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RISS 인기검색어
- 검색키워드
- 저자 : 오순환 ( Sun Whan Oh ) (검색결과 2 건)
- 무료
- 기관 내 무료
- 유료
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유빈 ( Bin Yoo ),박재경 ( Jae Kyoung Park ),오원일 ( Won Il Oh ),오순환 ( Sun Whan Oh ),문희범 ( Hee Bom Moon ) 대한류마티스학회 1997 대한류마티스학회지 Vol.4 No.1
Objective: To investigate whether the serum levels of IL-10 in patients with rheumatoid arthritis are different from those of normal controls and SLE patients and to find out any correlation with disease activity parameters of rheumatoid arthritis. Methods: Sera from 20 healthy normal persons, 16 rheumatoid arthritis patients and 16 patients with systemic lupus erythematosus were collected and measured for IL-10 and IL-6. Various disease activity parameters were measured in RA patients. Results: The serum level of IL-10 in RA patients was significantly elevated compared to normal controls but lower than those of SLE patients. In RA patients there was no definite correlation between the disease activity parameters and serum IL-10 levels. Despite significant improvements in terms of various disease activity parameters, there was no significant change of serum IL-10 levels after treatment in RA patients. In seropositive RA patients, positive correlation was found between serun IL-10 and rheumatoid factor levels. Conclusion: Our findings show that the serum IL-10 levels in patietns with RA are elevated compared to normal controls but lower than those of SLE patients. There was no correlation between serum IL-l0 levels and disease acivity parameters of RA.
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백서의 콜라겐 유도성 관절염 발생에 미치는 Interleukin-10의 영향
유빈 ( Bin Yoo ),김찬 ( Chan Kim ),최승원 ( Seung Won Choi ),김미정 ( Mi Jung Kim ),오순환 ( Sun Whan Oh ),문희범 ( Hee Bom Moon ) 대한류마티스학회 1997 대한류마티스학회지 Vol.4 No.2
콜라겐 유도성 관절염을 발생시키는 과정에서 IL-10을 투여한 본 연구에서는 관절염을 악화시키는 결과를 보였다. 이는 시험관내 실험상 염증억제효과뿐만 아니라 여러 면역세포 촉진 작용도 보인다고 알려진 IL-10이 본 연구에서의 용량으로 콜라겐 항원자극시부터 CIA 모델에 투여하면 관절염의 악화 효과를 보일 수 있음을 보여주었다. 관절염의 중증도나 IL-10투여와 무관하게 콜라겐항체 농도나 비장세포 자극지수가 증가함은 관절염의 악화에 콜라겐항체나 콜라겐 특이 반응세포의 역할외에 다른 기전의 역할임을 알 수 있었다. 본 연구 결과와 상반된 관찰을 보고한 다른 실험의 방법과 본 연구방법의 차이점을 고려할 때 IL-10은 다른 생물학적 제제들과 유사한 속성으로 작용 시기와 용량에 따라서 서로 다른 작용을 보일 가능성을 시사하였다. IL-10이 CIA 발생을 악화시킬 수 있는 기전은 항원제시 세포로서의 B 림프구의 자극, 세포독성 T 림프구의 자극, 대식세포로부터의 산화질소 생성 촉진 등이 가능하나 그 정확한 기전은 향후 더 연구되어야 할 과제라 생각된다. Objective: To evaluate the effect of IL-10 on development of collagen-induced arthritis, on humoral and cellular immunity and on the endogenous production of IL-10 in DBA/1J mice. Methods: DBA/1J mice were immunized with chicken type II collagen in Freund`s complete adjuvant. Murine recombinant IL-10 was given intraperitoneally twice a week from the day of second immunization (week 3) in doses of 0.002ug, 0.02ug and 0.2ug for 3 different groups, respectively. Dexamethasone was injected in one group to suppress the arthritis development and this group was used as negative control group. Levels of anti-collagen antibodies, serum IL-10 and stimulation indices of splenic monocytes to collagen were measured at the end of study. Results: The 0.02ug IL-10 and 0.2ug IL-10 treated groups developed earlier and more severe arthritis (week 6 and 8) compared to that of the control group while the 0.002ug IL-10 group has shown similar course to the control group in terms of incidence and severity of arthritis, At week 10, all groups with or without IL-10 injections developed arthritis with similar degree of severity while dexamethasone group showed far less incidence and severity of arthritis. The serum levels of anti-collagen antibody, IL-10 and spleen monocyte stimulation indices to collagen antigen showed no difference among control group, IL-10 injected groups and dexamethasone injected group. Conclusion: This study shows IL-10 could worsen the arthritis in CIA with the dosage used in this study without significant influence on the level of anti-collagen antibodies or stimulation indices of spenic monocyte to collagen.
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