신체활동 정도 및 식이섭취에 따른 대장통과시간의 비교

송봉길 서울대학교 스포츠과학연구소 2010 스포츠과학리뷰 Vol.4 No.2

선진국을 중심으로 신체활동 부족으로 인한 대장암 발병위험에 대한 연구들이 수행되 고 있으며 국내의 경우에는 적절한 신체활동으로 인하여 장의 연동운동이 활발해지고 대장통과시간(colon transit time)이 단축된다고 보고되고 있다. 또한 대장통과시간(colon transit time)이 단축됨으로써 대변내의 발암물질과 장점막의 접촉시간이 감소되어 대장 암의 발생을 억제한다고 알려지고 있다. 이러한 연구들에 근거하여 신체활동과 대장암 의 연관성에 관하여 많은 연구들이 진행되고 있다. 또한 대장암의 위험요인 중 하나이 변비는 불균형적인 식이 섭취와 불규칙적인 식습관으로 인하여 나타나며 신체활동 감 소에 따라 유병률이 증가한다는 보고가 있다. 신체활동 및 식습관을 통하여 변비를 대 장암의 위험요인을 감소시킬 수 있다는 많은 연구들이 진행되고 있다. Studies on the risk of occurrence of colorectal cancer due to the lack of physical activity have been studied in many developed countries. It is reported that adequate physical activity makes active peristalsis of colon and shorten the colon transit time in domestic level. It is also reported that the occurrence of colorectal cancer can be suppressed by the reduction of contact time of carcinogen and intestinal mucosa in excrement by the consequence of shorten of colon transit time. Many studies are in progress based on the relationship between physical activity and colorectal cancer. There is a report that constipation which is the one of the potential risk factors in colorectal cancer can be occurred due to the irregular intake of diet and the reduction of physical activity.Many studies are in progress concentrating on reduction of the potential risk factors of colorectal cancer through physical activity and diet.

인간 폐암세포주 H-460세포에서 加減十全大補湯과 As2O3의 병용처리에 의한 항종양 증진효과

송봉길,원진희,김동웅,이종덕,문구 한의병리학회 2004 동의생리병리학회지 Vol.18 No.4

This study was designed to elucidate the synergistic cytotoxic mechanisms of the cotreatment of Gagamsibjeondaebo-tang (GSD) and As2O3 in human lung cancer cell line, H-460. The combination of GSD and As2O3 synergistically augmented the cytotoxicity of GSD and As2O3 in H-460 cells. The nature of cytotoxicity was revealed as apoptosis which was characterized by chromatin condensation and fragmentaton in DAPI staining. The apoptotic cytotoxicity of GSD and As2O3 was accompanied by the cleavage of PARP. Of note, the expression of pro-apoptotic BclXS protein was increased, but the expressions of Bax and BclXL was not affected in H-460 cells treated with GSD and As2O3. In addition, antioxidant NAC completely blocked the apoptotic death of H-460 cells by GSD and As2O3. In conclusion, this results suggest that the cotreatment of GSD and As2O3 induces the synergistic apoptotis of human large cell lung cancer cell line, H-460 via the induction of BclXS and reactive oxygen species (ROS).

팔물탕합화적환(八珍湯合化積丸)의 항종양(抗腫瘍) 효과(效果)에 관(關)한 연구(硏究)

송봉길,이건업,원진희,문구,문석재,소홍섭,박래길,김성진,Song, Bong-Gil,Lee, Gun-Up,Won, Jin-Hee,Moon, Gu,Moon, Seok-Jae,So, Hong-Sup,Park, Rea-Gil,Kim, Sung-Jin 대한한방내과학회 2000 大韓韓方內科學會誌 Vol.21 No.1

Objectives : The effects of cotreatment of adriamycin and ethanol extract of herb (Palgin-tang hab Hwajuck-hwan a traditional medicine for cancer treatment in oriental medicine) on the induction of apoptotic cell death were investigated in human liver origin cell lines, Chang. Methods : Chang(ATCC) liver cells were cultured in RPMI-1640(Gibco SRL Co, Gaithersburg, MD) badge including 10% fetal bovine serum. Chang liver cells were treated with various concentrations(from 10 to $0.16{\mu}l$) of adriamycin and herb extract(from 500 to $31.25{\mu}l$) After 48h later, the cells were tested for viability by Crystal violet staining assay. Adriamycin and Herb extract induced ladder pattern of DNA fragmentation in Chang cells. Genomic DNA was isolated and separated on 1.5% agarose gels. The DNA was stained with ethidium bromide and visualized under UV light. Results : The death of Chang cells was synergistically induced by the cotreatment of adriamycin and ethanol extract of herb. In addition, the cotreatment-induced cell death of Chang cells was mediated by apoptotic death signal processes. The phosphotransferase activity of JNK1 remained in a basal level in Chang cells which was treated individually with the adriamycin and ethanol extract of herb. However, it was markedly increased in Chang cells which was cotreated with adriamycin and ethanol extract of herb. In addition, the expression of Fas and FasL was markedly induced by the cotreatment of adriamycin and herb extract. For a while, the expression of Sax was a eminently increased by the ethanol extract of herb. However, Scl2 expression was not affected by the individual or cotreatment of adriamycin and herb extract. Conclusions : our results suggest that the cotreatment of adriamycin aM ethanol extract of herb induces synergistic apoptotis of human liver origin Chang cells via the upregulation of JNK, Fas, FasL and Bax.

인간 肺癌細胞柱 H-460세포에서 八珍湯合化積丸과 As₂O₃의 병용처리에 의한 항종양 증진효과

송봉길(Bong gil Song),원진희(Jin Hee Won),김동웅(Dong Woung Kim),이종덕(Jong Duk Lee),문구(Goo Moon) 한의병리학회 2004 동의생리병리학회지 Vol.18 No.3

齒痛의 病因 病機에 對한 文獻的 考察

송영림,송봉길,임낙철,노석선 대전대학교 韓醫學연구소 1996 한의학연구소 논문집 Vol.5 No.1

인터넷에서 사상체질 관련 자료 검색 및 분류

주종천,노현수,송봉길,이병호,박상구,이상민,Joo, Jong-Chon,Lo, Hyun-Soo,Song, Bong-Gil,Lee, Byung-Ho,Park, Sang-Gu,Lee, Sang-Min 사상체질의학회 2003 사상체질의학회지 Vol.15 No.2

The internet contains enormous informations in various fields and therefore called 'sea of information'. It helps obtain quickly health related information including 'constitutional medicine'. But a lack of evaluation and oversight appear to result in inaccurate and misleading. So by using a series of equipment and www.naver.com, www.yahoo.co.kr, www.empas.com, the typical search engine for internet, the sites are researched by keyword 'constitutional medicine'. The results were classified into six groups as follows; The sites about pratitional Oriental Medical Doctor, private home page, advertisements of goods for health, associations of constitutional medicine, astrology or reading fortune, and etc. The internet is a useful tool that gives informations of health, easy and speedy, to users like as doctors and patients. But accuracy or reliabillity of this informations is mistrust. Especially informations of health are connected to safty of life directly, they must be verificated by the specialist and a criterion, that evaluate the sites it self, should be established.

옻에 의한 全身性 接觸皮膚炎 1例에 대한 症例報告

조정연,원진희,강태희,이건업,송봉길,이상관 대한한방성인병학회 2000 韓方成人病學會誌 Vol.6 No.1

Systemic contact dermatitis may be produced by the systemic administration of a drug to an individual who has been previously sensitized by the topical application of the drug or related chemicals. Rhus is a hot and a warm property, and is toxic. In Korea, Combination of the rhus and chicken, as a traditional food, has been used for the treatment of diseases such as gastrointestinal disorders(peptic ulcer, gastritis etc), stomach chill, general weakness and so forth. We treated a 31 year-old male patient who complained of fever, chilling, itching, burning pain, edema and vesicle etc. he had frequent rhus dermatitis and took rhus with chicken before above symptoms occurred. He was diagnosed as systemic contact dermatitis due to rhus, and responded well to treatment with Hwabanhaedok-tang(化斑解毒湯) and steroid drug(predinisolone) etc.

한국 청소년의 체육수업 참여와 스트레스 인지와의 연관성

오정우(JungWooOh),권현진(HyunJinKwon),송봉길(BongKilSong),이온(OnLee),김연수(YeonSooKim) 한국체육학회 2013 한국체육학회지 Vol.52 No.3

이 연구의 목적은 한국 청소년의 체육수업 참여와 스트레스 인지와의 연관성을 분석하는 것이다. ‘제8차(2012년) 청소년건강행태온라인조사’원시자료를 이용하여 중ㆍ고등학생 74,186명을 분석하였다. 주당 체육수업 참여빈도와 스트레스 인지와의 연관성을 분석하기 위하여 복합표본설계 로지스틱 회귀분석을 실시하였고, 보정변인으로 학년, 학업성적, 가구풍요도, 주관적 체형인지, 부모동거여부, 폭력피해 등을 포함하였다. 남학생의 경우, 체육수업에 전혀 참여하지 않는 학생들을 기준으로 주당 1회, 2회, 3회 이상의 체육수업 참여빈도에 대해 각각 .885(95% confidence interval(CI) .823-.952), .807(.753-.864), .753(.706-.803)의 위험비를 나타내었다. 여학생의 경우는 주당 1회, 2회, 3회 이상의 체육수업 참여빈도에 대해 각각 .963(.901-1.030), .907(.849-.969), .879(.821-.941)의 위험비를 나타내었다. 남녀학생 모두 주당 체육수업 참여빈도가 증가할수록 스트레스 인지가 감소하였으며, 이는 체육수업 참여빈도가 증가할수록 스트레스를 인지하는 학생 수가 감소하는 것을 의미한다. 결론적으로, 한국 청소년들의 스트레스 인지 감소를 위하여 적극적인 체육수업 참여가 필요할 것으로 사료된다. This study aims to examine the association between physical education class frequency and perceived stress in Korean adolescents. The study used data obtained from the eighth(2012) Korea Youth Risk Behavior Web-based Survey, targeting a total of 74,186 middle and high school students. In order to investigate the relationship between physical education class frequency and perceived stress, we performed complex sample design logistic regression to calculate Odds Ratio(0R) and Confidence Interval(CI) after adjusting for school grade, academic achievement, family affluence, self-rated physique, living with both parents, and violence victimization. The OR(95% CI) for male students participating once, twice, and more than thrice PE class, as compared to nonparticipation, were .885(.823-.952), .807(.753-.864), and .753(.706-.803), respectively. In the case of female students, OR values were .963(.901-1.030), .907(.849-.969), and .879(.821-.941), respectively. Through the logistic regression analysis, we found that the more PE classes students attend, the more perceived stress was alleviated in both male and female students. These results mean that increased PE class leads to a decline in the number of adolescents who perceive stress. In conclusion, in order to reduce perceived stress of Korean adolescents, it may be necessary to encourage PE class participation.

복합 운동이 정신분열증 환자의 기초체력 및 우울 증상에 미치는 영향

류승호 ( Seung Ho Ryu ),송봉길 ( Bong Gil Song ),김연수 ( Yeon Soo Kim ),권현진 ( Hyun Jin Kown ) 한국특수체육학회 2015 한국특수체육학회지 Vol.23 No.1

본 연구의 목적은 복합운동 트레이닝이 정신분열증 환자의 기초체력과 우울증상에 미치는 영향을 규명하는데 있다. 연구 대상은 충청북도에 위치한 S정신병원에 입원중인 정신분열증 환자들로 의사의 진단아래 운동 프로그램에 참여하는데 지장이 없는 남성을 모집한 후, 본인과 보호자의 동의를 받은 대상자를 선정하여, 무선 할당으로 운동군(n=14), 비운동군(n=14)으로 나누었다. 운동은 탄성밴드와 걷기를 병행한 복합운동 프로그램으로, 하루 60분, 주 3회, 12주간 실시하였으며, 비운동군은 평소 생활 습관을 유지하도록 하였다. 모든 변인의 측정은 운동 프로그램 전과 후 총 2번에 걸쳐 실시되었으며, 측정항목으로 기초체력은 악력, 각근력, 순발력, 유연성, 심폐지구력을 측정하였고, 우울증상은 벡우울척도(Beck depression inventory)를 이용하여 측정하였다. 12주간의 복합 운동 중재 후, 운동군에서 악력과 각근력에서 유의한 차이가 나타났으며, 우울증상의 변화에 있어서도 유의한 차이를 나타났다. 하지만, 순발력, 유연성, 심폐지구력에서는 유의한 차이가 나타나지 않았다. 본 연구 결과, 탄성밴드와 걷기를 이용한 복합운동 프로그램은 정신분열증 환자의 근력을 향상시키고 우울 증상을 완화 시키는데 긍정적인 효과를 나타내어, 복합 운동 프로그램이 정신분열증 환자에게 적용 가능한 프로그램이라는 것을 검증하였으나, 정신분열증 환자들의 전반적인 체력 향상과 우울 증상의 유의한 개선을 위하여 추후 다양한 신체활동 프로그램에 대한 적용과 적절한 중재가 필요할 것으로 사료된다. The purpose of this study was to investigate the effects of a 12-week combined aerobic and resistance exercise program on physical fitness and depression in patients with schizophrenia. Twenty-eight male patients with schizophrenia were randomly assigned into two groups; combined exercise group (CEG, n=14) and the control group (COG, n=14). The exercise program consisted of group walking and Thera-Band resistance exercises in 60-min sessions, three times a week for a 12-week period. Physical fitness consist of grip, leg strengths, power, flexibility, cardiorespiratory fitness. A secondary condition was self-reported symptoms of depression, assessed with the Beck depression inventory. The significant level was P<0.05. After 12 weeks, the CEG group was significantly in strength (Grip and Leg). Also Beck Depression Inventory was significantly in the CEG group. But, power, flexibility, cardiorespiratory fitness, there were no significant by combine exercise. Therefore, This research shows that strength (Grip and Leg) and depression symptoms of the combined exercise group improved significantly in 12 weeks due to the exercises. Combined exercises should be included in rehabilitation in order to improve physical capacity and depression symptoms.

팔진탕합화적환(八珍湯合化積丸)과 Adriamycin의 병용처리시 나타나는 synergistic 항종양(抗腫瘍) 효과(效果)에 관(關)한 작용기전 연구(硏究)

문구,문석재,원진희,조정연,박상구,송봉길,박래길,이병구,Moon, Gu,Moon, Seok-Jae,Won, Jin-Hee,Cho, Jung-Yun,Park, Sang-Gu,Song, Bong-Gil,Park, Rae-Gil,Lee, Byung-Gu 대한한방내과학회 2000 大韓韓方內科學會誌 Vol.21 No.3

Objective : This study was designed to evaluate the synergistic effect on cytotoxicity of combination with adriamycin and Palginhonhapwhajucwhan, a traditional prescription for cancer treatment in oriental medicine, in Chang, HL-60, Hep-3B and Alexander cells. Methods : We observed cell viability in Chang, HL-60, Hep-3B, and Alexander cells by crystal violet staining. Those cells were treated with various concentrations of adriamycin alone, Palginhonhapwhajucwhan alone and combination of two medications for 10 hr. On condition of $0.5{\mu}l/ml$ adriamycin alone, $15.6{\mu}l/ml$ Paljintanghapwhajucwhan alone and combination of two medications, at first, we observed colony forming of Chang and HL-60 cells. Second, we observed DNA fragmentation by agarose electrophoresis in Chang, HL-60, Hep-38 and Alexander cells. Third, we measured the catalytic activation of caspase-1, 2, 3, 6, 8, and 9 protease in Chang cells and caspase-3 protease in Chang, HL-60, Hep-3B and Alexander cells by using fluorogenic substrate. Finally, we isolated mRNA of Fas in Chang, HL-60, Hep-38 and Alexander cells and observed that Fas gene was amplified by RT-PCR Results : 1. The combination of adriamycin and Palginhonhapwhajucwhan synergistically augmented the cytotoxicity of Chang and HL-60 cells whereas did not in Hep-38 and Alexander cells. 2. Cotreatment of two drugs also markedly inhibited the colony forming ability both in Chang and HL-60 cells. 3. The cytotoxicity of these medicatons was revealed as apoptosis characterized by high molecular wight DNA fragmentaton. 4. The apoptotic cytotoxicity was mediated by activation of caspase-3 protease in Chang cells. 5. Synergistic increase in apoptotic cytotoxicity by combination of two medications was dependent on the expression of Fas in cancer cells. Conclusions : Combination of adriamycin and Palginhonhapwhajucwhan significantly augmented apoptotic cytotoxicity of Fas-positive cells such as Chang and HL-60 cells via acticaton of apoptosis signaling pathway.