이상지질혈증과 치료제 연구개발 경향

설인찬 ( In Chan Seol ) 대전대학교 한의학연구소 2009 한의학연구소 논문집 Vol.18 No.2

Most of the cholesterol is synthesized by liver in the body while about one of third is taken via dietary. The main functions of cholesterol is to protect membranes in cell surface, avoid the arterial bleeding by hypertension, and prolong the life of erythrocytes, and so on. However, overload of cholesterol leads to arteriosclerosis associated with leading death cause. Lack of physical activity, emotional and environmental stress, and low intake of protein or vitamin E induce the unbalance between HDL- and LDL-cholesterol so become a basis of ischemic disorders in heart, brain and elsewhere in the body. So far, four major classes of medications for hyperlipidemia are HMG-CoA reductase inhibitors (statins), bile acid sequestrants, nicotinic acid, and fibric acids. The statins can lower LDL and levels triglyceride, but may induce myopathy and an elevation of liver enzyme levels. The bile acid sequestrants lower LDL levels and raise HDL levels with no effect on triglyceride levels but side effects of gastrointestinal (GI) distress, constipation, and a decrease in the absorption of other drugs. Nicotinic acid and fibric acids lower LDL and triglyceride levels with showing flushing, hyperglycemia, hyperuricemia, GI distress, and hepatotoxicity dyspepsia, gallstones, myopathy, and unexplained noncardiac death as adverse effects. Above western drugs lower cholesterol by 15 to 30% while all have notable adverse effects. In traditional medicine, hyperlipidemia is regarded as retention of phlegm and fluid disease. Etiology and pathogenesis of hyperlipidemia is basically based on Spleen-Deficiency and Phlegm-Stagnation, accumulation and stasis of -heat, and Qi & blood stagnation induced by Phlegm-damp, water-dampness, and blood stasis. Thereby, strengthening Spleen and dissolving Phlegm, clearing away heat and diuresis, and supplementing Qi and activating blood circulation are commonly used therapeutic methods for hyperlipidemia. The traditional herbal medicine, have been used for patients with CVA, hypertension or hyperlipidemia in Oriental hospital or Oriental clinic. The lock and key theory is used to develop most of western medicine, however many diseases are caused by mixed factors in body-complex system. We expect that Oriental pharmacological theory could be newborn as a novel drug showing high advantage of blood levels of lipidsand QOL of performance without side effects.

靜脈血管內 低用量 He-Ne Laser 治療받은 腦梗塞 患者 20例에 對한 臨床考察

薛仁燦,金炳卓 대전대학교 韓醫學연구소 1997 한의학연구소 논문집 Vol.5 No.2

眩暈에 對한 文獻的 考察

설인찬,김병탁 대전대학교 韓醫學연구소 1996 한의학연구소 논문집 Vol.5 No.1

녹용의 임상 효능 및 이용

설인찬 한국양록협회 2002 한국양록 Vol.7 No.3

加味補陽還五湯이 高脂血症, 血栓, 高粘度血症, 高血壓 및 腦損傷에 미치는 影響

설인찬,김병탁 대한한방성인병학회 1998 韓方成人病學會誌 Vol.4 No.1

For the evaluation of effects of KBHT A including Salviae Radix and Achyranthis Radix, KBHT B including Mori Ramulus to KBHT A, experiments were done on hyperlipidemia induced by administration of cholesterol, thrombosis by dextran, hyperviscosity, hypertension and brain damage. The results were obtained as follows ; 1. In case of hyperlipidemia induced by cholesterol feed, serum cholesterol, triglyceride, and phospholipid were significantly decreased in both sample groups, while HDL-cholesterol and the number of platelets were significantly increased and also total lipid decreased only in sample B as compared with data of control. 2. In thrombosis by dextran, fibrinogen was significantly increased and aslo prothrombin time was significantly shortened in both sample groups, whereas numbers of platelet were significantly increased in sample A, but FDP was significantly decreased in sample B as compared with data of control. 3. In hyperviscosity by hydrocortisone acetate, fibrinogen, prothrombin time, viscosity of whole blood and serum were changed effectively with significance in both sample groups, while numbers of platelet and platelete aggregation were significantly increased in sample A and also hematocrit was decreased only in sample B as compared with data of control. 4. In experiment of hypertention, blood pressure was significnatly decreased in both sample groups on the first day after oral administration, while blood pressure was significnatly decreased in sample A on the 11th day after oral administration to SD rats as compared with data of control. 5. In damage of brain, shortening of coma duration by KCN, extension of suvival time to a lethal dose of KCN, extension of breathing time after decapitation and also after ligation of both common carotid arteries and extension of survival time after exposure to anoxia by Co2, N2 and vacuum pump were significantly exterted in both sample groups as compared with data of control. Above results suggest KBHT including Salviae Radix and Achyranthis Radix or Mori Ramulus has the posssiblty to be effectively applied to the cerebrocardiac diseases such as CVA and coronay diseases, which also need more clinical and experimental studies in future.

腦幹症候群患者 1例에 對한 臨床的 考察

安鍾石,薛仁燦 대전대학교 한방병원 2000 惠和醫學 Vol.9 No.1

A clinical study was carried out 1 case of patient for Brain-stem syndrome, who was treated in Dept of Oriental Internal Medicine Ⅱ, Oriental Medical Hospital, Taejon University. The results were as follows; 1. There is no identical name with this disease in Ancient Oriental Medicine books, but it is considered that it belongs to the category of Jung-Pung(中風). 2. In the view of oriental medicine, it was thought that channels and collaterals(經脈) are obstructed by DAMHWA(痰火)·O˘HYUL(瘀血), so DO-DAM-HWAL-HYUL-TANG(導痰活血湯) was used to GO˘YO˘HWA-DAM(祛瘀化痰) and U-HWANG-CHUNG-SIM-WHAN(牛黃淸心丸) to LYANGHAEYULDOK(凉解熱毒).

前胡藥鍼이 Ovalbumin-induced Asthma Mouse Model에 미치는 영향

노홍표,설인찬,김윤식 대한침구의학회 2005 대한침구의학회지 Vol.22 No.6

Objectives : The aim of this study was to investigate the effect of Peucedani Radix herbal acupuncture(PR-HA) at St36(joksamni) on ovalbumin-induced asthma in mice. Methods : C57BL/6 mice were sensitized and challenged with OVA(ovalbumin) for 12 weeks(once a week) C57BL/6 mice were injected, inhaled and sprayed with OVA for 12 weeks (3times a week). One of the two experimental groups was just treated with needle-prick on St36 and the other group was treated with 1% concentrations of PR-HAS at St36, for the later 8 weeks (3times /week). Results : 1. The weight and total cells of lung of the mice group treated with PR-HA decreased significantly compared with those of control group. 2. Total Leukocytes and Eosinophils in BALF of the mice group treated wtih PR-HA decreased significantly compared with those of control group. 3. Eosinophils in BALF of the mice group treated wtih PR-HA in Photomicrographs decreased significantly compared with those of control group. 4. According to Histological analysis of lung sections, it decreased significantly adhension of collagen in PR-HA than those of control group 5. The concentration of IgE, IL-4, IL-5, in BALF and IL-4, IL-5, Il-13 in serum of the mice group treated with PR-HA decreased significantly compared with that of control group. 6. The number of Gr-1+/CD11b+, CD11b+, CD3-/CCR3+, CD4+, CD3e+/CD69+ , CD23+/B220+ cells in the lungs of the mice group treated with PR-HA decreased significantly compared with those of control group. 7. The cytokine's manifestation of mRNA of the mice group treated with PR-HA with RT-PCR decreased significantly compared with that of control group. Conclusion : We conclude that PR-HA is effective on OVA-induced asthma of C57BL/6 mouse.

정천탕의 알러지에 대한 실험적 연구

손창규,설인찬 대한한의학회 2003 대한한의학회지 Vol.24 No.3

This report describes an inhibitory effect of Jungchuntang(JCT) on immediate hypersensitivity through IgE/mast cell/mediator pathaway. JCT is an Oriental herbal medication, which has been used for the treatment of allergic patients with espatially asthma in Korea. JCT significantly inhibited the IgE production in mice and IL-4 + anti CD40-mediated IgE production in vitro. JCT promoted IFN-expression but inhibited IL-4 and IL-6 mRNA expression. JCT dose-dependently inhibited the compound 48/80-induced histamine release from mast cell line, IC-2 cell. Thease results indicated that JCT has treatmentary effect on atopic disorder, such as asthma. 목적 : 정천탕(定喘湯, JCT)이 IgE/mast cell로 유도되는 천식(喘息)등의 알러지성 질환에 대한 효과를 실험적으로 검증하고자 하였다.

中風閉證에 對한 文獻的 考察

許美晶,薛仁燦,黃致元,安澤源 대전대학교 한방병원 1998 惠和醫學 Vol.7 No.1

The following results was obtained to study old books of oriental medicine about Sthenia-syndrome of apoplexy (中風閉證). 1. Sthenia-syndrome of apoplexy (中風閉證) and Collapse syndrome of apoplexy (中風閉證) was classifed by the "An Essential Medical Manual" at the first. Sthenia-syndrome of apoplexy(中風閉證) was classifed into yang-sthenia-synd rome(陽閉) and yin-sthenia-syndrome(陰閉) by recent literature. 2. The cause of Sthenia-syndrome of apoplexy(中風閉證) was "yang of wind stirring(中風閉證)" and "evil heat accelerating(邪熱亢盛)" due to "yin-deficiency of liver and kidney. The cause of yang-sthema-syndrome(陽閉) was "phlegm-fire shaking upside (痰火上援)" and "liver-wind stirring inside(肝風內動), The cause of yin-sthenia-syndrome(陰閉) was "mental disorder due to the stagnation of phlegm(痰濁內閉)" and "stagnation of phlegm-wetness(痰濕阻塞). 3. The syndrome of yang-sthenia-syndrome(陽閉) was severe headache, frequent vomiting, syncope, unconsciousness, trismus(牙關緊急), hands grasping(口臭), hemiparesis, seizure, facial color flushed, fever, snoring(鼻한氣粗), halitosis(口臭), fidgetiness(煩躁不寧), dysuria, constipation, bright red tongue (舌質紅絳), yellowish and dry fur(舌苔黃이而乾), pulse of smooth rapid or large(脈滑而數或洪大) etc. 4. The syndrome of yin-sthenia-syndrome(陰閉) was severe headache, dizziness, vomiting, facial color paled, syncope, unconsciousness, trismus(牙關緊急), hands grasping(兩水握固), hemiparesis, seizure, fidgetiness(靜臥不煩), cold limbs(四肢不溫), abundant expectoration(痰涎壅盛), snoring(鼻한), dysuria, constipation, black pale tongue(舌質暗淡), white pur(舌苔白니), pulse of sinking and smooth(脈象沈滑) etc. 5. The treatment of Sthenia-syndrome of apoplexy (中風廢證) was "clear away liver-fire and stop the winde(淸肝熄風), open the sensory organs(開竅), open the blocking(啓閉) by giving the first consideration to eliminate the evil factor(祛邪). 6. The treatment of yang-sthenia-syndrome(陽閉) was open the sensory organs of acrid flavour and warm nature(辛溫開竅), clear away liver-fire and stop the wind(淸肝熄風), clear away heat and disperse phlegm (淸熱化痰). The principal prescription of yang-sthenia-syndrome(陽閉) was YOUNGYANGGAKTANGGAGAM(羚羊角湯加感). 7. The treatment of yin-sthenia-syndrome(陰閉) was open the sensory organs of acrid flavour and cool nature(辛凉開竅), stop the wind by eliminatmg(辛痰熄風). The principal prescription of yin-sthenia-syndrome(陰閉) was CHUCKDAMTANG(??痰湯) 8. The principal drug of pill and powder was GIBODAN(至寶丹), WUHWANGCHUNGSIMHWAN(牛黃淸心丸) and cupuncture and moxibusdon therapy was points of open the sensory organs by wake up the patient from inconsciousness(醒腦開竅). The drug of injections was drugs of open the sensory organs by wake up the patient from inconsciousness(醒腦開竅) by refining and intravenous or intramuscular injection. 9. The first emergency measure was open the blocking(啓閉) and measure was Tracheotomy, measure of opening the blocking by acupuncture(鍼開閉方法) , measure of opening the sensory organs by drugs(藥物通竅方法), measure of nipping points(겹穴法), penetrating the nose(휵鼻法) etc. 10. The management of Sthenia-syndrome of apoplexy(中風閉證) was reducing movement, management of envimment, observation of the condition of a disease, mouth care, airway care, prevention of bed sore and infection, prevention of deformation of joints, management of emotion, management of urine and stool.

中風을 中心으로 한 東醫寶鑑 濕門의 處方 分析

최영,설인찬 대전대학교 한방병원 2000 惠和醫學 Vol.9 No.2

In the analysis of prescription in the Seup(濕) chapter of Donguibogam(東醫寶鑑), the following results were obtained. 1. According to the text, the efficacy of prescriptions is generaly to treat Seup(濕), and nothing to treat Pung(風). 2. The frequency of prescriptions is u˘ihakibmun(醫學入門), dangyesimbo˘b(丹溪心法), seu˘ideukhyobang(世醫得效方), u˘ihakjo˘ngjo˘n(醫學正傳) in sequence. 3. The classification of prescriptions by efficacy is haepyoyak(解表藥), boikyak(補益藥), cho˘ngyo˘lyak(淸熱藥), igiyak(理氣藥), isusamseupyak(利水渗濕藥), sahayak(瀉下藥), banghyanghwaseupyak(芳香化濕藥), onliyak(溫裏藥), etc. in sequence, and the prequency of used medicines is baekchul(白朮), changchul(蒼朮), bokryo˘ng(茯笭), go˘ngang(乾薑), hubak(厚朴), jinpi(陳皮), buja(附子), gangwhal(羌活), banha(半夏), etc., in sequence. 4. The so˘ng(性) of used medicines is mainly onso˘ng(溫性) and hanso˘ng(寒性), the mi(味) is sinmi(辛味), gomi(苦味) in sequence, the gwigyo˘ng(歸經) is bigyo˘ng(脾經), pyegyo˘ng(肺經), wigyo˘ng(胃經), singyo˘ng(腎經), gangyo˘ng(肝經), simgyo˘ng(心經), daejanggyo˘ng(大腸經), bangkwanggyo˘ng(膀胱經), etc., in sequence.