Is the ovarian preservation safe in young women with stages IB–IIA villoglandular adenocarcinoma of the uterine cervix?

유철주,Woo Dae Kang,김석모 대한부인종양학회 2018 Journal of Gynecologic Oncology Vol.29 No.4

OBJECTIVE: Because villoglandular adenocarcinoma (VGA) of the uterine cervix has favorable features and outcomes, patients receive less radical surgery and young women preserve their ovaries. We aimed to evaluate the clinicopathological features and outcomes of VGA and to see if the ovarian preservation is safe in young women with VGA. METHODS: We retrospectively reviewed medical records and identified patients with VGA, who had been treated and followed from January 2004 to December 2015. RESULTS: This study consisted of 17 patients with VGA, including 9 premenopausal women. International Federation of Gynecology and Obstetrics (FIGO) stage IB1 disease was found in 12 patients (70.6%), IA1 in 2, IA2 in 1, IB2 in 1, and IIA1 in 1. Of the 12 women diagnosed with stage IB1 disease, a young woman received only conization and she has not showed a recurrence. During a median follow-up of 58 months (range: 12-116), 4 patients, who had undergone radical surgery for stage IB1 disease, had a recurrence and one of them died due to disease progression. Among patients with stages IB-IIA disease, 2 premenopausal women did not receive simultaneous oophorectomy or chemoradiation therapy. Both of them had a recurrent tumor at adnexa. CONCLUSION: This study revealed favorable features and outcomes of VGA. However, the appropriate treatment for young women with early-stage VGA must be cautiously selected. Ovarian preservation might not be safe when young women with stages IB-IIA VGA undergo surgical procedures.

아동 호스피스 과정에서의 의료적 측면

유철주,Lyu, Chuhl-Joo 한국호스피스완화의료학회 2000 한국호스피스.완화의료학회지 Vol.3 No.1

혈액응고 기전에 대한 고찰

유철주 대한신생아학회 2011 Neonatal medicine Vol.18 No.1

Coagulation involves the regulated sequence of proteolytic activation of a series of proteins to achieve appropriate and timely hemostasis in an injured vessel. In the non-pathological state, the inciting event involves exposure of circulating factor VIIa to extravascularly expressed tissue factor, which brings into motion the series of steps which results in cell based model of coagulation. In the new concepts of coagulation system, initiation, amplification and propagation steps are involved to converse of fibrinogen to fibrin. The precisely synchronized cascade of events is counter-balanced by a system of anticoagulant mechanisms. Developmental hemostasis refers to the age-related changes in the coagulation system that are most marked during neonate and childhood. An understanding of these changes in crucial to the accurate diagnosis of hemostatic abnormalities in neonate and children. This review aims to elucidate the main events within the coagulation cascade as it is currently understood to operate in vivo, and also a short review of the anticoagulants as they relate to this model. Also this paper describes the common pitfalls observed in the clinical data related to the coagulation system in neonate to children.

Clinical Role of Bone Marrow Angiogenesis in Childhood Acute Lymphocytic Leukemia

유철주,라선영,원성철 연세대학교의과대학 2007 Yonsei medical journal Vol.48 No.2

Purpose: Vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) are associated with increased angiogenesis, growth, and metastasis in solid tumors. But, until today, the importance of theses factors on leukemia, especially childhood acute lymphocytic leukemia (ALL) has received limited attention. Therefore, this study examined the bone marrow plasma VEGF and bFGF levels in ALL patients and normal controls. Patients and Methods: Bone marrow plasmas at diagnosis from 33 ALL patients (median age 5.9 years; range 1.8-13.9 years) were used for analysis. The bone marrow levels of bFGF and VEGF were determined by enzyme-linked immunosorbent assay (R & D Systems) and compared with the bone marrow levels of 7 healthy control subjects (median age 11.98 years; 6 months -13.6 years). Results: Average VEGF was higher in relapse ALL (N=7, 216.6±79.9pg/mL) compared to standard (N=9, 36.8±12.1pg/mL) (p=0.013) or high risk ALL (N=17, 80.0±12.2pg/mL) (p=0.023). bFGF levels were also significantly higher in relapse than standard-, or high-risk ALL patients (relapse ALL; 48.6±15.4pg/mL, standard risk ALL; 18.9±5.5pg/mL, high risk ALL; 19.0±3.5pg/mL, normal control; 18.6±4.0pg/mL) (p=0.003). Three patients with refractory relapse and death had much higher VEGF and bFGF values (VEGF; 420.0±81.6pg/ mL, bFGF; 85.6±3.2pg/mL). Conclusion: Our data suggest that the increased levels of VEGF and bFGF in bone marrow may play an important role in prognosis of childhood ALL.

Supravalvular Aortic Stenosis (Williams Syndrome) 1례

유철주,차태수,김동수,설준희,고창준,이승규,진동식,최규옥,홍승록 대한순환기학회 1985 Korean Circulation Journal Vol.15 No.2

모래의 정적액상화에 영향을 미치는 요소

유철주,이광범,정진섭 대한토목학회 2000 대한토목학회 학술발표회 논문집 Vol.2000 No.2

실시간 안면인식 출입 시스템을 위한 Cloud Caching 기반의 연구

유철주,홍인식 한국지식정보기술학회 2023 한국지식정보기술학회 논문지 Vol.18 No.6

In recent years, facial recognition technology has garnered significant attention across various fields, playing crucial roles in personal identification, security systems, and access control. Particularly, facial recognition technology is widely used for smartphone unlocking and small-group access systems, owing to its stability and touchless convenience. However, deploying this technology in large-scale environments like public transportation presents complex challenges in real-time data processing for numerous simultaneous users. Addressing these challenges, this study proposes an innovative real-time cloud caching approach integrated with a facial recognition access system designed for new embedded boards. The method involves pre-copying user data from the cloud server to a local cache server upon detecting the user's MAC address, effectively reducing data access times. This approach significantly enhances the performance of real-time facial recognition systems, especially in scenarios with high data volume and concurrent users. Implementation and validation of this approach in a university lecture room setting, utilizing Raspberry Pi 3 Model B+, wireless AP, camera module, 'Dlib' library, and a 32GB SD card, demonstrate its efficacy in overcoming challenges related to data capacity and real-time processing, resulting in considerable time savings. These findings represent a noteworthy advancement in the field of large-scale facial recognition technology.

소아암-진단에서 치료

유철주 ( Chuhl Joo Lyu ) 대한임상미술치료학회 2007 임상미술치료학연구 Vol.2 No.2

소아암은 18~20세 이하에서 생기는 악성 종양으로, 우리나라에서 한 해에 약 1,200명 정도의 환자가 새로 진단되고 있다. 소아암은 성인에서 생기는 암과 비교하여, 종류와 치료 결과에 차이가 많다. 소아에서 가장 많이 생기는 암은 백혈병이며, 소아암의 약 1/3 정도를 차지하고 있다. 이외에 뇌종양, 악성 림프종, 신경모세포종, 윌름스종양 등이 있다. 소아암의 치료로는 수술, 항암제 투여, 방사선치료를 하게 된다. 소아암은 완치율이 높아 60~70% 정도의 완치율을 보인다. 완치율이 높아지면서, 치료 중 혹은 치료 후에 나타날 수 있는 합병증을 되도록 감소시키기 위한 노력이 중요시 되고 있다. 최근 소아암의 완치율이 많이 향상되었으나, 치료 과정은 아이 뿐 아니라 부모와 가족 등 주위 사람에게 상당한 고통을 안겨주게 되고, 어려운 상황들을 자주 접하게 된다. 이러한 어려운 치료과정을 잘 이겨내도록 최근에는 미술치료, 놀이치료, 음악치료 등 다양한 분야의 도움이 제공되고 있으며, 소아암 치료의 중요한 한 분야로 인식되어지고 있다. 본 논문은 소아암의 일반적 개요와 종류 및 빈도, 각 질환에 대한 소개, 치료에 대하여 기술하였다. (임상미술치료학연구 2007;2(2):104-108) Over the past several decades, great strides have been made in diagnosis, treatment, and survival of childhood cancer. In the 1960s the probability of survival for a child with cancer was less than 25%, whereas today it may exceed 70%. This dramatic change has occurred through significant and steady progress in our understanding of tumor biology, creation of specialized multidisciplinary care teams, incremental improvements in therapy. Also, recent progress in the understanding of psychological and social factors related to cancer is important because cancer is the most common fatal disease of childhood and adolescence. Research interest in children and adolescents who have survived cancer also has increased over the past several years. Attention has focused on the long-term socal outcomes of these children and adolescents. As health-related research on children shift from seeking information about children to seeking information directly form them, researchers recognize the need for developmentally appropriate methods such as drawing, playing, and music to help children communicate their experiences. (Journal of The Korean Academy of Clinical Art Therapy 2007;2(2):104-108)

Naegleria fowleri 감염 마우스에 있어서 interleukin-2 생성 및 T 림프구 아형변동

유철주(Chuhl-Joo Lyu),신주옥(Chu-Og Shin),임경일(Kyung-il Im) 대한기생충학열대의학회 1993 The Korean Journal of Parasitology Vol.31 No.3

Two Cases of Wernicke’s Encephalopathy in Young Age Patients Receiving Allogeneic Hematopoietic Stem Cell Transplantation

한정우,유철주,임승택,신혜선,박희진,정원재,권승연 연세대학교의과대학 2012 Yonsei medical journal Vol.53 No.5

Wernicke’s encephalopathy is an acute neurolopsychiatric syndrome caused by thiamine deficiency, and classically presents with the triad of opthalmopathy, ataxia and altered mentality. Both prolonged total parenteral nutrition and reduced oral intake can induce Wernicke’s encephalopathy during hematopoietic stem cell transplantation (HSCT). Although early treatment is important for recovery from Wernicke’s encephalopathy, the vague symptoms and characteristics hinder early diagnosis. Furthermore, Wernicke’s encephalopathy is not infrequent and can develop at any age during HSCT. Herein, we present two young patients developing Wernicke’s encephalopathy during HSCT.