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AIDS 환자에서 CD4+ T 세포수 감소에 따른 CMV 감염
조영걸,김유겸,오원일,조군제,Cho, Young-Keol,Kim, Yoo-Kyum,Oh, Won-Il,Cho, Goon-Jae 대한미생물학회 1998 Journal of Bacteriology and Virology Vol.28 No.4
Cytomegalovirus is the most common cause of life-threatening viral infection in HIV-infected patients. This study was done prospectively to investigate the incidence of CMV infection according to the decrease of CD4+ T cell count (CD4+) in Korean AIDS patients. Thirty-nine HIV-infected patients diagnosed before 1994 were followed for regular immunological monitoring. We have used urine shell vial method for the CMV detection from 1994 and have also checked clinical findings. Positive urine culture rate definitely depended on the CD4+ as follows; 45%, 22%, 17%, 11% and 0%, CD4+ <50, 50-100, 100-200, 200-500 and >500, respectively. Except culture positive 2 patients with CD4+ of $200{\sim}300/{\mu}l$, all eight culture positive patients with CD4+ less than $200/{\mu}l$ showed CMV related diseases on or before urine culture. But, we could not get a positive culture for a late AIDS patient with vision loss. With ganciclovir therapy, all culture results were at least negative just after or on late of first 14 days-ganciclovir infusion-course. These data suggest that the incidence of CMV disease in Korean AIDS patients is very high, and early diagnosis and treatment for CMV diseases is required for the prevention of life threatening results.
유빈 ( Bin Yoo ),박재경 ( Jae Kyoung Park ),오원일 ( Won Il Oh ),오순환 ( Sun Whan Oh ),문희범 ( Hee Bom Moon ) 대한류마티스학회 1997 대한류마티스학회지 Vol.4 No.1
Objective: To investigate whether the serum levels of IL-10 in patients with rheumatoid arthritis are different from those of normal controls and SLE patients and to find out any correlation with disease activity parameters of rheumatoid arthritis. Methods: Sera from 20 healthy normal persons, 16 rheumatoid arthritis patients and 16 patients with systemic lupus erythematosus were collected and measured for IL-10 and IL-6. Various disease activity parameters were measured in RA patients. Results: The serum level of IL-10 in RA patients was significantly elevated compared to normal controls but lower than those of SLE patients. In RA patients there was no definite correlation between the disease activity parameters and serum IL-10 levels. Despite significant improvements in terms of various disease activity parameters, there was no significant change of serum IL-10 levels after treatment in RA patients. In seropositive RA patients, positive correlation was found between serun IL-10 and rheumatoid factor levels. Conclusion: Our findings show that the serum IL-10 levels in patietns with RA are elevated compared to normal controls but lower than those of SLE patients. There was no correlation between serum IL-l0 levels and disease acivity parameters of RA.
뇌졸중 쥐 모델에서 인간 제대혈 유래 중간엽줄기세포의 치료 효과 연구
정창현 ( Chang Hyun Jeong ),임정연 ( Jung Yeon Lim ),박상인 ( Sang In Park ),김성묵 ( Seong Muk Kim ),전진애 ( Jin Ae Jun ),오원일 ( Won Il Oh ),이재권 ( Jae Kwon Lee ),전신수 ( Shin Soo Jeun ) 한국조직공학과 재생의학회 2006 조직공학과 재생의학 Vol.3 No.4
Mesenchymal stem cells(MSCs) have the ability to differentiate into multiple cell types. It has been reported that MSCs ameliorate functional deficits after transplantation into various neurologic disease models. In this study, to demonstrate the effect of human umbilical cord blood-derived MSCs(hUCB-MSCs) on stroke models, we transplanted the PKH-26 labeled hUCB-MSCs into the contralateral region of injured rat brain at 7 days after injury, and then examined the behavioral test, migration ability of transplanted hUCB-MSCs to injury site, and differentiation potentiality of transplanted hUCB-MSCs into neural cells. The results were: (1) a behavioral test(adhesive- removal and rotarod test) showed a significant improvement in the MSCs transplanted group as compared to the PBS injected group, (2) PKH-26 labeled MSCs were detected in the boundary zone of injured site at 4 weeks after transplantation, and (3) a few of transplanted MSCs exhibited a labeling for mature neural linage markers NeuN and GFAP. We suggest that hUCB-MSCs could be an effective cell source for treating ischemic brain injury.