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양종규,김성욱,백승철,김정원,박석영 ( Jong Kyu Yang,Sung Wook Kim,Seung Churl paik,Chung Won Kim,Suk Young Park ) 대한피부과학회 1997 대한피부과학회지 Vol.35 No.4
Angiocentric T-cell lymphoma is a subtype of peripheral T-cell lymphoma and histologically characterized by angiocentric and angioinvasive infiltration of lymphoid cells with varying degrees of cytological atypia, leading to angiodestruction. This disease represents the malignant end in the histological spectrum of angiocentric immunproliferative lesions. This malignancy is commonly a disease with considerable morbidity and is often fatal. However, primary cutaneous angiocentric T-cell lymphoma has a tendency to give a favorable prognosis. Epstein-Barr virus can be identified in involved tissue by immunostaining or by in situ hybridization and it is considered significant in the prognosis. We report a case of cutaneous angiocentric T-cell lymphoma, where the Epstein-Barr virus was identified within neoplastic cells. CVP(cyclophosphamide, vincristine, prednisone) chemotherapy was instigated and an initial complete remission was achieved. (Kor J Dermatol 1997;35(4): 772-777)
양종규,김성욱,백승철,김정원,김석영 ( Jong Kyu Yang,Sung Wook Kim,Seung Churl Paik,Chung Won Kim,Suk Young Kim ) 대한피부과학회 1997 대한피부과학회지 Vol.35 No.3
Iatrogenically developed immunosuppression-associated Kaposis sarcoma is the result of immunosuppressive therapy after an organ transplantation, particularly after a renal transplantation. Since the advent of powerful immunosuppressive agents such as cyclosporine, recently the incidence of Kaposis sarcoma has been increased. In addition to immunosuppression, other factors, such as genetic predisposition, environmental and geographic factors, and oncogenic viruses, may play a role in the pathogenesis of this tumor. Ilerein we report a case of Keposis sarcoma with multiple organ involvement of the skin, lung, small intestine and mesenteric lymph node in a renal allograft recipient who received cyclosporine and prednisolone. Reduction of the dosage of immunosuppressant for 1 month resulted in improvement of the cutaneous lesions. (Kor J Dermatol 1997;35(3): 551-555)
양종규 ( Jong Kyu Yang ),이상진 ( Sang Chin Lee ),김시용 ( Si Yong Kim ),김정원 ( Chung Won Kim ) 대한피부과학회 1998 大韓皮膚科學會誌 Vol.36 No.3
Background: The majority of Staphylococcus aureus strains isolated from atopic eczema skin produce toxins like enterotoxin B or toxic shock syndrome toxin-1(TSST-1) as a superantigen and these toxins may contribute to the exacerbation of this skin disease. Objective :We designed this study in order to investigate the effect of toxic shock syndrome toxin-1 on IL-4, interleukin-10(IL-10), interleukin-12(IL-12) and IFN- r production by peripheral blood mononuclear cells from normal and atopic patients. Methods : Peripheral mononuclear cells obtained from ten patients with severe atopic dermatitis and ten healthy volunteers were stimulated with TSST-1 and cultured for 4 days. The amount of IL-4, IL-10, IL-12 and IFN- r in the culture supernatants were determined by a solid-phase enzyme- linked immunosorbant assay. Results: l. After stimulation with TSST-1, IL-4, IL-10, IL-12 and INF- r, production of peripheral mononuclear cells from both atopic patients and healthy volunteers were increased. 2. After stimulation with TSST-1, the amount of IFN- r in the culture supernatants was significantly greater in the healthy controls than in the atopic patients. 3. After stimulation with TSST-1, the amount of IL-10 in the culture supernatants was significantly greater in the healthy controls than in the atopic patients. Conelusion : This data indicates that TSST-1 induces Thl-type and Th2-type cytokines associated with parallel Thl and Th2 stimulation in atopic patients and healthy donors. In addition, peripheral mononuclear cells from atopic patients have a diminished capacity to synthesize IFN- r and IL-10 in vitro in response to stimulation with TSST-1. Our results suggest that TSST-1 is not considered as a really important aggravating factor in atopic dermatitis. (Korean J Dermatol 1998;36(3): 385-390)
양종규 ( Jong Kyu Yang ),이현정 ( Hyun Jeong Lee ),백승철 ( Seung Churl Paik ),조백기 ( Baik Kee Cho ) 대한피부과학회 1996 대한피부과학회지 Vol.34 No.5
Delusions of parasitosis is a type of monosymptomatic hypochondrial psychosis and is defined as the fixed belief that one is infested with living organisms, in t.he abscence of any objective evidence that such infestation exists. A 43 year-old woman had a 2-month history of generalized pruritus and skin ulceration on the buttock representing dermatitis artefacta. She also complained of seeing small black insects crawling on her whole body skin, especially on the pubic area without evidence of cutaneous invasion by the parasites. She had no evidence of other medical diseases. She was treated with oral pimozide, starting with 1mg/day to 3mg/day. In two weeks, clinical symptoms and false belief that she is infested with parasites subsided. (Kor J Dermatol 1996;34(5): 856-860)
권오찬 ( Oh Chan Kwon ),양종규 ( Jong Kyu Yang ),윤두희 ( Dou Hee Yoon ),김태윤 ( Tae Yoon Kim ),김형옥 ( Hyung Ok Kim ) 대한피부과학회 1998 대한피부과학회지 Vol.36 No.3
Progressive zosteriform macular pigmented lesion(PZMPL) is a chronic pigmentary dermatosis similar to progressive cribriform and zosteriform hyperpigmentation(PCZH). This dermatosis described by Simoes in 1980 is characterized by a uniformly tanned macular pigmented lesion in a zosteriform distribution preceded by multiple pruritic macular pigmentation in a part of the dermatome for a period. PZMPL is not a fully understood disease entity but it is thought to be a variant of PCZH. It is differentiated from PCZH by accompanying pruritus as a prodromal symptom, a characteristic clinical course, and histological findings such as pigmentary incontinence. We report herein a case of PZMPL in a 17 year-old girl with the pigmentary skin lesion extending from the left forearm to the left chest along the Blaschkos line. The histological findings revealed increased melanin pigments in the basal layer and focal pigmentary incontinence in the upper dermis. To our knowledge, this case is the first report of PZMPL in korea thought to be the same case reported by Simoes. (Korean J Dermatol 1998;36(3): 456-459)
Pityriasis Rotunda with Familial Occurrence
이동원,조백기,양종규 대한피부과학회 1997 Annals of Dermatology Vol.9 No.3
Pityriasis rotunda is an uncommon chronic dermatosis characterized by multiple, round or oval, hyperpigmented or hypopigmented patches that have a fine scale on the trunk and extremities. Most of the cases reported predominantly occurred in Oriental and black patients in association with internal disease. However, in Caucasians it has been documented in healthy persons usually as a familial tendency. We report a case of pityriasis rotunda which showed familial occurrence and had no underlying disease.
A Case of Cutaneous Protothecosis
김태윤,박영민,김형옥,장인강,양종규,김중원 대한피부과학회 1996 Annals of Dermatology Vol.8 No.1
Protothecosis is a rare cutaneous soft tissue infection caused by the genus prototheca, most commonly Prototheca wickerhamii. An 80-year-old woman has had a painful or tender, non-healing, eczematous plaque on the extensor surface of the left forearm for 4 years. A biopsy specimen revealed the characteristic thick-walled morulalike sporangia in the dermis. P. wickerhamii was isolated in the culture and the biochemical studies. Electron microscopic examination showed the thick-walled spores containing dark dense bodies and amyloplasts. Oral itraconazole therapy for 4 weeks resulted in a marked improvement of the skin lesion.
거대 우췌상 desmoplastic Spitz 모반 1예
송계용,이종육,박철종,양종규,현정선 대한피부과학회 2000 大韓皮膚科學會誌 Vol.38 No.5
Desmoplastic Spitz nevus is a distinct histological variant of Spitz nevus characterized by thick desmoplastic stroma, nevus cells with intranuclear invaginations of cytoplasmic material, and little or no junctional activity, nest formation and melanin pigment. We, herein, present a 40-year-old man with an asymptomatic, 1.7×1.5×0.9cm, dark brown to black verrucous tumor of a 2-year duration on his left earlobe, posterior aspect. Histopathologic examination shows thick desmoplastic stroma, nevus cells with intranuclear invaginations of cytoplasmic material, junctional activity, nest formation, and melanin pigment.
김성욱,김정원,백승철,양종규,양지호 대한피부과학회 1997 Annals of Dermatology Vol.9 No.1
Cobb syndrome is a rare neurocutaneous angiomatosis characterized by a vascular skin nevus associated with a spinal cord angioma of the same metamere. A 14-year-old girl had an asymptomatic large cutaneous hemangioma distributed from the T1 dermatome downward to the L3 dermatome since birth and complained of a gait disturbance and urination difficulty for 1 year. A biopsy specimen in the skin lesion revealed the findings of capillary hemangioma. From C7 downward to L4 posterior epidural hemangioma composed of arteriovenous and cavernous components was diagnosed by radiological examination and surgical exploration. Because of very extensive cord hemangioma, only partial removal of the tumor at T11, T12 and L1 level was performed and postoperatively she was transferred to a special facility for rehabilitative therapy.