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청목향 Aristolochiae radix에 있어 F344 랫드의 독성
김충용,김용범,양병철,이종화,정문구,양기화,장동덕,한상섭,강부현,Kim, Choong-Yong,Kim, Yong-Bum,Yang, Byung-Chul,Lee, Jong-Hwa,Chung, Moon-Koo,Yang, Ki-Hwa,Jang, Dong-Deuk,Han, Sang-Seop,Kang, Boo-Hyon 대한수의학회 2005 大韓獸醫學會誌 Vol.45 No.1
13-week orally repeated dose toxicity was investigated to ascertain the toxic effects of Aristolochiae radix in F344 rats at dose levels of 0, 1 (0.003 AA, aristolochic acid, mg/kg), 5 (0.014 AA mg/kg), 25 (0.068 AA mg/kg), 125 (0.34 AA mg/kg), and 500mg/kg (AA 1.36 mg/kg). No mortalities were found in any of the dose groups including vehicle control groups of both sexes during the study period. Hematologic and serum biochemical examinations revealed no changes related to the test item in any of the dose groups of both sexes. However, gross findings at necropsy implicated thickening of the stomach wall. In histopathological examinations, prominent findings related to the test item treatment were observed in the stomach and urinary bladder. There were squamous cell papilloma, squamous cell hyperplasia, ulceration and erosion observed in the non-glandular stomach. Squamouse cell hyperplasia was observed at dose levels of more than 125 mg/kg in both sexes and squamous cell papilloma was observed at dose level of 500 mg/kg in both sexes. The incidence and severity of these proliferating lesions including squamous cell hyperplasia and squamous cell papilloma increased with dose dependency. Transitional cell hyperplasia was also observed in the urinary bladder at dose levels of more than 25 mg/kg in both sexes and the incidence and severity of the lesion increased with dose dependency. In conclusion, the toxic changes related to the test item treatment were observed in the stomach and urinary bladder, and the no-observed-adverse-effect level (NOAEL) was estimated to be 5 mg/kg/day for both males and females in F344 rats.
곽동걸(Dong-Kurl Kwak),김춘삼(Choon-Sam Kim),유주희(Joo-Hee Yu),양기철(Ki-Chul Yang) 대한전기학회 2010 대한전기학회 학술대회 논문집 Vol.2010 No.4
This paper presents a novel isolated buck-boost converter for high power factor and high efficiency. The switching devices in the proposed converter are operated by soft switching technique using a new resonant circuit, and are driven with discontinuous conduction mode (DCM) according to pulse width modulation. The resonant circuit makes use of a step up-down inductor and a loss-less snubber capacitor. The input ac current waveform in the proposed converter also becomes a quasi sinusoidal waveform in proportion to the magnitude of input ac voltage under constant switching frequency. As a result, the proposed converter make it possible that the switching power losses are low, the efficiency of the converter is high, and the input power factor is nearly unity.
고성능 절연형 벅-부스트 컨버터의 특성 해석에 관한 연구
곽동걸(Dong-Kurl Kwak),정도영(Do-Young Jung),이봉섭(Bong-Seob Lee),김춘삼(Choon-Sam Kim),심재선(Jae-Sun Shim),양기철(Ki-Chul Yang) 대한전기학회 2008 대한전기학회 학술대회 논문집 Vol.2008 No.10
This paper is studied on the characteristic analyses of a high performance buck-boost converter added electric isolation by using a soft switching method. To be achieved of a high performance system, the proposed buck-boost converter is constructed by using a partial resonant circuit. The control switches using in the converter are operated with soft switching for a partial resonant method. The controlling switches are operated without increasing their voltage and current stresses by the soft switching technology. The result is that the switching loss is very low and the converter efficiency is high. And the proposed converter is added in a electric isolation. When the power conversion system is required to electric isolation, the proposed converter is adopted with the system development of high efficiency. The soft switching operation and system efficiency of the proposed converter is verified by digital simulation and experimental results.
안기형,박현규,박재형,양기철,최부귀 東亞大學校 附設 情報通信硏究所 1997 情報通信硏究所論文誌 Vol.5 No.1
The control of Chaos system is difficult because the system has characteristics of nonlinear and unstable. In this paper, we confirm synchronization between transmitting and receiving systems using Chua's circuits. This system is controlled by negative feedback, continuously.