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당뇨병증 골절렛트의 골치유 과정에서 맥동성 초음파가 미치는 영향
민순규,천진성,용준환,유영대,Min, Soon-Gyu,Chun, Jin-Sung,Yong, Jun-Hwan,Yoo, Young-Dae 대한물리치료학회 2006 대한물리치료학회지 Vol.18 No.2
Purpose: The study to pulsed ultrasound effects of diabetes mellitus fracture model in rat. Methods: We used 36 Sprague-Dawely rats which were divided into 3 groups; the animals were divided into group of 4 rats each 4th, 14th and 28th days. All animal was induced diabetes mellitus model to used streptozotocin with 45 mg/kg. Pulsed wave were divided into $50\;mW/cm^2$ and $100\;mW/cm^2$. Results: T-ALP value was significantly change from group II, III on 14th, 28th days (p<0.05). Especially T-ALP value to between groups was significantly change from group II on 14th days (p<0.05). Osteocalcin value was significantly change from group II on 28th days(p<0.05). At fracture site, osteoblast, osteoclast expression was observed from 4th days after treatment and it reached its maximum intensity at 28th days. At fracture site, $TGF-{\beta}_1$ expression was observed from 4th days after treatment and it reached maximum intensity at 14th days. Conclusion: According to this study, diabetes mellitus fracture model to the more effective is divided into $50m\;W/cm^2$ pulsed ultrasound.
자궁평활근의 Carbachol 및 Oxytocin 수축에 있어서의 세포내 $Ca^{2+}$ 동원
김보경,정동수,김윤선,이윤호,용준환,이원창,이상목,Kim, Bo-Kyung,Chung, Dong-Su,Kim, Yoon-Sun,Lee, Yoon-Ho,Yong, Jun-Hwan,Lee, Won-Chang,Ozaki, Hiroshi,Karaki, Hideaki,Lee, Sang-Mog 대한약리학회 1996 대한약리학잡지 Vol.32 No.2
The properties of cytosolic $Ca^{2+}$ level$([Ca^{2+}]_i)$ movement of high KCl, carbachol and oxytocin were examined with myometrium isolated from non-pregnant rat(estrus cycle). High concentration of KCl$({\leq}23.3mM)$ induced rhythmic increases in $[Ca^{2+}]_i$ and muscle contraction. However, sustained $[Ca^{2+}]_i$ and contracion were obtained at higher KCl concentration $({\geq}30.3mM)$ The rhythmic and sustained contraction closely associated with changes in $[Ca^{2+}]_i$ induced by high KCl. Carbachol $(3{\sim}30{\mu}M$ generated rhythmic increases with tonic component in $[Ca^{2+}]_i$ and muscle contraction. Myometrial contraction stimulated by carbachol was also closely correlated with change in $[Ca^{2+}]_i$. And the $[Ca^{2+}]_i/contraction$ relationships were similar when muscle strips were stimulated by high KCl and carbachol. Maximal concentration of carbachol $(10{\mu}M)$ and oxytocin(100 nM) increased $[Ca^{2+}]_i$ and contraction which were slightly greater than that of high KCl in non-pregnant myometrium, respectively. However, the $[Ca^{2+}]_i$ and contraction were strongly inhibited by verapamil $(10{\mu}M)$, a 1-type $Ca^{2+}$ channel blocker, as in the case of high KCl. Additionally, although carbachol further increased $[Ca^{2+}]_i$ and contraction induced by high KCl, these changes also strongly inhibited by application of verapamil. These results suggest that uterotonic agents, carbachol and oxytocin, induced contraction by increase in $[Ca^{2+}]_i$ through $Ca^{2+}$ influx than by a regulation of $Ca^{2+}-sensitization$ in non-pregnant myometrium.
자궁평활근의 Carbachol 및 Oxytocin 수축에 있어서의 세포내 Ca<sup>2+</sup> 동원
김보경(Bo-Kyung Kim),정동수(Dong-Su Chung),김윤선(Yoon-Sun Kim),이윤호(Yoon-Ho Lee),용준환(Jun-Hwan Yong),이원창(Won-Chang Lee),Hiroshi Ozaki,Hideaki Karaki,이상목(Sang-Mog Lee) 대한약리학회 1996 대한약리학잡지 Vol.32 No.2
The properties of cytosolic Ca<sup>2+</sup> level([Ca<sup>2+</sup>]<sub>i</sub>) movement of high KCl, carbachol and oxytocin were examined with myometrium isolated from non-pregnant rat(estrus cycle). High concentration of KCl≤23.3mM) induced rhythmic increases in [Ca<sup>2+</sup>]<sub>i</sub> and muscle contraction. However, sustained [Ca<sup>2+</sup>]<sub>i</sub> and contracion were obtained at higher KCl concentration (≥30.3mM) The rhythmic and sustained contraction closely associated with changes in [Ca<sup>2+</sup>]<sub>i</sub> induced by high KCl. Carbachol (3 ~ 30μM generated rhythmic increases with tonic component in [Ca<sup>2+</sup>]<sub>i</sub> and muscle contraction. Myometrial contraction stimulated by carbachol was also closely correlated with change in [Ca<sup>2+</sup>]<sub>i</sub>. And the [Ca<sup>2+</sup>]<sub>i</sub>/contraction relationships were similar when muscle strips were stimulated by high KCl and carbachol. Maximal concentration of carbachol (10μM) and oxytocin(100 nM) increased [Ca<sup>2+</sup>]<sub>i</sub> and contraction which were slightly greater than that of high KCl in non-pregnant myometrium, respectively. However, the [Ca<sup>2+</sup>]<sub>i</sub> and contraction were strongly inhibited by verapamil (10μM), a 1-type Ca<sup>2+</sup> channel blocker, as in the case of high KCl. Additionally, although carbachol further increased [Ca<sup>2+</sup>]<sub>i</sub> and contraction induced by high KCl, these changes also strongly inhibited by application of verapamil. These results suggest that uterotonic agents, carbachol and oxytocin, induced contraction by increase in [Ca<sup>2+</sup>]<sub>i</sub> through Ca<sup>2+</sup> influx than by a regulation of Ca<sup>2+</sup>-sensitization in non-pregnant myometrium.