Streptozotocin 당뇨(糖尿)마우스의 췌도세포(膵島細胞)에 미치는 Aloe vera의 영향에 대한 병리조직학적(病理組織學的) 연구(硏究)

이상목,윤화중,이덕윤,박영의,Lee, Sang-mog,Yoon, Hwa-jung,Lee, Duck-yoon,Park, Young-e 대한수의학회 1989 大韓獸醫學會誌 Vol.29 No.4

This experiment was carried out to investigate the influence of Aloe vera in the pancreatic islets of streptozotocin diabetic mice. Experimental diabetes was induced in ICR mice with a single injection of SZ(140mg/kg body weight, ip). The mice demonstrating hyperglycemia 48 hours after SZ injection were treated for 16 days with Aloe vera(300, 800mg/kg). Plasma glucose was measured, and for morphological studies of the islets specimens were stained with hematoxylin-eosin and by immunocytochemical methods. Then we observed the morphological changes of islets. Polymorphonuclear cells were infiltrated at the periphery of the islets 48 hours after SZ injection in SZ-treated ICR mice, but no prominent WBC infiltration was observed throughout the experiment. Blood glucose in mice treated with Aloe vera after SZ injection was higher than that of SZ injected mice, and mononuclear cells were heavily infiltrated at the islets 16 days after Aloe vera treatment(300mg/kg), and significant islets infiltration of mononuclear cells was observed 30 days after Aloe vera treatment(800mg/kg). Islets of ICR mice treated with Aloe vera after SZ injection showed severer insulitis, degranulation and necrosis of B cells than those of SZ injected mice. These studies indicate that Aloe vera in SZ injected mice increases vascular permeability and number of WBC in pancreatic islets, and potentiates destruction of B cells by cell-mediated immune system.

국내 사육견의 심장사상충 실태조사

이상목,최석화,이현하,이원창,Lee Sang-mog,Choi Seok-hwa,Lee Hyun-ha,Lee Won-chang 대한수의사회 1992 대한수의사회지 Vol.28 No.6

This study was performed to investigate the infestation rate of heartworm(Dirofilaria immitis) in the peripheral blood of the dog being raised in Korea. Blood samples were obtained between 17 : 00 and 20 : 00 from June to August, 1991. Heartworm was exami

고고학 유물 속에 나타나는 상징ᆞ기호에 대한 연구

이상목 ( Sang Mog Lee ) 한국고대학회 2006 先史와 古代 Vol.25 No.-

Symboles et Signes des Sources Arch?ologiques - les Th?mes Iconographiques de Repr?sentation Pr?historique dans la Cor?e : 고고학 유물 속에 나타나는 상징ㆍ기호에 대한 연구

Sang-Mog LEE(이상목) 한국고대학회 2006 先史와 古代 Vol.25 No.-

이 글에서는 주로 우리나라 신석기시대에서 청동기시대 사이의 유적과 유물들 속에 나타난 상징과 기호들을 분석하고, 제작시대와 그 변화양상에 대해 살펴보았다. 연구 대상은 크게 사실적인 형상과 추상적인 형상으로 구분 할 수 있으며, 이는 유적의 성격과 시대적 차이에서 비롯된 것으로 판단할 수 있다. 즉, 수렵채집경제 단계에 해당하는 신석기시대의 조형물에서는 사실적이고도 다양한 동물 표현물이, 농경단계로 진입하는 청동기시대에서는 특정한 주제의 새로운 추상적 표현물들이 나타난다. 이러한 분석을 통해서 상징과 기호 대한 사회경제적인 의미와 당시의 생활상의 변화를 추론하였다. 본 연구를 통하여 사실적인 형상은 신석기시대의 수렵어로 경제단계의 소산물로, 사냥꾼사회의 계절적 식량사원 취득과 생업활동을 잘 반영한 것으로 여겨진다. 반면 청동기시대에 접어들면서 새로운 양식의 형상들이 출현하게 되며, 매우 추상적인 주제(방패, 동심원, 검, 여성음부 등)로 한정되어 있다. 이러한 상징의 변화는 농경이란 새로운 생활방식과 사회구조의 변화에 매우 중요한 역할을 하였을 것으로 추론할 수 있다. In a context archeological, we can gather into two categories theme of representations prehistory: that is to say the representation naturalist is the abstract figuration. The sites that have naturalistic representations probably relate to an early, pre-agricultural way of life. Others seem later - agricultural - as, for example, the site linked to megalithic culture. They can be dated by a very few direct stratigraphic contexts and by linking their images to objects of known prehistoric date, although many of the figures art ‘abstract’ and cannot be dated that way. One can be dated indirectly, a plethora of whale and seal bones and harpoons from a nearby shell midden, that suggests the people who lived there 7,000 to 3,500 years ago. Others are found on megalithic formations, particularly dolmens and menhirs. A close correlation has been shown to exist between the distribution of archeological and symbolic sites in this case. These sites of engravings probably belong to the Bronze Age (between 1,000 and 300BC). According to this analysis, we can suggest certain conclusions on the level of cultural development reached, living conditions, religious observance, etc. We can distinguish at least two different stages; one of the fishing-hunting and the other of agriculture. The majority of the representations of animals by the populations of hunters-fishers are rather close to reality, while the farming populations had an abstracted art symbolic system. In the populations of fishers-hunters, the realism can have a high value symbolic system. On the other hand, the agricultural societies are limited to some geometrical figurations and arms: circles, vulvas, daggers, etc. The suggestion concerning chronology may be further substantiated through their relationship to context. Rock-art has had a function in society and will therefore relate in some form to social structure. In conclusion, one global response to the result of environmental and technological change has been a creative explosion for inspiration on cultures the world over; not only in technology, but also in the arts . In other words, the hunter-fishers’ rock-art tradition came to an end and the symbolic expression of a new economy and ideology took its place. A symbol functioned as an important agent in legitimizing and mediating status and inequality in a period of stressful social transition.

자주국방과 적정 국방비 쟁점과 정책적 함의

이상목 ( Lee Sang Mog ) 한국군사학회 2004 군사논단 Vol.37 No.-

가야의 미술과 정신세계: 암각화

이상목 ( Sang Mog Lee ) 경북대학교 퇴계학연구소 2010 퇴계학과 유교문화 Vol.46 No.-

혈관 평활근 수축에 미치는 melatonin의 효과

이상목(Sang Mog Lee) 한국예방수의학회 1999 예방수의학회지 Vol.23 No.4

Vasodilatory effects of melatonin, the pineal hormone, were examined on the isolated rat aorta. Melatonin caused a sustained relaxation of rat aorta contracted with norepinephrine (NE), endothelin-1 (ET-1) and high KCI. The agonist-induced contraction was partially attenuated by verapamil, a voltage dependent Ca²⁺ channel blocker. Additional treatment of melatonin abolished the agonist-induced verapamil-resistant contraction, completely. Melatonin also inhibited 12-deoxyphorbol 13-isobutyrate (DPB, 1μM)-induced contraction in Ca²⁺-free physiological salt solution (PSS). These results show that melatonin effects on the contractile protein contributes to contraction in aortic smooth muscle. To investigate the mechanism of relaxation of melatonin, inhibitors of cyclooxygenase, nitric oxide synthase and guanylate cyclase were applied to the aorta relaxed by melatonin. Neither indomethacin (10μM), a cyclooxygenase inhibitor, nor NG-nitro-L-arginine (L-NNA, 10μM), a nitric oxide synthase inhibitor, altered the melatonin-induced relaxation. The melatonin-induced relaxation was abolished by the pretreatment of 1H-[1,2,4] oxadiazolo [4,3-a] quinoxalin-1-one (ODQ), a selective guanylate cyclase inhibitor, but not by methylene blue, a non-selective guanylate cyclase inhibitor. In conclusion, melatonin induces relaxation of rat aorta by activation of guanylate cyclase, which inhibits contractile protein(s) in aortic smooth muscle.

유산동(硫酸銅) 중독(中毒)이 랫트 간장(肝臟)의 미세구조(微細構造)에 미치는 영향(影響)

윤화중,이상목,장병준,Yoon, Hwa-joong,Lee, Sang-mog,Jang, Byoung-joon 대한수의학회 1990 大韓獸醫學會誌 Vol.30 No.1

This study was designed in order to investigate the effect of copper sulfate to the ultrastructural changes of the hepatocytes in Sprague Dawley rats. The animals were administered with copper sulfate (10mg/kg B.W.), which was dissolved in normal saline. The solution was injected into abdominal cavity every day. The animals were sacrificed at the 6th, 12th, and 24th day from the beginning of administration. The specimens obtained from the liver were observed with electron microscope and significant changes were as follows. 1. A prominent dilatation and disruption of the cisternae of rough endoplasmic reticulum were recognized. Also, the detachment of membrane bound ribosomes was shown. 2. The proliferation of smooth endoplasmic reticulum and the depletion of glycogen particles were noted. 3. The increase of primary lysosomes and autophagic vacuoles was obserbed. 4. The dilatation of mitochondrial cristae was obserbed. And it was irregulary scattered in the stroma of mitochondria. 5. The atrophy of microvilli in the bile canaliculi and space of Disse was prominent. 6. Membrane of hepatocytes was damaged and significant hydrophic degeneration was obserbed in the perisinusoidal regions. 7. The damage of Fat-storing cells was more significant than that of hepatocytes.

마우스의 비장에 미치는 7,12-Dimethylbenz[a]anthracene의 면역병리학적 연구

이덕윤,한상섭,이상목,Lee, Duck-Yoon,Han, Sang-Seop,Lee, Sang-Mog 한국독성학회 1992 Toxicological Research Vol.8 No.2

This study was carried out to investigate the immunopathological effects of 7,12-Dimethylbenz[a]anthracene(DMBA) on spleen in mice. DMBA was administered subcutaneously to BALB/C mice by interscapular single injection of 50 or 100${\mu}g/g$ of body weight. Each DMBA treatment group and additional corn oil control group of mice were studied on day 1,3,7,14 and 21 following the injection of DMBA. DMBA treatment resulted in marked decrease in weights and cellularity of spleen. Spleen weights showed the greatest decrease at 14days after 50${\mu}g/g$ DMBA treatment, and at 21days after 100${\mu}g/g$ DMBA treatment. Spleen cellularity was similarly deceased in comparison with spleen weights. Spleen showed morphologically no typical changes throughout the experiment after 50${\mu}g/g$ DMBA treatment. Following the treatment of 100${\mu}g/g$ DMBA the spleen showed severe fibrosis, hemosiderin precipitation, and megakaryocytes decrease in red pulp at 14 days, while hemopoietic function was partly restored in addition to the appearance of a few megakaryocytes at 21 days. In spleen sections treated with antibodies to IgM or Thy1.2, lymphocytes strongly stained with IgM antibody were infiltrated around the central artery within the white pulp, and T-lymphocytes of periarterial lymphatic sheath (PALS) were diminished and destructed in sections treated with Thy1.2 antibody, at 14 days after the treatment of 100${\mu}g/g$ DMBA. By the electron microscopy phagocytic epithelial cells or macrophages were remarkably increased in spleen at 14and 21days following the treatment of 100${\mu}g/g$ DMBA.

수의공중보건학적면에서 국내산원유의 조성에 관한 연구

이재순,이원창,이상목,윤종삼,주정건부,Yi Chae-Sun,Lee Won-Chang,Lee Sang-Mog,Yoon Chong-Sam,Sakai Takeo 대한수의사회 1991 대한수의사회지 Vol.27 No.4

In this fundamental study of autors observed on the general composition of raw milk of Holstein in Korea for Veterinary Public Health Science. It is hope that the information will be used for reference in the future endearvors of study in the field of vet