packing seawater increased by 1,674.75 mg/100 g and 0.98 McF, respectively. The reaction rate constants (K) were as follows: glycogen content, -0.18 (PE) and -0.10 (PET); soluble protein content, 0.29 (PE) and 0.26 (PET); and turbidity, 0.41 (PE) and 0.06 (PET). These results suggested that PET can be used as a new packaging container material for raw oysters because the quality is maintained and it offers more convenient handling during distribution.
윤나영,김형락,정해영,최재수 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.12
We conducted this study to isolate novel anti-hyperlipidemic agents derived from natural marine products. To accomplish this, we investigated the effects of ethanolic (EtOH) extracts of Ecklonia stolonifera and its phlorotannin constituents, eckol and dieckol, on serum lipid levels in rats with hyperlipidemia that was induced by a high-cholesterol diet or poloxamer 407. Treatment with the EtOH extracts of E. stolonifera and its phlorotannin-rich ethyl acetate (EtOAc) and n-butanol (n-BuOH) fractions induced a significant reduction in triglycerides (TG), total cholesterol (TC), and low-density lipoprotein-cholesterol (LDL-C) levels, as well as a significant increase in the high-density lipoprotein-cholesterol (HDLC) level in hyperlipidemic rats. However, treatment with the water (H2O) fraction did not exert any significant effects on the serum levels of hyperlipidemic rats. In addition, eckol and dieckol isolated from the active EtOAc fraction induced a significant reduction in serum TG, TC, and LDL-C levels, as well as in the atherogenic index (A.I.). Furthermore, treatment with dieckol induced a greater decrease in the serum TG, TC, and LDL-C levels of hyperlipidemic rats than eckol or lovastatin, as well as an increase in the serum HDL-C levels. Taken together, these results suggest that phlorotannins such as eckol and dieckol have the potential for use for the prevention of hyperlipidemic atherosclerosis.
윤나영,심길보,임치원,김상보 한국수산과학회 2013 Fisheries and Aquatic Sciences Vol.16 No.4
We investigated the antioxidant and angiotensin I converting enzyme (ACE) inhibitory activities of red snow crab Chionoecetes japonicas shell (RSCS) hydrolysate by enzymatic hydrolysis and its molecular weight cut-off fractions. The RSCS hydrolysatewas fractionated through two ultrafiltration membranes of 3 and 10 kDa cut-offs. Three fractions (<3 kDa, 3-10 kDa, and >10 kDa) were evaluated for total amino acid composition, antioxidant activities using 2′-azino-bis[3-ethylbenzthiazoline-6-sulfonic acid](ABTS+) radical scavenging and superoxide dismutase (SOD)-like activities and reducing power assays, and ACE inhibitory activity using Hou’s method. Although all fractions showed activity, the <3 kDa fraction of RSCS hydrolysate exhibited the greatestABTS+ radical scavenging, SOD-like and ACE inhibitory activities. However, these fractions exhibited low reducing power. These results suggest that the low-molecular-weight enzymatic hydrolysate of RSCS could be used as a functional ingredient to control oxidative stress and ACE activity.
Gemcitabine 이 봉입되고 CR2945가 결합된 표적지향적 리포좀 제제의 마우스 장기독성
윤나영,김진석 숙명여자대학교 약학연구소 2004 약학논문집-숙명여자대학교 Vol.21 No.-
Gemcitabine 이 봉입되고 CR2945가 결합된 리포좀이 성공적으로 제조 되었으며 이를 PANC-1 췌장암이 이식된 실험용 쥐의 꼬리 정맥에 주사한 후 생길 수 있는 주요 장기에 대한 독성을 평가하였다. 제조된 리포좀 제형의 크기(지름), 표면 하전, 약물봉입효율은 각각 500mm, -16.5mV, 그리고 84%였다. 주요 장기(신장, 간, 폐, 비장)의 헤마톡실린/에오신 염색 결과 본 리포좀 제형은 이러한 장기로의 암 전이를 막아줌을 알 수 있었는데, 이러한 효과는 다른 비교 제형 들로부터는 나타나지 않았다. 이러한 실험결과는 향후 안전하고 효과적인 리포좀 제형의 개발에 도움이 될 것으로 기대된다.