Mechanism of Food Restriction: Protection of Cellular Homeostasis

유병팔 부산수산대학교 생명과학연구소 1991 生命科學硏究報告 Vol.2 No.-

Prevention of Free Radical Damage by Food Restriction

유병팔 부산수산대학교 생명과학연구소 1991 生命科學硏究報告 Vol.2 No.-

Mechanism of Food Restriction: Protection of Cellular Homeostasis

유병팔 부산수산대학교 환경문제연구소 1990 環境問題硏究論文集 Vol.1 No.-

Food Restriction as An Effective Modulator of Free Radical Metabolism in Aging Rats

이동욱,유병팔 ( Dong Wook Lee,Byung Pal Yu ) 생화학분자생물학회 1991 BMB Reports Vol.24 No.2

Chronic dietary restiction without malnutrition extends both the mean and maximum life span of all laboratory organisms so far tested. This life-extension is attributed to numerous beneficial effects of well-maintained physiological systems, and the retardation of chronic diseases. Although the biological mechanisms of these anti-aging actions by dietary restriction are not known, recent evidence indicated that modulation of free radical activity might play important roles in such beneficial action. Our present study with SPF male Fischer 344 rats provides further data that the anti-radical action of dietary restriction suppresses the formation of reactive oxygen species, enhances the antioxidant capacity, and increases the membrane resistance against oxidative stress. Based on these results we propose that dietary restriction is an effective modulator of free radical activity.

The Role of Prostaglanding in the Aging Process

Choi, Jin-Ho,Yu, Byung P. 한국노화학회 1991 한국노화학회지 Vol.1 No.1

Epigenetic modifications of gene expression by lifestyle and environment

Qudeer Ahmed Abdul,유병팔,정해영,정현아,최재수 대한약학회 2017 Archives of Pharmacal Research Vol.40 No.11

Epigenetics oftenly described as the heritablechanges in gene expression independent of changes inDNA sequence. Various environmental factors such asnutrition-dietary components, lifestyle, exercise, physicalactivity, toxins, and other contributing factors remodel thegenome either in a constructive or detrimental way. Sinceepigenetic changes are reversible and nutrition is one of themany epigenetic regulators that modify gene expressionwithout changing the DNA sequence, dietary nutrients andbioactive food components contribute to epigenetic phenomenaeither by directly suppressing DNA methylation orhistone catalyzing enzymes or by changing the availabilityof substrates required for enzymatic reactions. Diets thatcontain catechol-dominant polyphenols are reported tosuppress enzyme activity and activate epigeneticallysilenced genes. Furthermore, several dietary nutrients playa crucial role in one-carbon metabolism including folate,cobalamin, riboflavin, pyridoxine, and methionine bydirectly affecting S-adenosyl-L-methionine. Soy polyphenolsblock DNA methyltransferases and histonedeacetylases to reverse aberrant CpG island methylation. Organosulfur rich compounds such as the sulforaphanefound in broccoli appear to normalize DNA methylationand activate miR-140 expression, which represses SOX9and ALDH1 and decreases tumor growth. The purpose ofthis short communication is to overview the epigeneticregulatory mechanisms of diet and other environmentalfactors. We discuss the epigenetic contributions of dietarycomponents with a particular focus on nutritionalpolyphenols and flavonoids as epigenetic mediators thatmodify epigenetic tags and control gene expression. Thesemechanisms provide new insights to better understand theinfluence of dietary nutrients on epigenetic modificationsand gene expression.

Age-related inflammation and insulin resistance: a review of their intricate interdependency

박민희,김대현,이은경,김남득,임동순,이재원,유병팔,정해영 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.12

Chronic inflammation is a major risk factorunderlying aging and the associated diseases of aging; ofparticular interest is insulin resistance during aging. Chronic inflammation impairs normal lipid accumulation,adipose tissue function, mitochondrial function, and causesendoplasmic reticulum (ER) stress, which lead to insulinresistance. However, some studies show that insulinresistance itself amplifies chronic inflammation. Theactivity of the insulin-dependent Akt signaling pathway ishighlighted because of its decrease in insulin-sensitiveorgans, like liver and muscle, which may underlie insulinresistance and hyperinsulinemia, and its increased levels innon-metabolic organs, such as kidney and aorta. In that theprevalence of obesity has increased substantially for all agegroups in recent years, our review summarizes the datashowing the involvement of chronic inflammation inobesity-induced insulin resistance, which perpetuatesreciprocal interactions between the chronic inflammatoryprocess and increased adiposity, thereby accelerating theaging process.

사회.심리적 스트레스에 미치는 마인드 토닉(Mind Tonic) 음료의 영향

최진호,김대익,박수현,김동우,조원기,유병팔 한국생명과학회 1999 생명과학회지 Vol.9 No.5

The effects of anti-stress mind tonic (ASMT) drink (ASMT-0.1% and ASMT-0.5% concentration) were tested for the anti-stress action. ICR male mice (20$\pm$2 g) were fed with basic experimental diets free access to water containing these ingredients for 18 days. Psychological stress/sociopsychological stress were exposed by foot-shock for 1 hour for 3 days. Both ASMT-0.1 and ASMT-0.5 groups in the sociopsychological stress resulted in a significant decrease of 19.1% and 41.9% in plasma corticosterone (CS) secretion compared with psychological stress (control group). Noradrenaline (NA) secretions in the brain were significantly increased 23.4% and 35.9%, respectively, in ASMT-0.1 and ASMT-0.5 groups compared with control group. MHPG-SO4 (3-Methoxy-4-hydroxyphenylethyleneglycol sulfate) levels in the brain resulted in a marked decreases of 27.1% and 19.6%, respectively in ASMT-0.1 and ASMT-0.5 groups. NA/MHPG-SO4 ratios in the brain of ASMT-0.1 and ASMT-0.5 groups resulted in a significantly increase of about 70% compared with control group. These suggest that mind tonic anti-stress drink can effectively ridded the sociopsychological stress.

사회.심리적 스트레스에 미치는 국화 추출 음료의 영향

최진호,김대익,박수현,김동우,조원기,유병팔 한국생명과학회 1999 생명과학회지 Vol.9 No.5

The effects of anti-stress chrysanthemum flower (ASCF) extract drink (ASCF-0.1% and ASCF-0.5% concentrations) were tested for the anti-stress action. ICR male mice (20$\pm$2 g) were fed with basic experimental diets and given free access to water containing these ingredients for 18 days. Psychological stress/sociopsychologcal stress exposed by foot-shock for 1 hour for 3 days. Both ASCF-0.1 and ASCF-0.5 groups in the sociopsychological stress resulted in a significant decrease of 28.1% and 27.3% in plasma corticosterone (CS) secretion compared with psychological stress (control group). Noradrenaline (NA) secretions in the brain were significantly increased 49.7% and 53.9%, respectively, in ASCF-0.1 and ASCF-0.5 groups compared with control group. MHPG-SO4 (3-Methoxy-4-hydroxyphenylethy-leneglycol sulfate) levels in the brain resulted in a marked decreases of 12.9% and 16.6%, respectively in ASCF-0.1 and ASCF-0.5 groups. NA/MHPG-SO4 ratios in the brain of ASCF-0.1 and ASCF-0.5 groups resulted in a significantly increase of 71.3% and 81.0%, respectively, compared with control group. These results suggest that anti-stress chrysanthemum flower (ASCF) drink can effectively ridded the sociopsychological stress.

사회.심리적 스트레스에 미치는 장미 추출 음료의 영향

최진호,김대익,박수현,김동우,조원기,유병팔 한국생명과학회 1999 생명과학회지 Vol.9 No.5

The effects of anti-stress rose fruit (ASRF) extract drink (ASRF-0.1% and ASRF-0.5% concentrations) were tested for the anti-stress action. ICR male mice (20$\pm$2 g) were fed with basic experimental diets and given free access to water containing these ingredients for 18 days. Psychological stress/sociopsychological stress exposed by foot-shock for 1 hour for 3 days. Both ASRF-0.1 and ASRF-0.5 groups in the sociopsychological stress resulted in a significant decrease of 24.3% and 38.0% in plasma corticosterone (CS) secretion compared with psychological stress (control group). Noradrenaline (NA) secretion in the brain were significantly increased 35.9% in ASRF-0.5 group, but NA secretion in ASRF-0.1 group could not be obtained significant result compared with control group. MHPG-SO4 (3-Methoxy-4-hydroxy-phenylethy leneglycol sulfate) levels in the brain resulted in a marked decreases of 16.5% and 18.9% respectively in ASRF-0.1 and ASRF-0.5 groups. NA/MHPG-SO4 ratios in the brain of ASRF-0.1 and ASRF-0.5 groups resulted in a significantly increase of 16.5% and 67.0%, respectively, compared with control group. These results suggest that anti-stress rose fruit (ASRF) drink also can effectively ridded the sociopsychological stress.