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활락탕(活絡湯)의 cDNA Microarray를 이용한 유전자 발현에 미치는 영향
신철경,이채우,유선애,윤현민,장경전,송춘호,안창범,김철홍,Sin, Cheol-Kyung,Lee, Chae-Woo,Yoo, Sun-Ae,Youn, Hyoun-Min,Jang, Kyung-Jeon,Song, Choon-Ho,Ahn, Chang-Beohm,Kim, Cheol-Hong 대한약침학회 2008 Journal of pharmacopuncture Vol.11 No.4
Objective This study was undertaken to determine the effect of Whallak-tang on expression of CD/cytokine Genes. Methods The expression of CD/Cytokine Genes were examined by cDNA microarray using the human mast cell line(HMC-1). Results The expression of ATP5F1, FLJ20671, unknown, KIAA0342, OAS2, unknown genes were increased in $200{\sim}300%$ range. The expression of unknown, MDS006, IFITM1, MRPL3, ZNF207, FTH1, FBP1, NRGN, NR1H2, KIAA0747 genes were decreased in $0{\sim}33%$ range. Conclusion These results would provide important basic data on the possibility of the clinical treatment of Whallak-tang in musculoskeletal disease.
김재규,허정은,손연희,정현윤,신철경,민성순,권정남,김영균,Kim, Jae-Kyu,Heo, Jeong-Eun,Son, Yeon-Hui,Jeong, Hyun-Yun,Sin, Cheol-Kyung,Min, Sung-Soon,Kwon, Jung-Nam,Kim, Young-Kyun 대한약침학회 2008 Journal of pharmacopuncture Vol.11 No.4
Objectives The aim of study was to evaluate the effect of Herbal medicine on post stroke cognitive deficit. Methods All groups were treated with acupunture treatment, moxa treatment, herbal medicines, physical and occupational therapy for 4 weeks, additionally cardiotonic pills(CP) were taken in the cardiotonic pills group. The effect of treatment was assessed using Verval fluency, MMSE-KC, Word List Immediate Recall test. Statistical significance was achived if the probability was less than 5%(p,0.05). Results Verval fluency, MMSE-KC, Word List Immediate Recall test scores increased in both group. MMSE-KC, Word List Immediate Recall test scores were significantly increased in the CP group. Verval fluency, MMSE-KC, Word List Immediate Recall test scores were significantly increased in the control group. In the Verval fluency, MMSE-KC, Word List Immediate Recall test of the CP group more increased compared to the control group. There were no significant differences between two groups. In the CP group, the scores of the infarction group more increased compared to the hemorrhage group. Conclusions According to the these results, herbal medicines are effective to improve post stroke cognitive-deficit. Futher studies are needed to know cardiotonic pills in the ischemic stroke.
심박변이도(HRV)에서 기능성 소화불량증과 기질성 소화불량증의 상관성 연구
김상헌,김효진,이수정,신철경,이상희,김원일,Kim, Sang-Heon,Kim, Hyo-Jin,Lee, Soo-Jung,Sin, Cheol-Kyung,Lee, Sang-Hee,Kim, Won-Il 대한한방내과학회 2008 大韓韓方內科學會誌 Vol.29 No.2
Objectives : This study was designed to research whether HRV can yield a suitable diagnosis for activity of autonomic nerve system on functional dyspepsia. Methods : The testing of HRV was carried out at the Oriental Medical Center of Dong-Eui University with the participation of 28 functional dyspepsia patients, 25 dyspepsia caused by organic disease patients and 33 control group people. We checked HRV of the three groups for 5 minutes and compared HRV index(frequency domain analysis: HF, LF, VLF, LF/HF Ratio, TP) between groups. Results were as follows : 1. In the frequency domain analysis, HF, LF, VLF, and TP were significantly lower than the control group in the functional dyspepsia patients and dyspepsia caused by organic disease groups. HF, LF, VLF, LF/HF ratio, and TP were not significantly different between functional dyspepsia group and dyspepsia caused by organic disease group. 2. Age in dyspepsia patient group was significantly higher than in the control group. 3. In the frequency domain analysis, LF, VLF, and TP were significantly lower in the functional dyspepsia group than the control group in age 20-30 years. HF, LF, VLF, LF/HF ratio, and TP were not significantly different between the control group and dyspepsia caused by organic disease group in ages 20-30 years. HF, LF, VLF, LF/HF ratio, and TP were not significantly different between functional dyspepsia group and dyspepsia caused by organic disease group in age 20-30 years. Conclusion : According to this study, autonomic nerve system and parasympathetic nerve system decreased more in the functional dyspepsia patient group compared with the control group.