동시 부문 수상 소감ㆍ약력_송재진

송재진 아동문학평론사 2015 兒童文學評論 Vol.40 No.2

신경이과 영역에서의 기능적 신경 영상 연구 기법

송재진 대한평형의학회 2016 Research in Vestibular Science Vol.15 No.1

Neuro-otologic symptoms such as dizziness, hearing loss, or tinnitus give rise to peripheral change-induced neuroplasticity or central pathology-induced structural or functional changes. In this regard, functional neuroimaging modalities such as positron emission tomography (PET), functional magnetic resonance imaging (fMRI), magnetoencephalography (MEG), quantitative electroencephalography (qEEG), or functional near infrared spectroscopy have provided researchers with possibility to observe neuro-otologic disease-induced central functional changes. Among these methods, PET and fMRI are advantageous over qEEG or MEG with regard to spatial resolution, while qEEG and MEG are advantageous over PET or fMRI with regard to temporal resolution. Also, fMRI or MEG is not suitable for patients with implanted devices, whereas PET is not ideal for repetitive measures due to radiation hazard. In other words, as these modalities are complementary to one another, researchers should choose optimum imaging modality on a case by case basis. Hereinafter, representative functional neuroi-maging modalities and their application to neuro-otologic research will be summarized. Res Vestib Sci 2016;15(1):5-10

반하(半夏)가 천식모델 생쥐의 면역세포 및 사이토카인에 미치는 영향

송재진,박양춘,Song, Jae-Jin,Park, Yang-Chun 대한한방내과학회 2005 大韓韓方內科學會誌 Vol.26 No.1

Objective : The purpose of this research is to examine the effects of Pinelliae Rhizoma (PR) extract on immune cells and cytokines in ovalbumin (OVA)-induced asthmatic mice. Methods : In vivo, C57BL/6 mice were sensitized and handicapped by OVA for 12 weeks. During this experiment, the one group was then treated with PR extract for the 8 weeks (3 times per week) and analyzed by ELISA and flow cytometer. Results : In vivo, there were significant decreases in eosinophils, IL-4, IL-5, IL-13, IgE in BALF (bronchoalveolar lavage fluid) compared with that of control group. However, $IFN-{\gamma}$ in BALF of GS group increased significantly, compared with that of control group. Additionally, the population of $CD3e^-/CCR3^+,\;CD69^+/CD3e^+,\;IgE^+/B220^+,\;CD11b^+/Gr-l^+$ cells in the PR group decreased, compared with that of control group. Conclusion : The results of this study support a role for PR as an effective treatment for asthma in its experimental success in significantly decreasing inflammation and asthma reactions, and in increasing $IFN-{\gamma}$, which helps prevent such reactions.

加味金水六君煎이 알러지反應과 肺損傷에 미치는 影響

宋在鎭,朴陽春,金炳卓,金聖勳 대한동의병리학회 2000 동의생리병리학회지 Vol.14 No.2

금수육군전은 『경악전서』에서 “治因肺腎虛寒 水泛爲痰 혹년만음허 血氣不足 外受風寒 痰盛喘急等症”이라하여 폐신음허로 인해 수범성담하여 발하는 해수 등의 증상을 치료하는 처방으로 만성기관지염, 기관지천식의 완해기에 다용되고 있다. 이에 저자는 대전대학교 부속한방병원에서 다용하는 가미금수육군전의 효능을 심험적으로 규명하고자 histamine 유리 cytokine 인 IL-4, IL-5, IL-6에 대한 억제효과 및 폐 TBA 반응성 물질함량을 측정하였던 바 compound 48/80에 의한 histamine 유리에 대해 유의성 있는 억제효과가 나타났고, 알러지 cytokine에 대한 효과는 IL-4, IL-5 및 IL-6의 발현량을 농도의 존적으로 감소시키는 효과가 나타냈다. 이상의 결과로 보아 가미금수육군전은 알러지반응을 억제시키는 효과가 인정되며 앞으로 이에 대한 지속적인 연구가 필요하리라 사료된다. To evaluate the effect of KamiGumsuyukunjeon(KGYJ) on allergy and chronic lung disease, studies were done experimentally. KGYJ significantly inhibited the histamine release from mast cell induced by compound 48/80(10㎕㎖). It also downregulated expression of IL-4, IL-5 and IL6. But it didn't show any statistical significance in the change of TBA. These results indicated KGYJ had anit-allergic activity and still needed additional study on its mechanism.

肺浮腫을 同伴한 喘息患者1例에 대한 臨床報告

송재진,고재찬,김준명,박양춘 대전대학교 한방병원 2000 惠和醫學 Vol.9 No.2

From 9th September 2000 to 25th September 2000, the clinical study was carried out about 1 case of asthma patient with pulmonary edema who had been hospitalised in the Dept. of Internal Medicine, Oriental Medical Hospital, Taejon University. The results were as follows: 1. The asthma is included in the category of 'HyoChun' (哮喘) in the oriental medicine. 2. Symptoms of asthma are dyspnea, coughing sign, wheezing sign etc. 3. In the asthma, it seems to be effective to the patient who was dispensed Sochungryongtang-gami(小靑龍湯加味) in the early period, and Geumsuyukunjeon-gami(金水六君煎加味) Boeumjeon(補陰煎加味)in the recovery period.

이명의 기능적 신경 영상 연구의 최신 지견

송재진 대한이비인후과학회 2015 대한이비인후과학회지 두경부외과학 Vol.58 No.1

Non-pulsatile subjective tinnitus is a phantom sound percept without any objective physical sound source. Recent advances in tinnitus research have suggested central rather than peripheral changes as the culprit of tinnitus perception. Moreover, researchers have shown that these central functional changes can be observed not only in the auditory cortex but also in non-auditory regions such as the frontal, parietal, and limbic areas in patients with tinnitus. In this regard, functional neuroimaging modalities such as positron emission tomography (PET), functional magnetic resonance imaging (fMRI), magnetoencephalography (MEG), and quantitative electroencephalography (qEEG) provided researchers with a window into the cerebral cortical activity orchestrating tinnitus. Among these methods, qEEG and MEG are advantageous over PET or fMRI with regard to temporal resolution, while PET and fMRI are advantageous over qEEG or MEG with regard to spatial resolution. In other words, there is no gold standard functional neuroimaging modality in the field of tinnitus, but these four modalities are complementary to one another. In this review article, these four representative functional neuroimaging modalities and their application to tinnitus research will be introduced. Moreover, future direction of functional neuroimaging research on the pathophysiology of tinnitus will be discussed briefly.

慢性 閉鎖性肺疾患의 藥鍼治療에 대한 文獻的 考察

宋在鎭,朴陽春,安澤源,薛仁燦,黃致元,金炳卓 대전대학교 韓醫學연구소 1999 한의학연구소 논문집 Vol.8 No.1

rf PECVD법으로 증착된 a-C:H 박막의 결합구조에 미치는 보조가스의 영향

송재진,김성진,Song, Jae-Jin,Kim, Seong-Jin 한국재료학회 1999 한국재료학회지 Vol.9 No.11

본 연구에서는 rf PECVD(13.56MHz)법을 이용하여 $CH_4$가스에 소량의 보조가스($O_2$와 $N_2$)를 혼합하여 a-C:H 박막을 얻었다. 이렇게 얻어진 박막의 증착속도는 rf power 증가에 따라서 증가하다가 200W에서는 다시 감소하였으며, 산소와 질소가스의 유량이 증가함에 따라 감소하였다. FT-IR분석으로 계산된 박막내의 수소함량은 rf power 증가와 산소 및 질소첨가량의 증가에 따라 감소하였다. 산소가스 첨가 시에는 C=O 결합이 생성되며, 질소가스 첨가 시에는 C=N 결합이 생성됨을 FT-IR 분석을 통하여 알 수 있었다. 이와 같이 산소와 질소를 보조가스로 첨가할 경우에 스퍼터링 효과로 박막내의 수소함량 감소와 더불어 a-C:H 박막의 구조 변화를 일으킬 수 있을 것으로 생각된다. Raman 분석결과 산소와 질소를 첨가함에 따라서 I(sub)D/I(sub)G비가 증가하였고, D line과 G line의 위치가 높은 파수 쪽으로 이동하였으며, D line의 폭은 넓어지는 반면에 G line의 폭은 감소됨을 보였다. 이것은 산소와 질소의 첨가로 박막내의 수소함량 감소, 결합각의 disorder 감소 및 micro-crystallite 흑연의 형성에 의한 것이라고 판단된다.

Increased Risk of Psychopathological Abnormalities in Subjects With Unilateral Hearing Loss: A Cross-Sectional Study

송재진,구유정,김서영,김의태,최영석,정한진 대한이비인후과학회 2021 Clinical and Experimental Otorhinolaryngology Vol.14 No.1

Objectives. Although unilateral hearing loss (UHL) has been proven to be associated with educational and behavioral problems, few studies have investigated psychopathological abnormalities in this population. The aim of this study was to evaluate the psychopathological influence of UHL among Korean 19-year-old males. Methods. The authors retrospectively compared the objective personality test profiles of 602 subjects with UHL with those of 23,790 peers with normal hearing. All participants in the current study were 19-year-old males who underwent a physical examination and completed the Korean Military Multiphasic Personality Inventory for conscription at the Military Manpower Administration from February 2015 to December 2016. Results. Significantly higher scores were found on neurosis scales in the UHL group than in the normal-hearing group (50.9±10.8 vs. 44.9±6.0 for anxiety; 51.0±10.5 vs. 44.9±5.2 for depression; 51.1±10.4 vs. 45.1±6.81 for somatization, all P<0.001). The psychopathy scales were also significantly higher in the UHL group than in the normal-hearing group (49.3±9.4 vs. 46.3±5.7 for schizophrenia; 51.1±11.2 vs. 44.3±5.8 for personality disorders; 51.1±10.5 vs. 45.7±3.7 for paranoia, all P<0.001). Conclusion. Nineteen-year-old males with UHL tended to have more abnormal results on personality tests than controls with normal hearing, suggesting that UHL may be related with a higher risk of psychopathology.

박동성 이명의 진단과 치료의 최신 지견

송재진 대한이비인후과학회 부산,울산,경남 지부회 2021 임상이비인후과 Vol.32 No.1

Pulsatile tinnitus (PT), in general, is not related to pathology of the auditory system. Although PT is not as common as non-pulsatile tinnitus, the diagnosis and treatment of PT is important as it is reported to be found in as much as 4% of general population and treatable vascular causes are found in 44~91% of subjects with PT. Three types of vascular origins (arterial, arteriovenous, and venous) of pulsatile tinnitus exist and the main causes of pulsatile tinnitus are related to aberrant/ectopic, stenosis, diverticulum, bony wall dehiscence, or other pathologies of blood vessels, either arterial or venous. Brain MRI with angiography, temporal bone high-resolution CT, Doppler ultrasonography, and classical transfemoral cerebral angiography are radiological diagnostic tools for pulsatile tinnitus, but basic findings at the outpatients’ clinic such as subjective psychoacoustic nature of the PT, otoendoscopic findings, and audiologic features are also very important as these can be of great help for the physicians to obtain presumptive diagnostic impression for each subject with PT. Dehiscence/diverticulum of the sigmoid sinus one of the most common surgically correctable venous cause of PT. Additionally, benign intracranial hypertension is also a very common cause of PT that should not be forgotten in obese PT subjects with normal radiologic findings. In this review, diagnostic steps and appropriate surgical- or interventional management options for each cause of PT will be discussed in detail.