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피부질환에 상피세포내 Transglutaminase E 변동에 관한 면역조직화학적 관찰
조윤화,송계용,노병인,박상철 ( Yoon Whoa Cho,Kye Yong Song,Byung In Ro,Sang Chul Park ) 대한피부과학회 1991 大韓皮膚科學會誌 Vol.29 No.6
N/A The εN-(?-L-glutamyl)-L-lysine cross-links in cornified envelope of the stratum corneum are formed by specific enzymes termed transglutaminase(TG). TG are calcium dependent enzymes that catalyse an acyl transfer reaction. Among them transglutaminase E(TGE) type is distributed in the granular layer and is also known as termiral differentiation marker of keratinocyte. This study was done to observe the distrubution pattern of TGE in the epidermis of various skin diseases by immunohistochemical PAP method using antihuman TGE antibody. Results were as follows : 1. Staining reaction for the TGE is strongest in the granular layer of the normal epidermis-TGE positive keratinocytes numbers are increased in the thickened granular and upper stratum spinosum in the dermatoses accompanying acanthosis with orthohyperkeratosis wherease decreased of absent in the dermatoses accompanying ?canthosis with parakeratosis. Atrophic epidermis shows decreased TGE staining reaction. 2. Staining reaction for the TGE is negative or weakly positive in dysplastic or atypical keratinocytes. Nonkeratinizing squamous cell carcinoma cells are negatively stained whereas keratinizing cells are positively stained according to the degree of keratinizing. Basal cells, whether in benign or malignant conditions were very weakly or negatively stained. Therefore, immunohistochemical staining for the TGE reveals the most abundant distribution in the granular layer and upper spinous layer in normal conditions and shows variation in its distribution with processes related to acanthosis, cornification and its terminal differentiation of keratinocytes.
노용관 ( Yong Kwan Rho ),김연진 ( Yeon Jin Kim ),안지영 ( Ji Young Ahn ),서성준 ( Seong Jun Seo ),홍창권 ( Chang Kwun Hong ),송계용 ( Kye Yong Song ) 대한피부과학회 2007 대한피부과학회지 Vol.45 No.11
Adult xanthogranuloma is nearly indistinguishable from juvenile xanthogranuloma characterized by yellow-red nodules on the skin, normal lipid findings and the proliferation of xanthomatizied histiocytes with foamy Touton cells, histologically. But unlike juvenile xanthogranuloma, there is no visceral involvement, spontaneous regression and more solitary lesions. Multiple adult xanthogranulomas are rare entities that present more spontaneous involution. Here we report a case of a 39-year-old patient with multiple xanthogranulomas which developed on the face, trunk and extremities. Diagnostic workup revealed normal lipid profile and no extracutaneous manifestations. (Korean J Dermatol 2007;45(11):1176∼117)
노용관 ( Yong Kwan Rho ),유광호 ( Kwang Ho Yoo ),김지영 ( Ji Young Kim ),이갑석 ( Kap Sok Li ),서성준 ( Seong Joon Seo ),홍창권 ( Chang Kwun Hong ),송계용 ( Kye Yong Song ) 대한피부과학회 2009 대한피부과학회지 Vol.47 No.1
Epidermal nevi are harmatormas that are the result of developmental malformations of the epidermis, and these lesions present with a variety of clinical and histological characteristics. Some tumors can arise in epidermal nevi because epidermal nevi develop from multipotent germinative cells. We report here on a 57-year-old woman who had epidermal nevi arranged in a linear pattern since childhood. Her epidermal nevi were located in her left chest, arm and shoulder, upon which multiple trichillemal cysts seemed to develop after several years. We think that this patient with linear epidermal nevi associated with multiple trichilemmal cysts is a rare and distinctive case. (Korean J Dermatol 2009;47(1):55~58)
김용준 ( Yong Joon Kim ),서성준 ( Seong Jun Seo ),김명남 ( Myeung Nam Kim ),홍창권 ( Chang Kwun Hong ),송계용 ( Kye Yong Song ),노병인 ( Byung In Ro ) 대한피부과학회 1996 대한피부과학회지 Vol.34 No.5
Background: Dermatofihromas are relatively common benign tumors which occur in the skin. However, clinical and histopathological studies have been rarely reported in Korea. Objective : This study was taken to evaluate the clinical and histopathological features of dermatofibromas in Korea. Methods : Fifty cases of dermatofibromas were selected from 10 years of laboratory files for during the period January 1985 to December 1994 at Chung Ang University Hospitals. Results : 1. The age range was from 18 to 61 and the average age at diagnosis was 38.7(male;37.6, female;39.4). The ratio of male to female was 1.0: 1.6(19:31). 2. The diameter of the dermatofibromas : 1) 5-20mm;32 cases(64.0%), 2) 5mm>;8 cases(16.0 %), 3) 20mm<;7 cases(14.0%), 4) unrecorded;3 cases(6.0%). 3. The most common color was brown(14 cases, 28.0% ), and other common colors were skin-color(7 cases, 14.0%), red(4 cases, 8.0%), black(3 cases, 6.0%), violaceous(2 cases, 4.0%), unknown(20 cases, 40.0%). 4. Thirty seven cases(74.0%) had solitary lesions, and thirteen cases(26.0%) had multiple lesions. 5. The lower extremeties(39 cases, 50.6%) were the most common sites followed by the back (10 cases, 13.0%), upper extremities(9 cases, 11.7%), shoulders(8 cases, 10.4%), abdomen(4 cases, 5.2%), hands(2cases, 2.6%), face(2 cases, 2.6%), neck(2 cases, 2.6%), breast(1 case, 1.3%). 6. Histopathologically, fibrous types were seen in 40 cases(80.0%), cellular types in 3 cases(6.0 %), mixed types in 5 cases(10.0%), and sclerosing hemangiomas in 2 cases(4.0%). Conclusion : The 50 cases of dermatofibromas, which were confirmed at Chung Ang University Hospitals from January 1985 to December 1994, were reviewed clinically and histopathologically. (Kor J Dermatol 1996;34(5): 769-774)
조광현,송계용,조미경,이유신,함의근 ( Kwang Hyun cho,Kye Yong Song,Mi Kyung Cho,Yoo Shin Lee,Eui Keun Ham ) 대한피부과학회 1988 大韓皮膚科學會誌 Vol.26 No.3
A histopathological study of erythema nodosum-like lesions in Behcet's disease was performed on 55 patients with incomplete and suspect types of Behcet's disease. Relatively common characteristics in histopathology of erythema nodosum-like lesions could be found in the patients with incomplete type of Behcet's disease. The histopathologic findings of erythema nodosum-like lesions in 21 patients with incomplete type of Behcet's disease were as follows : l. A moderate lymphocytic infiltration was found around the blood vessels and the sweat glands in the dermis. In the subcutaneous tissue, besides lymphohistiocytic infiltration, neutrophils were present in significant number in 9 cases (42.9%) 2. Vasculitis of small vessels was found within the periphery of fat lobules in 7 cases (81.0%), Five cases (23.8%) also showed thrombophlebitis. Seven cases (33.3%) showed histiocytic granuloma formation within the fat lobules. Microabscess formation in the subcutaneous tissue was seen in 5 cases (23.8 %), but it was not certain whether this was the charateristic feature.
김용준 ( Yong Joon Kim ),김명남 ( Myeung Nam Kim ),홍창권 ( Chang Kwun Hong ),송계용 ( Kye Yong Song ),노병인 ( Byung In Ro ) 대한피부과학회 1996 대한피부과학회지 Vol.34 No.5
Microcystic adnexal c~arcinoma(MAC) is an unusual carcinoma of eccrine glands, composed of pilar and: weat. duct structures. We report here a 64-year-old man with MAC on his left cutaneous upper lip. Microscopically, the tumor consisted of nests and gland-like str~i~ictures within desmoplastic stroma, and it stained positively for carcinoembryonic antigen. The clinical appearance and histopathologic findings of t,he tumor may be mistaken for other benign and malignant entities. The patient was treated with excision and skin flap, and no recurrence over a 31-month follow up period. (Kor J Dermatol 1996;34(5): 823-826)
노용관 ( Yong Kwan Rho ),유광호 ( Kwang Ho Yoo ),김지영 ( Ji Young Kim ),이갑석 ( Kap Sok Li ),서성준 ( Seong Joon Seo ),홍창권 ( Chang Kwun Hong ),송계용 ( Kye Yong Song ) 대한피부과학회 2008 대한피부과학회지 Vol.46 No.12
Spindle cell lipoma is a benign, subcutaneous neoplasm typically located on the neck, back and shoulder of men. Pseudoangiomatous spindle cell lipoma is a rare variant of spindle cell lipoma that is characterized by non-vascular branching spaces. A 64-year old man presented with 2 masses on the abdomen. Although 1 tumor had a very low fat component, it could be histologically diagnosed as pseudoangiomatous spindle cell lipoma due to CD 34 positive spindle cells, ropey collagen and blood vessels. We report a case of pseudoangiomatous spindle cell lipoma on the abdomen, which was diagnostically difficult due to a scanty fat component. (Korean J Dermatol 2008;46(12):1644∼1647)
전태진,김명남,송계용,노병인 ( Tae Jin Chun,Myeung Nam Kim,Kye Yong Song,Byung In Ro ) 대한피부과학회 1991 대한피부과학회지 Vol.29 No.5
Verrucous hemangioma is a variant of a capillary, carvernous, or mixed hemangioma which undergoes a reactive proliferative epidermal change. We report two cases which showed clinical and histopathologic findings of verrucous hemangioma. In both cases, reddish hemangiomatous lesions were present since birth and were verrucous crusty lesions of the right lower extremity. Skin biopsy revealed hyperkeratosis, acanthosis, and papilomatosis of the epidermis and proliferation and dilatation of capillaries in the upper dermis in addition to the capillary hemangioma in the deep dermis and subcutis.
김윤경,이제현,송계용,박성규,김정숙,Kim, Yun-Kyung,Lee, Je-Hyun,Song, Kye-Yong,Park, Seong-Kyu,Kim, Chung-Sook 대한한의학방제학회 2005 大韓韓醫學方劑學會誌 Vol.13 No.1
Objective : This study was carried out to evaluate the liver toxicities of Wild Aconiti Tuber decoction. Methods : The amounts of aconitine in the methanol extract of Wild Aconiti Tuber was measured by HPLC. Safeties was studied by LD50 in mice. Liver toxicities were evaluated histologically and by CBC, blood chemistry after 2 weeks of 0.4g/kg/day clinical dosage oral administrations in rat. Results : 1. The amounts of aconitine in the methanol extract of Wild Aconiti Tuber is $1.697{\pm}0.052mg/g$. But aconitine was not detected in the water decoction of Wild Aconiti Tuber. 2. To evaluate LD50 and safeties of Wild Aconiti Tuber decoction, ICR mice were given high dose of 2, 5, 10g/kg for single time and were observed for 2 weeks. There were no dead animal and abnormal clinical sign and no abnormalities at the autopsy. So, LD50 was admitted to higher than 10g/kg. 3. After 2 weeks of 0.4g/kg/day clinical dosage oral administrations in rat, there was no significant change in the CBC and blood chemistry. 4. In the liver tissues of clinical dosage, mitotic figures, apoptosis and individual cell death were observed, but clear liver toxicities like fatty liver or necrosis were not observed. the liver tissues of high dose in mice, hydropic changes were getting severe as dose grows. Conclusions : According to the results, though aconitine was not detected in the Wild Aconiti Tuber decoction, 0.4g/kg/day 2 weeks p. o (clinical dosage) group showed weak changes in the liver tissues and high dose group showed liver toxicities like hydropic changes.