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이종육(Jong Yuk Yi),조백기(Baik Kee Cho),허원(Won Houh),심상인(Sang In Shim) 대한피부과학회 1987 대한피부과학회지 Vol.25 No.1
We report herein a case of lymphomatoid papulosis in a 23-year-old female who had recurrent erythematous pinhead to pea sized papules and nodules on the both inner thighs and forearms for 4 years. Some lesions showed central hemorrhagic necrosis or scale formation. Individual lesions persisted for several months and showed spontaneous regression leaving pigmentation or depigmented atrophic scar. Histopathologically, there was marked cell infiltration, especially in the dermoepiderrnal junction and perivascular area. Infiltraled cells consisted of sorne ncutrophils and numerous atypical cells that had variable sized and irregular shaped nuclei. Electronmicroscopically, some atypical cells had cerebriform nuclei with marked peripheral condensation of chromatin and cytoplasm contained a few organelles, many polyribosomes and some dense bodies.
피부사상균증에 대한 Itraconazole 경구요법의 임상연구 - 공동연구 -
이종육 ( Jong Yuk Yi ),조백기 ( Baik Kee Cho ),윤재일 ( Jai Il Youn ),김진우 ( Jin Woo Kim ),전재복 ( Jae Bok Jun ),허충림 ( Choong Rim Haw ),박의수 ( Eui Soo Park ),신용우 ( Yong Woo Cinn ),김수남 ( Soo Nam Kim ),김계정 ( Kae Jeu 대한피부과학회 1989 大韓皮膚科學會誌 Vol.27 No.3
Itraconazole is the first orally active triazole antifungal agent. Authors performed multicenter trials to evaluate the therapeutic effect of itraconazole in dermatophytoses. During 6 months from September, 1988 to February, 1989, 246 patients with dermatophytoses were included in this study. 74 of these cases lost to follow-up and 3 cases developed drug eruption were excluded from analysis of therapeutic efficacy. Duration of therapy were 4 weeks in tinea pedis and tinea manus, and 2 weeks in tinea cruris and tinea corporis. The obtained results were as follows : 1. The everall cure rate of itraconazole in dermatophytoses were 81.3%, and the cure rate in each dermatophytosis were 80.3% in tinea pedis, 100.0% in tines manus, 85.3% in tinea cruris and 68.6% in tinea corporis. 2. The cure rate at two weeks after completion of the therapy(81.3%) was higher than that at the end of the therapy(74.3%). 3. Trichophyton rubrum(70.0%), Trichophyton mentagrophytes(81.3%), Microsporum canis(7.3%) and Epidermophyton floccosum(0.9%) were isolated from 110 cases among the enrolled patients. 4. Seven of the 190 patients experienced adverse effects of the treatment: abdominal discomfort(one); nusea(one); constipation(two); and drug eruption(three). Therefore we impressed that itraconazole is an effective and safe new oral therapeutic: agent for dermatophytoses.
바이러스 감염성 피부 질환에 대한 재조합 알파 인터페론 연고의 치료 효과에 관한 연구 - 공동연구 -
이종육(Jong Yuk Yi),조백기(Baik Kee Cho),허원(Won Houh),이규석(Kyu Suk Lee),신용우(Yong Woo Cinn),김선훈(Seon Hoon Kim),최영자(Young Ja Choi),이일수(Eil Soo Lee) 대한피부과학회 1987 대한피부과학회지 Vol.25 No.3
A study evaluating the therapeutic effect of recombinant interferon-a ointment on several viral skin diseases was done. A total of 204 patients, 92 of herpes simplex, 90 of herpes zoster and 22 of varicella, were included in this study. Two different concentration of recombinant interferon-a ointment(l*10IU/g; group A, 1*10IU/g; group B) and placebo vehicle(control group) were applied topically on the early lesion of the disease. The evaluation of therapeutic effect was done by the measurement of time interval from the day of vesicle formation to the day of crust formation, The results were as follows; 1. Herpes sirnplex: Crust formation observed within 6 days in 70. 1% of group A. 63.9% of group B and 26.7%, of control group. The time of crust formation of group A and B was shorter than that of control group (p<0.01, P<0.05). 2. Herpes zoster: Crust formation observed within 10 days in 64. 3% of group A. 46.7% of group B and 33. 3% of control group. The time of crust formation of group A was shorter than that of control group (p<0.05). 3. Varicella: Crust formation observed within 6 days in 87. 5% of group A, 72.7% of group B and 66.7% of control group. Therefore we have been impressed that recombinant interferon-a ointment is an effective topical therapeutic agent and 1*10IU/g recombinant interferon-a clintment is more effective than 1*10IU/g recombioant interferon-a ointment for above viral skin diseases.
피부암 및 피부암 전구증에서의 Acid Stable Trypsin Inhibitor ( ASTI ) 의 발현양상에 관한 연구
이종육 ( Jong Yuk Yi ),이동원 ( Dong Won Lee ),윤두희 ( Dou Hee Yoon ),조백기 ( Baik Kee Cho ),강창석 ( Chang Suk Kang ),이황희 ( Hwanghee Blaise Lee ),장원희 ( Won Hee Jang ),유욱준 ( Ook Joon Yoo ) 대한피부과학회 1996 대한피부과학회지 Vol.34 No.2
Background: Recently, much attention has been focused on the role of protease inhibitors such as acid stable trypsin inhibitor (ASTI) in the invasive growth of malignant tumors. However, there are no report on expression of ASTI from premalignant and/or malignant skin tumors. Objectives : In the present study the expression of ASTI was investigated in the different type of premalignant and/or, malignant skin tumors in attempt to clarify the relation between the expression of the ASTI and malignancy. Methods : For the detection of ASTI in the tumor tissue, the immunoperoxidase techniques that used mouse antibody raised against highly purified ASTI. The degree of ASTI immunoreactivity was semiquantitatively assessed for staining intensity as the percentage of ASTI-positive cells. Results : ASTI immunoreactivity was detected in most of the premalignant and malignant skin tissues. Especially, ASTI expression was present widespread in squamous cell carcinoma(SCC) with strong cytoplasmic membrane, where as in normal epidermis they were primarily present in the horny layer. The strong staining was the SCC, keratoacanthoma, Bowen's disease, actinic keratosis, basal cell epithelioma, Paget's disease in decreasing order. The significant difference in the staining intensity was observed between SCC and other groups. Conclusion : Results of immunohistochemical studies suggest that the tumor cells themselves could produce ASTI. Considering the suggestion that ASTI is a self protector, inhibitor to proteolytic protease as well as growth-stimulating factor. The present findings may indicate that ASTI expressed in malignant cells may play a role possibly closely associated with tumor development. (Kor J Dermatol 1996;34(2): 179-184)
이종육(Jong Yuk Yi),박천욱(Chun Wook Park),조백기(Baik Kee Cho),허원(Won Houh) 대한피부과학회 1986 대한피부과학회지 Vol.24 No.4
Numerous burrows developed in a 20-year-old male student who had been terated with topical fluorinated corticosteroid for 2 months. The number of burrows is the largest on scrotum(15/cm) and then interdigital web(10/cm), finger (7/cm), wrist (7/cm), penis (5/cm), abdomen (5/crn) and dorsurn of hand (5/cm) in decreasing order. The itch mites were also collected by brushing the skin surface and clotbes. Metronidazole was tried in this case, but living itch mites were still found at 7th day of treatment. No living itch mites were found after topical application of benzyl benzoate solution and crotamiton cream for 3 consecutive days.
문신의 임상 및 병리조직학적 연구 - 제2보 병리조직학적 연구 -
이종육(Jong Yuk Yi),김진우(Jin Wou Kim),조백기(Baik Kee Cho),허원(Won Houh) 대한피부과학회 1987 대한피부과학회지 Vol.25 No.5
Twenty six individuals with tattoos, who were seen during physical examination for conscription from Febrary to May, 1985, were biopsied for a histopatholigical study of tattoos. The results were as follows ; 1. There was perivascular deposition of pigment in all cases. 2. There cases showed deposition only in the upper dermis. 3. Six cases showed deposition in the upper and lower dermis. 4. Five cases showed deposition around the eccrine glands and two around the sebaceous glands. 5. Six cases showed mild lymphohistiocytic infiltrations in the dermis. 6. There was no difference in size of the particles regardless of infiltrated areas and tattoo materials.
가족력을 동반한 Piezogenic Pedal Papules
이종육(Jong Yuk Yi),박천욱(Chun Wook Park),최국주(Guk Joo Choi),조백기(Baik Kee Cho),허원(Won Houh) 대한피부과학회 1986 대한피부과학회지 Vol.24 No.4
We present herein a case of painless piezogenic pedal papules occurring on the both heels of 25-year-old female patient, Histopathologic findings showed normal adipose tissue surrounded by loose fib- rous tissue in the nid-dermis and thickening of venous wall. Hyalinized thick collagen bundles were distributed below the herniated adipose tissue in the nodu- lar pattern. Her parents, one brother and sister had the sarne clinical features.
이종육(Jong Yuk Yi),박천욱(Chun Wook Park),김영환(Yung Hwan Kim),김형옥(Hyung Ok Kim),김정원(Chung Won Kim) 대한피부과학회 1986 대한피부과학회지 Vol.24 No.1
We have recently experienced a case of cysticercosis treated with praziquantel. The patient, 22-year-old female, with 43 cystic masses had marked clinical response to the administration of praziquantel (75 mg/kg/day) for 7 days. It seems that praziquantel, anticestodal agent, might be a safe and effective therapy for this infection.
박현정,박철종,이종육,김형옥,이은정 ( Hyun Jeong Park,Chul Jong Park,Jong Yuk Yi,Hyung Ok Kim,Eun Jeong Lee ) 대한피부과학회 1997 대한피부과학회지 Vol.35 No.4
Subungual squamous cell earcinoma is an uncommon disease. Diagnosis of this condition is often delayed because of a resemblance to a variety of benign inflammatory conditions such as onychomycosis, chronic paronychia, eczema, and verruca vulgaris. The importance of an early skin biopsy for a chronic nonhealing subungual lesion is stressed. We present a case of subungual squamous cell carcinoma iri a 75-year-old man who had a 3-year history of intermittent swelling, erythema, and tenderness on the left 5th toe. The patient complained of a tender whitish verrucous 1.5cm-sized mass which had been present for a few months. A Histopathological study revealed invasive, well differentiated squamous cell carcinoma. (Kor J Dermatol 1997;35(4): 790-793)