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피부질환에 상피세포내 Transglutaminase E 변동에 관한 면역조직화학적 관찰
조윤화,송계용,노병인,박상철 ( Yoon Whoa Cho,Kye Yong Song,Byung In Ro,Sang Chul Park ) 대한피부과학회 1991 大韓皮膚科學會誌 Vol.29 No.6
N/A The εN-(?-L-glutamyl)-L-lysine cross-links in cornified envelope of the stratum corneum are formed by specific enzymes termed transglutaminase(TG). TG are calcium dependent enzymes that catalyse an acyl transfer reaction. Among them transglutaminase E(TGE) type is distributed in the granular layer and is also known as termiral differentiation marker of keratinocyte. This study was done to observe the distrubution pattern of TGE in the epidermis of various skin diseases by immunohistochemical PAP method using antihuman TGE antibody. Results were as follows : 1. Staining reaction for the TGE is strongest in the granular layer of the normal epidermis-TGE positive keratinocytes numbers are increased in the thickened granular and upper stratum spinosum in the dermatoses accompanying acanthosis with orthohyperkeratosis wherease decreased of absent in the dermatoses accompanying ?canthosis with parakeratosis. Atrophic epidermis shows decreased TGE staining reaction. 2. Staining reaction for the TGE is negative or weakly positive in dysplastic or atypical keratinocytes. Nonkeratinizing squamous cell carcinoma cells are negatively stained whereas keratinizing cells are positively stained according to the degree of keratinizing. Basal cells, whether in benign or malignant conditions were very weakly or negatively stained. Therefore, immunohistochemical staining for the TGE reveals the most abundant distribution in the granular layer and upper spinous layer in normal conditions and shows variation in its distribution with processes related to acanthosis, cornification and its terminal differentiation of keratinocytes.
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