한방병원에 입원한 소아.청소년 환자에 관한 임상적 연구

손미주,한재경,김윤희,Son, Mi-Ju,Han, Jae-Kyung,Kim, Yun-Hee 대한한방소아과학회 2011 대한한방소아과학회지 Vol.25 No.2

Objectives: The purpose of this study is to investigate clinical features of children and adolescents patients admitted to the oriental medical hospital. Methods: The study composed of 1284 inpatients aging from 0 to 19 who had been admitted in 4 oriental medical hospitals located in Daejeon and Chungcheong. Results: 1. In this study, 688 boys and 715 girls were examined, giving the ratio of 0.96:1. Average age of the children and adolescents was 11.5, and the number of inpatients has increased as getting older. 2. The percentage of children and adolescents inpatients has increased every year : 9.1% in 2005, 13.0% in 2006, 13.8% in 2007, 16.3% in 2008, 18.0% in 2009, with 22.2% in 2010, 7.8% until May 2011. The month scored the highest admittance was December and the lowest was March. 3. In systemic division, the musculoskeletal system was the most common, followed by neuromuscular system, respiratory system, digestive system, psychological system, and nervous system. 4. Most patients have admitted in acupuncture & moxibustion department, followed by oriental pediatrics, oriental rehabilitation medicine. 5. In Pediatrics, 196 boys and 166 girls were admitted. The age distribution showed that 6.4% were in infancy, 43.6% in preschool period, 30.1% in prepuberal period, 18.8% in early puberty and 1.1% in late puberty. The percentage of pediatrics inpatients has increased every year. Conclusions: More data of patients should be collated for further study. More detailed study with different kinds of diseases are expected based on this study.

Bu-Zhong-Yi-Qi-Tang for atopic dermatitis: A systematic review of randomized controlled trial

손미주,김안나,정지연,김영은 한약정보연구회 2022 한약정보연구회지 Vol.10 No.1

This systematic review aimed to assess the clinical evidence supporting the use of an herbal drug, Bojungikgi-Tang (BIT) for the treatment of atopic dermatitis (AD). Eleven databases, including PubMed, EMBASE, and the CENTRAL, were searched from their inception to December 2019. All randomized controlled trials that reported on the effects of BIT on AD, without language restrictions, were included. The methodological quality of and risk of bias in the trials were assessed using the Cochrane Collaboration tool. We identified 2,674 studies, of which two met the inclusion criteria. The overall risk of bias in the included trials was relatively low or unclear. There were statistically significant improvements in the oozing and crust score (p=0.04) and total equivalent amount (TEA) of topical agents (p=0.02) in the BIT group in comparison to those in the placebo group. The evidence suggests that BIT can significantly reduce the oozing and crust symptoms and TEA of topical agents compared with placebo. However, the limited number of trials and the small effect size make it difficult to draw firm conclusions. Trial registration number: CRD42018105173

RBL-2H3 비만세포의 알레르기 염증 반응에 미치는 생료사물탕(生料四物湯)의 영향

손미주,한재경,김윤희,Son, Mi-Ju,Han, Jae-Kyung,Kim, Yun-Hee 대한한방소아과학회 2011 대한한방소아과학회지 Vol.25 No.1

Objectives: SaengRyoSaMulTang is a herbal formula in Oriental Medicine, known anti-allergens. However, its mechanism and cellular targets have not been found yet. Thus the study has developed to investigate the suppressive effect of SaengRyoSaMulTang. Methods: In the study, cellular viability, IL-4, IL-13 mRNA expression, IL-4, IL-13 production, manifestations of GATA-1, GATA-2, NF-AT1, NF-AT2, AP-1 and NF-${\kappa}$B p65 transcription factors were examined by Real-Time PCR, ELISA analysis and western blotting. Results: As a result of treating with SaengRyoSaMulTang extract(SRSMT), the study has shown that the amount of Th2 cytokines, which include PI induced IL-4 and IL-13, plays a significant role in suppressing effect. RBL-2H3 mast cells significantly suppressed the PI-induced Th2 cytokine production including IL-4 and IL-13 in a dose dependent manner. PI-induced IL-4 and IL-13 production was significantly suppressed by SRSMT intervention. Western blot analysis of transcription factors involving IL-4 and IL-13 expression also revealed a prominent decreases of mast cell's specific transcription factors including GATA-1, GATA-2, NF-AT2, c-Jun and c-Fos, but NF-${\kappa}$B p65. Conclusions: The study suggests that the anti-allergenic activities of SRSMT may regulate the transcription factors GATA-1, GATA-2, NF-AT2, c-Jun and c-Fos inhibiting Th2 cytokines IL-4 and IL-13 in mast cells.

DNCB로 유발된 아토피 피부염 동물 모델에 대한 藿香正氣散 경구투여의 효과

손미주,이소민,박성환,김영은,정지연 대한한방안이비인후피부과학회 2019 한방안이비인후피부과학회지 Vol.32 No.2

Objectives : This study was conducted to investigate the effects of Gwakhyangjeonggi-san(GJS) on atopic dermatitis(AD) induced by 2,4-dinitrochlorobenzene(DNCB) in mice. Methods : The mice(Balb/c mice) were divided into three groups; normal Balb/c mice with oil treatment(Sham group), DNCB-induced AD mice(AD group), and GJS treated AD mice(GJS group). GJS group were orally administered GJS daily for 2 weeks. We observed changes of clinical skin severity score, the expression of thymic stromal lymphopoietin(TSLP), interleukin(IL)-4 and tumor necrosis factor(TNF)-α in skin and mast cell infiltration. Also, serum immunoglobulinE(IgE), IL-4, TNF-α and IL-6 were evaluated. Results : The clinical skin severity score of GJS group was decreased compared to AD group. In hematoxylin and eosin staining results, GJS group showed a significant reduction of epithelial skin thickness. In addition, expression of TSLP and mast cell infiltration in skin were also reduced by GJS treatment compared to those of AD group. Thus, we evaluated expression of IL-4, Th2-dependent cytokine, and TNF-α, pro-inflammatory cytokine in skin. GJS significantly reduced both IL-4 and TNF-α compared to AD mice. Moreover, levels of IgE, IL-4, TNF-α and IL-6 in plasma also significantly decreased by oral GJS treatment. Conclusion : The present study suggests that GJS can significantly reduced symptoms of AD, therefore it can be a promising candidate for anti-atopic dermatitis treatment.

황련해독탕이 비염 개선에 미치는 효과: 기초실험 연구 문헌 분석

손미주,정의민,김윤희,이동효,김성하,Son, Mi-Ju,Jerng, Ui-Min,Kim, Yun-Hee,Lee, Dong-Hyo,Kim, Sung-Ha 대한한방안이비인후피부과학회 2017 한방안이비인후피부과학회지 Vol.30 No.1

Objectives : This study aimed to assess the scientific evidence for the use of Hwanglyeonhaedok-tang, a traditional herbal formula, in the treatment of rhinitis, and prepare the basis for the investigational new drug application by analyzing the experimental studies. Methods : Ten electronic databases were searched up to December, 2016 without language limitation. Experimental studies on the anti-inflammatory and anti-allergic effects of Hwanglyeonhaedok-tang against rhinitis were included. We extracted data about study design, characteristics of intervention, outcomes, and pharmacological effects from the included studies and summarized them. Results : Eight hundred and thirty-three potentially relevant studies were identified, of which 18 experimental studies met our inclusion criteria. Of 18 included studies, 5 had conducted cell viability test, and all studies had reported that Hwanglyeonhaedok-tang was non-cytotoxic. Hwanglyeonhaedok-tang exhibits anti-inflammatory effect by regulating the inflammation-related cytokines including nitric oxide(NO), prostaglandin $E_2(PGE_2)$, interleukin-6(IL-6), and tumor necrosis $factor-{\alpha}(TNF-{\alpha})$ in vitro and in vivo. Hwanglyeonhaedok-tang exhibits anti-allergic effect by suppressing eosinophil, and histamine levels. Hwanglyeonhaedok-tang helps in the recovery of nasal mucous membrane by supressing goblet cells, heat shock protein 70, and substance P. Conclusions : This study suggests that Hwanglyeonhaedok-tang has the potential to be developed as therapeutic agent for rhinitis. Further experimental and clinical studies needed to be performed to prove the safety and efficacy.

寒熱 변증에 따른 한의 외용 치료제 비염고의 치료 효과 : 하위 그룹 분석

손미주,이동효 대한한방안이비인후피부과학회 2019 한방안이비인후피부과학회지 Vol.32 No.4

Objectives : Hwanglyeonhaedok-tang(黃連解毒湯) is a representative herbal formula with “clear heat(淸熱)” effects. The aim of this study was to evaluate the effects of Hwanglyeonhaedok-tang-based intranasal herbal ointment Biyeom-go based on the cold and heat pattern identification questionnaire(CHPIQ). Methods : We performed a subgroup analysis of the previously published prospective observational study. A total of 58 patients with rhinitis were administered Biyeom-go for 4 weeks, and its effects on the Total Nasal Symptom Score(TNSS), Mini Rhinoconjunctivitis Quality of Life Questionnaire(Mini-RQLQ) score, and nasal endoscopy index score were analyzed based on CHPIQ. Results : Among the 58 patients, the heat and non-heat patterns were shown by 39 and 19 patients, respectively, while the cold and non-cold patterns were shown by 46 and 12 patients, respectively. The change in TNSS from baseline negatively correlated with the heat pattern score(p=0.011). Improvement in TNSS was greater in the heat pattern group than in the non-heat pattern group, with a borderline significant difference(p=0.07). Mini-RQLQ and nasal endoscopy index scores tended to be lower in the heat pattern group than in the non-heat pattern group, but without a statistically significant difference. Conclusion : The findings indicate that CHPIQ is a useful tool for the diagnostic and prognostic evaluation of patients with rhinitis. This study provides fundamental evidence of the close association between the cold-heat pattern in patients with rhinitis and the treatment effects of Biyeom-go.

한의사들이 원하는 한의학 지식체계에 대한 고찰

손미주,김우영,정의민,박황진,한창현,Son, Mi-Ju,Kim, Wu-Young,Jerng, Ui-Min,Park, Hwang-Jin,Han, Chang-Hyun 대한예방한의학회 2012 대한예방한의학회지 Vol.16 No.3

Objectives : This study was carried out to know the status of clinical utilization of Korean medical knowledge and the Korean medical knowledge system which Korean medical doctors want. Methods : Questionnaires were distributed to Korean medical doctors registered for the Association of Korean medicine via the email and 249 answered questionnaires were analyzed. Results : 50.6 % of Korean medical doctors utilized the textbooks for Korean medicine when they treated their patients. The reason why they did not utilize the textbooks for Korean medicine was mostly that 'it could not be applied directly into clinical application with only contents of textbook because clinical approach (diagnosis and treatment methods) was not clearly described in the textbook'. 48.6 % of Korean medical doctors utilized the EBM materials when they treated their patients. EBM materials that they referred included domestic articles, other EBM materials excluding papers and international academic papers based on PubMed in order. The reasons why they did not utilize the EBM materials were mostly that 'it was difficult to find the evidence' and 'EBM materials were not actually helpful for the clinical practice.' It was found that Korean medical doctors approached the disease in aspects of Korean and Western Medicine concurrently upon the diagnosis of patients and performed the diagnosis and treatment of Korean medicine on the diseases which seemed to be effective with Korean medicine. It was also found that they thought that they needed to know the Western medical knowledge as much as general doctors who have a doctor's license or family medicine specialists who comprehensively treat the general diseases know. Korean medical doctors wanted to have the systematic summary of modern research performance in fields of acupoint, acupuncture, herbal drugs and formula. They thought that constitutional medicine and Sa-am acupuncture therapy were representative characteristics in Korean medicine differentiated from Traditional Chinese medicine and Kampo medicine. Conclusions : Korean medical doctors wanted to establish the Korean medical knowledge system based on evidence focusing on clinical and practical contents. New Korean medical knowledge system should be established based on these requirements in the future.

식간(食癎)으로 진단된 간질(癎疾) 환아(患兒) 2예(2例)에 대한 증례보고(證例報告)

손미주,한재경,김윤희,Son, Mi-Ju,Han, Jae-Kyung,Kim, Yun-Hee 대한한방소아과학회 2010 대한한방소아과학회지 Vol.24 No.2

Objectives The purpose of this study is to report two cases of epileptic children who were diagnosed as Sik-Gan(食癎) and were treated by oriental medical treatment. Methods We diagnosed the patients as Sik-Gan(食癎) and treated them with herbal medicine, acupuncture, moxa and oriental physical therapy. We observed the improvement of patient's disease by checking seizure frequency and clinical progression of gastrointestinal symptoms. Results Oriental medical treatment reduced patients' the number of seizures, and improved gastrointestinal symptoms. Conclusions This study showed that the oriental medicine can be a meaningful treatment for epileptic children who were diagnosed as Sik-Gan(食癎), but more relevant studies on epileptic children diagnosed as Sik-Gan(食癎) are needed.

허약아 증상연구를 통하여 본 학교생활 부적응의 한의학적 접근

손미주,한재경,김윤희,Son, Mi-Ju,Han, Jae-Kyung,Kim, Yun-Hee 대한한방소아과학회 2009 대한한방소아과학회지 Vol.23 No.3

Objectives This study is designed to evaluate the relationship between school life maladjustment and oriental medicine by diagnostic procedure based on the symptoms of weak children. Methods The questionnaire administrated to 130 fifth grade elementary school students in Daejeon was analyzed. Results 1. Comparing and analyzing different sexes in terms of school adjustment grades, girls were more adaptable than boys. 2. Weak score didn't show significant difference in sex and in the school adjustment 3. Based on the relationship between a group normal children and a group of children with weak lung, normal children group was more adaptable than group of children with weak lung. Conclusions School life maladjustment should be investigated as a new field of oriental medical treatment and further study needs to be done.

한의원 중심 알레르기 비염 개원의중심연구망 구축 사례 보고: 장벽 및 해결방안

손미주 한약정보연구회 2023 한약정보연구회지 Vol.11 No.1

This study aimed to describe the process of building an allergic rhinitis practice-based research network (PBRN) in Korean Medicine clinics, identify barriers, and propose solutions for future PBRN studies. The PBRN study was designed to evaluate the therapeutic effects of “decoction forms of herbal medicine,” which are difficult to study through clinical trials in South Korea. Based on the research experience of this study, seven solutions were proposed. It is necessary to develop a plan for KM doctors to increase their understanding of research, collect comprehensive endpoint data, and set widely applicable study designs. There is also a need to create mandatory research monitoring plans and foster networking among PBRN participants. Before participating in the study, rehearsal programs for new KM doctors and close relationships between primary care doctors and researchers will help ensure a successful PBRN clinical study. PBRNs can be an effective platform for providing KM clinical data and a source of KM big data. Given the growing demand for evidence-based practices in KM, clinical studies conducted in KM clinics are likely to be actively pursued in the future.